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26 条记录 (耗时 0.016 秒)

    METHOD FOR DETECTING THE DRUG EFFECTS OF DNA METHYLATION-INHIBITORS
    1.
    发明申请
    METHOD FOR DETECTING THE DRUG EFFECTS OF DNA METHYLATION-INHIBITORS 审中-公开
    检测DNA甲基化抑制剂药物作用的方法

    公开(公告)号：US20110159507A1

    公开(公告)日：2011-06-30

    申请号：US13060382

    申请日：2009-08-28

    申请人： Shinichiro Takahashi

    发明人： Shinichiro Takahashi

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158

    摘要： Disclosed is a method for detecting the drug effects of DNA methylation inhibitors that detects the drug sensitivity of gene-expressing cells to DNA methylation inhibitors based on gene expression of a transcription factor (PU. 1) and/or gene expression of metallothionein (MT) that participates in differentiation to neutrophil and monocyte lines or based on DNA methylation in the metallothionein (MT) gene promotor region. Hematopoietic tumors can be treated effectively and specifically after predicting the effects of DNA methylation inhibitors on the hematopoietic tumor cells of myelodysplastic syndrome, acute myelocytic leukemia (AML), and other hematopoietic organ diseases, so therapeutic results are improved.

    摘要翻译： 公开了一种基于转录因子（PU.1）和/或金属硫蛋白（MT）的基因表达的基因表达检测基因表达细胞对DNA甲基化抑制剂的药物敏感性的DNA甲基化抑制剂的药物作用的方法。 参与分化为嗜中性粒细胞和单核细胞系或基于金属硫蛋白（MT）基因启动子区域中的DNA甲基化。 在预测DNA甲基化抑制剂对骨髓增生异常综合征，急性骨髓性白血病（AML）和其他造血器官疾病的造血肿瘤细胞的作用的预测后，造血肿瘤可以有效治疗，治疗效果得到改善。

    Digital filter circuit
    4.
    发明授权
    Digital filter circuit 失效
    数字滤波电路

    公开(公告)号：US4686483A

    公开(公告)日：1987-08-11

    申请号：US824891

    申请日：1986-01-30

    申请人： Isao Isshiki ,  Shinichiro Takahashi

    发明人： Isao Isshiki ,  Shinichiro Takahashi

    IPC分类号： H03K3/013 ,  H03H17/02 ,  H03K5/05 ,  H03K5/1252 ,  H03K17/16 ,  H03K21/40

    CPC分类号： H03K5/1252

    摘要： A digital filter circuit includes first and second counters which set and reset a latch circuit at predetermined counts. Clock pulses and the input signal are passed through a gate circuit to the first counter which outputs a set signal to the latch circuit only if the input signal is maintained at a high level for the predetermined count. Clock pulses and the inverted input signal are passed through a gate circuit to the second counter which outputs a reset signal to the latch circuit only if the input signal is maintained at a low level for the predetermined count. In this manner noise pulses on the input signal are filtered out of the output signal obtained from the latch circuit.

    摘要翻译： 数字滤波电路包括第一和第二计数器，其以预定计数设置和复位锁存电路。 时钟脉冲和输入信号通过栅极电路传送到第一计数器，只有当输入信号保持在高电平以进行预定计数时，才将输出信号输出到锁存电路。 时钟脉冲和反相输入信号通过栅极电路传送到第二计数器，只有当输入信号保持在低电平达预定计数时才向锁存电路输出复位信号。 以这种方式，输入信号上的噪声脉冲从从锁存电路获得的输出信号中滤除。

    Power system stabilizer for generator
    5.
    发明授权
    Power system stabilizer for generator 失效
    发电机动力系统稳定器

    公开(公告)号：US5698968A

    公开(公告)日：1997-12-16

    申请号：US559486

    申请日：1995-11-15

    申请人： Yasuo Takagi ,  Yoshitaka Sakaki ,  Shinichiro Takahashi ,  Kozo Takagi ,  Yoichi Uemura ,  Yasuyuki Miyazaki

    发明人： Yasuo Takagi ,  Yoshitaka Sakaki ,  Shinichiro Takahashi ,  Kozo Takagi ,  Yoichi Uemura ,  Yasuyuki Miyazaki

    IPC分类号： H02P9/10

    CPC分类号： H02P9/105

    摘要： To improve the resistance against external low-frequency disturbance (represented by generator output change), the power system stabilizer for a generator, for inputting a voltage regulating signal (e), as an auxiliary signal, to an automatic voltage regulator to control a generator terminal voltage at a target voltage (V.sub.o), comprises: an angular acceleration observer for calculating an estimated angular acceleration change rate (.DELTA.as) of the generator on the basis of at least one of stabilizing signal change rates (.DELTA.P and/or .DELTA..omega.) of the generator; and a power stabilizer circuit for calculating a corrected voltage regulating signal (e) applied to the automatic voltage regulator on the basis of the estimated angular acceleration change rate value (.DELTA.as) calculated by the angular acceleration observer. Further, it is preferable to provide a plurality of observers and a plurality of power stabilizer circuits, separately for each fluctuation frequency.

