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![PREPARATION METHOD OF 2,6-DIOXASPIRO [4,5] DECANE DERIVATIVES AND SALTS THEREOF](/abs-image/US/2024/09/12/US20240300971A1/abs.jpg.150x150.jpg)
公开(公告)号：US20240300971A1
公开(公告)日：2024-09-12
申请号：US18582382
申请日：2024-02-20
发明人： Shuai GAO , Yanhua WU , Jiye ZHAO , Guanghui WANG , Wensheng LIAO
IPC分类号： C07D493/10
CPC分类号： C07D493/10
摘要： The present disclosure provides a preparation method of 2,6-dioxospiral [4,5] decane derivatives and their salts, which has mild reaction conditions, high reaction conversion rate, simple post-processing, and high product purity and is suitable for industrial production.
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公开(公告)号：US10406161B2
公开(公告)日：2019-09-10
申请号：US16144614
申请日：2018-09-27
发明人： Kaoxiang Sun , Rongcai Liang , Qilin Wang , Wenyan Wang , Wanhui Liu , Youxin Li
摘要： A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.
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3.发明申请公开(公告)号：US20140356442A1
公开(公告)日：2014-12-04
申请号：US14367096
申请日：2012-12-18
发明人： Kaoxiang Sun , Tao Song , Qilin Wang , Jie Han , Tao Wang , Jiangbin Han , Jianzhao Zhang , Shujiang Wang
CPC分类号： A61K38/22 , A61K9/0019 , A61K9/1623 , A61K9/1635 , A61K9/5031 , A61K38/09
摘要： Sustained release triptorelin microspheres include triptorelin or a salt of triptorelin, a copolymer of lactide and glycolide, and glucose or mannitol. The sustained release triptorelin microspheres have a relatively high initial release after administration, which allows the drug to produce its pharmaceutical effects immediately and to maintain long-term steady pharmaceutical effects.
摘要翻译： 缓释曲塞曲霉素微球包括曲普瑞林或曲普瑞林盐，丙交酯和乙交酯的共聚物，以及葡萄糖或甘露糖醇。 持续释放的曲普瑞林微管在施用后具有相对较高的初始释放，其允许药物立即产生其药物作用并保持长期稳定的药物作用。
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公开(公告)号：US20220340539A1
公开(公告)日：2022-10-27
申请号：US17763636
申请日：2020-09-29
发明人： Fengmei ZHOU , Wenjuan TAN , Qianqian TANG , Jinrong WANG , Rui ZHANG , Fei YU
IPC分类号： C07D333/10 , C07C69/017
摘要： Provided are a novel impurity compound of rotigotine behenate, rotigotine behenate or a preparation thereof containing less than 0.5 wt % of the impurity compound and use of the impurity compound as a reference substance in the impurity detection of the rotigotine behenate or the preparation thereof.
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公开(公告)号：US20200297729A1
公开(公告)日：2020-09-24
申请号：US16759287
申请日：2018-10-26
发明人： Youxin LI , Chunjie SHA , Fengjuan ZHAO , Changbing TU , Kaoxiang SUN , Wanhui LIU , Lifang SUN , Ying MENG
IPC分类号： A61K31/519 , A61K9/00
摘要： Provided herein are simplified dosing regimens for administering paliperidone palmitate to a patient in need of treatment of schizophrenia or schizoaffective disorders.
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![POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS OF PREPARING THE SAME AND USE OF THE SAME](/abs-image/US/2014/08/21/US20140235728A1/abs.jpg.150x150.jpg)
6.发明申请POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS OF PREPARING THE SAME AND USE OF THE SAME 审中-公开4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基苯甲酸酯盐酸盐的聚合物，其制备方法和使用该方法公开(公告)号：US20140235728A1
公开(公告)日：2014-08-21
申请号：US14259964
申请日：2014-04-23
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： C07C215/64 , C07C213/10
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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![POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYL-BENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME](/abs-image/US/2013/10/24/US20130281531A1/abs.jpg.150x150.jpg)
7.发明申请POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYL-BENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME 有权4- [2-二甲基氨基-1-（1-羟基环己基）乙基]苯基4-甲基苯甲酸酯盐酸盐的聚合物，其制备方法和使用方法公开(公告)号：US20130281531A1
公开(公告)日：2013-10-24
申请号：US13846773
申请日：2013-03-18
发明人： Youxin Li , Wanhui Liu , Yang Lv , Guanhua Du , Qingguo Meng , Mina Yang , Fengmei Zhou , Ju Li , Xuemei Zhang
IPC分类号： C07C219/28
CPC分类号： C07C215/64 , A61K31/235 , C07B2200/13 , C07C213/10 , C07C215/20 , C07C219/28
摘要： The present disclosure relates to polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same.
摘要翻译： 本公开涉及4- [2-二甲基氨基-1-（1-羟基环己基）乙基] -4-甲基苯甲酸苯酯盐酸盐的多晶型物，其制备方法及其用途。
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公开(公告)号：US20220340562A1
公开(公告)日：2022-10-27
申请号：US17634977
申请日：2020-08-11
发明人： Jingwei TIAN , Rui ZHANG , Liang YE , Dawei YU , Guangying DU , Zongliang LIU , Fangxia ZOU , Bo CUI
IPC分类号： C07D471/04
摘要： The present invention relates to a class of compounds that serve as VMAT2 inhibitors, and relates in particular to a compound represented by formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof, and a preparation method therefor, as well as the use thereof in the preparation of a medicament for treating diseases related to VMAT2.
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公开(公告)号：US20210403485A1
公开(公告)日：2021-12-30
申请号：US17281209
申请日：2019-09-29
发明人： Jianfei WANG , Yang ZHANG , Jikui SUN , Shuhui CHEN
IPC分类号： C07D498/22 , A61P35/00
摘要： The present invention discloses a compound of formula (II), a tautomer thereof or a pharmaceutically acceptable salt thereof, and relates to use thereof in preparing a medicament for treating solid tumor-related diseases.
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公开(公告)号：US11110094B2
公开(公告)日：2021-09-07
申请号：US16525502
申请日：2019-07-29
发明人： Kaoxiang Sun , Rongcai Liang , Oilin Wang , Wenyan Wang , Wanhui Liu , Youxin Li
摘要： A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.
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