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公开(公告)号：US07981624B2
公开(公告)日：2011-07-19
申请号：US12389293
申请日：2009-02-19
申请人： Daniel E. H. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
发明人： Daniel E. H. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
IPC分类号： G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N33/57419 , G01N33/57434 , G01N33/57488 , G01N2333/95
摘要： Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell membrane associated and secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provided are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. The invention also provides prognostic and diagnostic methods of examining a biological sample for evidence of disregulated cellular growth by comparing the status of 20P1F12/TMPRSS2 in the biological sample to the status of 20P1F12/TMPRSS2 in a corresponding normal sample, wherein alterations in the status of 20P1F12/TMPRSS2 in the biological sample are associated with disregulated cellular growth. The invention further provides various therapeutic compositions and strategies for treating prostate cancer, including particularly, 20P1F12/TMPRSS2 polypeptide and anti-20P1F12/TMPRSS2 antibody therapy methods and compositions, cancer vaccines, and small molecule therapy.
摘要翻译： 描述了衍生自或基于称为20P1F12 / TMPRSS2的新型前列腺特异性，雄激素调节的细胞膜相关和分泌的丝氨酸蛋白酶的前列腺和结肠癌的诊断和治疗的组合物。 提供了包含20P1F12 / TMPRSS2基因（本文中也称为20P1F12-GTC1）的整个编码序列的全长cDNA（图1）。 所提供的组合物是结合20P1F12 / TMPRSS2蛋白和其多肽片段的抗体，包括用可检测标记或毒素或治疗组合物标记的抗体。 本发明还提供了通过将生物样品中20P1F12 / TMPRSS2的状态与对应的正常样品中的20P1F12 / TMPRSS2的状态进行比较来检查生物样品以检测细胞生长失调的证据的预后和诊断方法，其中， 生物样品中的20P1F12 / TMPRSS2与细胞生长失调有关。 本发明还提供了治疗前列腺癌的各种治疗组合物和策略，特别包括20P1F12 / TMPRSS2多肽和抗-20P1F12 / TMPRSS2抗体治疗方法和组合物，癌症疫苗和小分子治疗。
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2.发明授权公开(公告)号：US07037667B1
公开(公告)日：2006-05-02
申请号：US09615285
申请日：2000-07-12
申请人： Daniel E. H. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
发明人： Daniel E. H. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
IPC分类号： G01N33/574 , G01N33/48 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N33/57419 , G01N33/57434 , G01N33/57488 , G01N2333/95
摘要： Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-related, cell membrane associated and secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provided are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. The invention also provides prognostic and diagnostic methods of examining a biological sample for evidence of disregulated cellular growth by comparing the status of 20P1F12/TMPRSS2 in the biological sample to the status of 20P1F12/TMPRSS2 in a corresponding normal sample, wherein alterations in the status of 20P1F12/TMPRSS2 in the biological sample are associated with disregulated cellular growth. The invention further provides various therapeutic compositions and strategies for treating prostate cancer, including particularly, 20P1F12/TMPRSS2 polypeptide and anti-20P1F12/TMPRSS2 antibody therapy methods and compositions, cancer vaccines, and small molecule therapy.
