公开(公告)号：US20120302613A1

公开(公告)日：2012-11-29

申请号：US13480051

申请日：2012-05-24

申请人： Aaron PEOPLES ,  Losee Lucy LING ,  Kim LEWIS ,  Slava S. EPSTEIN

发明人： Aaron PEOPLES ,  Losee Lucy LING ,  Kim LEWIS ,  Slava S. EPSTEIN

IPC分类号： C07D498/22 ,  A61P35/00 ,  A61P31/10 ,  A61P31/12 ,  A61K31/424 ,  A61P31/04

CPC分类号： C07D498/22

摘要： The invention relates generally to novel antibiotics and their analogs, to processes for the preparation of these novel antibiotics, to pharmaceutical compositions comprising the novel antibiotics; and to methods of using the novel antibiotics to treat or inhibit various disorders.

摘要翻译： 本发明一般涉及新型抗生素及其类似物，用于制备这些新型抗生素的方法，用于包含新型抗生素的药物组合物; 以及使用新型抗生素治疗或抑制各种疾病的方法。

公开(公告)号：US09249382B2

公开(公告)日：2016-02-02

申请号：US11732346

申请日：2007-04-03

申请人： Ekaterina Gavrish ,  Kim Lewis ,  Slava S. Epstein

发明人： Ekaterina Gavrish ,  Kim Lewis ,  Slava S. Epstein

IPC分类号： C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/16

CPC分类号： C12M23/20 ,  C12M1/16 ,  C12M25/14 ,  C12M29/04 ,  C12M33/14 ,  C12M47/02

摘要： Devices and methods for isolating and/or culturing microorganisms are provided. The devices comprise one or more semi-permeable membranes and may additionally include a growth medium for the microorganism. The devices and methods described herein can be used to isolate and culture both known and novel microorganisms from any environment.

摘要翻译： 提供用于分离和/或培养微生物的装置和方法。 这些装置包括一个或多个半透膜，并且还可以包括用于微生物的生长培养基。 本文所述的装置和方法可用于从任何环境分离和培养已知和新颖的微生物。

公开(公告)号：US07011957B2

公开(公告)日：2006-03-14

申请号：US10143551

申请日：2002-05-10

申请人： Kim Lewis ,  Slava S. Epstein ,  Tammi Kaeberlein

发明人： Kim Lewis ,  Slava S. Epstein ,  Tammi Kaeberlein

IPC分类号： C12Q1/04 ,  C12Q1/24

CPC分类号： C12R1/01 ,  C12Q1/24 ,  G01N2500/00

摘要： The method of the invention is directed to the novel use of a diffusion chamber within which previously “uncultivatible” microorganisms can be isolated. Rather than attempting to replicate the natural environment of an unknown microorganism, the method of the invention provides for exposing dividing microorganisms to all the components of the original environment while simultaneously containing the resulting colonies so that they can be isolated. The method of the invention can take advantage of the recognition that the preponderance of difficult-to-grow microorganisms do not form colonies visible to the naked eye. Therefore, these organisms must be isolated under a compound microscope as “microcolonies.” In addition, methods according to the invention permit the isolation of novel microorganisms capable of growing in artificial media only in co-culture in the presence of a companion microorganism.