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公开(公告)号：US20240148836A1
公开(公告)日：2024-05-09
申请号：US18233783
申请日：2023-08-14
发明人： Keon Wook KANG , Myung Geun SONG , Cho Rong PARK , Yun-Sang LEE , Hye Won YOUN , Ji Yong PARK , Se Ra OH
摘要： In a method for treating a cancer expressing secreted protein acidic and rich in cysteine (SPARC), a composition including an albumin and at least one cysteine bound thereto is administered to a subject in need thereof. The cancer expressing the SPARC may be at least one selected from the group consisting of a brain tumor, melanoma, breast cancer, rectal cancer and stomach cancer.
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2.发明公开公开(公告)号：US20230334662A1
公开(公告)日：2023-10-19
申请号：US18179846
申请日：2023-03-07
发明人： Sunghoon Kwon , Yongju Lee , Kyoungseob Shin , Kyung Chul Moon , Jeong Hwan Park , Sohee Oh
IPC分类号： G06T7/00 , G06T7/11 , G06V10/44 , G06V10/762 , G06V10/764 , G16H50/20 , G16H50/30
CPC分类号： G06T7/0012 , G06T7/11 , G06V10/44 , G06V10/762 , G06V10/764 , G16H50/20 , G16H50/30 , G06T2207/20084
摘要： The present invention relates to a method and apparatus for analyzing pathology patterns of whole-slide images based on graph deep learning, which may include: a whole-slide image (WSI) compression step of compressing WSI into a superpatch graph; a graph neural networks (GNN) analysis step of embedding node features and context features into the superpatch graph through a GNN model and calculating contributions for each node and edge; a biomarker acquisition step of classifying and grouping the superpatch graph according to the contributions for each node, connecting the classified and grouped superpatch graph in units of groups to generate connected graphs, normalizing and clustering features of the connected graphs, and acquiring environmental graph biomarkers for each group; and a diagnostic information extraction step of extracting and providing diagnostic information on the WSI based on the environmental graph biomarker for each group.
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公开(公告)号：US20230088644A1
公开(公告)日：2023-03-23
申请号：US17811403
申请日：2022-07-08
发明人： Kyong Soo PARK , Seung-Ah LEE , Yong Deok LEE , Hakmo LEE , Sung Soo CHUNG
摘要： The present invention relates to a composition for inducing differentiation into insulin-producing cells, and a method for inducing differentiation into insulin-producing cells. By using a differentiation inducing composition according to an exemplary embodiment or a differentiation inducing method according to an exemplary embodiment, insulin-producing cells can be prepared in a short period by effectively inducing the differentiation of various types of stem cells into insulin-producing cells, and can be mass-produced in a relatively simple manner, and thus a pharmaceutical composition for preventing or treating diabetes mellitus, comprising insulin-producing cells and/or insulin produced thereby, can be provided.
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公开(公告)号：US20200277630A1
公开(公告)日：2020-09-03
申请号：US16650993
申请日：2018-09-28
申请人： TOOLGEN INCORPORATED , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , SEOUL NATIONAL UNIVERSITY HOSPITAL
发明人： Dong Woo SONG , Jung Min LEE , Un Gi KIM , Jeong Hun KIM , Dong Hyun JO
IPC分类号： C12N15/86 , C12N15/113 , C12N9/22 , A61P27/02
摘要： The present invention relates to a composition for gene manipulation for treating or improving a retinal dysfunction disease or a method using the same. More particularly, the present invention relates to a composition for gene manipulation including a guide nucleic acid capable of targeting a retinal function-forming gene and a method of treating or improving a disease caused by retinal dysfunction by artificially manipulating and/or correcting a retinal function-forming gene using the same.
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5.发明申请RAPID ANTIMICROBIAL SUSCEPTIBILITY TEST, BASED ON AN ANALYSIS OF CHANGES IN MORPHOLOGY AND GROWTH PATTERN OF A MICROBIAL CELL UNDER DIFFERENT CONCENTRATIONS OF VARIOUS ANTIMICROBIAL AGENTS, AND AUTOMATED CELL IMAGE ANALYSIS SYSTEM THEREFOR 审中-公开基于各种抗微生物剂不同浓度下微生物细胞形态和生长模式变化的分析及其自动化细胞图像分析系统的快速抗微生物耐受性测试公开(公告)号：US20160102334A1
公开(公告)日：2016-04-14
申请号：US14883101
申请日：2015-10-14
申请人： Quanta Matrix Co., Ltd. , Seoul National University R&DB Foundation , Seoul National University Hospital
发明人： Yong-Gyun Jung , Eun-Geun Kim , Jung Heon Yoo , Sunghoon Kwon , Jungil Choi , Hee Chan Kim , Jung Chan Lee , Eui Jong Kim , Sang Hoon Song , Sei Ick Joo , Ji Soo Lee
IPC分类号： C12Q1/18
CPC分类号： C12Q1/18 , G06T2207/30024
摘要： Provided are a rapid antimicrobial susceptibility test, based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and an automated cell image analysis system therefor. The antimicrobial susceptibility test is rapidly performed based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and this makes it possible to obtain highly reliable test results faster by six to seven times than the standard method recommended by Clinical and Laboratory Standards Institute (CLSI).
