公开(公告)号：US09551690B2

公开(公告)日：2017-01-24

申请号：US14008739

申请日：2012-03-30

Applicant: Michel Joseph Gilles Gaudet ,  Robert Hayden Lumsden ,  Glenn Curtis Longhurst ,  Kristopher Kyle Jones ,  Stuart Thomas Craig ,  David Walter Dunford ,  Paul Gregory Adams ,  Kenneth Robert Chaplin ,  Helene Marie Hebert

Inventor： Michel Joseph Gilles Gaudet ,  Robert Hayden Lumsden ,  Glenn Curtis Longhurst ,  Kristopher Kyle Jones ,  Stuart Thomas Craig ,  David Walter Dunford ,  Paul Gregory Adams ,  Kenneth Robert Chaplin ,  Helene Marie Hebert

IPC: G01N29/04 ,  G01N29/26 ,  G01B17/02 ,  G21C17/017 ,  G01N29/22

CPC classification number: G01N29/04 ,  G01B17/02 ,  G01N29/225 ,  G01N29/262 ,  G01N2291/267 ,  G21C17/017

Abstract: A phased array ultrasonic probe may be mounted to a component to be inspected for wall thickness on an apparatus that includes a split ring adapted to be magnetically held in place on the component. In particular, the probe may be mounted to a carriage connected to the split ring in a manner that allows the carriage to rotate around the split ring while the probe is in operation. Between the probe and the component, a transducer shoe defining, by a flexible membrane, a cavity and an aperture. Conveniently, the construction of the flexible membrane allows wall thickness measurements to be acquired in portions of the component that have complex topography, such as welds. The apparatus is installed on an adaptor assembly for inspection of straight section of pipes. This adaptor assembly is not used in absence of straight section. By acquiring data from multiple output pulse transmitted at multiple incidence angles, processing software may conveniently produce an accurate wall thickness map of the area of interest on the component.

Abstract translation: 相控阵超声波探头可以在包括适于被磁性地保持在部件上就位的开口环上的装置上安装到要被检查的壁厚的部件上。 特别地，探针可以以允许滑架在探头工作时围绕分离环旋转的方式安装到连接到开口环的滑架上。 在探针和部件之间，传感器靴通过柔性膜限定空腔和孔。 方便地，柔性膜的结构允许在具有复杂形貌（例如焊缝）的部件的部分中获得壁厚测量。 该设备安装在适配器组件上，用于检查直管段。 在没有直线段的情况下不使用此适配器组件。 通过从多个入射角发射的多个输出脉冲获取数据，处理软件可以方便地在部件上产生感兴趣区域的准确的壁厚图。

公开(公告)号：US08618140B2

公开(公告)日：2013-12-31

申请号：US13616696

申请日：2012-09-14

Applicant: Kazuhiro Ito ,  Peter Strong ,  William Garth Rapeport ,  Peter John Murray ,  John King-Underwood ,  Jonathan Gareth Williams ,  Stuart Thomas Onions ,  Simon Christopher Hirst ,  David Michel Adrien Taddei ,  Catherine Elisabeth Charron

Inventor： Kazuhiro Ito ,  Peter Strong ,  William Garth Rapeport ,  Peter John Murray ,  John King-Underwood ,  Jonathan Gareth Williams ,  Stuart Thomas Onions ,  Simon Christopher Hirst ,  David Michel Adrien Taddei ,  Catherine Elisabeth Charron

IPC: A61K31/4439 ,  C07D401/02

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D403/12

Abstract: There are provided inter alia compounds of formula (I) wherein R1, Ar, L, X, R3 and Q are as defined in the specification for use in therapy, especially in the treatment of inflammatory diseases.

公开(公告)号：US20130156826A1

公开(公告)日：2013-06-20

申请号：US13805471

申请日：2011-06-17

Applicant: Peter John Murray ,  Stuart Thomas Onions ,  Jonathan Gareth Williams ,  Kevin Joly

Inventor： Peter John Murray ,  Stuart Thomas Onions ,  Jonathan Gareth Williams ,  Kevin Joly

IPC: C07D471/04 ,  C07D475/02 ,  C07D473/30

CPC classification number: C07D471/04 ,  A61K9/0075 ,  A61K31/437 ,  A61K31/4985 ,  C07D473/30 ,  C07D475/02 ,  C07D487/04 ,  Y10T428/2982

Abstract: The present invention relates to respiratory formulations comprising a compound of formula (I): and use of said compounds and compositions in treatment, for example in the treatment of an inflammatory disease or a respiratory disorder, in particular an inflammatory mediated and/or virally mediated respiratory disorder such as asthma and COPD or the treatment or prevention of viral infection, for example infection by influenza virus, rhinovirus or RSV. The invention also extends to certain novel compounds of formula (I).

