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11 条记录 (耗时 0.021 秒)

    Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor
    2.
    发明申请
    Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor 审中-公开
    使用两种或更多种肝细胞生长因子异构体治疗和预防心脏病症

    公开(公告)号：US20090202606A1

    公开(公告)日：2009-08-13

    申请号：US12359137

    申请日：2009-01-23

    申请人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn

    发明人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn

    IPC分类号： A61F2/00 ,  A61K38/16 ,  A61K31/7088

    CPC分类号： A61K38/1833 ,  A61K31/70

    摘要： The present invention relates to methods for treating or preventing cardiac conditions in a subject comprising administering to the subject two or more isoforms of hepatocyte growth factor (HGF). The present invention further relates to methods for promoting endothelial cell growth in a blood vessel comprising administering to the blood vessel two or more isoforms of hepatocyte growth factor (HGF). In one embodiment the two or more isoforms of HGF are administered as one or more polynucleotides encoding the isoforms.

    摘要翻译： 本发明涉及用于治疗或预防受试者心脏病症的方法，其包括向受试者施用两种或更多种肝细胞生长因子（HGF）的同种型。 本发明还涉及促进血管内皮细胞生长的方法，包括向血管施用两种或多种肝细胞生长因子（HGF）的同种型。 在一个实施方案中，HGF的两种或更多种同种型作为编码同种型的一种或多种多核苷酸给药。

    Lyophilized DNA formulations for enhanced expression of plasmid DNA
    4.
    发明授权
    Lyophilized DNA formulations for enhanced expression of plasmid DNA 有权
    用于增强质粒DNA表​​达的冻干DNA制剂

    公开(公告)号：US08389492B2

    公开(公告)日：2013-03-05

    申请号：US13045460

    申请日：2011-03-10

    申请人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn ,  WonSun Yoo

    发明人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn ,  WonSun Yoo

    IPC分类号： A61K31/7088

    CPC分类号： C07K14/4753

    摘要： The present invention provides for a method of treating or preventing ischemic or liver disease in a subject by administering a composition reconstituted from a lyophilized hepatocyte growth factor (HGF) DNA formulation, where the DNA formulation comprises an HGF plasmid DNA, salt and a carbohydrate. The invention further provides for a method of making such a lyophilized DNA formulation that preserves or enhances gene expression both in vitro and in vivo, thus maintaining or stimulating the biological activity of the expressed protein. The invention also provides for the DNA formulation, or the lyophilized DNA formulation according to the methods disclosed.

    摘要翻译： 本发明提供了通过施用从冻干的肝细胞生长因子（HGF）DNA制剂重组的组合物来治疗或预防受试者的缺血性或肝脏疾病的方法，其中所述DNA制剂包含HGF质粒DNA，盐和碳水化合物。 本发明进一步提供了制备这样的冻干DNA制剂的方法，其在体外和体内保留或增强基因表达，从而维持或刺激所表达的蛋白质的生物学活性。 本发明还提供了根据所公开的方法的DNA制剂或冻干的DNA制剂。

    Expression vectors with improved safety
    5.
    发明授权
    Expression vectors with improved safety 有权
    具有改善安全性的表达载体

    公开(公告)号：US08105575B2

    公开(公告)日：2012-01-31

    申请号：US11870361

    申请日：2007-10-10

    申请人： Sunyoung Kim ,  Sujeong Kim ,  Jun-Tae Lee

    发明人： Sunyoung Kim ,  Sujeong Kim ,  Jun-Tae Lee

    IPC分类号： C12N15/867 ,  C12N15/09 ,  C12N15/00

    CPC分类号： C12N15/86 ,  C12N2740/13043 ,  C12N2830/00

    摘要： The present invention relates to the use of internal promoters in mammalian expression vectors including plasmid vectors and enhancer-deleted retroviral vectors. The retroviral vectors have improved safety and optimal levels of transgene expression and vector titers.

