公开(公告)号：US20070053956A1

公开(公告)日：2007-03-08

申请号：US11218781

申请日：2005-09-06

申请人： Amos Tandler ,  William Koven ,  Shalom Zemach

发明人： Amos Tandler ,  William Koven ,  Shalom Zemach

IPC分类号： A23K1/165 ,  A23K1/17

CPC分类号： A23K1/188 ,  A23K20/142 ,  A23K20/158 ,  A23K20/195 ,  A23K40/30 ,  A23K50/80

摘要： An encapsulated formulation for food and bioactive agent delivery to aquatic animals includes various combinations of nutrients, a digestion enhancer, bioactive agents, and a local absorption enhancer. The bioactive agents and absorption enhancer may be encapsulated within a delay layer for targeted release at an area of the digestive tract distinct from the region of nutrient release. The bioactive agents and absorption enhancer may be coated with a sticky coating so that they tend to adhere to the inner surfaces of the wall of the digestive tract, thereby localizing their release and enhancing their effect. Instead of bioactive agents themselves, precursors may be delivered so as to generate the bioactive agents locally. The encapsulated precursors of a specific bioactive agent are separately contained in capsules which themselves can be adhesive to one another.

摘要翻译： 用于食物和生物活性剂递送至水生动物的包封制剂包括营养物，消化增强剂，生物活性剂和局部吸收增强剂的各种组合。 生物活性剂和吸收增强剂可以被包封在延迟层内，用于在不同于营养释放区域的消化道的区域上靶向释放。 生物活性剂和吸收增强剂可以用粘性涂层涂覆，使得它们倾向于粘附到消化道壁的内表面，从而定位其释放并增强其效果。 代替生物活性剂本身，可以递送前体以在本地产生生物活性剂。 特定生物活性剂的包封的前体分别包含在胶囊中，其本身可以彼此粘合。

公开(公告)号：US08865197B2

公开(公告)日：2014-10-21

申请号：US11218781

申请日：2005-09-06

申请人： Amos Tandler ,  William Koven ,  Shalom Zemach

发明人： Amos Tandler ,  William Koven ,  Shalom Zemach

IPC分类号： A01N25/08 ,  A01N25/00 ,  A01N25/24 ,  A01N25/34 ,  A01K97/04 ,  A23J1/00 ,  A61K31/56 ,  A61K31/54 ,  A61K31/19 ,  A23K1/00 ,  A23K1/18 ,  A23K1/16 ,  A23K1/17

CPC分类号： A23K1/188 ,  A23K20/142 ,  A23K20/158 ,  A23K20/195 ,  A23K40/30 ,  A23K50/80

摘要： An encapsulated formulation for food and bioactive agent delivery to aquatic animals includes various combinations of nutrients, a digestion enhancer, bioactive agents, and a local absorption enhancer. The bioactive agents and absorption enhancer may be encapsulated within a delay layer for targeted release at an area of the digestive tract distinct from the region of nutrient release. The bioactive agents and absorption enhancer may be coated with a sticky coating so that they tend to adhere to the inner surfaces of the wall of the digestive tract, thereby localizing their release and enhancing their effect. Instead of bioactive agents themselves, precursors may be delivered so as to generate the bioactive agents locally. The encapsulated precursors of a specific bioactive agent are separately contained in capsules which themselves can be adhesive to one another.

摘要翻译： 用于食物和生物活性剂递送至水生动物的包封制剂包括营养物，消化增强剂，生物活性剂和局部吸收增强剂的各种组合。 生物活性剂和吸收增强剂可以被包封在延迟层内，用于在不同于营养释放区域的消化道的区域上靶向释放。 生物活性剂和吸收增强剂可以用粘性涂层涂覆，使得它们倾向于粘附到消化道壁的内表面，从而定位其释放并增强其效果。 代替生物活性剂本身，可以递送前体以在本地产生生物活性剂。 特定生物活性剂的包封的前体分别包含在胶囊中，其本身可以彼此粘合。