摘要翻译： 描述了源自或基于名为20P1F12 / TMPRSS2的新型前列腺特异性雄激素相关的细胞膜相关和分泌的丝氨酸蛋白酶的前列腺和结肠癌的诊断和治疗的组合物。 提供了包含20P1F12 / TMPRSS2基因（本文中也称为20P1F12-GTC1）的整个编码序列的全长cDNA（图1）。 所提供的组合物是结合20P1F12 / TMPRSS2蛋白和其多肽片段的抗体，包括用可检测标记或毒素或治疗组合物标记的抗体。 本发明还提供了通过将生物样品中20P1F12 / TMPRSS2的状态与对应的正常样品中的20P1F12 / TMPRSS2的状态进行比较来检查生物样品以检测细胞生长失调的证据的预后和诊断方法，其中， 生物样品中的20P1F12 / TMPRSS2与细胞生长失调有关。 本发明还提供了治疗前列腺癌的各种治疗组合物和策略，特别包括20P1F12 / TMPRSS2多肽和抗-20P1F12 / TMPRSS2抗体治疗方法和组合物，癌症疫苗和小分子治疗。
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公开(公告)号：US20090226921A1
公开(公告)日：2009-09-10
申请号：US12389293
申请日：2009-02-19
申请人： Daniel E. H. AFAR , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
发明人： Daniel E. H. AFAR , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N33/57419 , G01N33/57434 , G01N33/57488 , G01N2333/95
摘要： Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell membrane associated and secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provided are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. The invention also provides prognostic and diagnostic methods of examining a biological sample for evidence of disregulated cellular growth by comparing the status of 20P1F12/TMPRSS2 in the biological sample to the status of 20P1F12/TMPRSS2 in a corresponding normal sample, wherein alterations in the status of 20P1F12/TMPRSS2 in the biological sample are associated with disregulated cellular growth. The invention further provides various therapeutic compositions and strategies for treating prostate cancer, including particularly, 20P1F12/TMPRSS2 polypeptide and anti-20P1F12/TMPRSS2 antibody therapy methods and compositions, cancer vaccines, and small molecule therapy.
摘要翻译： 描述了衍生自或基于称为20P1F12 / TMPRSS2的新型前列腺特异性，雄激素调节的细胞膜相关和分泌的丝氨酸蛋白酶的前列腺和结肠癌的诊断和治疗的组合物。 提供了包含20P1F12 / TMPRSS2基因（本文中也称为20P1F12-GTC1）的整个编码序列的全长cDNA（图1）。 所提供的组合物是结合20P1F12 / TMPRSS2蛋白和其多肽片段的抗体，包括用可检测标记或毒素或治疗组合物标记的抗体。 本发明还提供了通过将生物样品中20P1F12 / TMPRSS2的状态与对应的正常样品中的20P1F12 / TMPRSS2的状态进行比较来检查生物样品以检测细胞生长失调的证据的预后和诊断方法，其中， 生物样品中的20P1F12 / TMPRSS2与细胞生长失调有关。 本发明还提供了治疗前列腺癌的各种治疗组合物和策略，特别包括20P1F12 / TMPRSS2多肽和抗-20P1F12 / TMPRSS2抗体治疗方法和组合物，癌症疫苗和小分子治疗。
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4.发明授权Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权在人类癌症中表达的蛇纹石跨膜抗原及其用途公开(公告)号：US07166714B2
公开(公告)日：2007-01-23
申请号：US10750262
申请日：2003-12-31
申请人： Daniel E. H. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen C. Mitchell
发明人： Daniel E. H. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen C. Mitchell
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的六个跨膜上皮原体）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。
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公开(公告)号：US4802591A
公开(公告)日：1989-02-07
申请号：US167690
申请日：1988-03-14
申请人： William E. Lower , W. Nash McCauley , Stephen C. Mitchell , Roger C. Robins , Steven A. Schmidt
发明人： William E. Lower , W. Nash McCauley , Stephen C. Mitchell , Roger C. Robins , Steven A. Schmidt
CPC分类号： B07B1/54 , B07B1/12 , B07B1/46 , D21B1/023 , B07B2201/04
摘要： A machine and method for separating chip-like particles according to thickness which provides low blinding and high efficiency at high throughput in sustained operation. The machine has a sloping deck mounting a series of spaced flexible louvers or slats which extend parallel to the direction of chip flow down the deck. The slats are canted transversely to the direction of flow, and present unobstructed full length slot-like chip openings between them. The deck is driven with a horizontal gyratory motion such that during the upstream half of each cycle of movement, each slot moves toward chips on the adjacent slat which slopes toward it, and moves away from such chips during the downstream half of the cycle. The path of screening movement is uniform over the entire deck, that is, the motion of the lower or discharge end of the deck matches that of the upper or feed end. Adjacent slats are supported at alternate or staggered positions along their length so that they can deflect slightly relative to one other along their entire length. Ball cleaners are directed to impact on the slats in the transverse direction to deflect them and thereby dislodge chips stuck between the slats.
