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公开(公告)号：US20200345815A1
公开(公告)日：2020-11-05
申请号：US16637304
申请日：2018-08-07
IPC分类号： A61K38/28 , A61K38/46 , A61K38/51 , A61K38/17 , A61K31/519 , A61K31/541 , A61K31/5355 , A61K31/553 , A61K31/529 , A61K31/4985 , A61K31/437 , A61P3/10
摘要： The present invention relates to novel methods and therapies for treating, preventing or delaying the onset of type 1 diabetes. In one aspect, the invention provides a method of preventing, delaying the onset of, or delaying the progression of, type 1 diabetes (T1D) in an individual, the method comprising providing in the individual an anti-inflammatory compound; and a pancreatic autoantigen or a derivative or variant thereof; thereby preventing, delaying the onset of, or delaying the progression of, T1D in the individual.
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公开(公告)号：US11806386B2
公开(公告)日：2023-11-07
申请号：US16637304
申请日：2018-08-07
IPC分类号： A61K38/28 , A61P3/10 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/529 , A61K31/5355 , A61K31/541 , A61K31/553 , A61K38/17 , A61K38/46 , A61K38/51
CPC分类号： A61K38/28 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/529 , A61K31/5355 , A61K31/541 , A61K31/553 , A61K38/1709 , A61K38/465 , A61K38/51 , A61P3/10
摘要： The present invention relates to novel methods and therapies for treating, preventing or delaying the onset of type 1 diabetes. In one aspect, the invention provides a method of preventing, delaying the onset of, or delaying the progression of, type 1 diabetes (T1D) in an individual, the method comprising providing in the individual an anti-inflammatory compound; and a pancreatic autoantigen or a derivative or variant thereof; thereby preventing, delaying the onset of, or delaying the progression of, T1D in the individual.
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公开(公告)号：US09908933B2
公开(公告)日：2018-03-06
申请号：US14910172
申请日：2014-08-05
IPC分类号： C07K16/18 , A61K39/395 , G01N33/53 , C07H21/04 , G01N33/68
CPC分类号： C07K16/18 , C07K2299/00 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , G01N33/689 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/368
摘要： The present disclosure relates generally to a protocol to treat or prevent diseases or conditions associated with pathological forms of amyloid beta (Aβ), including Alzheimer's disease. Enabled herein is a reagent for use in the treatment and prophylaxis of Aβ-associated pathological conditions.
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4.发明申请公开(公告)号：US20130217726A1
公开(公告)日：2013-08-22
申请号：US13760992
申请日：2013-02-06
发明人： Siew Yeen Chai , Michael William Parker , Anthony Lloyd Albiston , Frederick A. O. Mendelsohn , Keith Geoffrey Watson
IPC分类号： C07D405/04
CPC分类号： C07D405/04
摘要： The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the inhibitors of the present invention may be useful in therapeutic applications including enhancing memory and learning functions.
摘要翻译： 本发明涉及胰岛素调节氨基肽酶抑制剂（IRAP）及其抑制方法，以及包含所述抑制剂的组合物。 特别地，本发明的抑制剂可用于治疗应用，包括增强记忆和学习功能。
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公开(公告)号：US20240033330A1
公开(公告)日：2024-02-01
申请号：US18475323
申请日：2023-09-27
IPC分类号： A61K38/28 , A61P3/10 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/529 , A61K31/5355 , A61K31/541 , A61K31/553 , A61K38/17 , A61K38/46 , A61K38/51
CPC分类号： A61K38/28 , A61P3/10 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/529 , A61K31/5355 , A61K31/541 , A61K31/553 , A61K38/1709 , A61K38/465 , A61K38/51
摘要： The present invention relates to novel methods and therapies for treating, preventing or delaying the onset of type 1 diabetes. In one aspect, the invention provides a method of preventing, delaying the onset of, or delaying the progression of, type 1 diabetes (T1D) in an individual, the method comprising providing in the individual an anti-inflammatory compound; and a pancreatic autoantigen or a derivative or variant thereof; thereby preventing, delaying the onset of, or delaying the progression of, T1D in the individual.