    摘要翻译： 本发明涉及内源启动子在哺乳动物表达载体中的应用，包括质粒载体和增强子缺失的逆转录病毒载体。 逆转录病毒载体改善了转基因表达和载体滴度的安全性和最佳水平。

    LYOPHILIZED DNA FORMULATIONS FOR ENHANCED EXPRESSION OF PLASMID DNA
    6.
    发明申请
    LYOPHILIZED DNA FORMULATIONS FOR ENHANCED EXPRESSION OF PLASMID DNA 有权
    用于增强PLASMID DNA表达的LYOPHILIZED DNA配方

    公开(公告)号：US20110166211A1

    公开(公告)日：2011-07-07

    申请号：US13045460

    申请日：2011-03-10

    申请人： JONG-MOOK KIM ,  Sujeong Kim ,  Woong Hahn ,  WonSun Yoo

    发明人： JONG-MOOK KIM ,  Sujeong Kim ,  Woong Hahn ,  WonSun Yoo

    IPC分类号： A61K31/7088

    CPC分类号： C07K14/4753

    摘要： The present invention provides for a method of treating or preventing ischemic or liver disease in a subject by administering a composition reconstituted from a lyophilized hepatocyte growth factor (HGF) DNA formulation, where the DNA formulation comprises an HGF plasmid DNA, salt and a carbohydrate. The invention further provides for a method of making such a lyophilized DNA formulation that preserves or enhances gene expression both in vitro and in vivo, thus maintaining or stimulating the biological activity of the expressed protein. The invention also provides for the DNA formulation, or the lyophilized DNA formulation according to the methods disclosed.

    摘要翻译： 本发明提供了通过施用从冻干的肝细胞生长因子（HGF）DNA制剂重组的组合物来治疗或预防受试者的缺血性或肝脏疾病的方法，其中所述DNA制剂包含HGF质粒DNA，盐和碳水化合物。 本发明进一步提供了制备这样的冻干DNA制剂的方法，其在体外和体内保留或增强基因表达，从而维持或刺激所表达的蛋白质的生物学活性。 本发明还提供了根据所公开的方法的DNA制剂或冻干的DNA制剂。

    Lyophilized DNA Formulations for Enhanced Expression of Plasmid DNA
    8.
    发明申请
    Lyophilized DNA Formulations for Enhanced Expression of Plasmid DNA 审中-公开
    用于增强质粒DNA表​​达的冻干DNA制剂

    公开(公告)号：US20090258932A1

    公开(公告)日：2009-10-15

    申请号：US12421425

    申请日：2009-04-09

    申请人： JONG-MOOK KIM ,  SUJEONG KIM ,  WOONG HAHN ,  WONSUN YOO

    发明人： JONG-MOOK KIM ,  SUJEONG KIM ,  WOONG HAHN ,  WONSUN YOO

    IPC分类号： A61K31/7088

    CPC分类号： C07K14/4753

    摘要： The present invention provides for a method of treating or preventing ischemic or liver disease in a subject by administering a composition reconstituted from a lyophilized hepatocyte growth factor (HGF) DNA formulation, where the DNA formulation comprises an HGF plasmid DNA, salt and a carbohydrate. The invention further provides for a method of making such a lyophilized DNA formulation that preserves or enhances gene expression both in vitro and in vivo, thus maintaining or stimulating the biological activity of the expressed protein. The invention also provides for the DNA formulation, or the lyophilized DNA formulation according to the methods disclosed.

    摘要翻译： 本发明提供了通过施用从冻干的肝细胞生长因子（HGF）DNA制剂重组的组合物来治疗或预防受试者的缺血性或肝脏疾病的方法，其中所述DNA制剂包含HGF质粒DNA，盐和碳水化合物。 本发明进一步提供了制备这样的冻干DNA制剂的方法，其在体外和体内保留或增强基因表达，从而维持或刺激所表达的蛋白质的生物学活性。 本发明还提供了根据所公开的方法的DNA制剂或冻干的DNA制剂。