公开(公告)号：US20180317567A1

公开(公告)日：2018-11-08

申请号：US15973473

申请日：2018-05-07

申请人： Ronald Henry Heisser

发明人： Ronald Henry Heisser

IPC分类号： A41B17/00 ,  A41B9/00 ,  A41B9/02

CPC分类号： A41B17/00 ,  A41B9/001 ,  A41B9/02 ,  A41B2300/20

摘要： An undergarment comprising at least one tubular portion, wherein the tubular portion is reinforced with stiffeners in the direction parallel to the axis of the tube, to prevent bunching when another garment is put on over the undergarment.

公开(公告)号：US20160127359A1

公开(公告)日：2016-05-05

申请号：US14530721

申请日：2014-11-01

申请人： RONALD Henry Minter ,  Edward Tomes ,  Pasteur Lutashu Banyoma Ntake ,  Rama Rama Mwikalo

发明人： RONALD Henry Minter ,  Edward Tomes ,  Pasteur Lutashu Banyoma Ntake ,  Rama Rama Mwikalo

IPC分类号： H04L29/06 ,  G06F17/30

CPC分类号： H04L63/0861 ,  G06F21/32 ,  G06K9/00892 ,  G06K9/00906 ,  H04L63/107

摘要： A system, method and a computer-readable medium for authenticating a user in a live manner in non-face-to-face transactions, including a user downloading an authentication application from a server to a pervasive computing device, and after downloading the application, having an icon residing on the display of the device. When the authentication application is activated by the user, biographical and multi-biometric information of the user is requested by the application, and subsequently submitted to an authentication engine residing in a secure network cloud. The authentication process further includes, verifying by the authentication engine all of the requested information, compliance with government regulations such as CFT/AML, and the 4th Data Protection Principle. Users have the ability to check their biographical data through a system called, RITE, forming part of this application. Memorised IDs and passwords are not required. The aliveness of the user is verified at each transaction request.

摘要翻译： 一种用于在非面对面交易中以实时方式认证用户的系统，方法和计算机可读介质，包括用户从服务器向普及计算设备下载认证应用，以及在下载所述应用之后， 具有驻留在设备的显示器上的图标。 当认证应用程序被用户激活时，应用程序请求用户的传记和多生物信息，随后提交给驻留在安全网络云中的认证引擎。 认证过程还包括认证引擎验证所有请求的信息，遵守CFT / AML等政府法规和第四种数据保护原则。 用户可以通过名为“RITE”的系统来检查他们的个人资料，构成本应用程序的一部分。 不需要记忆ID和密码。 在每个交易请求下验证用户的活力。

公开(公告)号：USD667046S1

公开(公告)日：2012-09-11

申请号：US29380780

申请日：2010-12-10

申请人： Ronald Henry Tse ,  Paula Scher

设计人： Ronald Henry Tse ,  Paula Scher

公开(公告)号：US08235372B2

公开(公告)日：2012-08-07

申请号：US12806020

申请日：2010-08-04

申请人： Ronald Henry Boucher

发明人： Ronald Henry Boucher

IPC分类号： B41L43/04

CPC分类号： B65H23/32 ,  B65H2301/4148 ,  B65H2801/21

摘要： A web guiding apparatus is provided. The web guiding apparatus includes an angle bar and an angle bar support supporting the angle bar. The angle bar support has a first end portion and a second end portion. The web guiding apparatus also includes a first actuator coupled to the angle bar support for moving the first end portion along a vertical axis and a second actuator coupled to the angle bar support for moving the second end portion along a horizontal axis. A folder for a printing press is also provided.

公开(公告)号：US20120129710A1

公开(公告)日：2012-05-24

申请号：US13165300

申请日：2011-06-21

申请人： John McCafferty ,  Anthony Richard Pope ,  Kevin Stuart Johnson ,  Hendricus Renerus Jacobus Mattheus Hoogenboom ,  Andrew David Griffiths ,  Ronald Henry Jackson ,  Kasper Philipp Holliger ,  James David Marks ,  Timothy Piers Clackson ,  David John Chiswell ,  Gregory Paul Winter ,  Timothy Peter Bonnert

发明人： John McCafferty ,  Anthony Richard Pope ,  Kevin Stuart Johnson ,  Hendricus Renerus Jacobus Mattheus Hoogenboom ,  Andrew David Griffiths ,  Ronald Henry Jackson ,  Kasper Philipp Holliger ,  James David Marks ,  Timothy Piers Clackson ,  David John Chiswell ,  Gregory Paul Winter ,  Timothy Peter Bonnert

