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公开(公告)号：US08859242B2
公开(公告)日：2014-10-14
申请号：US13404131
申请日：2012-02-24
申请人： Ryo Takeshita , Shinichi Sugimoto
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
摘要翻译： 一种通过发酵生产碱性物质的方法，包括在包含在发酵罐中的液体培养基中培养具有生产碱性物质的能力的微生物，以在培养基中产生和积累碱性物质，其中硫酸盐和/或氯离子的量 用作碱性物质的抗衡离子的方法是通过在培养过程的至少一部分时间内将培养基中的总氨浓度调节到特定浓度范围内来减少。
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公开(公告)号：US08673597B2
公开(公告)日：2014-03-18
申请号：US13114251
申请日：2011-05-24
申请人： Yuori Wakasa , Ryo Takeshita
发明人： Yuori Wakasa , Ryo Takeshita
摘要： A bacterium which belongs to the family Enterobacteriaceae, and has an ability to produce L-lysine, L-threonine, L-asparagine, L-aspartic acid, L-methionine, L-alanine, L-isoleucine, and/or L-homoserine. The bacterium has been modified so that expression of the gltP and/or gltS genes is/are increased when cultured in a medium, resulting in the accumulation of the L-amino acid(s) in the medium or bacterial cells.
摘要翻译： 属于肠杆菌科的细菌，具有产生L-赖氨酸，L-苏氨酸，L-天冬酰胺，L-天冬氨酸，L-甲硫氨酸，L-丙氨酸，L-异亮氨酸和/或L-高丝氨酸的能力 。 细菌已被修饰，使得在培养基中培养时，gltP和/或gltS基因的表达增加，导致L-氨基酸在培养基或细菌细胞中的积累。
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公开(公告)号：US20120149072A1
公开(公告)日：2012-06-14
申请号：US13404131
申请日：2012-02-24
申请人： Ryo Takeshita , Shinichi Sugimoto
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
摘要翻译： 一种通过发酵生产碱性物质的方法，包括在包含在发酵罐中的液体培养基中培养具有生产碱性物质的能力的微生物，以在培养基中产生和积累碱性物质，其中硫酸盐和/或氯离子的量 用作碱性物质的抗衡离子的方法是通过在培养过程的至少一部分时间内将培养基中的总氨浓度调节到特定浓度范围内来减少。
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公开(公告)号：US20110003347A1
公开(公告)日：2011-01-06
申请号：US12833547
申请日：2010-07-09
申请人： Ryo Takeshita , Naoki Kadotani , Kenji Abe
发明人： Ryo Takeshita , Naoki Kadotani , Kenji Abe
IPC分类号： C12P13/04
CPC分类号： C12P13/08 , C12N9/1205 , C12N9/2402 , C12P13/22 , C12Y302/0101
摘要： A method is described for producing a target substance utilizing a microorganism by culturing the microorganism in a medium to produce and accumulate the target substance in the medium, and then collecting the target substance from culture. The microorganism is imparted with isomaltase activity, or modified to increase isomaltase activity.
摘要翻译： 描述了一种用于通过在培养基中培养微生物来生产和利用微生物的目标物质生产和累积目标物质的方法，然后从培养物中收集目标物质。 赋予微生物异麦芽糖酶活性，或修饰以增加异麦芽糖酶活性。
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公开(公告)号：US08617852B2
公开(公告)日：2013-12-31
申请号：US12833547
申请日：2010-07-09
申请人： Ryo Takeshita , Naoki Kadotani , Kenji Abe
发明人： Ryo Takeshita , Naoki Kadotani , Kenji Abe
CPC分类号： C12P13/08 , C12N9/1205 , C12N9/2402 , C12P13/22 , C12Y302/0101
摘要： A method is described for producing a target substance utilizing a microorganism by culturing the microorganism in a medium to produce and accumulate the target substance in the medium, and then collecting the target substance from culture. The microorganism is imparted with isomaltase activity, or modified to increase isomaltase activity.
