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公开(公告)号：US5837542A
公开(公告)日：1998-11-17
申请号：US292620
申请日：1994-08-17
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N15/10 , C12N15/113 , C12Q1/68 , C12N15/85
CPC分类号： C12N15/113 , C07K14/4702 , C12N15/101 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： Enzymatic RNA molecules which cleave ICAM-1 mRNA.
摘要翻译： 切割ICAM-1 mRNA的酶RNA分子。
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2.发明授权公开(公告)号：US06469158B1
公开(公告)日：2002-10-22
申请号：US08433218
申请日：1995-05-02
申请人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
发明人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
IPC分类号： C07H100
CPC分类号： C12Q1/6806 , A61K38/00 , A61K48/00 , C07K14/005 , C12N15/1003 , C12N15/101 , C12N15/113 , C12N15/1131 , C12N15/1136 , C12N15/1138 , C12N15/85 , C12N15/86 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2760/10122 , C12N2770/00022 , C12N2770/28122 , C12Q1/701 , Y02P20/55 , C12Q2521/337 , C12Q2565/137
摘要： Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
摘要翻译： 用于酶促活性形式的RNA分子和酶促RNA分子的纯化和合成的方法。
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公开(公告)号：US07041817B2
公开(公告)日：2006-05-09
申请号：US10231874
申请日：2002-08-30
申请人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
发明人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
IPC分类号： C07H21/02
CPC分类号： C12Q1/6806 , A61K38/00 , A61K48/00 , C07K14/005 , C12N15/1003 , C12N15/101 , C12N15/113 , C12N15/1131 , C12N15/1136 , C12N15/1138 , C12N15/85 , C12N15/86 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2760/10122 , C12N2770/00022 , C12N2770/28122 , C12Q1/701 , Y02P20/55 , C12Q2521/337 , C12Q2565/137
摘要： Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
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4.发明授权公开(公告)号：US06649751B2
公开(公告)日：2003-11-18
申请号：US10156432
申请日：2002-05-28
申请人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
发明人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
IPC分类号： C07H2100
CPC分类号： C12N15/113 , A61K48/00 , C07K14/005 , C12N15/1003 , C12N15/101 , C12N15/1131 , C12N15/1136 , C12N15/1138 , C12N15/85 , C12N15/86 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2760/10122 , C12N2770/00022 , C12N2830/52 , C12Q1/6811 , C12Q1/701 , C12Q2541/101 , C12Q2521/337
摘要： Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification.
摘要翻译： 提供了具有至少一种化学改性的RNA分子的纯化和合成方法。
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5.发明授权Ribozyme treatment of diseases or conditions related to levels of intercellular adhesion molecule-1 (CAM-1) 失效与细胞间粘附分子-1（CAM-1）水平相关的疾病或病症的核酶治疗公开(公告)号：US06436644B1
公开(公告)日：2002-08-20
申请号：US09589628
申请日：2000-06-07
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C07K14/4702 , C12N9/6491 , C12N15/101 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： The present invention relates to enzymatic RNA molecules which cleave ICAM-1 mRNA.
摘要翻译： 本发明涉及切割ICAM-1mRNA的酶RNA分子
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6.发明授权Ribozyme treatment of diseases or conditions related to levels of intercellular adhesion molecule-1 (ICAM-1) 失效与细胞间粘附分子-1（ICAM-1）水平相关的疾病或病症的核酶治疗
公开(公告)号：US6132967A
公开(公告)日：2000-10-17
申请号：US71845
申请日：1998-05-01
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N15/10 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/63 , C12N15/85
CPC分类号： C12N15/113 , C07K14/4702 , C12N15/101 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： Enzymatic RNA molecules which cleave ICAM-1 mRNA.
摘要翻译： 切割ICAM-1 mRNA的酶RNA分子。
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7.发明授权公开(公告)号：US06437117B1
公开(公告)日：2002-08-20
申请号：US09363238
申请日：1999-07-27
申请人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
发明人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
IPC分类号： C07H106
CPC分类号： C12N15/113 , A61K48/00 , C07K14/005 , C12N15/1003 , C12N15/101 , C12N15/1131 , C12N15/1136 , C12N15/1138 , C12N15/85 , C12N15/86 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2760/10122 , C12N2770/00022 , C12N2830/52 , C12Q1/6811 , C12Q1/701 , C12Q2541/101 , C12Q2521/337
摘要： Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
摘要翻译： 用于酶促活性形式的RNA分子和酶促RNA分子的纯化和合成的方法。
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公开(公告)号：US20060223990A1
公开(公告)日：2006-10-05
申请号：US11223720
申请日：2005-09-09
申请人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
发明人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
IPC分类号： C07H21/02
摘要： Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
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