摘要翻译： 提供了基于不同浓度的各种抗微生物剂下微生物细胞的形态和生长模式变化的分析以及其自动化细胞图像分析系统的快速抗微生物敏感性试验。 基于不同浓度的各种抗菌剂对微生物细胞的形态和生长模式的变化进行分析，快速进行抗微生物敏感性试验，这使得可以获得高可靠性的测试结果比标准更快六至七倍 临床和实验室标准研究所（CLSI）推荐的方法。
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公开(公告)号：US11845951B2
公开(公告)日：2023-12-19
申请号：US16650993
申请日：2018-09-28
申请人： TOOLGEN INCORPORATED , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , SEOUL NATIONAL UNIVERSITY HOSPITAL
发明人： Dong Woo Song , Jung Min Lee , Un Gi Kim , Jeong Hun Kim , Dong Hyun Jo
IPC分类号： C12N15/86 , C12N15/113 , C12N9/22 , A61P27/02 , A61K48/00
CPC分类号： C12N15/86 , A61P27/02 , C12N9/22 , C12N15/113 , A61K48/00 , C12N2310/20 , C12N2800/80
摘要： The present invention relates to a composition for gene manipulation for treating or improving a retinal dysfunction disease or a method using the same. More particularly, the present invention relates to a composition for gene manipulation including a guide nucleic acid capable of targeting a retinal function-forming gene and a method of treating or improving a disease caused by retinal dysfunction by artificially manipulating and/or correcting a retinal function-forming gene using the same.
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公开(公告)号：US11825818B2
公开(公告)日：2023-11-28
申请号：US16846321
申请日：2020-04-11
申请人： SEOUL NATIONAL UNIVERSITY HOSPITAL , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Hee Seung Kim , Jeong Mook Lim , Ji Yeon Ahn , Na Ra Lee , Eun Ji Lee , Soo Jin Park , Sung Jong Lee
IPC分类号： A01K67/027
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2227/108 , A01K2267/0331
摘要： The present invention relates to a method for preparing a large animal model, with peritoneal carcinomatosis, which is an abdominal cavity metastasis of tumor commonly found in advanced or recurrent solid cancer, is induced using a large animal, and the method for preparing a large animal model with peritoneal carcinomatosis comprises injecting a cancer cell line into the abdominal cavity of a piglet in which the immune function is not completed. The method for preparing a large animal model with peritoneal carcinomatosis, when a human-derived immortalized cell line is inoculated into a pig, can overcome xenograft rejection and induce peritoneal carcinomatosis, can use animals with sufficient supply and demand, and can expect the spread of peritoneal carcinomatosis through breeding.
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8.发明公开公开(公告)号：US20230248665A1
公开(公告)日：2023-08-10
申请号：US18185061
申请日：2023-03-16
申请人： SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION , SEOUL NATIONAL UNIVERSITY HOSPITAL , CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Kyong Soo PARK , Sung Soo CHUNG , Ji Seon LEE , Kwang Yong PARK
摘要： Provided is a composition comprising a dimethylchalcone derivative for prevention or treatment of metabolic diseases and, more specifically, to a compositioncomprising a derivative of 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone as an active ingredient for the alleviation, prevention, or treatment of various metabolic diseases.
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公开(公告)号：US11339446B2
公开(公告)日：2022-05-24
申请号：US16494557
申请日：2018-03-08
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , INDUSTRY-ACADEMIC COOPERATION FOUNDATION OF SUNCHON NATIONAL UNIVERSITY , SEOUL NATIONAL UNIVERSITY HOSPITAL
发明人： Wonshik Han , Dong-Young Noh , Han-Byoel Lee , Eun-Kyu Kim , Ae-Kyung Park , Hyeong-Gon Moon
IPC分类号： C12Q1/6886
摘要： The present disclosure discloses a biomarker capable of predicting the therapeutic response to anticancer agents and prognosis of triple-negative breast cancer patients, and the use thereof. A biomarker according to the present disclosure allows the provision of optimized personal therapeutic methods through correct personalized treatment, contributing to the quality and prolongation of life of patients.
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公开(公告)号：US11123409B2
公开(公告)日：2021-09-21
申请号：US15661300
申请日：2017-07-27
申请人： INSTITUTE FOR BASIC SCIENCE , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , SEOUL NATIONAL UNIVERSITY HOSPITAL
发明人： Jin-Soo Kim , Jeong Hun Kim , Sung Wook Park , Kyoungmi Kim
摘要： Provided are a method of preventing and/or treating an eye disease, using a Cas9 protein and a guide RNA targeting VEGF-A, and a ribonucleoprotein including a Cas9 protein and a guide RNA targeting VEGF-A.
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