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公开(公告)号：US20110312891A1
公开(公告)日：2011-12-22
申请号：US13000130
申请日：2009-06-29
IPC分类号： A61K38/17 , A61P19/08 , C12N5/0775 , C07K14/47 , C12N5/071
CPC分类号： C07K14/78
摘要： Isolated active compound of a naturally occurring fraction of Enamel Matrix Derivatives (EMD), having at least one of each two N-terminal polypeptide fragments of amelogenin, which are at least 95% identical to an amino acid sequence as shown in SEQ. ID. No:1 and/or 2. The invention relates to the use of said isolated active compound of a fraction and/or of the fraction itself, and/or the at least one of each two polypeptide fragments for use as a medicament and/or for the manufacture of a pharmaceutical composition for a variety of different medical indications such as inducing and/or promoting cementogenesis, bone growth and/or binding between parts of living mineralised tissue, for bonding of a piece of living mineralised tissue to a bonding site on a piece of other living tissue, for endorsing binding between hard tissues, for inducing regeneration of dentin, and/or for filling a mineralized wound cavity and/or tissue defect following from a procedure and/or trauma.
摘要翻译： 具有至少与氨基酸序列至少95％相同的釉质蛋白的两个N末端多肽片段中至少一个的釉质基质衍生物（EMD）的天然存在部分的分离的活性化合物。 ID。 本发明涉及所述分离的活性成分和/或级分本身的分离活性化合物和/或每两种多肽片段中的至少一种用作药物和/或 用于制造用于各种不同医学适应症的药物组合物，例如诱导和/或促进活的矿化组织的部分之间的骨水泥生成，骨生长和/或结合，用于将一块活的矿化组织粘合到粘合部位上 用于在手术和/或创伤之后识别硬组织之间的结合，用于诱导牙质的再生和/或用于填充矿化的伤口腔和/或组织缺损的一块其它活组织。
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公开(公告)号：US08029769B2
公开(公告)日：2011-10-04
申请号：US12210350
申请日：2008-09-15
CPC分类号： A61K38/39 , A61K8/64 , A61K35/32 , A61K38/1709 , A61K2800/57 , A61L27/18 , A61L27/225 , A61L27/227 , A61L27/48 , A61L27/54 , A61L27/58 , A61L2300/252 , A61Q11/00 , C08L71/02 , C08L89/00
摘要： A low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, is intended to be used as a therapeutic, as a prophylactic and/or as a cosmetic agent. The active enamel substance is incorporated into a polymeric matrix, which is either suitable for cellular in-growth, or is cell-occlusive, so that it is released by degradation of the polymeric matrix, by enzymatic action and/or by diffusion. A new pharmaceutical and/or cosmetic formulation of an active enamel substance is provided at a lower total concentration within the formulation, wherein a spatial and/or selective regulation of release of said active enamel substance permits a greater percentage of the active enamel substance to be released at the time of appropriate cellular activity.
摘要翻译： 旨在用作活性搪瓷物质如釉质基质，釉质基质衍生物和/或釉质基质蛋白质的低浓度制剂作为预防剂和/或作为美容剂的治疗剂。 将活性搪瓷物质掺入聚合物基质中，其适用于细胞内生长或细胞闭塞，从而通过酶促作用和/或通过扩散将聚合物基质降解释放。 提供活性搪瓷物质的新的药物和/或化妆品制剂，其在制剂内的总浓度较低，其中所述活性搪瓷物质的释放的空间和/或选择性调节允许活性釉质物质的较大百分比为 在适当的细胞活动时释放。
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公开(公告)号：US07985845B2
公开(公告)日：2011-07-26
申请号：US11721192
申请日：2005-12-12
CPC分类号： A61K38/39 , A61K8/64 , A61K35/32 , A61K38/1709 , A61K2800/57 , A61L27/18 , A61L27/225 , A61L27/227 , A61L27/48 , A61L27/54 , A61L27/58 , A61L2300/252 , A61Q11/00 , C08L71/02 , C08L89/00
摘要： The present invention relates to a new and improved low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, intended to be used as therapeutic, as propylacetic and/or as cosmetic agent. In the present invention, said active enamel substance is incorporated into a polymeric matrix, which is either suitable for cellular in-growth, or cell-occlusive. The active enamel substance can be incorporated into the polymeric matrix so that it is released by degradation of the polymeric matrix, by enzymatic action and/or by diffusion. Comprised in the invention is thus in particular a new pharmaceutical and/or cosmetic formulation of an active enamel substance at a lower total concentration within the formulation, wherein a spatial and/or selective regulation of release of said active enamel substance permits a greater percentage of the active enamel substance to be released at the time of appropriate cellular activity.