    摘要翻译： 为了提高外部低频干扰（由发电机输出变化表示）的电阻，用于将用于输入电压调节信号（e）作为辅助信号的发电机的电力系统稳定器提供给自动电压调节器以控制发电机 目标电压（Vo）的端子电压包括：角加速度观测器，用于基于稳定信号变化率（DELTA P和/或DELTA）中的至少一个来计算发电机的估计角加速度变化率（DELTA as） 欧米茄）发电机; 以及功率稳定器电路，用于基于由角加速度观测器计算的估计角加速度变化率值（DELTA as）来计算施加到自动电压调节器的校正电压调节信号（e）。 此外，优选为每个波动频率分别设置多个观察者和多个功率稳定器电路。

    Floor-surface polisher equipped with function for adjusting pad pressure
    6.
    发明授权
    Floor-surface polisher equipped with function for adjusting pad pressure 失效
    地面抛光机配有调节垫压力的功能

    公开(公告)号：US5615437A

    公开(公告)日：1997-04-01

    申请号：US391036

    申请日：1995-02-21

    申请人： Shinichiro Takahashi ,  Eiji Nagayama

    发明人： Shinichiro Takahashi ,  Eiji Nagayama

    IPC分类号： A47L11/14 ,  A47L11/282 ,  A47L11/40

    CPC分类号： A47L11/4011 ,  A47L11/14 ,  A47L11/4038 ,  A47L11/4055 ,  A47L11/4058

    摘要： In a floor-surface polisher in which floor-surface is polished by a pad which is mounted within a pad cover and rotated at a high speed by a motor during the traveling operation of the polisher, a floor-surface polisher equipped with a function for adjusting a pad pressure being characterized in that the pad is resiliently supported by a support force, the support force directing upwardly to separate the pad away from the floor-surface, a plurality of very small spaces being formed within the pad so that a drawing force for lowering the pad toward the floor-surface against the upwardly-directing support force will be generated during a high speed rotation of the pad, electric-current value setter for adjusting, either automatically or manually, an electric-current value of the motor to a pre-set value, the setter being mounted on a control portion of the pad motor.

    摘要翻译： 在地板表面抛光机中，在抛光机行进操作期间，通过垫板抛光地板表面抛光机，底板表面抛光机被安装在垫盖内并通过马达高速旋转， 调节垫压力的特征在于，所述垫通过支撑力弹性地支撑，所述支撑力向上引导以将所述垫分离所述底板表面，在所述垫内形成多个非常小的空间，使得牵引力 用于在垫的高速旋转期间产生用于将垫朝向地板表面降低的向上引导的支撑力，电流值设定器用于自动或手动地将电动机的电流值自动调整为 预设值，安装器安装在垫马达的控制部分上。

    Vehicle window opening and closing method and apparatus for detecting an obstacle utilizing sound wave
    7.
    发明授权
    Vehicle window opening and closing method and apparatus for detecting an obstacle utilizing sound wave 失效
    用于检测利用声波的障碍物的车窗开闭方法和装置

    公开(公告)号：US5410227A

    公开(公告)日：1995-04-25

    申请号：US102990

    申请日：1993-07-28

    申请人： Morihiko Toyozumi ,  Shinichiro Takahashi

    发明人： Morihiko Toyozumi ,  Shinichiro Takahashi

    IPC分类号： B60J1/17 ,  B60J1/00 ,  E05F15/00 ,  E05F15/10 ,  G01B17/00 ,  G01S15/04 ,  G01V1/00 ,  H02P3/00

    CPC分类号： G01S15/04 ,  E05F15/431 ,  E05F2015/433 ,  E05Y2900/55

    摘要： This invention aims to prevent an obstacle from being trapped between a vehicle window and a window frame. A supersonic wave f is emitted into a vehicle window W. A reflection wave i of the supersonic wave is received to decide whether the reflection wave i is one reflected from peripheral faces of a target to be detected or not. If the received reflection wave i is one reflected from the peripheral faces from the target, a driving motor M for the vehicle window W is stopped. Thus, when an obstacle contacts with the peripheral faces of the vehicle window, it is possible to previously prevent the obstacle from being caught by the window since a driving source for the vehicle window is stopped.

    摘要翻译： 本发明旨在防止障碍物被困在车窗和窗框之间。 超声波f被发射到车窗W中。接收超声波的反射波i以决定反射波i是否是从被检测目标的外围面反射的反射波i。 如果接收到的反射波i是从目标的周边面反射的反射波，则车辆窗W的驱动马达M停止。 因此，当障碍物与车窗的周边面接触时，由于车窗的驱动源停止，所以可以预先防止障碍物被窗口卡住。

    Duty control circuit for gradually reducing the duty time
    9.
    发明授权
    Duty control circuit for gradually reducing the duty time 失效
    占空比控制电路逐渐减少占空比

    公开(公告)号：US4691330A

    公开(公告)日：1987-09-01

    申请号：US844478

    申请日：1986-03-26

    申请人： Shinichiro Takahashi ,  Isao Isshiki

    发明人： Shinichiro Takahashi ,  Isao Isshiki

    IPC分类号： G05B19/02 ,  G05B11/26 ,  G06F1/025 ,  H02M3/155 ,  H03K3/72 ,  H03K5/04 ,  H03K5/08 ,  H03K5/156 ,  H03K7/06 ,  H03K7/08 ,  H03K11/00 ,  H03K23/58 ,  H03K21/00

    CPC分类号： H03K7/08 ,  G06F1/025 ,  H03K11/00

    摘要： A duty control circuit for controlling a duty factor in various industrial applications is proposed. It comprises a n-pulse counter, a m-pulse counter, another n-pulse counter, and a magnitude comparator. The magnitude comparator compares the count of the first counter with the count of the third counter and the duty control circuit gives a signal corresponding to ON when the former is larger than or equal to the latter and a signal corresponding to OFF when the former is smaller than the latter.

    摘要翻译： 提出了一种用于控制各种工业应用中占空比的占空比控制电路。 它包括一个n脉冲计数器，一个m脉冲计数器，另一个n脉冲计数器和一个幅度比较器。 幅度比较器将第一计数器的计数与第三计数器的计数进行比较，当前者大于或等于后者时，占空比控制电路给出对应于ON的信号，当前者较小时，对应于OFF的信号 比后者。