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公开(公告)号：US11306066B2
公开(公告)日：2022-04-19
申请号：US15572554
申请日：2016-05-06
申请人： Monash University , The Florey Institute of Neuroscience and Mental Health , St. Vincent's Institute of Medical Research
IPC分类号： A61K31/351 , A61K31/352 , A61K31/35 , C07D309/32 , C07D311/74 , C07D311/02 , C07D311/00 , A61P25/28 , C07D405/04 , C07D405/10 , C07D493/04 , C07D407/10 , C07D409/10
摘要： The present disclosure relates generally, but not exclusively, to compounds and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosure further relates to inhibitors of IRAP and their use in the treatment or prevention of Alzheimer's disease and the treatment and prevention of memory and cognitive disorders.
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公开(公告)号：US20180148499A1
公开(公告)日：2018-05-31
申请号：US15875082
申请日：2018-01-19
CPC分类号： C07K16/18 , C07K2299/00 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , G01N33/689 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/368
摘要： The present disclosure relates generally to a protocol to treat or prevent diseases or conditions associated with pathological forms of amyloid beta (Aβ), including Alzheimer's disease. Enabled herein is a reagent for use in the treatment and prophylaxis of Aβ-associated pathological conditions.
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公开(公告)号：US20140072567A1
公开(公告)日：2014-03-13
申请号：US13972476
申请日：2013-08-21
申请人： Walter and Eliza Hall Institute of Medical Research, ACN 004 251 423 , St. Vincent's Institute of Medical Research, Can 004 705 640
发明人： Andreas Strasser , Mark McKenzie , Helen Thomas , Janette Allison , Tom Kay
IPC分类号： C12N15/113 , C07K16/22
CPC分类号： C12N15/1135 , A61K31/7088 , A61K31/713 , C07K16/22
摘要： The present invention relates to a method for treating and/or preventing a disease associated with glucose toxicity in a subject which may comprise administering to the subject a compound that reduces the level of Bim, PUMA and/or Bax activity in a cell of the subject. Furthermore, provided is a method for culturing cells susceptible to exposure to high concentrations of glucose, which may comprise delivering to the cells, or progenitor cells thereof, a compound that reduces the level of Bim, PUMA and/or Bax activity in the cells.
摘要翻译： 本发明涉及用于治疗和/或预防与受试者中葡萄糖毒性相关的疾病的方法，其可包括向受试者施用降低受试者细胞中Bim，PUMA和/或Bax活性水平的化合物 。 此外，提供了培养容易暴露于高浓度葡萄糖的细胞的方法，所述细胞可以包含向细胞或其祖细胞递送降低细胞中Bim，PUMA和/或Bax活性水平的化合物。
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公开(公告)号：US20180170891A1
公开(公告)日：2018-06-21
申请号：US15572554
申请日：2016-05-06
申请人： Monash University , The Florey Institute of Neuroscience and Mental Health , St. Vincent's Institute of Medical Research
IPC分类号： C07D309/32 , A61P25/28 , C07D405/10 , C07D405/04 , C07D409/10
CPC分类号： C07D309/32 , A61P25/28 , C07D405/04 , C07D405/10 , C07D407/10 , C07D409/10 , C07D493/04
摘要： The present disclosure relates generally, but not exclusively, to compounds and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosure further relates to inhibitors of IRAP and their use in the treatment or prevention of Alzheimer's disease and the treatment and prevention of memory and cognitive disorders.
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公开(公告)号：US20160194385A1
公开(公告)日：2016-07-07
申请号：US14910172
申请日：2014-08-05
CPC分类号： C07K16/18 , C07K2299/00 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , G01N33/689 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/368
摘要： The present disclosure relates generally to a protocol to treat or prevent diseases or conditions associated with pathological forms of amyloid beta (Aβ), including Alzheimer's disease. Enabled herein is a reagent for use in the treatment and prophylaxis of Aβ-associated pathological conditions.
摘要翻译： 本公开一般涉及治疗或预防与淀粉样蛋白β（A＆bgr）的病理形式（包括阿尔茨海默氏病）相关的疾病或病症的方案。 本文使用的是用于治疗和预防与疾病相关的病理状况的试剂。
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