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公开(公告)号：US07276474B2
公开(公告)日：2007-10-02
申请号：US10823218
申请日：2004-04-13
IPC分类号： A61K38/16
CPC分类号： C07K7/06 , A61L27/34 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C07K5/0817 , C07K5/1019 , C08B37/0021 , C08F8/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages. The hydrophilic side chain is selected from the group consisting of: a neutral oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged oligosaccharide, preferably a negatively charged oligosaccharide having a weight average molecular weight of less than 10,000; an oligopeptide of from about 3 to about 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a biomaterial are also provided.
摘要翻译： 提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。 这种表面活性剂聚合物包括具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团连接到所述主链的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链 。 疏水侧链包括含有2至18个亚甲基的烷基。 烷基通过酯键，仲胺键或优选酰胺键与聚合物主链相连。 亲水侧链选自：中性寡糖，其优选具有小于7000的重均分子量; 带电荷的寡糖，优选具有小于10,000的重均分子量的带负电荷的寡糖; 所述寡肽具有约3至约30个氨基酸残基的寡肽，所述寡肽具有与细胞表面上的蛋白受体相互作用的氨基酸序列; 及其组合。 还提供了使表面活性剂聚合物和使用表面活性剂聚合物改变生物材料的表面性质的方法。
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2.发明授权Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants 失效用于生产羟化等离子体聚合膜的方法以及用于增强生物医学植入物的兼容性的膜的使用
公开(公告)号：US5112457A
公开(公告)日：1992-05-12
申请号：US556740
申请日：1990-07-23
申请人： Roger E. Marchant
发明人： Roger E. Marchant
CPC分类号： A61L33/0088 , C08F8/04
摘要： The present invention is directed to a process for synthesizing hydroxylated plasma-polymerized films, as well as the hydroxylated plasma-polymerized films produced by the process of the invention. In addition, the present invention is directed to the use of hydroxylated plasma-polymerized films produced by the process of the invention for enhancing the compatibility and/or implantability of biomedical implants and/or devices.
摘要翻译： 本发明涉及一种合成羟基化等离子体聚合膜以及通过本发明方法制备的羟基化等离子体聚合膜的方法。 此外，本发明涉及通过本发明的方法制备的羟基化等离子体聚合膜用于增强生物医学植入物和/或装置的相容性和/或可植入性的用途。
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公开(公告)号：US20080262614A1
公开(公告)日：2008-10-23
申请号：US12062768
申请日：2008-04-04
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C08B37/0021 , C08B37/0078 , C08F8/00 , C08L101/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.
摘要翻译： 提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。 这种表面活性剂聚合物包含具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团与主链连接的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链 。 还提供了涂有表面活性剂聚合物的医疗装置。 表面活性剂聚合物可用于降低医疗装置的血栓形成性质，包封和细菌定植。
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公开(公告)号：US5741852A
公开(公告)日：1998-04-21
申请号：US254492
申请日：1994-06-06
CPC分类号： C08B37/0075 , A61L33/0029 , A61L33/08 , C08B37/0021 , C08B37/0063 , C08B37/0069 , Y10S525/937
摘要： Triblock polymers comprised of polysaccharide, such as heparin or dextran, and a hydrocarbon chain, have been prepared. The triblock polymer adsorbs strongly on the surface of hydrophobic polymer substrates such as polyethylene, through hydrophobic interaction between the polymer and the hydrophobic hydrocarbon chain of the triblock polymer. The surface adsorbed with triblock polymer is resistant to protein deposition, which renders the surface nonthrombogenic.
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公开(公告)号：US5455040A
公开(公告)日：1995-10-03
申请号：US978205
申请日：1992-11-19
申请人： Roger E. Marchant
发明人： Roger E. Marchant
CPC分类号： A61L33/0094 , A61L33/0029 , Y10S514/822
摘要： The present invention provides a method for surface modifying a substrate, such as an implant, to provide the substrate with anticoagulant activity and resistance to the deposition of plasma proteins; and the resulting substrate. The surface of the substrate is modified by first depositing a film of a plasma polymer such as plasma polymerized N-vinyl-2-pyrrolidone or allyl alochol on the surface of the substrate. Optionally, a neutral hydrophilic spacer molecule is attached to the plasma polymer. An anticoagulant, such as heparin, is attatched either directly to the substrate or indirectly to the substrate via attatchment to the spacer molecule, when such spacer molecule is present.
