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1.发明授权公开(公告)号：US07709002B1
公开(公告)日：2010-05-04
申请号：US09155590
申请日：1997-04-17
申请人： Jeffrey Schlom , Scott Abrams
发明人： Jeffrey Schlom , Scott Abrams
摘要： Mutant ras oncogene peptides may induce specific anti-ras cellular immune responses in vaccinated patients. Moreover, a human CD8+ CTL epitope(s) reflecting a specific point mutation in the K-ras oncogene at codon 12 was identified. The mutant ras peptide has implications for both active and passive immunotherapies in selected carcinoma patients. A nested 10-mer peptide was identified [i.e., ras5-14(Asp12)], which was shown to bind to HLA-A2 and display specific functional capacity for expansion of the in-vivo-primed CD8+ CTL precursors.
摘要翻译： 突变ras致癌基因肽可能在接种疫苗的患者中诱导特异性抗ras细胞免疫应答。 此外，鉴定了在密码子12反映K-ras致癌基因中的特异性点突变的人CD8 + CTL表位。 突变型ras肽对所选癌症患者的主动和被动免疫疗法都有影响。 鉴定了嵌合的10聚体肽[即ras5-14（Asp12）]，其显示与HLA-A2结合并显示用于扩增体内引发的CD8 + CTL前体的特异功能能力。
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2.发明申请MUTATED RAS PEPTIDES FOR GENERATION OF CD8+ CYTOTOXIC T LYMPHOCYTES 审中-公开用于产生CD8 + CYTOTOXIC T淋巴细胞的突变RAP肽公开(公告)号：US20100074945A1
公开(公告)日：2010-03-25
申请号：US12623062
申请日：2009-11-20
申请人： Jeffrey Schlom , Scott Abrams
发明人： Jeffrey Schlom , Scott Abrams
IPC分类号： A61K9/127 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61K35/12 , A61K38/20 , A61K38/21 , A61K38/16 , C12N5/00 , A61P35/00 , C07H21/00 , C12N15/63
摘要： Mutant ras oncogene peptides may induce specific anti-ras cellular immune responses in vaccinated patients. Moreover, a human CD8+ CTL epitope(s) reflecting a specific point mutation in the K-ras oncogene at codon 12 was identified. The mutant ras peptide has implications for both active and passive immunotherapies in selected carcinoma patients. A nested 10-mer peptide was identified [i.e., ras5-14(Asp12)], which was shown to bind to HLA-A2 and display specific functional capacity for expansion of the in vivo-primed CD8+ CTL precursors.
摘要翻译： 突变ras致癌基因肽可能在接种疫苗的患者中诱导特异性抗ras细胞免疫应答。 此外，鉴定了在密码子12反映K-ras致癌基因中的特异性点突变的人CD8 + CTL表位。 突变型ras肽对所选癌症患者的主动和被动免疫疗法都有影响。 鉴定了嵌合的10聚体肽[即ras5-14（Asp12）]，其显示与HLA-A2结合并显示用于体内引发的CD8 + CTL前体扩增的特异功能能力。
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3.发明授权公开(公告)号：US08883448B2
公开(公告)日：2014-11-11
申请号：US12623062
申请日：2009-11-20
申请人： Jeffrey Schlom , Scott Abrams
发明人： Jeffrey Schlom , Scott Abrams
摘要： Mutant ras oncogene peptides may induce specific anti-ras cellular immune responses in vaccinated patients. Moreover, a human CD8+ CTL epitope(s) reflecting a specific point mutation in the K-ras oncogene at codon 12 was identified. The mutant ras peptide has implications for both active and passive immunotherapies in selected carcinoma patients. A nested 10-mer peptide was identified [i.e., ras5-14(Asp12)], which was shown to bind to HLA-A2 and display specific functional capacity for expansion of the in vivo-primed CD8+ CTL precursors.