摘要翻译： 本发明涉及一种新的和改进的，旨在作为治疗用作预防和/或化妆品的活性搪瓷物质如釉质基质，釉质基质衍生物和/或釉质基质蛋白质的低浓度制剂 代理商 在本发明中，所述活性釉质物质掺入聚合物基质中，其适用于细胞生长或细胞闭塞。 可以将活性搪瓷物质并入聚合物基质中，使其通过降解聚合物基质，通过酶作用和/或通过扩散而释放。 因此，本发明包括特别是在制剂中具有较低总浓度的活性搪瓷物质的新的药物和/或化妆品制剂，其中所述活性搪瓷物质的释放的空间和/或选择性调节允许更大百分比的 在适当的细胞活性时待释放的活性搪瓷物质。
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公开(公告)号：US20090136575A1
公开(公告)日：2009-05-28
申请号：US11721192
申请日：2005-12-12
CPC分类号： A61K38/39 , A61K8/64 , A61K35/32 , A61K38/1709 , A61K2800/57 , A61L27/18 , A61L27/225 , A61L27/227 , A61L27/48 , A61L27/54 , A61L27/58 , A61L2300/252 , A61Q11/00 , C08L71/02 , C08L89/00
摘要： The present invention relates to a new and improved low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, intended to be used as therapeutic, as propylacetic and/or as cosmetic agent. In the present invention, said active enamel substance is incorporated into a polymeric matrix, which is either suitable for cellular in-growth, or cell-occlusive. The active enamel substance can be incorporated into the polymeric matrix so that it is released by degradation of the polymeric matrix, by enzymatic action and/or by diffusion. Comprised in the invention is thus in particular a new pharmaceutical and/or cosmetic formulation of an active enamel substance at a lower total concentration within the formulation, wherein a spatial and/or selective regulation of release of said active enamel substance permits a greater percentage of the active enamel substance to be released at the time of appropriate cellular activity.
摘要翻译： 本发明涉及一种新的和改进的，旨在作为治疗用作预防和/或化妆品的活性搪瓷物质如釉质基质，釉质基质衍生物和/或釉质基质蛋白质的低浓度制剂 代理商 在本发明中，所述活性釉质物质掺入聚合物基质中，其适用于细胞生长或细胞闭塞。 可以将活性搪瓷物质并入聚合物基质中，使其通过降解聚合物基质，通过酶作用和/或通过扩散而释放。 因此，本发明包括特别是在制剂中具有较低总浓度的活性搪瓷物质的新的药物和/或化妆品制剂，其中所述活性搪瓷物质的释放的空间和/或选择性调节允许更大百分比的 在适当的细胞活性时待释放的活性搪瓷物质。
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公开(公告)号：US09248009B2
公开(公告)日：2016-02-02
申请号：US13322610
申请日：2010-06-03
CPC分类号： A61C19/063 , A46B3/18 , A46D1/00 , A46D1/0207 , A61C3/005 , A61C5/40 , A61C8/00
摘要： A kit having a) a cleaning device, the cleaning device (1) including an elongated base member (2) formed of at least two wires (3) being twisted with each other, and a plurality of bristles (4) fixed between the twisted wires (3) and extending away from the twisted wires (3), whereby the bristles (4) are positioned in a cleaning section (5) at a first end (6) of the base member (2); wherein the bristles (4) consist of titanium or a titanium alloy; and b) a container having a composition including ethylene diaminotetraacetic acid (EDTA) is disclosed. A method for cleaning and/or debriding and/or conditioning a biological mineralized surface and/or a biological soft tissue surface and/or a dental implant is also disclosed. Additionally, there is disclosed a method for preventing and/or treating a condition in a patient in need of such treatment.
