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公开(公告)号：US11141508B2
公开(公告)日：2021-10-12
申请号：US16289626
申请日：2019-02-28
Applicant: Seraxis, Inc.
Inventor： William L Rust
IPC: A61K35/39 , A61L31/08 , A61P3/10 , A61L31/04 , A61P5/48 , A61P5/50 , A61L27/38 , A61L27/54 , A61K9/50 , A61K35/00
Abstract: Described are macro-capsules, barriers, and devices that can be used to prepare therapeutic cell implants, methods of encapsulating therapeutic cells, and methods of using the encapsulated cells in the treatment of disease.
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公开(公告)号：US20230031960A1
公开(公告)日：2023-02-02
申请号：US17959203
申请日：2022-10-03
Applicant: Seraxis, Inc.
Inventor： William L. Rust
Abstract: The present disclosure provides cell-based compositions for treating diabetes, methods for identifying cells that preferentially differentiate into endoderm cells, and methods for preparing insulin-producing pancreatic cells, as well as related methods of use for treating diseases related to insulin deficiency.
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公开(公告)号：US11484554B2
公开(公告)日：2022-11-01
申请号：US16968317
申请日：2019-02-08
Applicant: Seraxis, Inc.
Inventor： William L. Rust
Abstract: The present disclosure provides cell-based compositions for treating diabetes, methods for identifying cells that preferentially differentiate into endoderm cells, and methods for preparing insulin-producing pancreatic cells, as well as related methods of use for treating diseases related to insulin deficiency.
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4.发明申请公开(公告)号：US20130344594A1
公开(公告)日：2013-12-26
申请号：US13925248
申请日：2013-06-24
Applicant: Seraxis, Inc.
Inventor： William L. Rust
IPC: C12N5/071
CPC classification number: A61K35/39 , C12N5/0676 , C12N5/0678 , C12N2500/05 , C12N2500/25 , C12N2500/30 , C12N2500/38 , C12N2500/42 , C12N2501/115 , C12N2501/117 , C12N2501/15 , C12N2501/385 , C12N2501/41 , C12N2501/60 , C12N2506/22 , C12N2506/45
Abstract: Fresh human pancreas tissue can be used as a source of cells whence to identify and select a non-stem cell population that is predisposed to be a source for surrogate pancreatic cells that can be used in treating insulin-dependent diabetes. The progenitors of these surrogate pancreatic cells have no reprogramming genes integrated into their genomes, differentiate to the pancreatic lineage pursuant to a protocol that employs only defined reagents, and are substantially unable to differentiate to the mesodermal lineage.
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公开(公告)号：US11975031B2
公开(公告)日：2024-05-07
申请号：US15909449
申请日：2018-03-01
Applicant: Seraxis, Inc.
Inventor： William L. Rust
IPC: A61K35/39 , A61K9/00 , A61K9/48 , A61K9/50 , A61L27/20 , A61L27/38 , A61P5/48 , A61P5/50 , A61K35/12
CPC classification number: A61K35/39 , A61K9/0024 , A61K9/4825 , A61K9/5036 , A61K9/5052 , A61L27/20 , A61L27/3804 , A61P5/48 , A61P5/50 , A61K2035/124 , A61L27/20 , C08L5/04 , A61L27/20 , C08L1/00
Abstract: Described are macro-capsules and barriers that can be used to prepare therapeutic cell implants, methods of encapsulating therapeutic cells, and methods of using the encapsulated cells in the treatment of disease.
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Patent Agency Ranking
公开(公告)号：US20190269832A1
公开(公告)日：2019-09-05
申请号：US16289626
申请日：2019-02-28
Applicant: Seraxis, Inc.
Inventor： William L. Rust
Abstract: Described are macro-capsules, barriers, and devices that can be used to prepare therapeutic cell implants, methods of encapsulating therapeutic cells, and methods of using the encapsulated cells in the treatment of disease.
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公开(公告)号：US20180289746A1
公开(公告)日：2018-10-11
申请号：US15909449
申请日：2018-03-01
Applicant: Seraxis, Inc.
Inventor： William L. Rust
Abstract: Described are macro-capsules and barriers that can be used to prepare therapeutic cell implants, methods of encapsulating therapeutic cells, and methods of using the encapsulated cells in the treatment of disease.
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公开(公告)号：US20210008122A1
公开(公告)日：2021-01-14
申请号：US16968317
申请日：2019-02-08
Applicant: Seraxis, Inc.
Inventor： William L. Rust
Abstract: The present disclosure provides cell-based compositions for treating diabetes, methods for identifying cells that preferentially differentiate into endoderm cells, and methods for preparing insulin-producing pancreatic cells, as well as related methods of use for treating diseases related to insulin deficiency.
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9.发明授权公开(公告)号：US09968639B2
公开(公告)日：2018-05-15
申请号：US13925248
申请日：2013-06-24
Applicant: Seraxis, Inc.
Inventor： William L. Rust
CPC classification number: A61K35/39 , C12N5/0676 , C12N5/0678 , C12N2500/05 , C12N2500/25 , C12N2500/30 , C12N2500/38 , C12N2500/42 , C12N2501/115 , C12N2501/117 , C12N2501/15 , C12N2501/385 , C12N2501/41 , C12N2501/60 , C12N2506/22 , C12N2506/45
Abstract: Fresh human pancreas tissue can be used as a source of cells when to identify and select a non-stem cell population that is predisposed to be a source for surrogate pancreatic cells that can be used in treating insulin-dependent diabetes. The progenitors of these surrogate pancreatic cells have no reprogramming genes integrated into their genomes, differentiate to the pancreatic lineage pursuant to a protocol that employs only defined reagents, and are substantially unable to differentiate to the mesodermal lineage.
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10.发明授权Method for generating non-pluripotent progenitors of surrogate pancreatic cells 有权产生替代胰腺细胞的非多能祖细胞的方法公开(公告)号：US09474772B2
公开(公告)日：2016-10-25
申请号：US14693245
申请日：2015-04-22
Applicant: Seraxis, Inc.
Inventor： William L. Rust
CPC classification number: A61K35/39 , C12N5/0676 , C12N5/0678 , C12N2500/05 , C12N2500/25 , C12N2500/30 , C12N2500/38 , C12N2500/42 , C12N2501/115 , C12N2501/117 , C12N2501/15 , C12N2501/385 , C12N2501/41 , C12N2501/60 , C12N2506/22 , C12N2506/45
Abstract: Fresh human pancreas tissue can be used as a source of cells whence to identify and select a non-stem cell population that is predisposed to be a source for surrogate pancreatic cells that can be used in treating insulin-dependent diabetes. The progenitors of these surrogate pancreatic cells have no reprogramming genes integrated into their genomes, differentiate to the pancreatic lineage pursuant to a protocol that employs only defined reagents, and are substantially unable to differentiate to the mesodermal lineage.
Abstract translation: 新鲜的人胰腺组织可以用作细胞来源，从而识别并选择易于被用于治疗胰岛素依赖型糖尿病的替代胰腺细胞来源的非干细胞群体。 这些替代胰腺细胞的祖细胞没有整合到其基因组中的重编程基因，根据仅使用限定的试剂的方案分化为胰腺谱系，并且基本上不能区分到中胚层谱系。
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