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公开(公告)号：US20180180532A1
公开(公告)日：2018-06-28
申请号：US15390697
申请日：2016-12-26
发明人： Ming-Hui CHEN , Kang-Yu CHU , Sheng-Hao TSENG
CPC分类号： G01N21/255 , G01J3/00 , G01N21/31 , G01N21/474 , G01N2021/3181 , G01N2201/0221 , G01N2201/06113 , G01N2201/0627 , G01N2201/0634 , G02B5/0278 , G02B19/0014 , G02B19/0047 , G02B2003/0093
摘要： A multiple wavelength optical system includes plural solid state light sources, an optical diffuser, a lens assembly, and at least one photodetector. The solid state light sources have different wavelength ranges respectively. The optical diffuser has an incident surface and an exit surface opposite to the incident surface. The solid state light sources are disposed opposite the incident surface, and the lens assembly is disposed opposite the exit surface. Each of the solid state light sources faces the incident surface in the same direction. The lights of the solid state light sources enter the optical diffuser and exit from the exit surface, and then are focused by the lens assembly. Finally, the focused lights are projected on a surface of an object. At least one photodetector receives the reflected lights and the penetrating lights from the surface of the object.
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2.发明申请Method and Apparatus for Quantification of Optical Properties of Superficial Volumes Using Small Source-to-Detector Separations 有权用于使用小的源到检测器分离来定量表面体积的光学性质的方法和装置公开(公告)号：US20100160754A1
公开(公告)日：2010-06-24
申请号：US12643789
申请日：2009-12-21
申请人： Anthony J. Durkin , Sheng-hao Tseng
发明人： Anthony J. Durkin , Sheng-hao Tseng
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/0086 , A61B5/14532 , A61B5/4312 , A61B5/443 , A61B2562/0242
摘要： A probe for obtaining quantitative optical properties and chromophore concentrations of tissue components in tissue in-vivo at superficial depths and at source-detector separations of 5 mm or less includes a source fiber providing light to expose the tissue, a diffuser layer into which light from the source fiber is directed and then from the diffuser layer to and/or into the tissue, and a detector fiber arranged relative to the diffuser layer for detecting backscattered and/or reflected light returned from the tissue without transmission through the diffuser layer.
摘要翻译： 用于在表面深度和源检测器间隔5mm以下的组织中获得组织组分的定量光学性质和发色团浓度的探针包括提供光以暴露组织的源光纤，漫射层， 源光纤被引导，然后从扩散层引导到组织和/或进入组织，以及检测器光纤相对于漫射层布置，用于检测从组织返回的反向散射和/或反射光，而不通过扩散层传播。
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公开(公告)号：US10470693B2
公开(公告)日：2019-11-12
申请号：US15390698
申请日：2016-12-26
发明人： Ming-Hui Chen , Sheng-Hao Tseng , Kang-Yu Chu
IPC分类号： A61B5/1455 , A61B5/00
摘要： The optical sensing device is provided for receiving and transmitting a light signal. A light working area is defined according to a measurement range of the light signal. The optical sensing device includes a body, a transformation part and a signal unit. A light emitting unit and a light receiving unit are disposed at an end of the body, and the light emitting unit and the light receiving unit face the light working area. The transformation part pivots on the body. A light processing unit is disposed on the transformation part, and the light processing unit is capable of locating in the light working area for transmitting or receiving the light signal. The signal unit is configured for transmitting and processing the light signal.
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4.发明授权Method and apparatus for quantification of optical properties of superficial volumes 有权用于量化表面体积的光学性质的方法和装置公开(公告)号：US07304724B2
公开(公告)日：2007-12-04
申请号：US11104033
申请日：2005-04-12
申请人： Anthony J. Durkin , Sheng-Hao Tseng
发明人： Anthony J. Durkin , Sheng-Hao Tseng
IPC分类号： G01N21/00
CPC分类号： G01N21/49 , G01N21/31 , G01N21/3563 , G01N2201/08
摘要： A device and method for accurately performing quantitative diffuse optical spectroscopy on a sample includes a light source and a source optical fiber that is optically coupled to the light source. A diffuser material is interposed between the source optical fiber and the sample, the diffuser material comprising a high scattering, low absorption material. The diffuser material effectively increases the photon path length from the light source to the sample, which limits the depth of interrogation to superficial volumes despite the penetrating nature of the radiation typically used. A detector optical fiber is provided adjacent to or laterally disposed from the source optical fiber. The detector optical fiber is coupled to a detector which detects photons collected in the detector optical fiber. The detector optical fiber and the source optical fiber may be separated by a distance of less than 5 mm while still permitting the diffusion approximation to remain valid.