IPC分类号： C40B30/04 ,  C12N7/01 ,  G01N33/53 ,  C12N15/63

CPC分类号： C07K16/005 ,  B01J2219/00718 ,  C07K16/00 ,  C07K16/18 ,  C07K16/26 ,  C07K16/34 ,  C07K16/40 ,  C07K16/44 ,  C07K16/462 ,  C07K16/468 ,  C07K19/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/41 ,  C07K2319/735 ,  C12N15/1037 ,  C12N15/62 ,  C12N15/73 ,  C40B40/02 ,  G01N33/53 ,  G01N33/6857 ,  Y10S530/867

摘要： A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods.

摘要翻译： 特异性结合对（sbp）的成员通过在重组宿主细胞中表达编码这种sbp成员的遗传多样性群体的DNA来鉴定，其中sbp成员以分泌重组遗传显示包（rgdp）的表面以功能形式显示 ），其含有编码sbp成员或其多肽组分的DNA，其中sbp成员或其多肽组分被表达为与rgdp的衣壳组分的融合物。 显示的sbps可以通过与补充sbp成员的亲和力来选择，并且从所选的rgdps中恢复的DNA用于表达所选择的sbp成员。 因此可以获得抗体sbp成员，其中不同的链表达，一个与衣壳组分融合，另一个与游离形式融合，用于与融合伴侣多肽结合。 噬菌粒可以用作表达载体，所述衣壳融合有助于包装噬菌粒DNA。 使用这种方法，可以组合编码这种多聚体sbp成员的各个链的DNA文库，从而获得在sbp成员中比通过常规方法容易地获得的更大的遗传多样性。

公开(公告)号：USD653701S1

公开(公告)日：2012-02-07

申请号：US29380777

申请日：2010-12-10

申请人： Ronald Henry Tse ,  Paula Scher

设计人： Ronald Henry Tse ,  Paula Scher

公开(公告)号：US07368111B2

公开(公告)日：2008-05-06

申请号：US10625307

申请日：2003-07-23

申请人： Julia Elizabeth Thompson ,  Tristan John Vaughan ,  Andrew James Williams ,  Jonathan Alexander Green ,  Ronald Henry Jackson ,  Louise Bacon ,  Kevin Stuart Johnson ,  Alison Jane Wilton ,  Philip Ronald Tempest ,  Raymond Paul Field ,  Steven Paul Ruddock ,  Gregory Paul Winter

发明人： Julia Elizabeth Thompson ,  Tristan John Vaughan ,  Andrew James Williams ,  Jonathan Alexander Green ,  Ronald Henry Jackson ,  Louise Bacon ,  Kevin Stuart Johnson ,  Alison Jane Wilton ,  Philip Ronald Tempest ,  Raymond Paul Field ,  Steven Paul Ruddock ,  Gregory Paul Winter

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K16/22 ,  A61K38/00 ,  C07K2317/21 ,  C07K2317/622

摘要： Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGFβ) bind specifically isoforms TGFβ2 and TGFβ1 or both, preferentially compared with TGFβ3. Specific binding members may be isolated and utilized in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for particularly advantageous specific binding member which binds the active form of TGFβ2, neutralizing its activity, but does not bind the latent member.

摘要翻译： 包含对人转化生长因子β（TGFbeta）特异性的人抗体结合结构域的特异性结合成员特异性结合TGFβ2和TGFbeta1或两者，优先与TGFbeta3相比较。 特异性结合成员可以被分离并用于治疗疾病，特别是纤维化疾病以及免疫/炎性疾病。 使用体外和体内模型证明治疗效用。 提供了完整的序列和结合信息，包括用于结合TGFβ2活性形式的特别有利的特异性结合成员的表位序列信息，中和其活性但不结合潜伏成员。

公开(公告)号：US06948427B2

公开(公告)日：2005-09-27

申请号：US10190444

申请日：2002-07-05

申请人： Ronald Henry Boucher ,  Lev Zlatin

发明人： Ronald Henry Boucher ,  Lev Zlatin

IPC分类号： B41F13/03 ,  B41F13/54

CPC分类号： B41F13/03

摘要： A web infeed device for rotary printing presses includes a pointed nose piece having concave side portions. The flexible infeed element is received in a guide, and driving elements are provided for driving the infeed element along the guide.

