Hollow rack and hollow rack manufacturing method
    4.
    发明授权
    Hollow rack and hollow rack manufacturing method 有权
    空心架和空心架制造方法

    公开(公告)号:US08499660B2

    公开(公告)日:2013-08-06

    申请号:US13347486

    申请日:2012-01-10

    IPC分类号: F16H1/04

    摘要: The one end side portion is nipped by a jig including a jig member having a pair of convex portions which are to be fitted to a depressions in contact with a tooth side face and a inclined portion and positioning a bar and a jig member which is to be clamped/opened with respect to the jig member. A die having an inside diameter smaller than the diameter of the outer periphery is pressed onto the outer periphery of the end portion of the cylindrical end side portion projected from the jig up to a press-in depth determined preliminarily based on the rack, so as to reduce the diameter of the end portion.

    摘要翻译: 一端侧部分被夹具夹持,该夹具包括具有一对凸起部分的夹具构件,所述夹具构件将被配合到与齿侧面和倾斜部分接触的凹部,并且定位杆和夹具构件 相对于夹具构件夹紧/打开。 具有小于外周直径的内径的模具被按压到从夹具突出的圆筒形端侧部分的端部的外周上,直到基于架子预先确定的压入深度,以便 以减小端部的直径。

    Recombinant human hepatitis C virus-like particle and method for producing the same
    5.
    发明授权
    Recombinant human hepatitis C virus-like particle and method for producing the same 有权
    重组人类丙型肝炎病毒样颗粒及其制备方法

    公开(公告)号:US08183044B2

    公开(公告)日:2012-05-22

    申请号:US11992646

    申请日:2006-09-29

    IPC分类号: C12N15/63

    摘要: The present invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising the steps of introducing into (i) a cell in which an RNA replicon comprising a nucleotide sequence comprising the 5′ untranslated region, the nucleotide sequence coding for the NS3, NS4A, NS4B, NS5A, and NS5B proteins, and the 3′ untranslated region of a genome RNA derived from a hepatitis C virus strain autonomously replicates, (ii) a vector expressing the Core, E1, E2, and p7 proteins derived from a hepatitis C virus strain that is the same as or different from that as defined in the above (i), culturing the cell, and recovering the produced virus-like particle, and a recombinant hepatitis C virus particle produced by this method.

    摘要翻译: 本发明涉及一种重组丙型肝炎病毒样颗粒的制备方法,包括以下步骤:(i)将包含5'非翻译区的核苷酸序列的RNA复制子,编码 NS3,NS4A,NS4B,NS5A和NS5B蛋白,并且来源于丙型肝炎病毒株的基因组RNA的3'非翻译区自主复制,(ii)表达来源于核苷酸的核心,E1,E2和p7蛋白的载体 与上述(i)所定义的相同或不同的丙型肝炎病毒株,培养细胞,回收所产生的病毒样颗粒,以及通过该方法生产的重组丙型肝炎病毒颗粒。

    High Production System for Infectious Hepatitis C Virus Particle
    6.
    发明申请
    High Production System for Infectious Hepatitis C Virus Particle 失效
    传染性丙型肝炎病毒颗粒高生产系统

    公开(公告)号:US20100035345A1

    公开(公告)日:2010-02-11

    申请号:US11992837

    申请日:2006-09-29

    IPC分类号: C12N15/63

    摘要: The present invention relates to a method for producing infectious hepatitis C virus (HCV) particles, comprising a step of introducing an expression vector into a cell that allows HCV proliferation, such expression vector comprising: DNA sequences encoding the 5′ untranslated region, structural proteins, and, if necessary, non-structural proteins of HCV and DNA sequences encoding non-structural proteins and the 3′ untranslated region derived from the HCV JFH1 strain, which are located downstream of a polymerase I promoter; and a DNA fragment containing an RNA polymerase I terminator, which is located further downstream thereof.

    摘要翻译: 本发明涉及一种生产感染性丙型肝炎病毒(HCV)颗粒的方法,包括将表达载体导入允许HCV增殖的细胞中的步骤,所述表达载体包含:编码5'非翻译区的DNA序列,结构蛋白 ,如果需要,HCV的非结构蛋白和编码非结构蛋白的DNA序列以及来源于HCV JFH1株的3'非翻译区,位于聚合酶I启动子的下游; 和包含位于其下游的RNA聚合酶I终止子的DNA片段。

    Novel Recombinant Human Hepatitis C Virus-Like Particle and Method for Producing the Same
    7.
    发明申请
    Novel Recombinant Human Hepatitis C Virus-Like Particle and Method for Producing the Same 有权
    新型重组人类丙型肝炎病毒样颗粒及其生产方法