摘要翻译： 用于在样品上精确地进行定量扩散光谱的装置和方法包括光源和光学耦合到光源的源光纤。 漫射材料插入在源光纤和样品之间，漫射材料包含高散射低吸收材料。 扩散器材料有效地增加了从光源到样品的光子路径长度，这限制了询问到表面体积的深度，尽管通常使用的辐射的穿透性质。 检测器光纤被设置成与源光纤相邻或横向设置。 检测器光纤耦合到检测器，该检测器检测在检测器光纤中收集的光子。 检测器光纤和源光纤可以分开小于5mm的距离，同时仍允许扩散近似保持有效。
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5.发明申请Method and apparatus for quantification of optical properties of superficial volumes 有权用于量化表面体积的光学性质的方法和装置公开(公告)号：US20050226548A1
公开(公告)日：2005-10-13
申请号：US11104033
申请日：2005-04-12
申请人： Anthony Durkin , Sheng-Hao Tseng
发明人： Anthony Durkin , Sheng-Hao Tseng
CPC分类号： G01N21/49 , G01N21/31 , G01N21/3563 , G01N2201/08
摘要： A device and method for accurately performing quantitative diffuse optical spectroscopy on a sample includes a light source and a source optical fiber that is optically coupled to the light source. A diffuser material is interposed between the source optical fiber and the sample, the diffuser material comprising a high scattering, low absorption material. The diffuser material effectively increases the photon path length from the light source to the sample, which limits the depth of interrogation to superficial volumes despite the penetrating nature of the radiation typically used. A detector optical fiber is provided adjacent to or laterally disposed from the source optical fiber. The detector optical fiber is coupled to a detector which detects photons collected in the detector optical fiber. The detector optical fiber and the source optical fiber may be separated by a distance of less than 5 mm while still permitting the diffusion approximation to remain valid.
摘要翻译： 用于在样品上精确地进行定量扩散光谱的装置和方法包括光源和光学耦合到光源的源光纤。 漫射材料插入在源光纤和样品之间，漫射材料包含高散射低吸收材料。 扩散器材料有效地增加了从光源到样品的光子路径长度，这限制了询问到表面体积的深度，尽管通常使用的辐射的穿透性质。 检测器光纤被设置成与源光纤相邻或横向设置。 检测器光纤耦合到检测器，该检测器检测在检测器光纤中收集的光子。 检测器光纤和源光纤可以分开小于5mm的距离，同时仍允许扩散近似保持有效。
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公开(公告)号：US20180177441A1
公开(公告)日：2018-06-28
申请号：US15390698
申请日：2016-12-26
发明人： Ming-Hui CHEN , Sheng-Hao TSENG , Kang-Yu CHU
IPC分类号： A61B5/1455 , A61B5/00
CPC分类号： A61B5/14552 , A61B5/6826 , A61B2560/0418
摘要： The optical sensing device is provided for receiving and transmitting a light signal. A light working area is defined according to a measurement range of the light signal. The optical sensing device includes a body, a transformation part and a signal unit. A light emitting unit and a light receiving unit are disposed at an end of the body, and the light emitting unit and the light receiving unit face the light working area. The transformation part pivots on the body. A light processing unit is disposed on the transformation part, and the light processing unit is capable of locating in the light working area for transmitting or receiving the light signal. The signal unit is configured for transmitting and processing the light signal.
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7.发明授权Method and apparatus for quantification of optical properties of superficial volumes using small source-to-detector separations 有权用于使用小的源到检测器分离来定量表面体积的光学性质的方法和装置公开(公告)号：US08301216B2
公开(公告)日：2012-10-30
申请号：US12643789
申请日：2009-12-21
申请人： Anthony J. Durkin , Sheng-hao Tseng
发明人： Anthony J. Durkin , Sheng-hao Tseng
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/0086 , A61B5/14532 , A61B5/4312 , A61B5/443 , A61B2562/0242
摘要： A probe for obtaining quantitative optical properties and chromophore concentrations of tissue components in tissue in-vivo at superficial depths and at source-detector separations of 5 mm or less includes a source fiber providing light to expose the tissue, a diffuser layer into which light from the source fiber is directed and then from the diffuser layer to and/or into the tissue, and a detector fiber arranged relative to the diffuser layer for detecting backscattered and/or reflected light returned from the tissue without transmission through the diffuser layer.
摘要翻译： 用于在表面深度和源检测器间隔5mm以下的组织中获得组织组分的定量光学性质和发色团浓度的探针包括提供光以暴露组织的源光纤，漫射层， 源光纤被引导，然后从扩散层引导到组织和/或进入组织，以及检测器光纤相对于漫射层布置，用于检测从组织返回的反向散射和/或反射光，而不通过扩散层传播。
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