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    Systems and methods for extending the useful life of optical sensors
    4.
    发明授权
    Systems and methods for extending the useful life of optical sensors 有权
    延长光学传感器使用寿命的系统和方法

    公开(公告)号：US08502167B2

    公开(公告)日：2013-08-06

    申请号：US12123087

    申请日：2008-05-19

    申请人： Arthur Earl Colvin, Jr. ,  Jeffery C. Lesho ,  Carrie R. Lorenz

    发明人： Arthur Earl Colvin, Jr. ,  Jeffery C. Lesho ,  Carrie R. Lorenz

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6428 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B2560/0209

    摘要： The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.

    摘要翻译： 本发明提供了一种增加光学传感器寿命的方法。 一方面，该方法包括配置光学传感器的步骤，使得传感器的辐射源的占空比在传感器周期性地获得关于分析物的数据的连续时间量的时间内小于100％。 通过根据上述发明方法操作传感器，在需要传感器提供关于物质的存在或浓度的数据的整个连续时间段期间，光学传感器的指示剂分子不被激发。 因此，该方法增加指示剂分子的寿命。

    Non-covalent immobilization of indicator molecules
    6.
    发明授权
    Non-covalent immobilization of indicator molecules 有权
    指示剂分子的非共价固定化

    公开(公告)号：US07713745B2

    公开(公告)日：2010-05-11

    申请号：US10822670

    申请日：2004-04-13

    申请人： Arthur E. Colvin, Jr. ,  Carrie R. Lorenz

    发明人： Arthur E. Colvin, Jr. ,  Carrie R. Lorenz

    IPC分类号： G01N21/63 ,  G01N21/64

    CPC分类号： G01N31/22 ,  A61B5/0071 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14735

    摘要： The invention relates to immobilization methods, in particular for immobilizing indicator molecules on supports such as sensors and to sensors having those molecules immobilized to their surface. Non-covalent immobilization of macromolecular indicator molecules on those supports via mechanical interlacing with polymers at the surface of a support and via ionic bonding via charged moieties of indicator molecules and ionic groups on the surface of the support are disclosed.

    摘要翻译： 本发明涉及固定化方法，特别是用于将指示剂分子固定在诸如传感器的载体上，以及将具有固定在其表面上的那些分子的传感器。 公开了通过在载体的表面与聚合物的机械交织，通过在载体表面上的指示剂分子和离子基团的带电部分经由离子键合，将大分子指示剂分子非共价固定在这些载体上。

    Systems and methods for extending the useful life of optical sensors
    8.
    发明授权
    Systems and methods for extending the useful life of optical sensors 有权
    延长光学传感器使用寿命的系统和方法

    公开(公告)号：US07375347B2

    公开(公告)日：2008-05-20

    申请号：US10831346

    申请日：2004-04-26

    申请人： Arthur Earl Colvin, Jr. ,  Jeffery C. Lesho ,  Carrie R. Lorenz

    发明人： Arthur Earl Colvin, Jr. ,  Jeffery C. Lesho ,  Carrie R. Lorenz

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6428 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B2560/0209

    摘要： The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.

    摘要翻译： 本发明提供了一种增加光学传感器寿命的方法。 一方面，该方法包括配置光学传感器的步骤，使得传感器的辐射源的占空比在传感器周期性地获得关于分析物的数据的连续时间量的时间内小于100％。 通过根据上述发明方法操作传感器，在需要传感器提供关于物质的存在或浓度的数据的整个连续时间段期间，光学传感器的指示剂分子不被激发。 因此，该方法增加指示剂分子的寿命。

    SYSTEMS AND METHODS FOR EXTENDING THE USEFUL LIFE OF OPTICAL SENSORS
    10.
    发明申请
    SYSTEMS AND METHODS FOR EXTENDING THE USEFUL LIFE OF OPTICAL SENSORS 有权
    扩展光传感器有效寿命的系统和方法

    公开(公告)号：US20090146078A1

    公开(公告)日：2009-06-11

    申请号：US12123087

    申请日：2008-05-19

    申请人： Arthur Earl Colvin, JR. ,  Jeffery C. Lesho ,  Carrie R. Lorenz

    发明人： Arthur Earl Colvin, JR. ,  Jeffery C. Lesho ,  Carrie R. Lorenz

    IPC分类号： G01J1/58

    CPC分类号： G01N21/6428 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B2560/0209

    摘要： The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.

    摘要翻译： 本发明提供了一种增加光学传感器寿命的方法。 一方面，该方法包括配置光学传感器的步骤，使得传感器的辐射源的占空比在传感器周期性地获得关于分析物的数据的连续时间量的时间内小于100％。 通过根据上述发明方法操作传感器，在需要传感器提供关于物质的存在或浓度的数据的整个连续时间段期间，光学传感器的指示剂分子不被激发。 因此，该方法增加指示剂分子的寿命。