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    Treatment of Non-Alcoholic Steatotic Hepatitis (Nash)
    2.
    发明申请
    Treatment of Non-Alcoholic Steatotic Hepatitis (Nash) 审中-公开
    非酒精性脂肪性肝炎的治疗

    公开(公告)号：US20080280823A1

    公开(公告)日：2008-11-13

    申请号：US11570917

    申请日：2005-06-20

    申请人： Sander Jan Hendrik van Deventer

    发明人： Sander Jan Hendrik van Deventer

    IPC分类号： A61K31/7088 ,  A61K38/16 ,  A61P31/12

    CPC分类号： A61K38/465 ,  A61K48/00 ,  A61K48/005 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12Y301/01034

    摘要： The present invention relates to a method for treating nonalcoholic steatotic hepatitis (NASH) in a subject by administering an effective amount of a lipoprotein lipase (LPL) therapeutic to the subject. The LPL therapeutic is advantageously a S447X protein or a derivative or variant thereof, or a nucleic acid encoding such a protein. The LPL therapeutic may be used in a gene therapy vector.

    摘要翻译： 本发明涉及通过向受试者施用有效量的脂蛋白脂肪酶（LPL）治疗剂来治疗受试者中的非酒精性脂肪性肝炎（NASH）的方法。 LPL治疗剂有利地是S447X蛋白或其衍生物或变体，或编码这种蛋白质的核酸。 LPL治疗剂可用于基因治疗载体。

    IL-10 gene transfer to peripheral mononuclear cells
    3.
    发明授权
    IL-10 gene transfer to peripheral mononuclear cells 有权
    IL-10基因转移到外周单核细胞

    公开(公告)号：US08119401B2

    公开(公告)日：2012-02-21

    申请号：US10506881

    申请日：2003-03-07

    申请人： Sander Jan Hendrik Van Deventer ,  Catherine Van Montfrans

    发明人： Sander Jan Hendrik Van Deventer ,  Catherine Van Montfrans

    IPC分类号： A61K48/00 ,  C12N5/071 ,  C12N5/0783

    CPC分类号： C07K14/5428 ,  A61K48/005 ,  C12N2510/02

    摘要： The present invention to methods for producing mononuclear cells overexpressing IL-10. The method comprises the ex vivo introduction of an expression construct comprising a nucleotide sequence encoding a polypeptide having IL-10 activity into peripheral blood mononuclear cells of a subject. The thus obtained peripheral blood mononuclear cells have an altered phenotype as a result of the expression of an introduced IL-10 transgene. In particular the invention relates to CD4+ T cells that functionally behave as regulatory T cells as a result of the expression of an IL-10 transgene. The IL-10 transgenic mononuclear cells may be used to treat a variety of inflammatory diseases, particularly T helper 1-mediated inflammatory diseases.

    摘要翻译： 本发明涉及生产过表达IL-10的单核细胞的方法。 该方法包括将包含编码具有IL-10活性的多肽的核苷酸序列的表达构建体体外引入受试者的外周血单核细胞。 由此获得的外周血单核细胞由于引入的IL-10转基因的表达而具有改变的表型。 特别地，本发明涉及作为IL-10转基因表达的结果，功能上表现为调节性T细胞的CD4 + T细胞。 IL-10转基因单核细胞可用于治疗各种炎性疾病，特别是T辅助1介导的炎性疾病。

    Synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome
    4.
    发明授权
    Synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome 失效
    具有抗菌和内毒素中和特性的合成肽用于治疗败血症综合征

    公开(公告)号：US06624140B1

    公开(公告)日：2003-09-23

    申请号：US09493211

    申请日：2000-01-28

    申请人： Philip Richard Abraham ,  Bernard Jan Appelmelk ,  Sander Jan Hendrik Van Deventer

    发明人： Philip Richard Abraham ,  Bernard Jan Appelmelk ,  Sander Jan Hendrik Van Deventer

    IPC分类号： A01N3718

    CPC分类号： G01N33/579 ,  A61K38/00 ,  C07K14/4723 ,  C07K14/4742 ,  Y02A50/411 ,  Y02A50/58

    摘要： A peptide with an amino acid composition such that the peptide is amphipathic, cationic and forms a stable &agr;-helix and has the following structure comprising at least 12 amino acids R1-R2-A1-B1-(A2-B2-C1-A3)m-(C2)n-R3, wherein A=an amino acid selected from the basic amino acids Lys,Arg or His B=an amino acid selected from the aromatic amino acids Phe, Trp or Tyr C=an amino acid selected from the group comprising the hydrophobic amino acids Leu, Ile, Val or Ala, and said peptide has either the orientation according to the formula or the retro orientation thereof, wherein at least 0-m of the repetitive sequence motifs (A2-B2-C1-A3) have the retro orientation and the remaining repetitive motifs (A2-B2-C1-A3) have the orientation as presented in the formula and wherein, R1-R2- and R3 are a number of amino acids, and wherein m=1-10, preferably 2-8, more preferably 2-5 and n=1-3, a pharmaceutical composition comprising such a peptide application thereof in treatment or diagnosis related to i.a. parasite infection topical and systemic tumors and septic shock.

    摘要翻译： 具有氨基酸组成的肽，使得肽是两亲性的，阳离子的并形成稳定的α-螺旋，并且具有包含至少12个氨基酸的以下结构A =选自碱性氨基酸Lys，Arg或HisB =的氨基酸 氨基酸选自芳族氨基酸Phe，Trp或TyrC =选自疏水性氨基酸Leu，Ile，Val或Ala的氨基酸，所述肽具有根据式的取向或其复古方向， 其中至少0-m的重复序列基序（A2-B2-C1-A3）具有反向取向，并且其余的重复基序（A2-B2-C1-A3）具有如式中所示的取向，并且其中R1 -R2-和R3是多个氨基酸，并且其中m = 1-10，优选2-8，更优选2-5和n = 1-3，药物组合物包含其在治疗或诊断中的这种肽应用 ia 寄生虫感染局部和全身肿瘤和败血性休克。

    TREATMENT OF NON-ALCOHOLIC STEATOTIC HEPATITIS (NASH)
    6.
    发明申请
    TREATMENT OF NON-ALCOHOLIC STEATOTIC HEPATITIS (NASH) 审中-公开
    治疗非酒精性肠胃炎（NASH）

    公开(公告)号：US20110081332A1

    公开(公告)日：2011-04-07

    申请号：US12960081

    申请日：2010-12-03

    申请人： SANDER JAN HENDRIK VAN DEVENTER

    发明人： SANDER JAN HENDRIK VAN DEVENTER

    IPC分类号： A61K38/46 ,  A61K31/711 ,  A61P1/16

    CPC分类号： A61K38/465 ,  A61K48/00 ,  A61K48/005 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12Y301/01034

    摘要： The present invention relates to a method for treating non-alcoholic steatotic hepatitis (NASH) in a subject by administering an effective amount of a lipoprotein lipase (LPL) therapeutic to the subject. The LPL therapeutic is advantageously a S447X protein or a derivative or variant thereof, or a nucleic acid encoding such a protein. The LPL therapeutic may be used in a gene therapy vector.

    摘要翻译： 本发明涉及通过对受试者施用有效量的脂蛋白脂肪酶（LPL）治疗剂来治疗受试者中的非酒精性脂肪性肝炎（NASH）的方法。 LPL治疗剂有利地是S447X蛋白或其衍生物或变体，或编码这种蛋白质的核酸。 LPL治疗剂可用于基因治疗载体。