Abstract translation: 本发明涉及包含式（I）化合物的呼吸制剂：以及所述化合物和组合物在治疗中的用途，例如治疗炎性疾病或呼吸障碍，特别是炎性介导和/或病毒介导的 呼吸障碍如哮喘和COPD或治疗或预防病毒感染，例如流感病毒，鼻病毒或RSV感染。 本发明还延伸到某些新的式（I）化合物。

公开(公告)号：US20130040962A1

公开(公告)日：2013-02-14

申请号：US13639959

申请日：2011-04-08

Applicant: John King-Underwood ,  Peter John Murray ,  Jonathan Gareth Williams ,  Ildiko Buck ,  Stuart Thomas Onions

Inventor： John King-Underwood ,  Peter John Murray ,  Jonathan Gareth Williams ,  Ildiko Buck ,  Stuart Thomas Onions

IPC: C07D401/12 ,  C07D413/14 ,  A61K31/5377 ,  C07D401/14 ,  A61K31/496 ,  A61K31/444 ,  C07D409/14 ,  C07D405/14 ,  C07D403/12 ,  A61K31/506 ,  A61P11/00 ,  A61P11/06 ,  A61P11/02 ,  A61P27/02 ,  A61P17/00 ,  A61P17/06 ,  A61P1/04 ,  A61P29/00 ,  A61P19/02 ,  A61P1/18 ,  A61P21/00 ,  A61P35/00 ,  A61P35/04 ,  A61K31/4439

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

Abstract: There is provided a compound of formula (I): wherein: J represents (A): or (B): compositions comprising same, processes for preparing said compounds and use thereof in treatment, particularly in the treatment of inflammatory disease, such as asthma, COPD and 15 rheumatoid arthritis.

Abstract translation: 提供式（I）的化合物：其中：J表示（A）：或（B）：包含其的组合物，制备所述化合物的方法及其在治疗中的用途，特别是治疗炎性疾病如哮喘 ，COPD和15种类风湿关节炎。

公开(公告)号：US08106091B2

公开(公告)日：2012-01-31

申请号：US12447271

申请日：2007-10-29

Applicant: David Charles Festus Moffat ,  Stephen John Davies ,  Michael Hugh Charlton ,  Simon Christopher Hirst ,  Stuart Thomas Onions ,  Jonathon Gareth Williams

Inventor： David Charles Festus Moffat ,  Stephen John Davies ,  Michael Hugh Charlton ,  Simon Christopher Hirst ,  Stuart Thomas Onions ,  Jonathon Gareth Williams

IPC: A61K31/381 ,  C07D333/36

CPC classification number: C07D333/38

Abstract: Compounds of formula (IA) or (IB) are inhibitors of IkB kinase (IKK) activity, and are useful in the treatment of autoimmune and inflammatory diseases: wherein R7 is hydrogen or optionally substituted (C1-C6)alkyl; ring A is an optionally substituted aryl or heteroaryl ring of 5-13 ring atoms; Z is a radical of formula R-L1-Y1—(CH2)z—, wherein: z is 0 or 1; R is a radical of formula (X) or (Y) R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; R6 is hydrogen, or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl or heteroaryl or —(C═O)R3, —(C═O)OR3, or —(C═O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl; Y1 is a bond, —(C═O)—, —S(O2)—, —C(═O)O—, —OC(═O)—, —(C═O)NR3—, —NR3(C═O)—, —S(O2)NR3—, —NR3S(O2)—, or —NR3(C═O)NR4—, wherein R3 and R4 are independently hydrogen or optionally substituted (C1-C6)alkyl, L1 is a divalent linker radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, Q, Alk1 and Alk2 are as defined in the claims.

