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    Treatment for otitis externa
    1.
    发明授权
    Treatment for otitis externa 有权
    外耳炎治疗

    公开(公告)号：US07950396B2

    公开(公告)日：2011-05-31

    申请号：US11741604

    申请日：2007-04-27

    Applicant: Andreas Rose ,  Nicholas G. Loebel ,  Cale Street ,  Roger Andersen

    Inventor： Andreas Rose ,  Nicholas G. Loebel ,  Cale Street ,  Roger Andersen

    IPC: A61B19/00

    CPC classification number: A61N5/0603 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0605 ,  A61N2005/0607 ,  A61N2005/0644 ,  A61N2005/0645 ,  A61N2005/0662

    Abstract: The present invention presents devices, kits, systems and methods that can be used to otitis externa. For example, a method of present invention includes applying a photosensitizing composition to treatment site within ear cavity where microbes causing otitis externa are located; inserting at least a portion of a light delivery device into the cavity; and applying light to the treatment site at a wavelength absorbed by the photosensitizing composition so as to inhibit or eliminate the microbes and/or to reduce inflammation at the treatment site but without causing physiological damage to host tissue within the ear cavity; wherein the light is delivered by the light delivery device to the treatment site and the light delivery device is in light communication with a light source via a waveguide.

    Abstract translation: 本发明提供了可用于外耳炎的装置，试剂盒，系统和方法。 例如，本发明的方法包括将光敏组合物施用于引起耳外耳道微生物的耳腔内的治疗部位; 将光输送装置的至少一部分插入空腔中; 以光吸收组合物吸收的波长向处理部位施加光，以抑制或消除微生物和/或减少治疗部位的炎症，但不会对耳腔内的宿主组织造成生理损伤; 其中所述光被所述光输送装置输送到所述处理部位，并且所述光输送装置经由波导与光源光连通。

    Therapy and device for treatment of nail infections
    2.
    发明申请
    Therapy and device for treatment of nail infections 审中-公开
    治疗和治疗指甲感染的装置

    公开(公告)号：US20090234270A1

    公开(公告)日：2009-09-17

    申请号：US12075393

    申请日：2008-03-11

    Applicant: Nicholas G. Loebel ,  Fergus R. McKenzie ,  Cale Street ,  Roger Andersen ,  Robert Scott

    Inventor： Nicholas G. Loebel ,  Fergus R. McKenzie ,  Cale Street ,  Roger Andersen ,  Robert Scott

    IPC: A61N1/30

    CPC classification number: A61K31/125 ,  A61B18/14 ,  A61B2018/00452 ,  A61B2018/00577 ,  A61K31/045 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0645 ,  A61N2005/0652

    Abstract: The present invention includes a method for treating fungal infections, particularly onychomycosis. The method includes: applying a composition includes a photosensitizer, an effective amount of antifungal agent, and a pharmaceutically acceptable delivery system to a locus and irradiating the locus with a light source at a wavelength absorbed by the photosensitizer so as to destroy microbes at the locus. The present invention also includes a light delivery device for use in photodynamic treatment of onychomycosis comprising (i) a housing adapted to cover a nail beneath which a locus is situated; (ii) a light source; (iii) an energy source in power communication to the light source; and a controller that controls amount of light to be applied to the locus by the light source.

    Abstract translation: 本发明包括一种治疗真菌感染，特别是甲真菌病的方法。 该方法包括：施用组合物包括光敏剂，有效量的抗真菌剂和药学上可接受的递送系统到一个场所，并用光敏元件吸收的波长的光源照射该场所，从而破坏该位点处的微生物 。 本发明还包括用于光动力治疗甲真菌病的光输送装置，其包括（i）适于覆盖位于其下的指甲的壳体; （ii）光源; （iii）与光源的电力通信中的能量源; 以及控制器，其控制由光源施加到轨迹的光量。

    METHOD AND DEVICE FOR ELIMINATING MICROBES WITHIN INDUSTRIAL PIPELINES
    3.
    发明申请
    METHOD AND DEVICE FOR ELIMINATING MICROBES WITHIN INDUSTRIAL PIPELINES 审中-公开
    用于消除工业管道中微生物的方法和装置