摘要翻译： 描述了一种用于通过在培养基中培养微生物来生产和利用微生物的目标物质生产和累积目标物质的方法，然后从培养物中收集目标物质。 赋予微生物异麦芽糖酶活性，或修饰以增加异麦芽糖酶活性。
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6.发明授权L-amino acid producing bacterium which has enhanced expression of at least one of the nhaA gene, the nhaB gene, the nhaR gene, the chaA gene, the mdfA gene and a method of producing L-amino acid 有权具有增加nhaA基因，nhaB基因，nhaR基因，chaA基因，mdfA基因中的至少一种的表达的L-氨基酸生产菌和产生L-氨基酸的方法公开(公告)号：US08008047B2
公开(公告)日：2011-08-30
申请号：US12137666
申请日：2008-06-12
申请人： Mayu Iyo , Ryo Takeshita , Shinichi Sugimoto
发明人： Mayu Iyo , Ryo Takeshita , Shinichi Sugimoto
摘要： L-amino acid is produced by culturing a bacterium belonging to the Enterobacteriaceae family which has L-amino acid-producing ability and is modified so that expression of the nhaA gene, nhaB gene, nhaR gene, chaA gene, mdfA gene, or combinations thereof is enhanced.
摘要翻译： L-氨基酸是通过培养具有L-氨基酸生产能力的属于肠杆菌科的细菌产生的，并被修饰以使nhaA基因，nhaB基因，nhaR基因，chaA基因，mdfA基因或其组合的表达 增强了。
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公开(公告)号：US07790422B2
公开(公告)日：2010-09-07
申请号：US11697794
申请日：2007-04-09
申请人： Ryo Takeshita , Shinichi Sugimoto
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
摘要翻译： 一种通过发酵生产碱性物质的方法，包括在包含在发酵罐中的液体培养基中培养具有生产碱性物质的能力的微生物，以在培养基中产生和积累碱性物质，其中硫酸盐和/或氯离子的量 用作碱性物质的抗衡离子的方法是通过在培养过程的至少一部分时间内将培养基中的总氨浓度调节到特定浓度范围内来减少。
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公开(公告)号：US20070243590A1
公开(公告)日：2007-10-18
申请号：US11697794
申请日：2007-04-09
申请人： Ryo Takeshita , Shinichi Sugimoto
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
摘要翻译： 一种通过发酵生产碱性物质的方法，包括在包含在发酵罐中的液体培养基中培养具有生产碱性物质的能力的微生物，以在培养基中产生和积累碱性物质，其中硫酸盐和/或氯离子的量 用作碱性物质的抗衡离子的方法是通过在培养过程的至少一部分时间内将培养基中的总氨浓度调节到特定浓度范围内来减少。
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9.发明授权公开(公告)号：US08765407B2
公开(公告)日：2014-07-01
申请号：US12179988
申请日：2008-07-25
申请人： Mayu Iyo , Ryo Takeshita , Shinichi Sugimoto
发明人： Mayu Iyo , Ryo Takeshita , Shinichi Sugimoto
CPC分类号： C12P13/08
摘要： An L-amino acid is produced by culturing an L-amino acid-producing bacterium which belongs to the Enterobacteriaceae family and which has been modified so that the activity of an iron transporter is increased by enhancing expression of one or more genes of the following genes: tonB gene, fepA gene, and fecA.
摘要翻译： L-氨基酸是通过培养属于肠杆菌科的L-氨基酸产生细菌而经过修饰的，通过增强以下基因的一个或多个基因的表达来增加铁转运蛋白的活性 ：tonB基因，fepA基因和fecA。
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公开(公告)号：US20110281311A1
公开(公告)日：2011-11-17
申请号：US13114251
申请日：2011-05-24
申请人： Yuori Wakasa , Ryo Takeshita
发明人： Yuori Wakasa , Ryo Takeshita
摘要： A bacterium which belongs to the family Enterobacteriaceae, and has an ability to produce L-lysine, L-threonine, L-asparagine, L-aspartic acid, L-methionine, L-alanine, L-isoleucine, and/or L-homoserine. The bacterium has been modified so that expression of the gltP and/or gltS genes is/are increased when cultured in a medium, resulting in the accumulation of the L-amino acid(s) in the medium or bacterial cells.
摘要翻译： 属于肠杆菌科的细菌，具有产生L-赖氨酸，L-苏氨酸，L-天冬酰胺，L-天冬氨酸，L-甲硫氨酸，L-丙氨酸，L-异亮氨酸和/或L-高丝氨酸的能力 。 细菌已被修饰，使得在培养基中培养时，gltP和/或gltS基因的表达增加，导致L-氨基酸在培养基或细菌细胞中的积累。
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