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    Encoded self-assembling chemical libraries (esachel)
    2.
    发明申请
    Encoded self-assembling chemical libraries (esachel) 审中-公开
    编码自组装化学文库（esachel）

    公开(公告)号：US20060154246A1

    公开(公告)日：2006-07-13

    申请号：US10507140

    申请日：2002-04-15

    申请人： Dario Neri ,  Samu Melkko

    发明人： Dario Neri ,  Samu Melkko

    IPC分类号： C40B40/08 ,  C07H21/02

    CPC分类号： C12Q1/6837 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/1068 ,  C12Q1/6813 ,  C40B30/04 ,  C40B40/06 ,  G01N33/58 ,  C12Q2565/501 ,  C12Q2565/101 ,  C12Q2563/179

    摘要： The invention concerns a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule (e.g. a biological target) and further comprising an oligonucleotide (b) or functional analogue thereof. In a first embodiment according to the invention, the chemical compound is characterized in that the oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1′) of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In a second embodiment according to the invention, the chemical compound which comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) is characterized in that the chemical compound further comprises at least one self-assembly moiety (m) capable of performing a combination reaction with at least one self-assembly moiety (m′) of a similar chemical compound comprising a chemical moiety (q). The invention comprises corresponding libraries of chemical compounds as well as methods of biopanning of target molecules and of identifying such targets.

    摘要翻译： 本发明涉及包含能够与靶分子（例如生物靶标）进行结合相互作用并且还包含寡核苷酸（b）或其功能类似物的化学部分（p）的化合物。 在根据本发明的第一实施方案中，化合物的特征在于寡核苷酸（b）或功能类似物包含能够与至少一个自组装序列进行组合反应的至少一个自组装序列（b1） b1'）与包含化学部分（q）的另一化合物结合的互补寡核苷酸或功能性类似物。 在根据本发明的第二个实施方案中，包含编码化学部分（p）的编码序列（b1）的化合物的特征在于化学化合物还包含至少一个自组装部分（m） 能够与包含化学部分（q）的类似化学化合物的至少一个自组装部分（m'）进行组合反应。 本发明包括相应的化学化合物文库以及目标分子的生物淘选方法和识别这些靶标。

    Encoded self-assembling chemical libraries (ESACHEL)
    4.
    发明授权
    Encoded self-assembling chemical libraries (ESACHEL) 有权
    编码自组装化学文库（ESACHEL）

    公开(公告)号：US08642514B2

    公开(公告)日：2014-02-04

    申请号：US12555707

    申请日：2009-09-08

    申请人： Dario Neri ,  Samu Melkko

    发明人： Dario Neri ,  Samu Melkko

    IPC分类号： C40B40/06 ,  C07H21/00 ,  C07H21/04

    CPC分类号： C12Q1/6837 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/1068 ,  C12Q1/6813 ,  C40B30/04 ,  C40B40/06 ,  G01N33/58 ,  C12Q2565/501 ,  C12Q2565/101 ,  C12Q2563/179

    摘要： The invention provides a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule, and an oligonucleotide (b) or functional analogue thereof. The oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1′) of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In a some embodiments, the chemical compound comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) and further comprises at least one self-assembly moiety (m) capable of performing a combination reaction with at least one self-assembly moiety (m′) of a similar chemical compound comprising a chemical moiety (q). The invention also provides corresponding libraries of chemical compounds as well as methods of biopanning for target molecules and of identifying such targets.

    摘要翻译： 本发明提供了包含能够与靶分子进行结合相互作用的化学部分（p）和寡核苷酸（b）或其功能类似物的化合物。 寡核苷酸（b）或功能类似物包含至少一个能够与互补寡核苷酸的至少一个自组装序列（b1'）进行组合反应的自组装序列（b1）或与另一化合物结合的功能性类似物 化学部分（q）。 在一些实施方案中，化合物包含编码化学部分（p）的鉴定的编码序列（b1），并且还包含能够与至少一个自身进行组合反应的至少一个自组装部分（m） 包含化学部分（q）的类似化学化合物的组装部分（m'）。 本发明还提供了相应的化学化合物文库以及靶分子的生物淘选方法和鉴定这些靶标。

    ENCODED SELF-ASSEMBLING CHEMICAL LIBRARIES (ESACHEL)
    5.
    发明申请
    ENCODED SELF-ASSEMBLING CHEMICAL LIBRARIES (ESACHEL) 有权
    编码自组装化学图书馆（ESACHEL）

    公开(公告)号：US20100184611A1

    公开(公告)日：2010-07-22

    申请号：US12555707

    申请日：2009-09-08

    申请人： Dario Neri ,  Samu Melkko

    发明人： Dario Neri ,  Samu Melkko

    IPC分类号： C40B30/04 ,  C40B40/06

    CPC分类号： C12Q1/6837 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/1068 ,  C12Q1/6813 ,  C40B30/04 ,  C40B40/06 ,  G01N33/58 ,  C12Q2565/501 ,  C12Q2565/101 ,  C12Q2563/179

    摘要： The invention concerns a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule (e.g. a biological target) and further comprising an oligonucleotide (b) or functional analogue thereof. In a first embodiment according to the invention, the chemical compound is characterized in that the oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1′) of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In a second embodiment according to the invention, the chemical compound which comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) is characterized in that the chemical compound further comprises at least one self-assembly moiety (m) capable of performing a combination reaction with at least one self-assembly moiety (m′) of a similar chemical compound comprising a chemical moiety (q). The invention comprises corresponding libraries of chemical compounds as well as methods of biopanning of target molecules and of identifying such targets.

