公开(公告)号：US07246990B2

公开(公告)日：2007-07-24

申请号：US11020483

申请日：2004-12-23

申请人： Ming Xie ,  Stephen C. Mitchell ,  Donald George LaChapelle ,  Lee A. Blanton ,  Richard T. Price ,  David W. Crall ,  Frank Worthoff

发明人： Ming Xie ,  Stephen C. Mitchell ,  Donald George LaChapelle ,  Lee A. Blanton ,  Richard T. Price ,  David W. Crall ,  Frank Worthoff

IPC分类号： F01D22/00

CPC分类号： F01D21/045 ,  D04C1/02 ,  D10B2505/02 ,  F01D25/24 ,  F05D2300/44 ,  F05D2300/603 ,  F05D2300/702 ,  Y02T50/672

摘要： A composite fan casing for a gas turbine engine is provided includes, in an exemplary embodiment, a core having a plurality of core layers of reinforcing fiber bonded together with a thermosetting polymeric resin. Each core layer includes a plurality of braided reinforcing fibers with the braids of reinforcing fibers aligned in a circumferential direction.

摘要翻译： 提供一种用于燃气涡轮发动机的复合风扇壳体，在示例性实施例中包括具有多个与热固性聚合物树脂结合在一起的增强纤维芯层的芯。 每个芯层包括多个编织增强纤维，其中增强纤维的编织物沿圆周方向排列。

公开(公告)号：US07166714B2

公开(公告)日：2007-01-23

申请号：US10750262

申请日：2003-12-31

申请人： Daniel E. H. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen C. Mitchell

发明人： Daniel E. H. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas C. Saffran ,  Stephen C. Mitchell

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/00

CPC分类号： C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的六个跨膜上皮原体）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

公开(公告)号：US07037667B1

公开(公告)日：2006-05-02

申请号：US09615285

申请日：2000-07-12

申请人： Daniel E. H. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas Saffran ,  Stephen C. Mitchell ,  Aya Jakobovits ,  Mary Faris ,  Igor Vivanco

发明人： Daniel E. H. Afar ,  Rene S. Hubert ,  Kahan Leong ,  Arthur B. Raitano ,  Douglas Saffran ,  Stephen C. Mitchell ,  Aya Jakobovits ,  Mary Faris ,  Igor Vivanco

IPC分类号： G01N33/574 ,  G01N33/48 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/154 ,  G01N33/57419 ,  G01N33/57434 ,  G01N33/57488 ,  G01N2333/95

摘要： Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-related, cell membrane associated and secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provided are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. The invention also provides prognostic and diagnostic methods of examining a biological sample for evidence of disregulated cellular growth by comparing the status of 20P1F12/TMPRSS2 in the biological sample to the status of 20P1F12/TMPRSS2 in a corresponding normal sample, wherein alterations in the status of 20P1F12/TMPRSS2 in the biological sample are associated with disregulated cellular growth. The invention further provides various therapeutic compositions and strategies for treating prostate cancer, including particularly, 20P1F12/TMPRSS2 polypeptide and anti-20P1F12/TMPRSS2 antibody therapy methods and compositions, cancer vaccines, and small molecule therapy.

摘要翻译： 描述了源自或基于名为20P1F12 / TMPRSS2的新型前列腺特异性雄激素相关的细胞膜相关和分泌的丝氨酸蛋白酶的前列腺和结肠癌的诊断和治疗的组合物。 提供了包含20P1F12 / TMPRSS2基因（本文中也称为20P1F12-GTC1）的整个编码序列的全长cDNA（图1）。 所提供的组合物是结合20P1F12 / TMPRSS2蛋白和其多肽片段的抗体，包括用可检测标记或毒素或治疗组合物标记的抗体。 本发明还提供了通过将生物样品中20P1F12 / TMPRSS2的状态与对应的正常样品中的20P1F12 / TMPRSS2的状态进行比较来检查生物样品以检测细胞生长失调的证据的预后和诊断方法，其中， 生物样品中的20P1F12 / TMPRSS2与细胞生长失调有关。 本发明还提供了治疗前列腺癌的各种治疗组合物和策略，特别包括20P1F12 / TMPRSS2多肽和抗-20P1F12 / TMPRSS2抗体治疗方法和组合物，癌症疫苗和小分子治疗。

公开(公告)号：US5301814A

公开(公告)日：1994-04-12

申请号：US961430

申请日：1992-10-15

申请人： William E. Lower ,  Stephen C. Mitchell

发明人： William E. Lower ,  Stephen C. Mitchell

IPC分类号： B07B1/38 ,  B07B1/42 ,  B07B1/34

CPC分类号： B07B1/42 ,  B07B1/38 ,  Y10T74/18344

摘要： The screening efficiency of a gyratory screening machine, of the type having a moving base, is significantly increased by mounting to the base a spring/mass system which is tuned so that operation of the machine drive produces amplified movement of the mass along at least one of two perpendicular axes on which the base moves. Movement of the mass reduces the net force on the base along the axis on which the mass oscillates. The reaction force of the machine drive on the base along the other of the two perpendicular axes may be offset by a rotary counterbalance operated by the drive. Movement of the base relative to the ground is thereby reduced, and movement of the screen deck relative to ground is increased. This both increases the effectiveness of the screening motion and decreases the total reaction force transmitted through the base.

