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公开(公告)号：US20100317653A1
公开(公告)日：2010-12-16
申请号：US12849158
申请日：2010-08-03
申请人： Alan Martin BIRCH , Suzanne Saxon Bowker , Roger John Butlin , Craig Samuel Donald , William Mccoull , Thorsten Nowak , Alleyn Plowright
发明人： Alan Martin BIRCH , Suzanne Saxon Bowker , Roger John Butlin , Craig Samuel Donald , William Mccoull , Thorsten Nowak , Alleyn Plowright
IPC分类号： A61K31/55 , C07D413/12 , A61K31/5377 , C07D413/14 , A61K31/496 , A61K31/454 , A61K31/444 , C07D271/07 , A61K31/4245 , C07D417/14 , A61K31/541 , A61K31/506 , A61P3/04 , A61P3/10
CPC分类号： C07D271/113 , C07D413/12
摘要： Compounds of formula (I), and salts and pro-drugs thereof: wherein for example R1 is optionally substituted aryl or heteroaryl; Y is a linking group selected from, for example, a direct bond, and a (substituted) alkyl chain; R2 is an optionally substituted aryl, an optionally substituted cycloalkyl or an optionally substituted heterocyclic group; are described. Processes to make such compounds and their use as DGAT inhibitors, for example in the treatment of obesity, are also described.
摘要翻译： 式（I）化合物及其盐和前药：其中例如R 1为任选取代的芳基或杂芳基; Y是选自例如直接键和（取代的）烷基链的连接基团; R2是任选取代的芳基，任选取代的环烷基或任选取代的杂环基; 被描述。 还描述了制备这些化合物的方法及其作为DGAT抑制剂的用途，例如用于治疗肥胖症。
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公开(公告)号：US20090227592A1
公开(公告)日：2009-09-10
申请号：US12363899
申请日：2009-02-02
申请人： Scott BOYD , Peter William Rodney CAULKETT , Rodney Brian HARGREAVES , Suzanne Saxon BOWKER , Roger JAMES , Clifford David JONES , Darren McKERRECHER , Michael Howard BLOCK , Craig JOHNSTONE
发明人： Scott BOYD , Peter William Rodney CAULKETT , Rodney Brian HARGREAVES , Suzanne Saxon BOWKER , Roger JAMES , Clifford David JONES , Darren McKERRECHER , Michael Howard BLOCK , Craig JOHNSTONE
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , C07D403/02
CPC分类号： C07D213/75 , A61K31/165 , A61K31/195 , A61K31/425 , A61K31/445 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/26 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/66 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物或其盐，溶剂合物或前药，其中R1，R2，R3，n和m如说明书中所述，用于制备用于治疗或 预防通过葡萄糖激酶（GLK）介导的疾病状况，如2型糖尿病。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。
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公开(公告)号：US07390908B2
公开(公告)日：2008-06-24
申请号：US10486496
申请日：2002-08-15
申请人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Craig Johnstone , Clifford David Jones , Darren McKerrecher , Michael Howard Block
发明人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Craig Johnstone , Clifford David Jones , Darren McKerrecher , Michael Howard Block
IPC分类号： C07D277/22 , C07D277/20 , A31K31/425 , A61K31/425
CPC分类号： C07D213/75 , A61K31/165 , A61K31/195 , A61K31/425 , A61K31/445 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/26 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/66 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物或其盐，溶剂合物或前体药物的用途，其中R 1，R 2，R 3， N和m如说明书中所述，在制备用于治疗或预防通过葡萄糖激酶（GLK）如2型糖尿病介导的疾病状况的药物中的描述。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。
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公开(公告)号：US07951830B2
公开(公告)日：2011-05-31
申请号：US12363899
申请日：2009-02-02
申请人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
发明人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
IPC分类号： A61K31/425 , A61K31/415 , A61K31/496 , A61K31/433
CPC分类号： C07D213/75 , A61K31/165 , A61K31/195 , A61K31/425 , A61K31/445 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/26 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/66 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物或其盐，溶剂合物或前药，其中R1，R2，R3，n和m如说明书中所述，用于制备用于治疗或 预防通过葡萄糖激酶（GLK）介导的疾病状况，如2型糖尿病。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。
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公开(公告)号：US07795283B2
公开(公告)日：2010-09-14
申请号：US11792922
申请日：2005-12-09
申请人： Alan Martin Birch , Suzanne Saxon Bowker , Roger John Butlin , Craig Samuel Donald , William McCoull , Thorsten Nowak , Alleyn Plowright
发明人： Alan Martin Birch , Suzanne Saxon Bowker , Roger John Butlin , Craig Samuel Donald , William McCoull , Thorsten Nowak , Alleyn Plowright
IPC分类号： A61K31/4245 , C07D271/113
CPC分类号： C07D271/113 , C07D413/12
摘要： Compounds of formula (I), and salts and pro-drugs thereof: Formula (I) wherein for example R1 is optionally substituted aryl or heteroaryl; Y is a linking group selected from, for example, a direct bond, and a (substituted) alkyl chain; R2 is an optionally substituted aryl, an optionally substituted cycloalkyl or an optionally substituted heterocyclic group; are described. Processes to make such compounds and their use as DGAT inhibitors, for example in the treatment of obesity, are also described.
摘要翻译： 式（I）化合物及其盐和前药：式（I）其中例如R 1为任选取代的芳基或杂芳基; Y是选自例如直接键和（取代的）烷基链的连接基团; R2是任选取代的芳基，任选取代的环烷基或任选取代的杂环基; 被描述。 还描述了制备这些化合物的方法及其作为DGAT抑制剂的用途，例如用于治疗肥胖症。
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公开(公告)号：US07524957B2
公开(公告)日：2009-04-28
申请号：US12024561
申请日：2008-02-01
申请人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
发明人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
IPC分类号： C07D213/02 , C07D231/10 , C07D277/20 , C07D285/12 , C07D295/00 , A61K31/496 , A61K31/426 , A61K31/415 , A61K31/433
CPC分类号： C07D213/75 , A61K31/165 , A61K31/195 , A61K31/425 , A61K31/445 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/26 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/66 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物或其盐，溶剂合物或前药，其中R1，R2，R3，n和m如说明书中所述，用于制备用于治疗或 预防通过葡萄糖激酶（GLK）介导的疾病状况，如2型糖尿病。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。
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公开(公告)号：US20080207636A1
公开(公告)日：2008-08-28
申请号：US12024561
申请日：2008-02-01
申请人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
发明人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
IPC分类号： A61K31/496 , C07D277/20 , A61K31/426 , A61K31/433 , A61P3/10 , A61K31/4436 , A61K31/415 , C07D231/10 , C07D213/02 , A61P3/04 , C07D285/12 , C07D295/00
CPC分类号： C07D213/75 , A61K31/165 , A61K31/195 , A61K31/425 , A61K31/445 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/26 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/66 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物或其盐，溶剂合物或前体药物的用途，其中R 1，R 2，R 3， N和m如说明书中所述，在制备用于治疗或预防通过葡萄糖激酶（GLK）如2型糖尿病介导的疾病状况的药物中的描述。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。
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