摘要翻译： 用于旋转印刷机的卷筒纸进给装置包括具有凹侧部分的尖头部件。 柔性进给元件被容纳在引导件中，并且提供驱动元件用于沿引导件驱动进给元件。

公开(公告)号：US06916605B1

公开(公告)日：2005-07-12

申请号：US09196522

申请日：1998-11-20

申请人： John McCafferty ,  Anthony Richard Pope ,  Kevin Stuart Johnson ,  Hendricus Renerus Jacobus Mattheus Hoogenboom ,  Andrew David Griffiths ,  Ronald Henry Jackson ,  Kaspar Philipp Holliger ,  James David Marks ,  Timothy Piers Clackson ,  David John Chiswell ,  Gregory Paul Winter ,  Timothy Peter Bonnert

发明人： John McCafferty ,  Anthony Richard Pope ,  Kevin Stuart Johnson ,  Hendricus Renerus Jacobus Mattheus Hoogenboom ,  Andrew David Griffiths ,  Ronald Henry Jackson ,  Kaspar Philipp Holliger ,  James David Marks ,  Timothy Piers Clackson ,  David John Chiswell ,  Gregory Paul Winter ,  Timothy Peter Bonnert

IPC分类号： C07K16/00 ,  C07K16/18 ,  C07K16/34 ,  C07K16/40 ,  C07K16/44 ,  C07K16/46 ,  C07K19/00 ,  C12N15/10 ,  C12N15/62 ,  C12N15/73 ,  C40B40/02 ,  G01N33/53 ,  G01N33/68 ,  C12Q1/70 ,  C07H21/02 ,  C12N15/00

CPC分类号： C40B40/02 ,  B01J2219/00718 ,  C07K16/00 ,  C07K16/18 ,  C07K16/34 ,  C07K16/40 ,  C07K16/44 ,  C07K16/462 ,  C07K16/468 ,  C07K19/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/41 ,  C07K2319/735 ,  C12N15/1037 ,  C12N15/62 ,  C12N15/73 ,  G01N33/53 ,  G01N33/6857

摘要： A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods.

摘要翻译： 特异性结合对（sbp）的成员通过在重组宿主细胞中表达编码这种sbp成员的遗传多样性群体的DNA来鉴定，其中sbp成员以分泌重组遗传显示包（rgdp）的表面以功能形式显示 ），其含有编码sbp成员或其多肽组分的DNA，其中sbp成员或其多肽组分被表达为与rgdp的衣壳组分的融合物。 显示的sbps可以通过与补充sbp成员的亲和力来选择，并且从所选的rgdps中恢复的DNA用于表达所选择的sbp成员。 因此可以获得抗体sbp成员，其中不同的链表达，一个与衣壳组分融合，另一个与游离形式融合，用于与融合伴侣多肽结合。 噬菌粒可以用作表达载体，所述衣壳融合有助于包装噬菌粒DNA。 使用这种方法，可以组合编码这种多聚体sbp成员的各个链的DNA文库，从而获得在sbp成员中比通过常规方法容易地获得的更大的遗传多样性。

公开(公告)号：US06902135B2

公开(公告)日：2005-06-07

申请号：US10320273

申请日：2002-12-16

申请人： Ronald Henry Boucher

发明人： Ronald Henry Boucher

IPC分类号： B65H23/26 ,  B65H23/32 ,  G03B1/42 ,  B65H20/24

CPC分类号： B65H23/26 ,  B65H23/32

摘要： A device for guiding a web includes a frame, a first angle bar angled with respect to the entering web direction and supported by the frame for movement along a first path, the first angle bar having a first and a second side, a second angle bar angled with respect to the entering web direction and supported by the frame for movement along a second path, and a roller for changing a direction of the web between the first angle bar and second angle bar, the roller being moveable along a third path so as to be movable laterally beyond both the first side and second side of the angle bar.

摘要翻译： 用于引导幅材的装置包括框架，相对于进入纸幅方向成角度并且由框架支撑的第一角度条，用于沿第一路径移动，第一角度杆具有第一和第二侧面，第二角度条 相对于进入幅面方向成角度并且由框架支撑以沿着第二路径移动;以及辊，用于改变幅材在第一角度杆和第二角度杆之间的方向，辊可沿第三路径移动，以便 能够横向移动超过角杆的第一侧和第二侧。