    公开(公告)号:US20090221028A1

    公开(公告)日:2009-09-03

    申请号:US11992646

    申请日:2006-09-29

    IPC分类号: C12P21/00 C07K14/00

    摘要: The present invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising the steps of introducing into (i) a cell in which an RNA replicon comprising a nucleotide sequence comprising the 5′ untranslated region, the nucleotide sequence coding for the NS3, NS4A, NS4B, NS5A, and NS5B proteins, and the 3′ untranslated region of a genome RNA derived from a hepatitis C virus strain autonomously replicates, (ii) a vector expressing the Core, E1, E2, and p7 proteins derived from a hepatitis C virus strain that is the same as or different from that as defined in the above (i), culturing the cell, and recovering the produced virus-like particle, and a recombinant hepatitis C virus particle produced by this method.

    摘要翻译: 本发明涉及一种重组丙型肝炎病毒样颗粒的制备方法,包括以下步骤:(i)将包含5'非翻译区的核苷酸序列的RNA复制子,编码 NS3,NS4A,NS4B,NS5A和NS5B蛋白,并且来源于丙型肝炎病毒株的基因组RNA的3'非翻译区自主复制,(ii)表达来源于核苷酸的核心,E1,E2和p7蛋白的载体 与上述(i)所定义的相同或不同的丙型肝炎病毒株,培养细胞,回收所产生的病毒样颗粒,以及通过该方法生产的重组丙型肝炎病毒颗粒。

    Method and apparatus for smelting titanium metal
    8.
    发明授权
    Method and apparatus for smelting titanium metal 失效
    冶金钛金属的方法和设备

    公开(公告)号:US07264765B2

    公开(公告)日:2007-09-04

    申请号:US10491293

    申请日:2002-10-11

    IPC分类号: C22B1/10

    摘要: This invention relates to a method and an apparatus for smelting titanium metal by the thermal reduction of titanium oxide (TiO2) to titanium metal (Ti); a mixed salt of calcium chloride (CaCl2) and calcium oxide (CaO) contained in a reaction vessel is heated to form a molten salt which constitutes a reaction region, the molten salt in the reaction region is electrolyzed thereby converting the molten salt into a strongly reducing molten salt containing monovalent calcium ions (Ca+) and/or calcium (Ca), titanium oxide is supplied to the strongly reducing molten salt and the titanium oxide is reduced and the resulting titanium metal is deoxidized by the monovalent calcium ions and/or calcium. The method and the apparatus make it feasible to produce commercially titanium metal suitable for a variety of applications from titanium oxide.

    摘要翻译: 本发明涉及一种通过将钛氧化物(TiO 2)热还原成钛金属(Ti)而熔化钛金属的方法和装置。 将包含在反应容器中的氯化钙(CaCl 2/2)和氧化钙(CaO)的混合盐加热以形成构成反应区域的熔融盐,将反应区域中的熔融盐电解 从而将熔融盐转化为含有一价钙离子(Ca +)和/或钙(Ca)的强还原熔融盐,将氧化钛供给强还原性熔融盐,氧化钛还原 并且所得到的钛金属被一价钙离子和/或钙脱氧。 该方法和设备使得可以生产适合于二氧化钛各种应用的市售钛金属。

    Hollow rack end diameter reducing method
    9.
    发明授权
    Hollow rack end diameter reducing method 有权
    空心齿条端径减小法

    公开(公告)号:US08595936B2

    公开(公告)日:2013-12-03

    申请号:US13347482

    申请日:2012-01-10

    IPC分类号: B21D41/02

    摘要: The one end side portion is nipped by a jig including a jig member having a pair of convex portions which are to be fitted to a depressions in contact with a tooth side face and a inclined portion and positioning a bar and a jig member which is to be clamped/opened with respect to the jig member. A die having an inside diameter smaller than the diameter of the outer periphery is pressed onto the outer periphery of the end portion of the cylindrical end side portion projected from the jig up to a press-in depth determined preliminarily based on the rack, so as to reduce the diameter of the end portion.

    摘要翻译: 一端侧部分被夹具夹持,该夹具包括具有一对凸起部分的夹具构件,所述夹具构件将被配合到与齿侧面和倾斜部分接触的凹部,并且定位杆和夹具构件 相对于夹具构件夹紧/打开。 具有小于外周直径的内径的模具被按压到从夹具突出的圆筒形端侧部分的端部的外周上,直到基于架子预先确定的压入深度,以便 以减小端部的直径。