    摘要翻译： 本发明涉及包含能够与靶分子（例如生物靶标）进行结合相互作用并且还包含寡核苷酸（b）或其功能类似物的化学部分（p）的化合物。 在根据本发明的第一实施方案中，化合物的特征在于寡核苷酸（b）或功能类似物包含能够与至少一个自组装序列进行组合反应的至少一个自组装序列（b1） b1'）与包含化学部分（q）的另一化合物结合的互补寡核苷酸或功能性类似物。 在根据本发明的第二个实施方案中，包含编码化学部分（p）的编码序列（b1）的化合物的特征在于化学化合物还包含至少一个自组装部分（m） 能够与包含化学部分（q）的类似化学化合物的至少一个自组装部分（m'）进行组合反应。 本发明包括相应的化学化合物文库以及目标分子的生物淘选方法和识别这些靶标。

    Encoded self-assembling chemical libraries (ESACHEL)
    6.
    发明授权
    Encoded self-assembling chemical libraries (ESACHEL) 有权
    编码自组装化学文库（ESACHEL）

    公开(公告)号：US08673824B2

    公开(公告)日：2014-03-18

    申请号：US12613475

    申请日：2009-11-05

    申请人： Dario Neri ,  Samu Melkko

    发明人： Dario Neri ,  Samu Melkko

    IPC分类号： C40B40/06 ,  C40B30/04 ,  C07H21/00 ,  C07H21/04

    CPC分类号： C12Q1/6837 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/1068 ,  C12Q1/6813 ,  C40B30/04 ,  C40B40/06 ,  G01N33/58 ,  C12Q2565/501 ,  C12Q2565/101 ,  C12Q2563/179

    摘要： The invention provides a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule, and an oligonucleotide (b) or functional analogue thereof. The oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1′) of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In some embodiments, the chemical compound comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) and further comprises at least one self-assembly moiety (m) capable of performing a combination reaction with at least one self-assembly moiety (m′) of a similar chemical compound comprising a chemical moiety (q). The invention also provides corresponding libraries of chemical compounds as well as methods of biopanning of for target molecules and of identifying such targets.

    摘要翻译： 本发明提供了包含能够与靶分子进行结合相互作用的化学部分（p）和寡核苷酸（b）或其功能类似物的化合物。 寡核苷酸（b）或功能类似物包含至少一个能够与互补寡核苷酸的至少一个自组装序列（b1'）进行组合反应的自组装序列（b1）或与另一化合物结合的功能性类似物 化学部分（q）。 在一些实施方案中，化学化合物包含编码化学部分（p）的鉴定的编码序列（b1），并且还包含能够与至少一个自身组分进行组合反应的至少一个自组装部分（m） 包含化学部分（q）的类似化学化合物的组合部分（m'）。 本发明还提供了相应的化学化合物文库以及靶分子的生物淘选方法和鉴定这些靶标。

    ENCODED SELF-ASSEMBLING CHEMICAL LIBRARIES (ESACHEL)
    7.
    发明申请
    ENCODED SELF-ASSEMBLING CHEMICAL LIBRARIES (ESACHEL) 有权
    编码自组装化学图书馆（ESACHEL）

    公开(公告)号：US20110319278A1

    公开(公告)日：2011-12-29

    申请号：US12613475

    申请日：2009-11-05

    申请人： Dario Neri ,  Samu Melkko

    发明人： Dario Neri ,  Samu Melkko

    IPC分类号： C40B30/04 ,  C40B40/06

    CPC分类号： C12Q1/6837 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/1068 ,  C12Q1/6813 ,  C40B30/04 ,  C40B40/06 ,  G01N33/58 ,  C12Q2565/501 ,  C12Q2565/101 ,  C12Q2563/179

    摘要： The invention concerns a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule (e.g. a biological target) and further comprising an oligonucleotide (b) or functional analogue thereof. In a first embodiment according to the invention, the chemical compound is characterized in that the oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1′) of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In a second embodiment according to the invention, the chemical compound which comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) is characterized in that the chemical compound further comprises at least one self-assembly moiety (m) capable of performing a combination reaction with at least one self-assembly moiety (m′) of a similar chemical compound comprising a chemical moiety (q). The invention comprises corresponding libraries of chemical compounds as well as methods of biopanning of target molecules and of identifying such targets.

    摘要翻译： 本发明涉及包含能够与靶分子（例如生物靶标）进行结合相互作用并且还包含寡核苷酸（b）或其功能类似物的化学部分（p）的化合物。 在根据本发明的第一实施方案中，化合物的特征在于寡核苷酸（b）或功能类似物包含能够与至少一个自组装序列进行组合反应的至少一个自组装序列（b1） b1'）与包含化学部分（q）的另一化合物结合的互补寡核苷酸或功能性类似物。 在根据本发明的第二个实施方案中，包含编码化学部分（p）的编码序列（b1）的化合物的特征在于化学化合物还包含至少一个自组装部分（m） 能够与包含化学部分（q）的类似化学化合物的至少一个自组装部分（m'）进行组合反应。 本发明包括相应的化学化合物文库以及目标分子的生物淘选方法和识别这些靶标。