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1.发明授权Plasma gas discharge treatment for improving the biocompatibility of biomaterials 失效用于提高生物材料生物相容性的等离子体气体放电处理
公开(公告)号：US4656083A
公开(公告)日：1987-04-07
申请号：US709990
申请日：1985-03-11
CPC分类号： B05D1/62 , A61F2/06 , A61L27/507 , A61L33/0088 , A61L33/0094 , B05D3/142 , Y10S128/22 , Y10T428/31544 , Y10T442/2525
摘要： A method of treating articles to improve their biocompatibility is disclosed. A substrate material is positioned within a reactor vessel and exposed to plasma gas discharge in the presence of an atmosphere of an inert gas and then in the presence of an organic gas, such as a halocarbon or halohydrocarbon gas, capable of forming a thin, biocompatible surface covalently bonded to the surface of the substrate. The method is particularly useful in the treatment of vascular graft materials to improve their biocompatibility.
摘要翻译： 公开了一种治疗制品以提高其生物相容性的方法。 衬底材料定位在反应器容器内并在惰性气体气氛存在下暴露于等离子体气体放电，然后在有机气体如卤化碳或卤代烃气体存在下，能够形成薄的生物相容性 表面共价结合到基材的表面。 该方法特别可用于治疗血管移植材料以改善其生物相容性。
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2.发明授权Plasma gas discharge treatment for improving the compatibility of biomaterials 失效用于提高生物材料相容性的等离子体气体放电处理
公开(公告)号：US5034265A
公开(公告)日：1991-07-23
申请号：US398312
申请日：1989-08-21
CPC分类号： B05D1/62 , A61F2/06 , A61L27/507 , A61L33/0088 , A61L33/0094 , B05D3/142 , Y10S623/921 , Y10T428/31544 , Y10T442/2549
摘要： A method of treating articles to improve their biocompatibility is disclosed. A polymeric substrate material is positioned within a reactor vessel and exposed to plasma gas discharge in the presence of an atmosphere of an inert gas and then in the presence of an organic gas, such as a fluorinated hydrocarbon gas, which forms a thin, biocompatible surface covalently bonded to the surface of the substrate. The method is particularly useful in the treatment of vascular graft materials to produce grafts that are both thrombi- and emboli-resistant.
摘要翻译： 公开了一种治疗制品以提高其生物相容性的方法。 聚合物基材材料位于反应器容器内并在惰性气体气氛存在下暴露于等离子体气体放电，然后在有机气体如氟化烃气体存在下形成薄的生物相容性表面 共价键合到基材表面。 该方法在治疗血管移植材料以产生血栓和栓塞抗性的移植物中特别有用。
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3.发明申请Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor 审中-公开降低血小板循环水平的试剂的控释组合物及其方法公开(公告)号：US20090324710A1
公开(公告)日：2009-12-31
申请号：US12456443
申请日：2009-06-16
CPC分类号： A61K9/1676 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2054 , A61K9/2081 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K31/00 , A61K31/519 , A61L27/025 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/42 , A61L2300/602 , A61L2300/608 , A61L2300/622 , A61L2300/63 , A61L2420/08 , C07D239/72 , C07D487/04 , C08L3/04 , C08L1/02
摘要： Provided are prophylactic and therapeutic methods of treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents, including anagrelide and anagrelide derivatives, which reduce the number of circulating platelets to low normal or to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
摘要翻译： 本发明提供了通过包括阿那格雷和阿那格雷衍生物在内的给药试剂抑制血管闭塞事件（包括栓塞）的方法来治疗受试者的预防和治疗方法，其将循环血小板数量降低到正常水平或低于正常水平。 提供包含这些试剂的方法和药物制剂。
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4.发明授权公开(公告)号：US07022521B2
公开(公告)日：2006-04-04
申请号：US10602293
申请日：2003-06-24
申请人： Stephen R. Hanson
发明人： Stephen R. Hanson
CPC分类号： A61K45/06 , A61K9/1647 , A61K9/204 , A61K31/00 , A61K31/4365 , A61K31/4965 , A61K31/519 , A61K31/522 , A61K31/557 , A61K31/60 , A61K31/616 , A61K38/49 , A61K47/34 , A61K2300/00
摘要： The invention relates to the treatment of subjects for the purpose inhibiting vaso-occlusive events, including thrombosis and embolism, by administering agents which reduce the number of circulating platelets to low or below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
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公开(公告)号：US5399352A
公开(公告)日：1995-03-21
申请号：US46622
申请日：1993-04-14
申请人： Stephen R. Hanson
发明人： Stephen R. Hanson
CPC分类号： A61F2/06 , A61F2/064 , A61M25/0021 , A61M37/00 , A61F2250/0067 , A61M2025/0063 , A61M25/0041
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body, having a first clement capable of contacting the lumen of the conduit and a second element which overlays first element, a reservoir being formed between the first element and the second element, the interior of the reservoir being capable of fluid communication with the conduit such that a substance placed in the reservoir is delivered into the conduit. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
摘要翻译： 一种用于将物质局部递送到哺乳动物体内的天然组织导管中的装置，其具有能够接触导管的内腔的第一部件和覆盖第一元件的第二元件，形成在第一元件和第二元件之间的储存器 第二元件，储存器的内部能够与管道流体连通，使得放置在储存器中的物质被输送到管道中。 还提供了利用本发明的装置将物质局部输送到哺乳动物体内的天然组织导管中的方法。
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公开(公告)号：US5350578A
公开(公告)日：1994-09-27
申请号：US782817
申请日：1991-10-25
IPC分类号： A61K38/43 , A61K38/46 , A61K38/48 , A61K38/54 , A61K45/06 , A61P7/02 , C12N9/64 , A61K37/547
CPC分类号： C12N9/6464 , A61K38/166 , A61K38/49 , C12Y304/21069 , A61K38/00
摘要： The method of preventing arterial thrombotic occlusion or thromboembolism by administering plasma-derived or recombinant produced protein C alone or in combination with a thrombolytic agent or combinations of thrombolytic agents.