摘要翻译： 一种具有a）清洁装置的清洁装置，所述清洁装置（1）包括由相互扭曲的至少两根丝线（3）形成的细长基部构件（2），以及固定在所述扭曲 电线（3）并且远离绞线（3）延伸，由此刷毛（4）位于基部构件（2）的第一端（6）处的清洁部分（5）中; 其中所述刷毛（4）由钛或钛合金构成; 和b）具有包含乙二胺四乙酸（EDTA）的组合物的容器。 还公开了用于清洁和/或清除和/或调理生物矿化表面和/或生物软组织表面和/或牙科植入物的方法。 此外，公开了一种预防和/或治疗需要这种治疗的患者的状况的方法。
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公开(公告)号：US20130115248A1
公开(公告)日：2013-05-09
申请号：US13515728
申请日：2010-12-14
CPC分类号： A61K8/29 , A61C3/00 , A61C8/00 , A61C17/00 , A61C17/005 , A61K8/044 , A61K8/22 , A61K2800/28 , A61K2800/413 , A61Q11/00 , A61Q11/02 , A61Q17/005 , B82Y5/00
摘要： The present invention relates to a new and inventive composition for implant cleaning and/or debridement of hard surfaces in the oral cavity, which comprises optimally activated nanoparticles of TiO2, having a mean particle diameter (D50) of about 10-100 nm at a concentration between 0.5-500 g/L, and H2O2, at a concentration of at the most 7.5% by volume, said composition being antibacterial, without causing microbial resistance, and anti-inflammatory, and wherein said composition further comprises solid microparticles, having a mean particle diameter (D50) of about 100-200 μm at a concentration between 0.5-300 g/L, for improved mechanical debridement and/or cleaning of rough surfaces in the oral cavity and/or on an implant.
摘要翻译： 本发明涉及一种用于在口腔中进行植入物清洁和/或硬化表面清创的新型和本发明的组合物，其包含TiO 2的最佳活化纳米颗粒，其浓度为10-100nm的平均粒径（D50） 0.5-500g / L和H 2 O 2之间，其浓度最多为7.5体积％，所述组合物是抗菌的，不引起微生物抗性和抗炎，并且其中所述组合物还包含固体微粒，具有平均值 浓度在0.5-300g / L之间的约100-200μm的粒径（D50），用于改善口腔和/或植入物中粗糙表面的机械清创和/或清洁。
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公开(公告)号：US20120308623A1
公开(公告)日：2012-12-06
申请号：US13514958
申请日：2010-12-15
IPC分类号： A61K33/40 , A61K9/107 , A61K8/02 , A61K8/29 , A61P31/00 , A61P17/02 , A61P17/00 , A61K9/00 , A61Q15/00 , B82Y40/00 , B82Y5/00 , B82Y99/00
CPC分类号： A61K33/24 , A61K9/14 , A61K33/00 , A61K33/40 , A61L15/18 , A61L15/46 , A61L26/0004 , A61L26/0066 , A61L2300/102 , A61L2400/12 , B82Y30/00 , C01G23/047 , C01P2004/62 , C01P2004/64 , A61K2300/00
摘要： The present invention is directed to a composition comprising nanoparticles of TiO2 having a mean particle diameter (D50) of about 20-50 nm at a concentration of about 1-2000 g/L and H2O2 at a final concentration at about 2.5-25% by volume. The TiO2 particles are activated by the H2O2 in the composition to form radicals. The composition has antimicrobial and anti-inflammatory properties and may be used for e.g. wound debridement. The invention further concerns medical and cosmetic products and devices comprising the composition.
摘要翻译： 本发明涉及一种组合物，其包含浓度为约1-2000g / L的平均粒径（D50）为约20-50nm的TiO 2纳米颗粒，最终浓度为约2.5-25％的H 2 O 2通过 卷。 TiO 2颗粒被组合物中的H 2 O 2活化以形成自由基。 该组合物具有抗微生物和抗炎特性，可用于例如 伤口清创。 本发明还涉及包含该组合物的医疗和化妆品和装置。
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公开(公告)号：US20120129129A1
公开(公告)日：2012-05-24
申请号：US13322610
申请日：2010-06-03
IPC分类号： A61C17/00
CPC分类号： A61C19/063 , A46B3/18 , A46D1/00 , A46D1/0207 , A61C3/005 , A61C5/40 , A61C8/00
摘要： The present invention relates to the field of cleaning and/or conditioning of biological and dental implant surfaces. More particularly, the invention relates to a kit comprising a) a cleaning device said cleaning device (1) comprising: an elongated base member (2) formed of at least two wires (3) being twisted with each other, and a plurality of bristles (4) fixed between said twisted wires (3) and extending away from said twisted wires (3), whereby said bristles (4) are positioned in a cleaning section (5) at a first end (6) of said base member (2) wherein said bristles (4) consist of titanium or a titanium alloy; and b) a container comprising a composition comprising ethylene diaminotetraacetic acid (EDTA). The kit may be used for the cleaning and/or debridement and/or conditioning of a biological or dental implant surface in order to e.g. improve implant attachment and facilitate wound healing.
