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    Optical-based sensing devices
    5.
    发明授权
    Optical-based sensing devices 有权
    光传感器

    公开(公告)号：US06330464B1

    公开(公告)日：2001-12-11

    申请号：US09383148

    申请日：1999-08-26

    申请人： Arthur E. Colvin, Jr. ,  Gregory A. Dale ,  Paul Samuel Zerwekh ,  Jeffery C. Lesho ,  Robert W. Lynn

    发明人： Arthur E. Colvin, Jr. ,  Gregory A. Dale ,  Paul Samuel Zerwekh ,  Jeffery C. Lesho ,  Robert W. Lynn

    IPC分类号： A61B500

    CPC分类号： A61B5/076 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6861 ,  A61B2560/0219 ,  A61B2562/12 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y10S128/903

    摘要： An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

    摘要翻译： 一种光学传感器，用于使用指示器和参考通道来检测分析物的存在或量。 该传感器具有一个传感器体，其中嵌有辐射源。 源发射的辐射与靠近身体表面的指示剂膜指示剂分子相互作用。 这些指示剂分子的至少一种光学特性随分析物浓度而变化。 例如，荧光指示剂分子的荧光水平或光吸收指示剂分子吸收的光量可以作为分析物浓度的函数而变化。 此外，源发射的辐射也与靠近身体表面的参考膜指示剂分子相互作用。 由这些指示剂分子发射或反射的辐射（例如，光）进入并在内部反射在传感器主体中。 传感器体内的感光元件产生指示通道和参考通道信号，以提供分析物浓度的准确指示。 优选的实施方案是完全独立的并且其尺寸和形状用于人体内的体内。 这样的实施例优选地包括电源，例如电源。 电感器，其使用外部装置为辐射源供电，以及发射器，例如， 电感器，用于向外部拾取装置传输表示分析物水平的信号。

    Non-covalent immobilization of indicator molecules
    6.
    发明授权
    Non-covalent immobilization of indicator molecules 有权
    指示剂分子的非共价固定化

    公开(公告)号：US07713745B2

    公开(公告)日：2010-05-11

    申请号：US10822670

    申请日：2004-04-13

    申请人： Arthur E. Colvin, Jr. ,  Carrie R. Lorenz

    发明人： Arthur E. Colvin, Jr. ,  Carrie R. Lorenz

    IPC分类号： G01N21/63 ,  G01N21/64

    CPC分类号： G01N31/22 ,  A61B5/0071 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14735

    摘要： The invention relates to immobilization methods, in particular for immobilizing indicator molecules on supports such as sensors and to sensors having those molecules immobilized to their surface. Non-covalent immobilization of macromolecular indicator molecules on those supports via mechanical interlacing with polymers at the surface of a support and via ionic bonding via charged moieties of indicator molecules and ionic groups on the surface of the support are disclosed.

    摘要翻译： 本发明涉及固定化方法，特别是用于将指示剂分子固定在诸如传感器的载体上，以及将具有固定在其表面上的那些分子的传感器。 公开了通过在载体的表面与聚合物的机械交织，通过在载体表面上的指示剂分子和离子基团的带电部分经由离子键合，将大分子指示剂分子非共价固定在这些载体上。

    Optical-based sensing devices
    8.
    发明授权
    Optical-based sensing devices 有权
    光传感器

    公开(公告)号：US07822450B2

    公开(公告)日：2010-10-26

    申请号：US11953166

    申请日：2007-12-10

    申请人： Arthur E. Colvin, Jr. ,  Casey J. O'Connor ,  Andrew D. DeHennis

    发明人： Arthur E. Colvin, Jr. ,  Casey J. O'Connor ,  Andrew D. DeHennis

    IPC分类号： A61B5/145

    CPC分类号： G01N21/645 ,  A61B5/0031 ,  A61B5/0084 ,  A61B5/07 ,  A61B5/6861 ,  A61B2560/0219 ,  G01N21/77 ,  G01N2021/7786

    摘要： The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.

    摘要翻译： 本发明提供一种用于检测分析物的存在或浓度的电光检测装置。 更具体地说，本发明涉及（但不是在所有情况下都必须限于）光学感测装置，其特征在于是完全独立的，具有平滑和圆形的长圆形，椭圆形或椭圆形（例如，豆 - 或药物胶囊形状）和允许将装置植入人体以便各种分析物的原位检测的尺寸。

    High performance fluorescent optical sensor
    9.
    发明授权
    High performance fluorescent optical sensor 有权
    高性能荧光光学传感器

    公开(公告)号：US07190445B2

    公开(公告)日：2007-03-13

    申请号：US11165129

    申请日：2005-06-24

    申请人： Arthur E. Colvin, Jr. ,  Steven J. Walters

    发明人： Arthur E. Colvin, Jr. ,  Steven J. Walters

    IPC分类号： G01J1/42 ,  G01N21/01

    CPC分类号： G01N21/645 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2201/0642

    摘要： An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.

    摘要翻译： 用于确定分析物的存在或浓度的光学传感器装置包含设置在光源上的波导和安装在基板的表面上并由内部挡板隔开的光检测器，其中波导具有对应于远的 由光源和光检测器之间的遮光挡板确定的光源的场发射点。 分析物指示矩阵设置在波导的外表面上。 传感器装置的几何形状仅利用指示矩阵的直接照明，并且直接收集指示矩阵照明，而不会被所述波导的任何明显的反射。 由光源产生的不良光线噪声通过波导直接从器件中流出。

    High performance fluorescent optical sensor
    10.
    发明授权
    High performance fluorescent optical sensor 有权
    高性能荧光光学传感器

    公开(公告)号：US06940590B2

    公开(公告)日：2005-09-06

    申请号：US10316188

    申请日：2002-12-11

    申请人： Arthur E. Colvin, Jr. ,  Steven J. Walters

    发明人： Arthur E. Colvin, Jr. ,  Steven J. Walters

    IPC分类号： G01N21/64 ,  G01N21/77 ,  G01J1/42 ,  G01N21/01

    CPC分类号： G01N21/645 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2201/0642

    摘要： An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.

    摘要翻译： 用于确定分析物的存在或浓度的光学传感器装置包含设置在光源上的波导和安装在基板的表面上并由内部挡板隔开的光检测器，其中波导具有对应于远的 由光源和光检测器之间的遮光挡板确定的光源的场发射点。 分析物指示矩阵设置在波导的外表面上。 传感器装置的几何形状仅利用指示矩阵的直接照明，并且直接收集指示矩阵照明，而不会被所述波导的任何明显的反射。 由光源产生的不良光线噪声通过波导直接从器件中流出。