Exposed proliferation-related peptides, ligands and methods employing the same
    2.
    发明申请
    Exposed proliferation-related peptides, ligands and methods employing the same 有权
    暴露的增殖相关肽,配体和使用其的方法

    公开(公告)号:US20100173329A1

    公开(公告)日:2010-07-08

    申请号:US12601326

    申请日:2008-05-23

    申请人: Staffan Eriksson

    发明人: Staffan Eriksson

    CPC分类号: C12N9/1211

    摘要: Novel thymidine kinase (TK1) derived peptide consisting of the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2 is employed to obtain ligands having specificity to the peptide. The ligand may be an antibody or fragment thereof and may be used in various methods and kits for health screening and the like.

    摘要翻译: 使用由SEQ ID NO:1或SEQ ID NO:2的氨基酸序列组成的新型胸苷激酶(TK1)衍生肽获得对肽具有特异性的配体。 配体可以是抗体或其片段,并且可以用于各种用于健康检查等的方法和试剂盒。

    GENERATING SWEEP SEQUENCES
    3.
    发明申请
    GENERATING SWEEP SEQUENCES 有权
    生成SWEEP序列

    公开(公告)号:US20090052278A1

    公开(公告)日:2009-02-26

    申请号:US12174406

    申请日:2008-07-16

    IPC分类号: G01V1/28

    CPC分类号: G01V1/005

    摘要: A technique includes generating one or more sweep sequences for one or more seismic vibrators for a seismic survey and evaluating a cost for the sequence(s). The technique includes perturbing the sequence(s) and continuing the evaluation and perturbing until the cost is within a limit or a maximum number of perturbations is reached.

    摘要翻译: 一种技术包括为一个或多个地震振动器产生用于地震勘测的一个或多个扫掠序列,并评估序列的成本。 该技术包括扰乱序列并继续评估和扰动,直到成本在限度内或达到最大扰动数。

    Generating sweep sequences
    4.
    发明授权
    Generating sweep sequences 有权
    生成扫描序列

    公开(公告)号:US09069091B2

    公开(公告)日:2015-06-30

    申请号:US12174406

    申请日:2008-07-16

    IPC分类号: G01V1/00

    CPC分类号: G01V1/005

    摘要: A technique includes generating one or more sweep sequences for one or more seismic vibrators for a seismic survey and evaluating a cost for the sequence(s). The technique includes perturbing the sequence(s) and continuing the evaluation and perturbing until the cost is within a limit or a maximum number of perturbations is reached.

    摘要翻译: 一种技术包括为一个或多个地震振动器产生用于地震勘测的一个或多个扫掠序列,并评估序列的成本。 该技术包括扰乱序列并继续评估和扰动,直到成本在限度内或达到最大扰动数。

    PREDICTING CANCER PROGRESSION
    5.
    发明申请
    PREDICTING CANCER PROGRESSION 审中-公开
    预测癌症进展

    公开(公告)号:US20100311081A1

    公开(公告)日:2010-12-09

    申请号:US12626802

    申请日:2009-11-27

    IPC分类号: G01N33/574

    摘要: A method of predicting the likelihood of cancer relapse in a patient undergoing treatment for cancer is provided. The binding response level of an immunoreactive material (IM) comprising thymidine kinase 1 (TK1) protein is determined in a body fluid sample of a patient and the likelihood of relapse of the cancer disease is predicted based on this determined IM binding response level. Those patients that run a risk of cancer progress and relapse 1-15 years after the cancer treatment may be identified directly by the IM binding response level within a few months following initiation of the treatment.

    摘要翻译: 提供了一种预测在接受癌症治疗的患者中癌症复发的可能性的方法。 在患者的体液样品中测定包含胸苷激酶1(TK1)蛋白的免疫反应性物质(IM)的结合反应水平,并且基于所确定的IM结合反应水平预测癌症疾病复发的可能性。 在癌症治疗后1-15年内发生癌症进展和复发的患者可以在治疗开始后的几个月内通过IM结合反应水平直接鉴定。

    Exposed proliferation-related peptides, ligands and methods employing the same
    6.
    发明授权
    Exposed proliferation-related peptides, ligands and methods employing the same 有权
    暴露的增殖相关肽,配体和使用其的方法

    公开(公告)号:US08501419B2

    公开(公告)日:2013-08-06

    申请号:US12601326

    申请日:2008-05-23

    申请人: Staffan Eriksson

    发明人: Staffan Eriksson

    CPC分类号: C12N9/1211

    摘要: Novel thymidine kinase (TK1) derived peptide consisting of the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2 is employed to obtain ligands having specificity to the peptide. The ligand may be an antibody or fragment thereof and may be used in various methods and kits for health screening and the like.

    摘要翻译: 使用由SEQ ID NO:1或SEQ ID NO:2的氨基酸序列组成的新型胸苷激酶(TK1)衍生肽获得对肽具有特异性的配体。 配体可以是抗体或其片段,并且可以用于各种用于健康检查等的方法和试剂盒。

    Predicting cancer progression
    7.
    发明申请
    Predicting cancer progression 审中-公开
    预测癌症进展

    公开(公告)号:US20070141650A1

    公开(公告)日:2007-06-21

    申请号:US10555935

    申请日:2004-05-14

    IPC分类号: G01N33/574 G06F19/00

    摘要: The present invention involves early prediction of progression of a cancer disease in patients treated for cancer. According to the invention the binding response level of an immunoreactive material (IM) comprising thymidine kinase 1 (TK1) protein is determined in a body fluid sample of a patient and the likelihood of progress of the cancer disease is estimated based directly on this determined IM binding response level. Those patients that run a risk of cancer progress and tumor relapse 1-15 years after the cancer treatment may be identified directly by the IM binding response level according to the invention within a few months following initiation of the treatment.

    摘要翻译: 本发明涉及对癌症患者中癌症疾病进展的早期预测。 根据本发明,在患者的体液样品中测定包含胸苷激酶1(TK1)蛋白的免疫反应性物质(IM)的结合应答水平,并且直接基于所确定的IM估计癌症疾病进展的可能性 绑定响应级别。 患癌症进展风险的患者和癌症治疗后1-15年的肿瘤复发可以在治疗开始后的几个月内通过本发明的IM结合反应水平直接鉴定。

    Method for determination of thymidine kinase 1 activity and the use thereof
    8.
    发明申请
    Method for determination of thymidine kinase 1 activity and the use thereof 审中-公开
    胸苷激酶1活性的测定方法及其用途

    公开(公告)号:US20060035295A1

    公开(公告)日:2006-02-16

    申请号:US10522870

    申请日:2003-07-11

    摘要: The present invention concerns a new method that enables safe, rapid, accurate and specific determination of thymidine kinase 1 activity in human or animal body fluids and tissue/cell extracts for routine analysis of samples with low levels of activity by using AZT or 3′ derivatives of thymidine as substrate and determining the phosphorylated products formed in the reaction with thymidine kinase 1 activity. The invention further relates to the use of said method for the diagnosis, monitoring and prognostics of diseases such as cancer.

    摘要翻译: 本发明涉及使用AZT或3'衍生物在人或动物体液和组织/细胞提取物中安全,快速,准确和特异性地测定胸苷激酶1活性的新方法,用于常规分析具有低活性水平的样品的样品 的胸苷作为底物并测定在与胸苷激酶1活性的反应中形成的磷酸化产物。 本发明还涉及所述方法用于诊断,监测和预后诸如癌症的疾病的用途。