摘要翻译： 通过单独施用血浆来源的或重组产生的蛋白C或与血栓溶解剂或血栓溶解剂的组合联合来预防动脉血栓闭塞或血栓栓塞的方法。
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公开(公告)号：US08808255B2
公开(公告)日：2014-08-19
申请号：US12747048
申请日：2008-12-12
申请人： Stephen R. Hanson
发明人： Stephen R. Hanson
CPC分类号： A61M31/002 , A61F2/06 , A61F2/064 , A61F2250/0067 , A61M5/14276
摘要： Embodiments provide a drug delivery cuff including a drug reservoir. In an embodiment, an integrated drug pump may be provided. A drug delivery cuff in accordance with an embodiment may be placed around any suitable vascular graft (e.g., ePTFE) or directly around any natural tissue conduit (e.g., perivascularly), at any position along the graft/conduit or overlapping a graft and conduit, either at the time of graft surgical placement or separate therefrom.
摘要翻译： 实施例提供了包括药物储存器的药物递送袖带。 在一个实施例中，可以提供集成的药物泵。 根据实施例的药物输送袖带可以放置在任何合适的血管移植物（例如ePTFE）周围或者在任何天然组织导管周围（例如血管周围）放置在沿着移植物/管道的任何位置处或与移植物和导管重叠， 无论是在移植手术放置时还是从其分离。
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8.发明申请公开(公告)号：US20130022671A1
公开(公告)日：2013-01-24
申请号：US13551526
申请日：2012-07-17
IPC分类号： A61K9/00 , A61K9/20 , A61K31/519 , A61P9/00 , A61P7/00 , A61P3/10 , A61P3/06 , A61P9/12 , A61P9/10 , A61K31/56 , A61K38/17 , A61K38/54 , A61K39/395 , A61K31/704 , A61K38/20 , A61K38/21 , A61K9/48
CPC分类号： A61K9/1676 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2054 , A61K9/2081 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K31/00 , A61K31/519 , A61L27/025 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/42 , A61L2300/602 , A61L2300/608 , A61L2300/622 , A61L2300/63 , A61L2420/08 , C07D239/72 , C07D487/04 , C08L3/04 , C08L1/02
摘要： Provided are prophylactic and therapeutic methods of treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents, including anagrelide and anagrelide derivatives, which reduce the number of circulating platelets to low normal or to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
摘要翻译： 本发明提供了通过包括阿那格雷和阿那格雷衍生物在内的给药试剂抑制血管闭塞事件（包括栓塞）的方法来治疗受试者的预防和治疗方法，其将循环血小板数量降低到正常水平或低于正常水平。 提供包含这些试剂的方法和药物制剂。
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公开(公告)号：US06706512B2
公开(公告)日：2004-03-16
申请号：US10165442
申请日：2002-06-07
申请人： Andras Gruber , Stephen R. Hanson , Enrico De Cera
发明人： Andras Gruber , Stephen R. Hanson , Enrico De Cera
IPC分类号： C12N964
CPC分类号： C12N9/6464 , A61K38/00 , C12N9/6429 , C12Q1/40 , C12Y304/21005 , C12Y304/21069 , G01N33/86
摘要： The present invention relates to novel antithrombotic variants of thrombin or fragments thereof that are capable of proteolytically activating protein C, but which are substantially free of fibrinogen cleavage activity. The present invention further relates to variant polypeptidess that may be cleaved to yield active thrombin variants. The present invention also relates to methods of inhibiting thrombus formation in an animal or human subject by delivering an antithrombotic variant thrombin of the present invention to the blood of the subject. The present invention relates also to methods that use the novel variant thrombins for determining the level of protein C activation in a blood sample, or the thrombogenic potential of a patient.
摘要翻译： 本发明涉及能够蛋白水解活化蛋白C但基本上不含纤维蛋白原裂解活性的凝血酶或其片段的新型抗血栓形成变体。 本发明还涉及可被切割以产生活性凝血酶变体的变体多肽。 本发明还涉及通过将本发明的抗血栓形成变体凝血酶递送至受试者的血液来抑制动物或人受试者中血栓形成的方法。 本发明还涉及使用新型变体血栓素来测定血液样品中蛋白C活化水平或患者血栓形成潜力的方法。
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公开(公告)号：US5877224A
公开(公告)日：1999-03-02
申请号：US508577
申请日：1995-07-28
CPC分类号： A61K9/146 , A61K9/2031 , A61K9/204 , A61K9/7007
摘要： Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compatible polymer matrix, and a second, phase-disrupting polymer that is non-miscible with the tissue-compatible polymer and is present in an amount sufficient to form phase-separated microdomains of the second polymer in the tissue-compatible polymer matrix, so that the release rate of the water-soluble drug from the tissue-compatible polymer matrix is related to the amount of the second polymer. Methods of preparing the polymeric drug formulations are also described, as well as methods for site-specific drug delivery utilizing the polymeric drug formulations.
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