    公开(公告)号：US20090317293A1

    公开(公告)日：2009-12-24

    申请号：US12431991

    申请日：2009-04-29

    Applicant: Cale Street ,  Joe Ridge ,  Nicolas Loebel ,  Roger Andersen

    Inventor： Cale Street ,  Joe Ridge ,  Nicolas Loebel ,  Roger Andersen

    IPC: A61L2/18 ,  A61L2/02

    CPC classification number: A61L2/084 ,  A61L2/18 ,  B08B9/0553

    Abstract: The present invention provides a method to inhibit microbes located within a pipeline comprising: applying a photosensitizer composition to a predetermined interior surface area of the pipeline where microbes are located; and applying light to the area at a wavelength that is absorbed by the photosensitizer composition so as to inhibit or eliminate the microbes; wherein the light is applied by a photodynamic disinfection device adapted to provide light to the area. The present invention also provided a photodynamic disinfection device comprising a pipeline inspection gauge (pig) adapted to include a circumferential high energy light source and an energy source wherein the light source is in communication with and powered by the energy source via communication means.

    Abstract translation: 本发明提供一种抑制位于管线内的微生物的方法，包括：将光敏剂组合物施用到微生物所在管道的预定内表面区域; 以及在由所述光敏剂组合物吸收的波长处向所述区域施加光，以抑制或消除所述微生物; 其中所述光通过适于向所述区域提供光的光动力消毒装置施加。 本发明还提供了一种光动力消毒装置，其包括适于包括周向高能光源和能量源的管线检查计（pig），其中光源通过通信装置与能源通信并由其供电。

    TREATMENT FOR OTITIS EXTERNA
    4.
    发明申请
    TREATMENT FOR OTITIS EXTERNA 有权
    OTITIS EXTERNA治疗

    公开(公告)号：US20080119914A1

    公开(公告)日：2008-05-22

    申请号：US11741604

    申请日：2007-04-27

    Applicant: Andreas Rose ,  Nicolas G. Loebel ,  Guenter Herr ,  Kyle Johnston ,  Cale Street ,  Roger Andersen

    Inventor： Andreas Rose ,  Nicolas G. Loebel ,  Guenter Herr ,  Kyle Johnston ,  Cale Street ,  Roger Andersen

    IPC: A61N5/06

    CPC classification number: A61N5/0603 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0605 ,  A61N2005/0607 ,  A61N2005/0644 ,  A61N2005/0645 ,  A61N2005/0662

    Abstract: The present invention presents devices, kits, systems and methods that can be used to otitis externa. For example, a method of present invention includes applying a photosensitizing composition to treatment site within ear cavity where microbes causing otitis externa are located; inserting at least a portion of a light delivery device into the cavity; and applying light to the treatment site at a wavelength absorbed by the photosensitizing composition so as to inhibit or eliminate the microbes and/or to reduce inflammation at the treatment site but without causing physiological damage to host tissue within the ear cavity; wherein the light is delivered by the light delivery device to the treatment site and the light delivery device is in light communication with a light source via a waveguide.

    Abstract translation: 本发明提供了可用于外耳炎的装置，试剂盒，系统和方法。 例如，本发明的方法包括将光敏组合物施用于引起耳外耳道微生物的耳腔内的治疗部位; 将光输送装置的至少一部分插入空腔中; 并以由光敏组合物吸收的波长对处理部位施加光，以抑制或消除微生物和/或减少治疗部位的炎症，但不会对耳腔内的宿主组织造成生理损伤; 其中所述光被所述光输送装置输送到所述处理部位，并且所述光输送装置经由波导与光源光连通。

    METHODS TO PREVENT VERTICAL TRANSMISSION OF INFECTIOUS DISEASES
    6.
    发明申请
    METHODS TO PREVENT VERTICAL TRANSMISSION OF INFECTIOUS DISEASES 审中-公开
    方法预防感染性疾病的垂直传播