摘要翻译： 具有移动底座的旋转筛选机的筛选效率通过将弹簧/质量系统安装到基座而显着增加，该弹簧/质量系统被调整为使得机器驱动器的操作产生沿着至少一个 两个垂直轴在基座上移动。 质量的运动减少了基体上沿着质量振荡轴线的净力。 沿着两个垂直轴中的另一个的机器驱动器在基座上的反作用力可能被由驱动器操作的旋转平衡平衡构成。 因此，底座相对于地面的移动减少，并且屏幕甲板相对于地面的运动增加。 这两者都增加了筛选运动的有效性，并降低了通过基底传递的总反作用力。

公开(公告)号：US5069778A

公开(公告)日：1991-12-03

申请号：US611835

申请日：1990-11-13

申请人： William E. Lower ,  Stephen C. Mitchell

发明人： William E. Lower ,  Stephen C. Mitchell

IPC分类号： B07B1/12 ,  B07B1/46 ,  B07B1/54

CPC分类号： B07B1/4609 ,  B07B1/12 ,  B07B1/54

摘要： A screen deck having spaced, canted parallel slats which present screening slots between them, wherein the slats are mounted on pedestals that are positioned and aligned by parallel rods which extend transversely through the pedestals. The pedestals are spaced apart by spacers between them, the spacers being held in place by the rods. Slat mounting is facilitated and slot width uniformity is improved by use of the pedestals.

摘要翻译： 具有间隔开的倾斜平行板条的筛板，其在它们之间形成筛分槽，其中板条安装在基座上，所述基座通过横向延伸穿过基座的平行杆定位和对齐。 基座之间由间隔件间隔开，间隔件通过杆保持就位。 通过使用底座来促进板条安装并提高槽宽均匀性。

公开(公告)号：US06763948B2

公开(公告)日：2004-07-20

申请号：US10062592

申请日：2002-01-31

申请人： Brady P. Ballman ,  Daniel Ferris ,  Stephen C. Mitchell ,  Jeff Pielage ,  Anthony J. Yanka

发明人： Brady P. Ballman ,  Daniel Ferris ,  Stephen C. Mitchell ,  Jeff Pielage ,  Anthony J. Yanka

IPC分类号： B07B142

CPC分类号： B07B1/46 ,  B07B1/42

摘要： A screening machine of the type used to separate or classify mixtures of solid particles of different sizes includes a fixed base and a perforate screen deck mounted for movement relative to the base during a screening operation. Leaf springs connect the tail end of the screen deck to the fixed base so that the leaf springs support the tail end of screen deck for movement relative to the base. The leaf springs are oriented horizontally to avoid introducing vertical movement to the screen deck as it moves to and from the head and tail ends. The leaf springs are offset or deflected when the machine is at rest or in the neutral mid-point of its stroke. This arrangement advantageously utilizes the bias of the leaf springs to accelerate, assist or enhance movement of the screen deck during portions of its stroke and likewise to decelerate, hinder or retard the movement during other portions of its stroke. With an appropriate offset, an increase in the effectiveness of the screening process (i.e., fewer defective particles passing through the screen deck) while a decrease in the screening time is attained.

摘要翻译： 用于分离或分类不同尺寸的固体颗粒的混合物的类型的筛选机包括固定基座和在筛选操作期间相对于基部移动的穿孔筛板。 板簧将屏幕甲板的尾端连接到固定底座，使得板簧支撑屏幕甲板的尾端相对于底座运动。 板簧水平定向，以避免当其移动到头部和尾端时，垂直移动到屏幕甲板上。 当机器处于静止状态或其行程的中立中点时，板簧偏移或偏转。 这种布置有利地利用板簧的偏压来加速，帮助或增强筛板在其行程的部分期间的移动，并且同样在其行程的其他部分期间减速，阻碍或延迟移动。 通过适当的偏移，在筛选时间的减少的同时，筛选过程的有效性（即，穿过筛板的缺陷颗粒越少）的增加。

公开(公告)号：US5887726A

公开(公告)日：1999-03-30

申请号：US688391

申请日：1996-07-30

申请人： Stephen C. Mitchell

发明人： Stephen C. Mitchell

IPC分类号： B07B13/16 ,  F16L27/107 ,  B07B1/00

CPC分类号： B07B13/16 ,  F16L27/107

摘要： A coupling for directing a stream of particles falling from a feed spout through an opening on the top cover of the screen box of a screening machine. An upper diaphragm seals the feed spout within the mouth of a funnel. A lower diaphragm seals the funnel discharge opening within the top cover opening. Both diaphragms are flexible and permit the funnel to tilt axially and accommodate movement of the top cover opening with respect to the feed spout. Optionally, a gimble may support the funnel and diaphragms and thereby relieve the diaphragms from the weight of the coupling.

