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公开(公告)号:US20070054916A1
公开(公告)日:2007-03-08
申请号:US11240590
申请日:2005-09-30
申请人: Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
发明人: Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
IPC分类号: A61K31/525 , A61K31/519 , A61K31/517
CPC分类号: C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译: 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病,包括炎症,癌症和相关病症的化合物。 化合物具有通式I,其中A 1,A 2,A 3,B,R 1, R 2,R 3和R 4在本文中定义。 因此,本发明还包括含有本发明化合物的药物组合物,使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法,以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号:US20070072851A1
公开(公告)日:2007-03-29
申请号:US11506381
申请日:2006-08-18
申请人: John Buchanan , William Buckner , Mario Cardozo , Erin DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Jiao , Frank Kayser , David Kopecky , Craig Masse , Susan Tomlinson , Ryan White , Xiaotian Zhu
发明人: John Buchanan , William Buckner , Mario Cardozo , Erin DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Jiao , Frank Kayser , David Kopecky , Craig Masse , Susan Tomlinson , Ryan White , Xiaotian Zhu
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/519 , A61K31/503 , A61K31/498 , A61K31/497 , A61K31/496 , C07D487/02 , C07D471/02
CPC分类号: C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要: The present invention relates to compounds of Formula I or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译: 本发明涉及式I化合物或立体异构体,互变异构体,溶剂合物,药学上可接受的盐或前药,含有化合物的药物制剂,使用该化合物的治疗方法,例如蛋白质酪氨酸激酶相关 诸如免疫学和肿瘤学障碍的疾病以及制备包含该化合物的药物的方法。
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