    公开(公告)号：US20080269205A1

    公开(公告)日：2008-10-30

    申请号：US11877212

    申请日：2007-10-23

    Applicant: Nicolas G. Loebel ,  Roger Andersen

    Inventor： Nicolas G. Loebel ,  Roger Andersen

    IPC: A61K31/5415 ,  A61P31/12

    CPC classification number: A61N5/0624 ,  A61N5/0601 ,  A61N5/062

    Abstract: The present invention presents a method of preventing vertical transmission of an infectious disease comprising: (a) applying a photosensitizing composition to host tissues of birth canal of a mother during the intrapartum period; and (b) applying light to the host tissues after the step (a) at a wavelength absorbed by the photosensitizing composition so as to inhibit or eliminate infectious disease microorganisms that come into contact with the host tissues. The infectious disease may be caused by human immunodeficiency virus type 1, hepatitis B virus, hepatitis C virus, Group B Streptococcus, cytomegalovirus, Listeria monocytogenes, Chiamydia trachomatis, Escherichia coli, herpes simplex virus, Epstein-Barr virus, Toxoplasma gondii, human papilloma virus, and Candida.

    Abstract translation: 本发明提供一种防止感染性疾病的垂直传播的方法，包括：（a）在产品期间将感光组合物施用于母亲的产道组织; 和（b）在步骤（a）之后以由光敏组合物吸收的波长向宿主组织照射光，以便抑制或消除与宿主组织接触的感染性疾病微生物。 感染性疾病可能是由人类免疫缺陷病毒1型，乙型肝炎病毒，丙型肝炎病毒，B组链球菌，巨细胞病毒，单核细胞增多性李斯特菌，沙眼衣原体，大肠杆菌，单纯疱疹病毒，爱泼斯坦 - 巴尔病毒，弓形虫，人乳头状瘤 病毒和念珠菌。

    NASAL DECOLONIZATION OF MICROBES
    7.
    发明申请
    NASAL DECOLONIZATION OF MICROBES 审中-公开
    微生物的NASAL分解

    公开(公告)号：US20070255357A1

    公开(公告)日：2007-11-01

    申请号：US11741627

    申请日：2007-04-27

    Applicant: Andreas Rose ,  Nicolas G. Loebel ,  Guenter Herr ,  Kyle Johnston ,  Cale Street ,  Roger Andersen

    Inventor： Andreas Rose ,  Nicolas G. Loebel ,  Guenter Herr ,  Kyle Johnston ,  Cale Street ,  Roger Andersen

    IPC: A61N5/06

    CPC classification number: A61N5/0603 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0605 ,  A61N2005/0607 ,  A61N2005/0644 ,  A61N2005/0645 ,  A61N2005/0662

    Abstract: The present invention presents devices, kits, systems and methods that can be used for nasal decolonization of microbes and treatment of MRSA, E. coli, and E. fecalis. For example, it includes a method for nasal decolonization of microbes comprising: applying a photosensitizing composition comprising methylene blue to anterior nares; inserting at least a portion of a light delivery device into the nasal cavity; and applying light to the anterior nares at a wavelength ranges from about 650 nm to 680 nm; wherein the light is delivered by the light delivery device to the anterior nares; the light delivery device is in light communication with a light source via a waveguide; and over 90% of the microbes at the anterior nares is eliminated by the nasal decolonization.

    Abstract translation: 本发明提供了可用于微生物鼻非殖民化和MRSA，大肠杆菌和E.粪便的治疗的装置，试剂盒，系统和方法。 例如，它包括一种用于微生物鼻腔非殖民化的方法，包括：将包含亚甲蓝的光敏组合物施用于前鼻孔; 将光输送装置的至少一部分插入鼻腔中; 并在约650nm至680nm的波长范围内向前鼻孔施加光; 其中所述光由所述光输送装置输送到所述前鼻孔; 光输送装置经由波导与光源光连通; 前鼻孔的超过90％的微生物被鼻非殖民化所消除。

    Method of reducing odor associated with hexanal production in plant products
    8.
    发明授权
    Method of reducing odor associated with hexanal production in plant products 失效
    降低与植物产品中己醛生产有关的气味的方法

    公开(公告)号：US5017386A

    公开(公告)日：1991-05-21

    申请号：US416674

    申请日：1989-10-05

    Applicant: David F. Hildebrand ,  Thomas R. Kemp ,  Roger Andersen ,  John H. Loughrin

