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公开(公告)号：US20060223990A1
公开(公告)日：2006-10-05
申请号：US11223720
申请日：2005-09-09
申请人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
发明人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
IPC分类号： C07H21/02
摘要： Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
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2.发明授权公开(公告)号：US06437117B1
公开(公告)日：2002-08-20
申请号：US09363238
申请日：1999-07-27
申请人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
发明人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
IPC分类号： C07H106
CPC分类号： C12N15/113 , A61K48/00 , C07K14/005 , C12N15/1003 , C12N15/101 , C12N15/1131 , C12N15/1136 , C12N15/1138 , C12N15/85 , C12N15/86 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2760/10122 , C12N2770/00022 , C12N2830/52 , C12Q1/6811 , C12Q1/701 , C12Q2541/101 , C12Q2521/337
摘要： Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
摘要翻译： 用于酶促活性形式的RNA分子和酶促RNA分子的纯化和合成的方法。
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3.发明授权公开(公告)号：US06469158B1
公开(公告)日：2002-10-22
申请号：US08433218
申请日：1995-05-02
申请人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
发明人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
IPC分类号： C07H100
CPC分类号： C12Q1/6806 , A61K38/00 , A61K48/00 , C07K14/005 , C12N15/1003 , C12N15/101 , C12N15/113 , C12N15/1131 , C12N15/1136 , C12N15/1138 , C12N15/85 , C12N15/86 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2760/10122 , C12N2770/00022 , C12N2770/28122 , C12Q1/701 , Y02P20/55 , C12Q2521/337 , C12Q2565/137
摘要： Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
摘要翻译： 用于酶促活性形式的RNA分子和酶促RNA分子的纯化和合成的方法。
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公开(公告)号：US07041817B2
公开(公告)日：2006-05-09
申请号：US10231874
申请日：2002-08-30
申请人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
发明人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
IPC分类号： C07H21/02
CPC分类号： C12Q1/6806 , A61K38/00 , A61K48/00 , C07K14/005 , C12N15/1003 , C12N15/101 , C12N15/113 , C12N15/1131 , C12N15/1136 , C12N15/1138 , C12N15/85 , C12N15/86 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2760/10122 , C12N2770/00022 , C12N2770/28122 , C12Q1/701 , Y02P20/55 , C12Q2521/337 , C12Q2565/137
摘要： Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
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5.发明授权公开(公告)号：US06649751B2
公开(公告)日：2003-11-18
申请号：US10156432
申请日：2002-05-28
申请人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
发明人： Nassim Usman , Francine Wincott , David Sweedler , Leonid Beigelman , Lech W. Dudycz , Susan Grimm , Anthony DiRenzo , Danuta Tracz
IPC分类号： C07H2100
CPC分类号： C12N15/113 , A61K48/00 , C07K14/005 , C12N15/1003 , C12N15/101 , C12N15/1131 , C12N15/1136 , C12N15/1138 , C12N15/85 , C12N15/86 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2760/10122 , C12N2770/00022 , C12N2830/52 , C12Q1/6811 , C12Q1/701 , C12Q2541/101 , C12Q2521/337
摘要： Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification.
摘要翻译： 提供了具有至少一种化学改性的RNA分子的纯化和合成方法。
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公开(公告)号：US5998203A
公开(公告)日：1999-12-07
申请号：US632882
申请日：1996-04-16
申请人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
发明人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
CPC分类号： C12N15/113 , C07H19/06 , C07H19/16 , C07H21/00 , C12N2310/121
摘要： An enzymatic nucleic acid molecule comprising a 5'- and/or a 3'-cap structure, wherein said structure is not a 5'-5'-linked inverted nucleotide or a 3'-3'-linked inverted nucleotide.
摘要翻译： 包含5'和/或3'帽结构的酶核酸分子，其中所述结构不是5'-5'-连接的倒置核苷酸或3'-3'-连接的倒置核苷酸。
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公开(公告)号：US20050074760A1
公开(公告)日：2005-04-07
申请号：US10430562
申请日：2003-05-06
申请人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
发明人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
IPC分类号： C07H19/06 , C07H19/16 , C07H21/00 , C12N15/113 , C12Q1/68 , A61K48/00 , C07H21/04 , C12N5/00
CPC分类号： C12N15/113 , C07H19/06 , C07H19/16 , C07H21/00 , C12N2310/121
摘要： An enzymatic nucleic acid molecule comprising a 5′- and/or a 3′-cap structure, wherein said structure is not a 5′-5′-linked inverted nucleotide or a 3′-3′-linked inverted nucleotide.
摘要翻译： 包含5'和/或3'帽结构的酶核酸分子，其中所述结构不是5'-5'-连接的倒置核苷酸或3'-3'-连接的倒置核苷酸。
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公开(公告)号：US06586238B1
公开(公告)日：2003-07-01
申请号：US09419125
申请日：1999-10-15
申请人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
发明人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
IPC分类号： C07H2104
CPC分类号： C12N15/113 , C07H19/06 , C07H19/16 , C07H21/00 , C12N2310/121
摘要： An enzymatic nucleic acid molecule comprising a 5′- and/or a 3′-cap structure, wherein said structure is not a 5′-5′-linked inverted nucleotide or a 3′-3′-linked inverted nucleotide.
摘要翻译： 包含5'和/或3'帽结构的酶核酸分子，其中所述结构不是5'-5'-连接的倒置核苷酸或3'-3'-连接的倒置核苷酸。
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公开(公告)号：US5891683A
公开(公告)日：1999-04-06
申请号：US363253
申请日：1994-12-23
IPC分类号： C12N15/09 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/04 , C12N9/00 , C12N9/22 , C12N15/113 , C12P19/34 , A01N43/04 , C07H21/02 , C12Q1/68
CPC分类号： C07H21/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12Y304/24017 , C12N2310/121 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346 , C12N2330/30
摘要： Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
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公开(公告)号：US06849726B2
公开(公告)日：2005-02-01
申请号：US10390206
申请日：2003-03-17
IPC分类号： C12N15/09 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/04 , C12N9/00 , C12N9/22 , C12N15/113 , C07H21/02 , C12Q1/68
CPC分类号： C07H21/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/121 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346 , C12N2330/30 , C12Y304/24017 , C12N2310/3521
摘要： The present invention relates to RNA molecules containing one or more non-nucleotide mimetics.
摘要翻译： 本发明涉及含有一种或多种非核苷酸模拟物的RNA分子。
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