摘要翻译： 根据厚度分离芯片状颗粒的机器和方法，其在持续操作中以高产量提供低盲目性和高效率。 该机器具有倾斜的甲板，其安装了一系列间隔开的柔性百叶窗或板条，其平行于芯片沿着甲板流动的方向延伸。 板条横向于流动方向倾斜，并且在它们之间呈现无阻碍的全长槽状切屑开口。 甲板由水平回转运动驱动，使得在每个运动循环的上游一半期间，每个槽向靠近其倾斜的相邻板条上的切屑移动，并在该循环的下半部分期间离开这种切屑。 整个甲板上的筛选运动的路径是均匀的，也就是说，甲板的下部或排放端的运动与上部或进料端的运动相匹配。 相邻的板条沿着它们的长度被支撑在交替或交错的位置处，使得它们可以沿其整个长度相对于彼此稍微偏转。 球形清洁剂被引导以在横向上对板条的冲击以使其偏转，从而移除卡在板条之间的碎屑。
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公开(公告)号：US3977728A
公开(公告)日：1976-08-31
申请号：US537359
申请日：1974-12-30
CPC分类号： F01D5/028 , F01D5/282 , Y02T50/672 , Y02T50/673
摘要： A wheel comprising a plurality of wheel plies, each wheel ply including concentric inner and outer hoops and a plurality of circumferentially spaced spoke loops therebetween, wherein each of the spoke loops is entrapped within the hoops. In one embodiment the wheel comprises a laminate of alternating wheel plies and intermediate plies bonded together. A spoked frame comprising one or more of the wheels is provided, the frame including fairing means to substantially envelope the spokes and retain the individual wheels in their proper spacial relationship.
摘要翻译： 包括多个轮子层的车轮，每个车轮帘布层包括同心的内圈和外圈以及在其间的多个周向间隔的轮辐环，其中每个轮辐环被夹在箍中。 在一个实施例中，车轮包括交替的轮子层和粘结在一起的中间帘布层的叠层。 提供了包括一个或多个轮的发射框架，框架包括整流装置，以基本上包围辐条并将各个车轮保持在适当的空间关系。
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公开(公告)号：US5511604A
公开(公告)日：1996-04-30
申请号：US355128
申请日：1994-12-13
申请人： Richard Ravenhall , Charles R. Wojciechowski , Stephen C. Mitchell , Gary D. Mercer , Thomas J. Kelly , Melvin A. Schobert , Harvey M. Maclin
发明人： Richard Ravenhall , Charles R. Wojciechowski , Stephen C. Mitchell , Gary D. Mercer , Thomas J. Kelly , Melvin A. Schobert , Harvey M. Maclin
CPC分类号： F01D5/282 , C22C1/1036 , Y02T50/672 , Y10S60/909 , Y10T428/12486
摘要： A cast article having a reinforced structural composite core is disclosed. The cast article includes a structural element which is embedded in the otherwise cast metal article. The structural element is comprised of a metal matrix composite structural core. It includes a plurality of reinforcing fibers within a metal matrix. The fibers are generally a non-metallic material such as a ceramic which degrade at a temperature below the melting temperature of the cast metal comprising the article. The metal matrix composite structural core is encased with a sheath. The sheath, attached to and completely surrounding the core, is made of the same metal as the cast metal article. In a preferred embodiment, the article is a titanium alloy strut for a gas turbine engine.