摘要翻译： 本发明涉及生物和牙科植入物表面的清洁和/或调理领域。 更具体地说，本发明涉及一种试剂盒，其包括：a）清洁装置，所述清洁装置包括：由至少两根彼此扭曲的丝线形成的细长基部构件，以及多个刷毛 （4）固定在所述绞合线（3）之间并远离所述绞合线（3）延伸，由此所述刷毛（4）位于所述基底构件（2）的第一端（6）处的清洁部分（5） ），其中所述刷毛（4）由钛或钛合金构成; 和b）包含包含乙二胺四乙酸（EDTA）的组合物的容器。 该试剂盒可用于生物或牙齿植入物表面的清洁和/或清创和/或调理，以便例如。 改善植入物附着并促进伤口愈合。
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公开(公告)号：US20090060999A1
公开(公告)日：2009-03-05
申请号：US12210350
申请日：2008-09-15
CPC分类号： A61K38/39 , A61K8/64 , A61K35/32 , A61K38/1709 , A61K2800/57 , A61L27/18 , A61L27/225 , A61L27/227 , A61L27/48 , A61L27/54 , A61L27/58 , A61L2300/252 , A61Q11/00 , C08L71/02 , C08L89/00
摘要： The present invention relates to a new and improved low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, intended to be used as therapeutic, as prophylactic and/or as cosmetic agent. In the present invention, said active enamel substance is incorporated into a polymeric matrix, which is either suitable for cellular in-growth, or cell-occlusive. The active enamel substance can be incorporated into the polymeric matrix so that it is released by degradation of the polymeric matrix, by enzymatic action and/or by diffusion.Comprised in the invention is thus in particular a new pharmaceutical and/or cosmetic formulation of an active enamel substance at a lower total concentration within the formulation, wherein a spatial and/or selective regulation of release of said active enamel substance permits a greater percentage of the active enamel substance to be released at the time of appropriate cellular activity.
摘要翻译： 本发明涉及一种新的和改进的，旨在作为治疗用作预防和/或化妆品的活性搪瓷物质如釉质基质，釉质基质衍生物和/或釉质基质蛋白质的低浓度制剂 代理商 在本发明中，所述活性釉质物质掺入聚合物基质中，其适用于细胞生长或细胞闭塞。 可以将活性搪瓷物质并入聚合物基质中，使其通过降解聚合物基质，通过酶作用和/或通过扩散而释放。 因此，本发明包括特别是在制剂中具有较低总浓度的活性搪瓷物质的新的药物和/或化妆品制剂，其中所述活性搪瓷物质的释放的空间和/或选择性调节允许更大百分比的 在适当的细胞活性时待释放的活性搪瓷物质。
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公开(公告)号：US07423013B2
公开(公告)日：2008-09-09
申请号：US11301123
申请日：2005-12-12
IPC分类号： C07K14/00
CPC分类号： A61K38/39 , A61K8/64 , A61K35/32 , A61K38/1709 , A61K2800/57 , A61L27/18 , A61L27/225 , A61L27/227 , A61L27/48 , A61L27/54 , A61L27/58 , A61L2300/252 , A61Q11/00 , C08L71/02 , C08L89/00
摘要： A low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, is intended to be used as a therapeutic, as a prophylactic and/or as a cosmetic agent. The active enamel substance is incorporated into a polymeric matrix, which is either suitable for cellular in-growth, or is cell-occlusive, so that it is released by degradation of the polymeric matrix, by enzymatic action and/or by diffusion. A new pharmaceutical and/or cosmetic formulation of an active enamel substance is provided at a lower total concentration within the formulation, wherein a spatial and/or selective regulation of release of said active enamel substance permits a greater percentage of the active enamel substance to be released at the time of appropriate cellular activity.
摘要翻译： 旨在用作活性搪瓷物质如釉质基质，釉质基质衍生物和/或釉质基质蛋白质的低浓度制剂作为预防剂和/或作为化妆剂的治疗剂。 将活性搪瓷物质掺入聚合物基质中，其适用于细胞内生长或细胞闭塞，从而通过酶促作用和/或通过扩散将聚合物基质降解释放。 提供活性搪瓷物质的新的药物和/或化妆品制剂，其在制剂内的总浓度较低，其中所述活性搪瓷物质的释放的空间和/或选择性调节允许活性釉质物质的较大百分比为 在适当的细胞活动时释放。
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