Abstract translation: 式（IA）或（IB）的化合物是IkB激酶（IKK）活性的抑制剂，可用于治疗自身免疫性和炎性疾病：其中R 7为氢或任选取代的（C 1 -C 6）烷基; 环A是任选取代的5-13个环原子的芳基或杂芳基环; Z是式R-L1-Y1-（CH2）z-的基团，其中：z是0或1; R是式（X）或（Y）的基团，R 1是羧酸基团（-COOH）或可被一个或多个细胞内酯酶水解成羧酸基团的酯基; R 6是氢或任选取代的C 1 -C 6烷基，C 3 -C 7环烷基，芳基或杂芳基或 - （C = O）R 3， - （C = O）OR 3或 - （C = O）NR 3，其中R 3是氢或 任选取代的（C 1 -C 6）烷基; Y1是一个键， - （C = O） - ， - S（O 2） - ， - C（= O）O-，-OC（= O） - ， - （C = O）NR 3 - ， - NR 3 （O） - ， - S（O 2）NR 3 - ， - NR 3 S（O 2） - 或-NR 3（C = O）NR 4 - ，其中R 3和R 4独立地是氢或任选取代的（C 1 -C 6） 式 - （Alk1）m（Q）n（Alk2）p的二价连接基团其中m，n，p，Q，Alk1和Alk2如权利要求中所定义。

公开(公告)号：US20110039920A1

公开(公告)日：2011-02-17

申请号：US12989022

申请日：2008-04-23

Applicant: David Festus Charles Moffat ,  Stephen John Davies ,  Michael Hugh Charlton ,  Simon Christopher Hirst ,  Jonathon Gareth Williams ,  Stuart Thomas Onions

Inventor： David Festus Charles Moffat ,  Stephen John Davies ,  Michael Hugh Charlton ,  Simon Christopher Hirst ,  Jonathon Gareth Williams ,  Stuart Thomas Onions

IPC: A61K31/381 ,  C07D333/38 ,  C12N9/99 ,  A61P35/00 ,  A61P37/06 ,  A61P29/00 ,  A61P19/02 ,  A61P3/10 ,  A61P11/06 ,  A61P1/04 ,  A61P25/28

CPC classification number: C07D333/38

Abstract: Cyclopentyl(2S,4E)-2-amino-5-{3-[4-carbamoyl-5(carbamoylamino)-2-thienyl]phenyl}pent-4-enoate; Cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate; Cyclopentyl(2S,4E)-2-amino-5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]-5-methylphenyl}pent-4-enoate; Cyclopentyl(25,4E)-2-amino-5-{5-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]-2-methylphenyl}pent-4-enoate; Cyclopentyl O-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-homoserinate; Cyclopentyl O-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-homoserinate; Cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}-L-alaninate; and tert-Butyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}-L-alaninate are hydrolysed to the corresponding carboxylic acids by intracellular carboxylesterases, and are useful for the inhibition of IKKβ activity.

Abstract translation: （2S，4E）-2-氨基-5- {3- [4-氨基甲酰基-5（氨基甲酰基氨基）-2-噻吩基]苯基}戊-4-烯酸酯; 5- {3- [4-氨甲酰基-5-（氨基甲酰基氨基）-2-噻吩基]苯基} -L-降冰片烯环戊酯; （2S，4E）-2-氨基-5- {3- [4-氨基甲酰基-5-（氨基甲酰基氨基）-2-噻吩基] -5-甲基苯基}戊-4-烯酸酯; 环戊基（25,4E）-2-氨基-5- {5- [4-氨基甲酰基-5-（氨基甲酰基氨基）-2-噻吩基] -2-甲基苯基}戊-4-烯酸酯; 环戊基O- {3- [4-氨基甲酰基-5-（氨基甲酰基氨基）-2-噻吩基]苯基} -L-高丝氨酸酯; 环戊基O- {3- [4-氨基甲酰基-5-（氨基甲酰基氨基）-2-噻吩基]苯基} -L-高丝氨酸酯; N- {3- [4-氨基甲酰基-5-（氨基甲酰基氨基）-2-噻吩基]苄基} -L-丙氨酸酯的环戊基酯; 和N- {3- [4-氨基甲酰基-5-（氨基甲酰基氨基）-2-噻吩基]苄基} -L-丙氨酸叔丁酯通过细胞内羧酸酯酶水解成相应的羧酸，并且可用于抑制IKK和bgr; 活动。

公开(公告)号：US06540742B1

公开(公告)日：2003-04-01

申请号：US09485361

申请日：2000-12-14

Applicant: Stuart Thomas ,  David Ross ,  Arianwen Rees ,  Robert Paterson ,  Michael Daly ,  Ilija Koevski