摘要翻译： 公开了一种具有增强结构复合芯的铸造制品。 铸造制品包括嵌入另外的铸造金属制品中的结构元件。 结构元件由金属基复合结构芯构成。 它在金属基体内包括多个增强纤维。 纤维通常是非金属材料，例如陶瓷，其在低于包含制品的铸造金属的熔融温度的温度下降解。 金属基复合结构芯被护套包裹。 附着在并完全围绕芯的护套由与铸造金属制品相同的金属制成。 在优选实施例中，制品是用于燃气涡轮发动机的钛合金支柱。
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公开(公告)号：US5074012A
公开(公告)日：1991-12-24
申请号：US701788
申请日：1991-05-17
申请人： Stephen C. Mitchell
发明人： Stephen C. Mitchell
IPC分类号： B07B1/46 , B07B1/48 , F16B39/282
CPC分类号： F16B39/282 , B07B1/46 , B07B1/48 , Y10T24/44504 , Y10T24/44598 , Y10T24/44974 , Y10T403/32393 , Y10T403/583
摘要： A self-locking clamp has a handle which locks to a non-rotating member if the handle starts to turn while in clamping use. The clamp has a retractable collar which is splined to the handle and is biased toward locking engagement with a sleeve that in turn seats against the member to be clamped. The collar can be held retracted from the sleeve for tightening and loosening the clamp.
摘要翻译： 如果手柄在夹紧使用时开始转动，则自锁夹具具有锁定到非旋转构件的手柄。 夹具具有可伸缩的套环，其可以花键连接到手柄并被偏压以与套筒锁定接合，该套筒又抵靠待夹紧的构件。 套环可以从套筒中缩回以收紧和松开夹具。
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公开(公告)号：US07390161B2
公开(公告)日：2008-06-24
申请号：US11274972
申请日：2005-11-16
申请人： Ming Xie , Stephen C. Mitchell , Donald G. LaChapelle , Michael Scott Braley , Gary D. Roberts , Dale Hopkins
发明人： Ming Xie , Stephen C. Mitchell , Donald G. LaChapelle , Michael Scott Braley , Gary D. Roberts , Dale Hopkins
IPC分类号： F01D21/00
CPC分类号： F01D21/045 , D04C1/02 , D10B2505/02 , F01D25/24 , F05D2300/44 , F05D2300/603 , F05D2300/702 , Y02T50/672
摘要： A composite fan casing for a gas turbine engine includes, in an exemplary embodiment, a core having a plurality of core layers of reinforcing fiber bonded together with a thermosetting polymeric resin. Each core layer includes a plurality of braided reinforcing fiber tows. The braids of reinforcing fiber tows are aligned in a circumferential direction with each fiber tow including a plurality of reinforcing fibers. The core also includes at least one additional fiber tow braided into at least one predetermined axial location to form at least one concentrated stiffening ring.
摘要翻译： 在示例性实施例中，用于燃气涡轮发动机的复合风扇壳体包括具有多个与热固性聚合物树脂结合在一起的增强纤维芯层的芯体。 每个芯层包括多个编织的增强纤维束。 增强纤维丝束的编织物在圆周方向上排列，每条纤维束包括多根增强纤维。 芯还包括至少一个额外的纤维束，其编织成至少一个预定的轴向位置以形成至少一个集中的加强环。
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公开(公告)号：US5437538A
公开(公告)日：1995-08-01
申请号：US144098
申请日：1993-10-28
申请人： Stephen C. Mitchell
发明人： Stephen C. Mitchell
CPC分类号： F01D21/045 , D04C1/02 , F41H5/02 , F05D2220/327 , Y02T50/671 , Y10S428/902 , Y10S428/911 , Y10T428/24058
摘要： An improved blade containment structure including a projectile shield having a braided ballistic fabric is disclosed. The braided fabric includes ballistic strands arranged in a preferred orientation and is effective for increasing the ability of the fabric to contain projectiles and absorb energy therefrom. The braided ballistic fabric provides substantial improvement in performance over conventional woven ballistic fabrics.
摘要翻译： 公开了一种改进的叶片容纳结构，其包括具有编织弹道织物的抛射屏蔽。 编织物包括以优选取向布置的防弹绳，并且有效地增加织物包含弹丸并从中吸收能量的能力。 编织弹道织物在性能上比传统的编织弹道织物提供了显着的改进。
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