摘要翻译： 用于引导从进料喷口落下的颗粒流穿过筛选机的筛箱的顶盖上的开口的联接器。 上隔膜将漏斗内的进料口密封。 下隔膜密封顶盖开口内的漏斗排放口。 两个隔膜都是柔性的，并允许漏斗轴向倾斜并适应顶盖开口相对于进料口的运动。 可选地，柔性部件可以支撑漏斗和隔膜，从而使隔膜免受联轴器的重量的影响。

公开(公告)号：US5771680A

公开(公告)日：1998-06-30

申请号：US576249

申请日：1995-12-21

申请人： Ahmad P. Zahedi ,  Stephen C. Mitchell

发明人： Ahmad P. Zahedi ,  Stephen C. Mitchell

IPC分类号： B32B15/14 ,  F01D25/24 ,  F02C2/20

CPC分类号： F01D25/24 ,  B32B15/14 ,  Y02T50/672 ,  Y10S60/909 ,  Y10T156/1002 ,  Y10T428/1362 ,  Y10T428/1369

摘要： A stiffened composite is provided exhibiting multi-directional reinforcement with continuous long fibers. The composite has a substrate and serpentine stiffeners adhered thereto. The stiffeners merge toward, join with and diverge from adjacent stiffeners to provide a stiffener matrix on the substrate. The serpentine stiffener permit the matrix to exhibit multi-directional reinforcement with the continuous long fibers within the serpentine ribs. The composite structures are useful as aircraft bypass ducts, and as other composite products.

摘要翻译： 提供了具有连续长纤维的多方向加强件的加强复合材料。 复合材料具有粘附到其上的基底和蛇形加强件。 加强件与相邻的加强件相融合并与其分离，以在基板上提供加强筋基体。 蛇形加强筋允许基体在蜿蜒肋内连续的长纤维展现出多方向的增强。 复合结构可用作飞机旁路管道以及其他复合材料。

公开(公告)号：US5730297A

公开(公告)日：1998-03-24

申请号：US565628

申请日：1995-11-27

申请人： William E. Lower ,  Stephen C. Mitchell

发明人： William E. Lower ,  Stephen C. Mitchell

IPC分类号： B07B1/34 ,  B07B1/38 ,  B07B1/42

CPC分类号： B07B1/42 ,  B07B1/38

摘要： A screening machine of the moving base type has an oscillating force reducer and a single counterbalance drive, with the weight of the drive counterbalance sized to underbalance the longitudinal reaction force exerted by the deck on the drive shaft, but to substantially overbalance the lateral reaction force exerted by the deck on the drive shaft. The weight of the force reducer, the spring constant of the spring which oscillates the force reducer, and overall cost are surprisingly reduced.

摘要翻译： 移动式底座的筛分机具有摆动力减速器和单个平衡驱动装置，其中驱动平衡重的重量大小使得甲板在驱动轴上施加的纵向反作用力不平衡，但是基本上使横向反作用力过度平衡 由甲板在驱动轴上施加。 力减速器的重量，使减速器振动的弹簧的弹簧常数和总成本惊人地减少。

公开(公告)号：US5439750A

公开(公告)日：1995-08-08

申请号：US76670

申请日：1993-06-15

申请人： Richard Ravenhall ,  Charles R. Wojciechowski ,  Stephen C. Mitchell ,  Gary D. Mercer ,  Thomas J. Kelly ,  Melvin A. Schobert ,  Harvey M. Maclin

发明人： Richard Ravenhall ,  Charles R. Wojciechowski ,  Stephen C. Mitchell ,  Gary D. Mercer ,  Thomas J. Kelly ,  Melvin A. Schobert ,  Harvey M. Maclin

IPC分类号： C22C1/10 ,  F01D5/28 ,  B32B15/02

CPC分类号： F01D5/282 ,  C22C1/1036 ,  Y02T50/672 ,  Y10S60/909 ,  Y10T428/12486

摘要： A cast article having a reinforced structural composite core is disclosed. The cast article includes a structural element which is embedded in the otherwise cast metal article. The structural element is comprised of a metal matrix composite structural core. It includes a plurality of reinforcing fibers within a metal matrix. The fibers are generally a non-metallic material such as a ceramic which degrade at a temperature below the melting temperature of the cast metal comprising the article. The metal matrix composite structural core is encased with a sheath. The sheath, attached to and completely surrounding the core, is made of the same metal as the cast metal article. In a preferred embodiment, the article is a titanium alloy strut for a gas turbine engine.

摘要翻译： 公开了一种具有增强结构复合芯的铸造制品。 铸造制品包括嵌入另外的铸造金属制品中的结构元件。 结构元件由金属基复合结构芯构成。 它在金属基体内包括多个增强纤维。 纤维通常是非金属材料，例如陶瓷，其在低于包含制品的铸造金属的熔融温度的温度下降解。 金属基复合结构芯被护套包裹。 附着在并完全围绕芯的护套由与铸造金属制品相同的金属制成。 在优选实施例中，制品是用于燃气涡轮发动机的钛合金支柱。