Very high molecular weight &bgr;-glucans
    1.
    发明授权
    Very high molecular weight &bgr;-glucans 失效
    非常高分子量的β-葡聚糖

    公开(公告)号:US06369216B1

    公开(公告)日:2002-04-09

    申请号:US09325152

    申请日:1999-06-03

    IPC分类号: A61K31715

    CPC分类号: C08B37/0024

    摘要: The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble &bgr;-glucan composition comprising &bgr;-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).

    摘要翻译: 本发明涉及用于通过施用包含平均分子量至少为1,000,000道尔顿的β-葡聚糖分子的可溶性β-葡聚糖组合物来治疗/预防动物或人类感染的组合物和治疗和预防方法,如多角度 激光散射(VHMW-葡聚糖)。

    Use of neutral soluble glucan preparations to stimulate platelet
production
    2.
    发明授权
    Use of neutral soluble glucan preparations to stimulate platelet production 失效
    使用中性可溶性葡聚糖制剂刺激血小板生成

    公开(公告)号:US5488040A

    公开(公告)日:1996-01-30

    申请号:US60418

    申请日:1993-05-11

    摘要: The present invention relates to neutral soluble .beta.-glucans which exert potent and specific hematopoietic and immunological effects without stimulating the production of certain cytokines, to preparations containing the novel .beta.-glucans, and to a novel manufacturing process therefor. The neutral soluble glucan preparation has a high affinity for the .beta.-glucan receptor of human mono-cytes and retains two primary biological (or immunological) activities, (1) the enhancement of microbicidal activity of phagocytic cells, and (2) monocyte and neutrophil hemopoietic activity. Unlike soluble glucans described in the prior art, the neutral soluble glucan of this invention neither induces nor primes IL-1 and TNF production in vitro and in vivo. Safe and efficacious preparations of neutral soluble glucan of the present invention can be used in therapeutic and/or prophylactic treatment regimens of humans and animals to enhance their immune response, without stimulating the production of certain biochemical mediators (e.g., IL-1, TNF and leukotrienes) that can cause detrimental side effects, such as fever and inflammation.

    摘要翻译: 本发明涉及在不刺激某些细胞因子产生的情况下发挥有效和特异性的造血和免疫学作用的中性可溶性β-葡聚糖,含有新型β-葡聚糖的制剂及其制造方法。 中性可溶性葡聚糖制剂对人单核细胞的β-葡聚糖受体具有高亲和力,并保留两种主要的生物(或免疫)活性,(1)增强吞噬细胞的杀微生物活性,和(2)单核细胞和嗜中性粒细胞 造血活性。 与现有技术中描述的可溶性葡聚糖不同,本发明的中性可溶性葡聚糖在体外和体内都不诱导或引发IL-1和TNF产生。 本发明的中性可溶性葡聚糖的安全有效的制剂可用于人和动物的治疗和/或预防性治疗方案中,以增强其免疫应答,而不刺激某些生物化学介质(例如IL-1,TNF和 白细胞三烯),其可引起有害的副作用,例如发烧和炎症。

    Glucan compositions and process for preparation thereof
    4.
    发明授权
    Glucan compositions and process for preparation thereof 失效
    葡聚糖组合物及其制备方法

    公开(公告)号:US5250436A

    公开(公告)日:1993-10-05

    申请号:US893583

    申请日:1992-06-02

    摘要: Three dimensional glucan matrix compositions are prepared by separating growing yeast from its growth medium, subjecting the yeast with cell walls intact to an alkali material, thereby extracting whole glucan particles having an intact cell wall structure. The whole glucans can then, optionally, be treated with acetic acid to alter the .beta.(1-6) linkages, or with glucanase to alter the .beta.(1-3) linkages. The glucans have viscosity characteristics dependent upon the strain of yeast utilized and are useful as stabilizers or thickeners.

    摘要翻译: 通过从其生长培养基中分离生长的酵母,将酵母细胞壁完整地进行碱性物质制备三维葡聚糖基质组合物,从而提取具有完整细胞壁结构的全部葡聚糖颗粒。 然后可以任选地用乙酸处理整个葡聚糖以改变β(1-6)键或用葡聚糖酶改变β(1-3)键。 葡聚糖具有取决于所用酵母的菌株的粘度特性,并且可用作稳定剂或增稠剂。

    Method for producing soluble glucans
    9.
    发明授权
    Method for producing soluble glucans 失效
    生产可溶性葡聚糖的方法

    公开(公告)号:US5633369A

    公开(公告)日:1997-05-27

    申请号:US464528

    申请日:1995-06-05

    摘要: A method for producing soluble preparations of neutral glucan polymers is disclosed. The method involves treating whole glucan particles with a unique sequence of acid and alkaline treatments to produce soluble glucan. The soluble glucan can be purified to obtain a physiologically acceptable solution of neutral glucan molecules. A soluble neutral glucan preparation is obtained which forms a clear solution at a neutral pH and is equilibrated in a pharmaceutically acceptable carrier.

    摘要翻译: 公开了一种生产中性葡聚糖聚合物的可溶性制剂的方法。 该方法包括用独特的酸和碱处理序列处理全葡聚糖颗粒以产生可溶性葡聚糖。 可溶性葡聚糖可以纯化得到中性葡聚糖分子的生理上可接受的溶液。 获得可溶性中性葡聚糖制剂,其在中性pH下形成澄清溶液,并在药学上可接受的载体中平衡。

    Glucan composition and process for preparation thereof
    10.
    发明授权
    Glucan composition and process for preparation thereof 失效
    葡聚糖组合物及其制备方法

    公开(公告)号:US5037972A

    公开(公告)日:1991-08-06

    申请号:US504523

    申请日:1990-04-03

    IPC分类号: C08B37/00 C09K3/00 C12P19/04

    摘要: Three dimensional glucan matrix compositions are prepared by separating growing yeast from its growth medium, subjecting the yeast with cell walls intact to an alkali material, thereby extracting whole glucan particles having an intact cell wall structure. The whole glucans can then, optionally, be treated with acetic acid to alter the .beta.(1-6) linkages, or with glucanase to alter the .beta.(1-3) linkages. The glucans have viscosity characteristics dependent upon the strain of yeast utilized and are useful as stabilizers or thickeners.

    摘要翻译: 通过从其生长培养基中分离生长的酵母,将酵母细胞壁完整地进行碱性物质制备三维葡聚糖基质组合物,从而提取具有完整细胞壁结构的全部葡聚糖颗粒。 然后可以任选地用乙酸处理整个葡聚糖以改变β(1-6)键或用葡聚糖酶改变β(1-3)键。 葡聚糖具有取决于所用酵母的菌株的粘度特性,并且可用作稳定剂或增稠剂。