公开(公告)号：US20050250744A1

公开(公告)日：2005-11-10

申请号：US11182247

申请日：2005-07-14

Applicant: Stuart Levy ,  Mark Nelson

Inventor： Stuart Levy ,  Mark Nelson

IPC: C07D295/10 ,  A01N37/44 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/65 ,  A61P31/00 ,  A61P31/04 ,  C07C237/26 ,  C07C255/43 ,  C07C323/60 ,  C07C323/61 ,  C07C323/63 ,  C07D207/08 ,  C07D295/155

CPC classification number: C07D295/155 ,  C07C237/26 ,  C07C255/43 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18

Abstract: The invention includes new substituted tetracycline-type compounds that exhibit significant antibacterial activity, including against both gram-positive and gram-negative bacteria. It has been found that compounds of the invention are highly active against both gram positive and gram negative tetracycline sensitive and tetracycline resistant bacteria.

Abstract translation: 本发明包括显示出显着的抗菌活性的新的取代的四环素型化合物，包括抗革兰氏阳性细菌和革兰氏阴性细菌。 已经发现，本发明的化合物对革兰氏阳性和革兰氏阴性四环素敏感性和四环素抗性细菌均具有高度活性。

公开(公告)号：US20050261165A1

公开(公告)日：2005-11-24

申请号：US10629340

申请日：2003-07-28

Applicant: Margret Oethinger ,  Stuart Levy

Inventor： Margret Oethinger ,  Stuart Levy

IPC: G01N33/50 ,  A61K31/00 ,  A61K31/085 ,  A61K31/496 ,  A61K45/06 ,  A61P31/00 ,  A61P31/04 ,  A61P43/00 ,  C12Q1/02 ,  G01N33/15

CPC classification number: C12Q1/689 ,  A61K31/085 ,  A61K31/09 ,  A61K31/47 ,  A61K31/496 ,  A61K45/06 ,  C12Q1/18 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  Y02A50/481 ,  A61K2300/00

Abstract: The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.

Abstract translation: 本方法和组合物代表了控制微生物耐药性的进展。 已经发现AcrAB样外排泵控制对药物的抵抗力，即使在高度耐药的微生物中也是如此。 因此，提供了治疗感染的方法，筛选AcrAB样外排泵的抑制剂的方法以及增强药物的抗微生物活性的方法。 还提供了包含AcrAB样外排泵和抗微生物剂的抑制剂的药物组合物。

公开(公告)号：US20050215532A1

公开(公告)日：2005-09-29

申请号：US10982728

申请日：2004-11-04

Applicant: Stuart Levy ,  Mark Nelson

Inventor： Stuart Levy ,  Mark Nelson

IPC: A61K45/00 ,  A61K31/65 ,  A61K31/7036 ,  A61P1/12 ,  A61P33/00 ,  A61P33/02 ,  C07C237/26

CPC classification number: A61K31/65 ,  C07C237/26 ,  C07C2601/10 ,  Y02A50/488

Abstract: Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included.

Abstract translation: 讨论了用于治疗哺乳动物中隐孢子虫相关疾病的方法和组合物。 还包括可用于治疗隐孢子虫相关病症的几种新型四环素化合物。

公开(公告)号：US20250041033A1

公开(公告)日：2025-02-06

申请号：US18921272

申请日：2024-10-21

Applicant: Stuart Levy

Inventor： Stuart Levy

IPC: A61C13/225 ,  A61C9/00 ,  A61C13/34 ,  B23K26/38 ,  B33Y10/00 ,  B33Y50/02 ,  B33Y80/00

Abstract: A method of manufacturing a pad to secure a dental appliance to a gum of a patient including creating a digital model of a gum facing portion of the dental appliance and using the digital model to manufacture the pad. Manufacturing the pad includes creating a profile defining a perimeter of the pad from the digital model and cutting the pad from a sheet of material using the profile. Manufacturing the pad includes 3D printing the pad. Creating the digital model includes 3D scanning the gum facing portion of the dental appliance. Creating the digital model includes 3D scanning an impression of the gum facing portion of the dental appliance.

公开(公告)号：US20070244316A1

公开(公告)日：2007-10-18

申请号：US11542883

申请日：2006-10-04

Applicant: John Amedio ,  Peter Caravan ,  Vincent Jacques ,  Kevin Zhou ,  Stuart Levy ,  Shirley Kalogeropoulos ,  Matthew Greenfield

Inventor： John Amedio ,  Peter Caravan ,  Vincent Jacques ,  Kevin Zhou ,  Stuart Levy ,  Shirley Kalogeropoulos ,  Matthew Greenfield

IPC: C07D257/02 ,  C07K7/06 ,  C07K7/08

CPC classification number: A61K49/10 ,  A61K49/085 ,  A61K49/106 ,  A61K49/14 ,  C07D257/02

Abstract: Organic chelating ligands, organic chelating ligand precursors, and metal chelates are disclosed. Methods for synthesizing the same are also described, including methods for preparing optically-enriched or optically-pure compositions of the same.