摘要翻译： 本发明提供了一种用于表面改性诸如植入物的底物以提供底物抗凝血活性和抵抗血浆蛋白沉积的方法; 和所得到的底物。 通过首先将等离子体聚合物膜（例如等离子体聚合的N-乙烯基-2-吡咯烷酮或烯丙基醇）沉积在基材的表面上来改性基材的表面。 任选地，中性亲水间隔分子连接到等离子体聚合物上。 当存在这种间隔分子时，抗凝血剂（例如肝素）通过粘附到间隔物分子直接被引入底物或间接地附着于底物。
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公开(公告)号：US5993890A
公开(公告)日：1999-11-30
申请号：US911786
申请日：1997-08-15
CPC分类号： C08B37/0075 , A61L33/0029 , A61L33/08 , C08B37/0021 , C08B37/0063 , C08B37/0069 , Y10S525/937
摘要： Triblock polymers comprised of polysaccharide, such as heparin or dextran, and a hydrocarbon chain, have been prepared. The triblock polymer adsorbs strongly on the surface of hydrophobic polymer substrates such as polyethylene, through hydrophobic interaction between the polymer and the hydrophobic hydrocarbon chain of the triblock polymer. The surface adsorbed with triblock polymer is resistant to protein deposition, which renders the surface nonthrombogenic.
摘要翻译： 已经制备了由多糖如肝素或葡聚糖组成的三嵌段聚合物和烃链。 三嵌段聚合物通过聚合物和三嵌段聚合物的疏水性烃链之间的疏水相互作用，强烈吸附在疏水聚合物基材如聚乙烯的表面上。 吸附三嵌段聚合物的表面对蛋白质沉积具有抗性，这使得表面不产生血栓形成。
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公开(公告)号：US06759388B1
公开(公告)日：2004-07-06
申请号：US09302195
申请日：1999-04-29
IPC分类号： B32B2700
CPC分类号： C07K7/06 , A61L27/34 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C07K5/0817 , C07K5/1019 , C08B37/0021 , C08F8/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages. The hydrophilic side chain is selected from the group consisting of: a neutral oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged oligosaccharide, preferably a negatively charged oligosaccharide having a weight average molecular weight of less than 10,000; an oligopeptide of from about 3 to about 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a biomaterial are also provided.
摘要翻译： 提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。 这种表面活性剂聚合物包括具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团连接到所述主链的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链 。 疏水侧链包括含有2至18个亚甲基的烷基。 烷基通过酯键，仲胺键或优选酰胺键与聚合物主链相连。 亲水侧链选自：中性寡糖，其优选具有小于7000的重均分子量; 带电荷的寡糖，优选具有小于10,000的重均分子量的带负电荷的寡糖; 所述寡肽具有约3至约30个氨基酸残基的寡肽，所述寡肽具有与细胞表面上的蛋白受体相互作用的氨基酸序列; 及其组合。 还提供了使表面活性剂聚合物和使用表面活性剂聚合物改变生物材料的表面性质的方法。
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公开(公告)号：US08163302B2
公开(公告)日：2012-04-24
申请号：US12062768
申请日：2008-04-04
IPC分类号： A61F2/08
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C08B37/0021 , C08B37/0078 , C08F8/00 , C08L101/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.
摘要翻译： 提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。 这种表面活性剂聚合物包含具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团与主链连接的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链 。 还提供了涂有表面活性剂聚合物的医疗装置。 表面活性剂聚合物可用于降低医疗装置的血栓形成性质，包封和细菌定植。
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公开(公告)号：US20080247988A1
公开(公告)日：2008-10-09
申请号：US11751498
申请日：2007-05-21
CPC分类号： C07K7/06 , A61L27/34 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C07K5/0817 , C07K5/1019 , C08B37/0021 , C08F8/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages. The hydrophilic side chain is selected from the group consisting of: a neutral oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged oligosaccharide, preferably a negatively charged oligosaccharide having a weight average molecular weight of less than 10,000; an oligopeptide of from about 3 to about 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a biomaterial are also provided.
摘要翻译： 提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。 这种表面活性剂聚合物包括具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团连接到所述主链的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链 。 疏水侧链包括含有2至18个亚甲基的烷基。 烷基通过酯键，仲胺键或优选酰胺键与聚合物主链相连。 亲水侧链选自：中性寡糖，其优选具有小于7000的重均分子量; 带电荷的寡糖，优选具有小于10,000的重均分子量的带负电荷的寡糖; 所述寡肽具有约3至约30个氨基酸残基的寡肽，所述寡肽具有与细胞表面上的蛋白受体相互作用的氨基酸序列; 及其组合。 还提供了使表面活性剂聚合物和使用表面活性剂聚合物改变生物材料的表面性质的方法。
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