公开(公告)号：US09029139B2

公开(公告)日：2015-05-12

申请号：US12730701

申请日：2010-03-24

申请人： Makio Iwashima ,  Robert Love ,  Rudolf Karl Braun ,  Perianna Sethupathi ,  Katherine Lathrop Knight

发明人： Makio Iwashima ,  Robert Love ,  Rudolf Karl Braun ,  Perianna Sethupathi ,  Katherine Lathrop Knight

IPC分类号： C12N5/00 ,  C12N5/071 ,  C12N5/074 ,  A01N63/00 ,  C12N5/0775 ,  A61K35/12

CPC分类号： C12N5/0667 ,  A61K35/12

摘要： Methods for generating and using omentum cells, and particularly stromal cells and/or omentum stem cells, in medical treatments such as tissue repair and regeneration to facilitate healing from traumatic injury to an abdominal organ, and immune modulation treatments such as suppression of immune responses and inflammation and prevention of tissue fibrosis. According to one aspect, a medical procedure is performed on a patient that involves harvesting omental tissue from the patient, and then transferring the omental tissue to an organ of the patient. At least a portion of the harvested omental tissue may be activated prior to transferring the omental tissue to the organ. Alternatively, the transferred omental tissue may comprise non-lymphoid cells isolated from the omentum tissue and obtained by homogenizing at least a portion of the harvested omental tissue. The invention also encompasses a medical procedure comprising the transfer of omental stem cells to a patient, and a procedure comprising in vitro activation of omental stem cells by T cells to enhance immunomodulatory functions of the omental stem cells.

摘要翻译： 用于在诸如组织修复和再生的医学治疗中产生和使用网膜细胞，特别是基质细胞和/或网膜干细胞的方法，以促进从创伤性损伤到腹部器官的愈合，以及免疫调节治疗如抑制免疫应答和 炎症和预防组织纤维化。 根据一个方面，对涉及从患者收集网膜组织，然后将网膜组织转移到患者器官的患者进行医疗程序。 在将网膜组织转移到器官之前，至少一部分收获的网状组织可以被活化。 或者，转移的网膜组织可以包括从网状组织分离并通过使至少一部分收获的网膜组织匀化获得的非淋巴细胞。 本发明还包括包括将网膜干细胞转移到患者的医学过程，以及包括T细胞体外激活网膜干细胞以增强网膜干细胞的免疫调节功能的方法。

公开(公告)号：US20110081321A1

公开(公告)日：2011-04-07

申请号：US12730701

申请日：2010-03-24

申请人： Makio Iwashima ,  Robert Love ,  Rudolf Karl Braun ,  Perianna Sethupathi ,  Katherine Lathrop Knight

发明人： Makio Iwashima ,  Robert Love ,  Rudolf Karl Braun ,  Perianna Sethupathi ,  Katherine Lathrop Knight

IPC分类号： A61K35/37 ,  A61P29/00 ,  A61P37/02 ,  A61P1/18 ,  A61P1/16 ,  C12N5/02

CPC分类号： C12N5/0667 ,  A61K35/12

摘要： Methods for generating and using omentum cells, and particularly stromal cells and/or omentum stem cells, in medical treatments such as tissue repair and regeneration to facilitate healing from traumatic injury to an abdominal organ, and immune modulation treatments such as suppression of immune responses and inflammation and prevention of tissue fibrosis. According to one aspect, a medical procedure is performed on a patient that involves harvesting omental tissue from the patient, and then transferring the omental tissue to an organ of the patient. At least a portion of the harvested omental tissue may be activated prior to transferring the omental tissue to the organ. Alternatively, the transferred omental tissue may comprise non-lymphoid cells isolated from the omentum tissue and obtained by homogenizing at least a portion of the harvested omental tissue. The invention also encompasses a medical procedure comprising the transfer of omental stem cells to a patient, and a procedure comprising in vitro activation of omental stem cells by T cells to enhance immunomodulatory functions of the omental stem cells.

摘要翻译： 用于在诸如组织修复和再生的医学治疗中产生和使用网膜细胞，特别是基质细胞和/或网膜干细胞的方法，以促进从创伤性损伤到腹部器官的愈合，以及免疫调节治疗如抑制免疫应答和 炎症和预防组织纤维化。 根据一个方面，对涉及从患者收集网膜组织，然后将网膜组织转移到患者器官的患者进行医疗程序。 在将网膜组织转移到器官之前，至少一部分收获的网状组织可以被活化。 或者，转移的网膜组织可以包括从网状组织分离并通过使至少一部分收获的网膜组织匀化获得的非淋巴细胞。 本发明还包括包括将网膜干细胞转移到患者的医学过程，以及包括T细胞体外激活网膜干细胞以增强网膜干细胞的免疫调节功能的方法。