公开(公告)号：US20070281883A1

公开(公告)日：2007-12-06

申请号：US11422091

申请日：2006-06-05

申请人： Hanna Rosenfeld ,  Shalom Zemach

发明人： Hanna Rosenfeld ,  Shalom Zemach

IPC分类号： C07K14/59 ,  C07H21/04

CPC分类号： C07K14/59

摘要： The invention provides recombinant forms of piscine follicle-stimulating hormone (FSH) with characteristic intramolecular disulfide bonds and modified glycosylation patterns in the β-subunit that enhance the stability and metabolic activity of the hormone. Also provided are recombinant materials to produce the FSH β and glycoprotein α-subunits singly or in combination to obtain complete heterodimeric hormone of regulated glycosylation pattern. The piscine FSH agonists of the invention are therapeutically useful to expedite the onset of puberty in captive fish and to alleviate reproductive dysfunctions in fish. Likewise, the piscine FSH antagonists of the invention will be therapeutically useful to halt gonadal development, thereby contributing to body weight gain of the fish,

摘要翻译： 本发明提供了具有特征性分子内二硫键的鱼类促卵泡激素（FSH）和β-亚基中修饰的糖基化模式的重组形式，其增强了激素的稳定性和代谢活性。 还提供了单独或组合产生FSHβ和糖蛋白α亚单位以获得调节糖基化模式的完全异二聚体激素的重组材料。 本发明的鱼FSH激动剂在治疗上有助于加速捕获鱼的青春期发作并减轻鱼中的生殖功能障碍。 同样地，本发明的鱼类FSH拮抗剂对于阻止性腺发育将是治疗有用的，从而有助于鱼的体重增加，

公开(公告)号：US20080070289A1

公开(公告)日：2008-03-20

申请号：US11841008

申请日：2007-08-20

申请人： Shalom Zemach

发明人： Shalom Zemach

IPC分类号： C12N1/04

CPC分类号： A23K50/80 ,  A01K61/00 ,  A01K61/20

摘要： A process for preserving and storing nematodes having an increased feeding value for later use as needed in the feeding of aquaculture organisms. In this process, nematodes are enriched with an additive such as essential fatty acids, vaccines, hormones, immunostimulants, attractants, nutrients and pigments. Liposomes can serve as a medium for feeding the additives to the nematodes. The enriched nematodes are then desiccated by inducing a quiescent anhydrobiosis (dehydration) and stored for off-the-shell use as needed. When required for feeding, the desiccated enriched nematodes are rehydrated and fed to the aquaculture organisms.

摘要翻译： 一种保存和储存具有增加的饲料值的线虫的方法，以便随后在水产养殖生物体的喂养中根据需要使用。 在这个过程中，线虫富含添加剂，如必需脂肪酸，疫苗，激素，免疫刺激剂，引诱剂，营养素和颜料。 脂质体可用作将添加剂喂入线虫的培养基。 然后通过诱导静止的脱水生物（脱水）将富集的线虫干燥并根据需要储存用于脱壳使用。 当需要进食时，干燥的富集线虫被再水合并加入到养殖生物体中。

公开(公告)号：US06481378B1

公开(公告)日：2002-11-19

申请号：US09659423

申请日：2000-09-11

申请人： Shalom Zemach

发明人： Shalom Zemach

IPC分类号： A01K6100

CPC分类号： A01K61/60 ,  Y02A40/826

摘要： The invention provides a deep-water fish farming system comprising a fish cage of controllable buoyancy having one or more chambers, which can be submerged and refloated at a controllable rate to any depth. A winch mechanism mounted preferably on a platform that covers a section of the cage releases and gathers a cable connected to a sinker. When the combined weight of the system overcomes the buoyancy, the fish cage is submerged to a depth determined by the effective length of the cable between the winch mechanism and the sinker, with the sinker touching the sea bottom. The submerged cage is refloated to the surface by remotely activating the winch mechanism, thus releasing the cable, while keeping the sinker on the sea bottom. When the cage is refloated to the surface, the buoyancy is increased to allow pulling of the sinker from the bottom. The invention further provides a method for submerging and raising a fish cage at a controlled rate to any desired depth in deep water.