摘要翻译： 突变ras致癌基因肽可能在接种疫苗的患者中诱导特异性抗ras细胞免疫应答。 此外，鉴定了在密码子12反映K-ras致癌基因中的特异性点突变的人CD8 + CTL表位。 突变型ras肽对所选癌症患者的主动和被动免疫疗法都有影响。 鉴定了嵌合的10聚体肽[即ras5-14（Asp12）]，其显示与HLA-A2结合并显示用于体内引发的CD8 + CTL前体扩增的特异功能能力。
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公开(公告)号：US06947456B2
公开(公告)日：2005-09-20
申请号：US09735315
申请日：2000-12-12
申请人： Jesse Chin , Miaobin Gao , Robert Elsheimer , Matthew Scott Abrams , Heng-ju Cheng , Takashi Hidai , Myunghee Lee , Song Liu
发明人： Jesse Chin , Miaobin Gao , Robert Elsheimer , Matthew Scott Abrams , Heng-ju Cheng , Takashi Hidai , Myunghee Lee , Song Liu
CPC分类号： H01S5/4025 , H01S5/042 , H01S5/0617 , H01S5/062
摘要： A laser driver for generating drive waveforms that are suitable for driving a single VCSEL or an array of VCSELs. A digital controller is integrated into the laser driver and is utilized to initially program and selectively adjust during the operation of the driver one or more of the following VCSEL drive waveform parameters: (1) bias current, (2) modulation current, (3) negative peaking depth, and (4) negative peaking duration. The laser driver has an aging compensation mechanism for monitoring the age of the laser and for selectively adjusting the dc and ac parameters of the VCSEL drive waveform to compensate for the aging of the laser. The laser driver also has a temperature compensation mechanism for monitoring the temperature of the driver IC and selectively adjusting the dc and ac parameters of the VCSEL drive waveform to compensate for the changes in temperature.
摘要翻译： 用于产生适用于驱动单个VCSEL或VCSEL阵列的驱动波形的激光驱动器。 一个数字控制器集成到激光驱动器中，用于在驱动器运行期间对以下VCSEL驱动波形参数中的一个或多个进行初始编程和选择性调整：（1）偏置电流，（2）调制电流，（3） 负峰值深度，（4）负峰值持续时间。 激光驱动器具有老化补偿机制，用于监测激光器的寿命，并选择性地调整VCSEL驱动波形的直流和交流参数，以补偿激光器的老化。 激光驱动器还具有用于监视驱动器IC的温度的温度补偿机构，并且选择性地调节VCSEL驱动波形的直流和交流参数以补偿温度变化。
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公开(公告)号：US07412122B2
公开(公告)日：2008-08-12
申请号：US11376352
申请日：2006-03-15
IPC分类号： G02B6/12
CPC分类号： H01L27/0203
摘要： An integrated circuit cast on a single die having a plurality of receivers in a receiver region, a plurality of transmitters in a transmitter region, and a spatial separation region having a plurality of n-type and p-type subregions disposed on the single die to separate the transmitter region from the receiver region. The pn-junctions between the n-type and p-type subregions are reverse-biased thereby reducing or eliminating coupling of noise and crosstalk between the transmitter and receiver is reduced.
摘要翻译： 在单个管芯上投射的集成电路，其具有接收器区域中的多个接收器，发射器区域中的多个发射器，以及具有设置在单个管芯上的多个n型和p型子区域的空间分隔区域 将发射机区域与接收机区域分开。 n型和p型子区域之间的pn结被反向偏置，从而减少或消除噪声的耦合，并减少发射机和接收机之间的串扰。
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公开(公告)号：US07076124B2
公开(公告)日：2006-07-11
申请号：US10327216
申请日：2002-12-20
IPC分类号： G02B6/12
CPC分类号： H01L27/0203
摘要： An integrated circuit cast on a single die having a plurality of receivers in a receiver region, a plurality of transmitters in a transmitter region, and a spatial separation region having a plurality of n-type and p-type subregions disposed on the single die to separate the transmitter region from the receiver region. The pn-junctions between the n-type and p-type subregions are reverse-biased thereby reducing or eliminating coupling of noise and crosstalk between the transmitter and receiver is reduced.
摘要翻译： 在单个管芯上投射的集成电路，其具有接收器区域中的多个接收器，发射器区域中的多个发射器，以及具有设置在单个管芯上的多个n型和p型子区域的空间分隔区域 将发射机区域与接收机区域分开。 n型和p型子区域之间的pn结被反向偏置，从而减少或消除噪声的耦合，并减少发射机和接收机之间的串扰。
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