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    Furanopyridine derivatives and methods of use
    3.
    发明申请
    Furanopyridine derivatives and methods of use 有权
    呋喃并吡啶衍生物和使用方法

    公开(公告)号：US20060046977A1

    公开(公告)日：2006-03-02

    申请号：US11184237

    申请日：2005-07-18

    申请人： Joseph Nunes ,  Matthew Martin ,  Ryan White ,  David McGowan ,  Jean Bemis ,  Frank Kayser ,  Jiasheng Fu ,  Jinqian Liu ,  Xian Jiao

    发明人： Joseph Nunes ,  Matthew Martin ,  Ryan White ,  David McGowan ,  Jean Bemis ,  Frank Kayser ,  Jiasheng Fu ,  Jinqian Liu ,  Xian Jiao

    IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/4741 ,  C07F7/02 ,  C07D491/02 ,  A61K31/695

    CPC分类号： C07D491/04 ,  C07D491/14

    摘要： The present invention relates to furanopyridine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.

    摘要翻译： 本发明涉及具有通式I的呋喃并吡啶化合物及其立体异构体，互变异构体，溶剂合物，药用盐和衍生物及其前药。 本发明还包括药物组合物，其包含式I化合物，调节Lck和ACK-1酶的方法以及治疗各种相关疾病和病症，包括炎症，T细胞活化抑制，增殖，关节炎，器官移植，缺血或再灌注 损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球肾炎，过敏性疾病，哮喘 ，干草组织，湿疹，癌症，结肠癌，胸腺瘤，仅举几个例子，在哺乳动物中，包括向哺乳动物施用治疗有效量的如上所述的式I化合物和制备包含以下化合物的药物的方法： 一级方程式

    Furanopyridine derivatives and methods of use
    4.
    发明授权
    Furanopyridine derivatives and methods of use 有权
    呋喃并吡啶衍生物和使用方法

    公开(公告)号：US07674907B2

    公开(公告)日：2010-03-09

    申请号：US11184237

    申请日：2005-07-18

    申请人： Joseph J. Nunes ,  Matthew W. Martin ,  Ryan White ,  David McGowan ,  Jean E. Bemis ,  Frank Kayser ,  Jiasheng Fu ,  Jinqian Liu ,  XianYun Jiao

    发明人： Joseph J. Nunes ,  Matthew W. Martin ,  Ryan White ,  David McGowan ,  Jean E. Bemis ,  Frank Kayser ,  Jiasheng Fu ,  Jinqian Liu ,  XianYun Jiao

    IPC分类号： C07D491/048 ,  A61K31/4355

    CPC分类号： C07D491/04 ,  C07D491/14

    摘要： The present invention relates to furanopyridine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.

    摘要翻译： 本发明涉及具有通式I的呋喃并吡啶化合物及其立体异构体，互变异构体，溶剂合物，药用盐和衍生物及其前药。 本发明还包括药物组合物，其包含式I化合物，调节Lck和ACK-1酶的方法以及治疗各种相关疾病和病症，包括炎症，T细胞活化抑制，增殖，关节炎，器官移植，缺血或再灌注 损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球肾炎，过敏性疾病，哮喘 ，干草组织，湿疹，癌症，结肠癌，胸腺瘤，仅举几个例子，在哺乳动物中，包括向哺乳动物施用治疗有效量的如上所述的式I化合物和制备包含以下化合物的药物的方法： 一级方程式