Abstract translation: 公开了有机螯合配体，有机螯合配体前体和金属螯合物。 还描述了合成它们的方法，包括制备其光学富集或光学纯的组合物的方法。

公开(公告)号：US20070155957A1

公开(公告)日：2007-07-05

申请号：US11707404

申请日：2007-02-16

Applicant: Michael Alekshun ,  Stuart Levy ,  James Head ,  Barbara Seaton

Inventor： Michael Alekshun ,  Stuart Levy ,  James Head ,  Barbara Seaton

IPC: C07K14/705 ,  G06F19/00

CPC classification number: C07K14/245 ,  C07K2299/00 ,  G01N23/20

Abstract: The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described.

公开(公告)号：US20060194773A1

公开(公告)日：2006-08-31

申请号：US10996119

申请日：2004-11-22

Applicant: Stuart Levy ,  Michael Draper ,  Mark Nelson ,  Graham Jones

Inventor： Stuart Levy ,  Michael Draper ,  Mark Nelson ,  Graham Jones

IPC: A61K31/65

CPC classification number: C07C237/26 ,  A61K31/65 ,  A61K45/06 ,  Y02A50/411

Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.

Abstract translation: 描述了用具有目标治疗活性的四环素化合物治疗疾病的方法和化合物。

公开(公告)号：US20050136460A1

公开(公告)日：2005-06-23

申请号：US10989992

申请日：2004-11-15

Applicant: Stuart Levy

Inventor： Stuart Levy

IPC: C12N15/52 ,  C12Q1/68 ,  C12Q1/18

CPC classification number: C12N15/52 ,  C12Q1/6897

Abstract: An isolated and cloned region of a bacterial chromosome containing a multiple antibiotic resistance operon is disclosed. A description of the structure and function of the operon is provided as are assorted recombinant DNA constructs involving the operon or fragments thereof. The diagnostic, therapeutic and experimental uses of these constructs are also disclosed. Methods of evaluating the antibiotic effectiveness of compositions are disclosed and methods of treatment employing effective compositions are provided.

Abstract translation: 公开了含有多种抗生素抗性操纵子的细菌染色体的分离克隆区域。 还提供了涉及操纵子或其片段的各种重组DNA构建体的操纵子的结构和功能的描述。 还公开了这些构建体的诊断，治疗和实验用途。 公开了评估组合物的抗生素效力的方法，并提供了使用有效组合物的治疗方法。

公开(公告)号：US20050124678A1

公开(公告)日：2005-06-09

申请号：US10700661

申请日：2003-11-03

Applicant: Stuart Levy ,  Michael Alekshun ,  Brent Podlogar ,  Kwasi Ohemeng ,  Atul Verma ,  Tadeusz Warchol ,  Beena Bhatia ,  Todd Bowser ,  Mark Grier

Inventor： Stuart Levy ,  Michael Alekshun ,  Brent Podlogar ,  Kwasi Ohemeng ,  Atul Verma ,  Tadeusz Warchol ,  Beena Bhatia ,  Todd Bowser ,  Mark Grier

IPC: A61K31/40 ,  A61K31/407 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/535 ,  A61K31/55 ,  A61K31/555 ,  A61K31/4184

CPC classification number: A61K31/40 ,  A61K31/407 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/535 ,  A61K31/55 ,  A61K31/555 ,  Y02A50/401 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483

Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Abstract translation: 提供了可用作降低微生物的抗性，毒力或生长的抗感染药物的取代的苯并咪唑化合物。 制备和使用取代的苯并咪唑化合物的方法，以及其药物制剂，例如降低抗生素抗性和抑制生物膜。

公开(公告)号：US5889866A

公开(公告)日：1999-03-30

申请号：US655159

申请日：1996-05-29

Applicant: Gary Cyras ,  Stuart Levy ,  David C. Scheer

Inventor： Gary Cyras ,  Stuart Levy ,  David C. Scheer

IPC: G06F21/00 ,  G06F13/12

CPC classification number: G06F21/34 ,  G06F2211/007

Abstract: A method and apparatus for controlling access to a detachably connectable computer device using encryption is disclosed. The method and apparatus include a connector for coupling the device to a computer, an input for receiving a password from a user, encrypting logic for encrypting the password and comparing logic for comparing the received password with a key. The key is determined by encrypting a user-assigned password and storing it as the key. Further included is circuitry for determining whether the received password corresponds to the key, and circuitry for sending an enable signal to configuration logic of the detachably connectable computer device, upon a determination that the received password corresponds to the key.

Abstract translation: 公开了一种使用加密来控制对可拆卸连接的计算机设备的访问的方法和装置。 该方法和装置包括用于将设备耦合到计算机的连接器，用于从用户接收密码的输入，用于加密密码的加密逻辑以及用于将接收的密码与密钥进行比较的逻辑。 密钥通过加密用户分配的密码并将其存储为密钥来确定。 进一步包括用于确定所接收的密码是否对应于密钥的电路，以及用于在确定所接收的密码对应于密钥的情况下，将启用信号发送到可拆卸连接的计算机设备的配置逻辑的电路。