    Inventor： David F. Hildebrand ,  Thomas R. Kemp ,  Roger Andersen ,  John H. Loughrin

    IPC: A21D2/36 ,  A23L5/20

    CPC classification number: C12Y113/11012 ,  A21D2/362 ,  A23L5/25

    Abstract: A method of reducing the formation of hexanal by plant parts comprises breaking the plant parts, adding thereto an agent comprising lipoxygenase 3 enzyme and allowing the plant parts to remain in contact with the enzyme under conditions effective to attain the desired effect. A method of producing a low odor plant part meal or flour comprises breaking up the plant parts, adding an agent with lipoxygenase 3 enzyme and allowing the plant parts to remain in contact with the enzyme under conditions effective to attain the desired effect. An improved composition comprises a hexanal producing plant part meal or flour and an agent with lipoxygenase 3 enzyme which is substantially devoid of lipoxygenase enzyme 1 and 2 activities, optionally with other edible ingredients such as other low-hexanal producing flours. Improved edible products are produced using the invention which have less objectionable odor and flavor. This invention facilitates better tailoring of the flavor of food products to the desires of the consumers.

    Abstract translation: 通过植物部分减少己醛形成的方法包括破坏植物部分，向其中加入包含脂氧合酶3酶的试剂，并允许植物部分在有效达到所需效果的条件下与酶保持接触。 生产低气味植物部分膳食或面粉的方法包括分解植物部分，加入具有脂氧合酶3酶的试剂，并允许植物部分在有效达到所需效果的条件下与酶保持接触。 一种改进的组合物包含己产生的植物部分膳食或面粉和具有基本上不含脂氧合酶1和2活性的脂氧合酶3酶的试剂，任选地与其它可食用成分如其他低生产的产生的面粉一起使用。 使用具有较少令人讨厌的气味和风味的本发明生产改良的食用产品。 本发明有助于根据消费者的欲望更好地定制食品的风味。

    METHOD OF SINUSITIS TREATMENT
    9.
    发明申请
    METHOD OF SINUSITIS TREATMENT 审中-公开
    神经细胞治疗方法

    公开(公告)号：US20150142046A1

    公开(公告)日：2015-05-21

    申请号：US14543065

    申请日：2014-11-17

    Applicant: Roger Andersen ,  Martin Yvon Desrosiers ,  Nicolas Loebel ,  Sinuwave Technologies, Inc.

    Inventor： Roger Andersen ,  Martin Yvon Desrosiers ,  Nicolas Loebel

    IPC: A61M25/10

    CPC classification number: A61M25/10 ,  A61B17/24 ,  A61M2025/105 ,  A61M2025/107 ,  A61M2025/1084 ,  A61M2202/0014 ,  A61M2202/20 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2210/0618 ,  A61M2210/0681 ,  A61M2210/1089

    Abstract: The present invention provides a method to treat sinusitis, a method for improved medication delivery to the sinus mucosa, and a method for staunching bleeding of the sinus mucosa comprising of comprising compressing sinus mucosa of a sinus of a patient against bone tissue of the sinus to a predetermined level without damaging the bone tissue. The present invention further provides a method to treat nasal polyposis comprising compressing nasal polyps contained within the nasal cavity against its lining to reduce volume of the nasal polyps. The present invention provides a method to treat chronic urethral syndrome comprising compressing interior surfaces of an urethra in order to stimulate and cause excretion out of urethral mucosa located along length of the urethra. The present invention further provides additional methods relating to drug delivery and visualization.

    Abstract translation: 本发明提供了一种治疗鼻窦炎的方法，改善向鼻窦粘膜的药物输送的方法，以及用于猝死窦粘膜出血的方法，包括将患者窦的窦粘膜压制成窦的骨组织， 预定水平而不破坏骨组织。 本发明还提供一种治疗鼻息肉病的方法，其包括将鼻腔内包含的鼻息肉压在其内衬上以减少鼻息肉的体积。 本发明提供了一种治疗慢性尿道综合症的方法，其包括压缩尿道的内表面，以便刺激尿道粘膜并从尿道的长度排出。 本发明还提供了与药物递送和可视化有关的其它方法。

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