摘要翻译： 本发明提供了一种深水鱼养殖系统，其包括具有一个或多个室的可控浮力的鱼笼，其可以以可控速率被浸没和重新净化到任何深度。 优选地安装在覆盖笼的一部分的平台上的绞盘机构释放并收集连接到沉降片的缆线。 当系统的组合重量克服浮力时，鱼笼被淹没到由绞盘机构和沉降片之间的电缆的有效长度确定的深度，沉没片接触海底。 通过远程激活绞车机构将浸没的笼子重新浮起，从而释放电缆，同时将沉降片保持在海底。 当保持架被重新铺满表面时，浮力将增加，从而可以从底部拉出沉降片。 本发明还提供了一种以可控制的速度将鱼笼浸入和升高到深水中任何所需深度的方法。

公开(公告)号：US06399118B1

公开(公告)日：2002-06-04

申请号：US09893875

申请日：2001-06-29

申请人： Shalom Zemach ,  Amos Tandler ,  William Koven

发明人： Shalom Zemach ,  Amos Tandler ,  William Koven

IPC分类号： A01K67033

CPC分类号： A01K67/033 ,  A23K50/80

摘要： A process for preserving and storing nematodes having an increased feeding value for later use as needed in the feeding of aquaculture organisms. In this process, nematodes are enriched with an additive such as essential fatty acids, vaccines, hormones, immunostimulants, attractants, nutrients and pigments. Liposomes can serve as a medium for feeding the additives to the nematodes. The enriched nematodes are then desiccated by inducing a quiescent anhydrobiosis (dehydration) and stored for off-the-shelf use as needed. When required for feeding, the desiccated enriched nematodes are rehydrated and fed to the aquaculture organisms.

摘要翻译： 一种保存和储存具有增加的饲料值的线虫的方法，以便随后在水产养殖生物体的喂养中根据需要使用。 在这个过程中，线虫富含添加剂，如必需脂肪酸，疫苗，激素，免疫刺激剂，引诱剂，营养素和颜料。 脂质体可用作将添加剂喂入线虫的培养基。 然后通过诱导静止的脱水生物（脱水）将浓缩的线虫干燥并根据需要储存以用于现成的使用。 当需要进食时，干燥的富集线虫被再水合并加入到养殖生物体中。

公开(公告)号：US5412903A

公开(公告)日：1995-05-09

申请号：US197993

申请日：1994-02-17

申请人： Shalom Zemach ,  Yitzhak Farin

发明人： Shalom Zemach ,  Yitzhak Farin

IPC分类号： A01K63/00 ,  A01K61/00 ,  A01K71/00

CPC分类号： A01K61/007

摘要： A fish cage system, which includes a fish cage having one or more cables connected to it. The fish cage and cable(s) have a combined buoyancy which is such that at least a portion of the fish cage is normally located at or above the water surface. The cable(s) are connected to a sinker whose weight is sufficient to overcome the combined buoyancy of the fish cage cable(s). The sinker is also connected to a second cable which is connected to a buoy. The buoy contains a winch for alternately shortening and lengthening the effective length of the second cable so as to alternately allow said fish cage to float or to submerge.

摘要翻译： 鱼笼系统，其包括具有连接到其的一个或多个电缆的鱼笼。 鱼笼和电缆具有组合的浮力，使得鱼笼的至少一部分通常位于水面以上。 电缆连接到其重量足以克服鱼笼电缆的组合浮力的沉降片。 沉降片还连接到连接到浮标的第二缆线。 浮标包括用于交替地缩短和延长第二缆线的有效长度的绞盘，以便交替地允许所述鱼笼浮起或淹没。