Inventor： Stuart Thomas ,  David Ross ,  Arianwen Rees ,  Robert Paterson ,  Michael Daly ,  Ilija Koevski

IPC: A61B1814

CPC classification number: A61B18/1402 ,  A61B17/00234 ,  A61B18/1492 ,  A61B2017/00088 ,  A61B2017/00101 ,  A61B2017/00243 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61N1/06

Abstract: An elongate, malleable ablation probe including an elongate malleable body (38) and a plurality of longitudinally spaced apart electrodes (40) disposed at a distal end thereof. The electrodes (40) are separated one from another by insulative material. In one embodiment, a malleable insert is provided for insertion into a flexible longitudinal sleeve, the flexible longitudinal sleeve conforming to the shape of the malleable insert upon such insertion. In other embodiments, a malleable core is surrounded by a flexible body, the electrodes (40) being mounted to the body.

Abstract translation: 一种细长的，可延展的消融探头，其包括细长的可延展体（38）和设置在其远端处的多个纵向间隔开的电极（40）。 电极（40）由绝缘材料彼此分开。 在一个实施例中，提供可延展的插入件用于插入柔性纵向套筒中，柔性纵向套管在这种插入时符合有韧性的插入物的形状。 在其他实施例中，可延展的芯由柔性体围绕，电极（40）安装到主体上。

公开(公告)号：US06175499B1

公开(公告)日：2001-01-16

申请号：US09510615

申请日：2000-02-22

Applicant: Stuart Thomas Adams ,  William Vincent Cranston, III ,  Will Eugene Hamel ,  Jochem K. Koenig ,  John E. McCloskey

Inventor： Stuart Thomas Adams ,  William Vincent Cranston, III ,  Will Eugene Hamel ,  Jochem K. Koenig ,  John E. McCloskey

IPC: H05K720

CPC classification number: H01L23/4093 ,  H01L23/3677 ,  H01L2924/0002 ,  Y10T24/308 ,  H01L2924/00

Abstract: The locking member of a ZIF socket, which is movable between a locked position, in which high contact forces are present between contact springs within the socket and pins extending from an electronic module into the socket, and an unlocked position, in which the pins are released from the contact springs, is held in the locked position by means of a portion of a clamping spring inserted into a gap between the locking member and a portion of the housing of the ZIF socket. The clamping spring also holds a heat sink in place on the electronic module.

Abstract translation: ZIF插座的锁定构件可在锁定位置之间移动，在锁定位置之间存在高接触力，插座内的接触弹簧和从电子模块延伸到插座中的销以及锁定位置 从接触弹簧释放的夹持弹簧通过插入到锁定构件和ZIF插座的壳体的一部分之间的间隙中的夹紧弹簧的一部分保持在锁定位置。 夹紧弹簧还将电子模块上的散热器保持在适当位置。

公开(公告)号：US4099948A

公开(公告)日：1978-07-11

申请号：US822257

申请日：1977-08-05

Applicant: John Stuart Thomas

Inventor： John Stuart Thomas

IPC: C03B37/09 ,  C03B37/02

CPC classification number: C03B37/091 ,  Y10S65/04 ,  Y10T29/49988

Abstract: This invention relates to a bushing for processing molten glass. The bushing has a bottom wall provided with orifices to deliver downwardly flowing streams of molten glass, side walls and end walls. The bushing is provided with oppositely arranged terminals to receive electrical conductors for heating the bushing. The end walls of the bushing and the terminal means are moulded integrally from rhodium or platinum/rhodium alloy.

Abstract translation: 本发明涉及一种用于加工熔融玻璃的衬套。 衬套具有设置有孔口的底壁，以向下流动的熔融玻璃，侧壁和端壁流。 衬套设置有相对布置的端子，以接收用于加热衬套的电导体。 衬套和端子装置的端壁由铑或铂/铑合金一体成型。

公开(公告)号：US1935253A

公开(公告)日：1933-11-14

申请号：US58010031

申请日：1931-12-10

Applicant: STUART THOMAS F ,  MOORE HENRY A

Inventor： STUART THOMAS F ,  MOORE HENRY A

IPC: E05B1/00

CPC classification number: E05B1/0038 ,  Y10S292/37 ,  Y10T16/506 ,  Y10T292/1053 ,  Y10T292/85 ,  Y10T292/865 ,  Y10T292/91