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公开(公告)号：US20080207636A1
公开(公告)日：2008-08-28
申请号：US12024561
申请日：2008-02-01
申请人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
发明人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
IPC分类号： A61K31/496 , C07D277/20 , A61K31/426 , A61K31/433 , A61P3/10 , A61K31/4436 , A61K31/415 , C07D231/10 , C07D213/02 , A61P3/04 , C07D285/12 , C07D295/00
CPC分类号： C07D213/75 , A61K31/165 , A61K31/195 , A61K31/425 , A61K31/445 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/26 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/66 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物或其盐，溶剂合物或前体药物的用途，其中R 1，R 2，R 3， N和m如说明书中所述，在制备用于治疗或预防通过葡萄糖激酶（GLK）如2型糖尿病介导的疾病状况的药物中的描述。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。
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公开(公告)号：US07390908B2
公开(公告)日：2008-06-24
申请号：US10486496
申请日：2002-08-15
申请人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Craig Johnstone , Clifford David Jones , Darren McKerrecher , Michael Howard Block
发明人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Craig Johnstone , Clifford David Jones , Darren McKerrecher , Michael Howard Block
IPC分类号： C07D277/22 , C07D277/20 , A31K31/425 , A61K31/425
CPC分类号： C07D213/75 , A61K31/165 , A61K31/195 , A61K31/425 , A61K31/445 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/26 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/66 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物或其盐，溶剂合物或前体药物的用途，其中R 1，R 2，R 3， N和m如说明书中所述，在制备用于治疗或预防通过葡萄糖激酶（GLK）如2型糖尿病介导的疾病状况的药物中的描述。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。
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公开(公告)号：US07951830B2
公开(公告)日：2011-05-31
申请号：US12363899
申请日：2009-02-02
申请人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
发明人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
IPC分类号： A61K31/425 , A61K31/415 , A61K31/496 , A61K31/433
CPC分类号： C07D213/75 , A61K31/165 , A61K31/195 , A61K31/425 , A61K31/445 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/26 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/66 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物或其盐，溶剂合物或前药，其中R1，R2，R3，n和m如说明书中所述，用于制备用于治疗或 预防通过葡萄糖激酶（GLK）介导的疾病状况，如2型糖尿病。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。
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公开(公告)号：US07524957B2
公开(公告)日：2009-04-28
申请号：US12024561
申请日：2008-02-01
申请人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
发明人： Scott Boyd , Peter William Rodney Caulkett , Rodney Brian Hargreaves , Suzanne Saxon Bowker , Roger James , Clifford David Jones , Darren McKerrecher , Michael Howard Block , Craig Johnstone
IPC分类号： C07D213/02 , C07D231/10 , C07D277/20 , C07D285/12 , C07D295/00 , A61K31/496 , A61K31/426 , A61K31/415 , A61K31/433
CPC分类号： C07D213/75 , A61K31/165 , A61K31/195 , A61K31/425 , A61K31/445 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/26 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/66 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物或其盐，溶剂合物或前药，其中R1，R2，R3，n和m如说明书中所述，用于制备用于治疗或 预防通过葡萄糖激酶（GLK）介导的疾病状况，如2型糖尿病。 本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。
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5.发明申请Enantiomers of Selected Fused Pyrimidones and Uses in the Treatment and Prevention of Cancer 审中-公开所选融合嘧啶酮及其用途在治疗和预防癌症中的对映体公开(公告)号：US20080293744A1
公开(公告)日：2008-11-27
申请号：US11573683
申请日：2005-08-16
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel John Russell , Marie-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel John Russell , Marie-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/519 , C07D513/04 , A61P35/00
CPC分类号： C07D498/04 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译： 本发明涉及具有结构式（I）的新化合物及其药物组合物及其使用方法。 这些新化合物提供癌症的治疗或预防。
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公开(公告)号：US20060041129A1
公开(公告)日：2006-02-23
申请号：US11207128
申请日：2005-08-18
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/519 , C07D498/02 , C07D491/02
CPC分类号： C07D498/04 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
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公开(公告)号：US20090099210A1
公开(公告)日：2009-04-16
申请号：US12340855
申请日：2008-12-22
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Ann Filla , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Ann Filla , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： C07D498/04 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译： 本发明涉及具有结构式（I）的新化合物及其药物组合物及其使用方法。 这些新化合物提供癌症的治疗或预防。
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公开(公告)号：US07498333B2
公开(公告)日：2009-03-03
申请号：US11207128
申请日：2005-08-18
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Ann Filla , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Ann Filla , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号： C07D498/04 , A61K31/505
CPC分类号： C07D498/04 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译： 本发明涉及具有结构式（I）的新化合物及其药物组合物及其使用方法。 这些新化合物提供癌症的治疗或预防。
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公开(公告)号：US07408064B2
公开(公告)日：2008-08-05
申请号：US10488982
申请日：2002-09-09
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： The use of a compound of formula (I) in the manufacture of a medicament for the treatment, in a warm-blooded animal, of disorders mediated by the neuropeptide Y5 receptor: wherein: R1, R2, R3 and X1-X6 are as defined within or a pharmaceutically acceptable salt, prodrug or solvate thereof, is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described.
摘要翻译： 式（I）化合物在制备用于在温血动物中治疗由神经肽Y5受体介导的病症的药物中的用途：其中：R 1，R 2， R 2，R 3和X 1 -X 6如本文所定义或其药学上可接受的盐，前药或溶剂化物 描述。 还描述了制备式（I）化合物的药物组合物，方法和方法。
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10.发明授权Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor 有权用于治疗由NPY5受体介导的病症的氨基取代的二苯并噻吩衍生物公开(公告)号：US07332492B2
公开(公告)日：2008-02-19
申请号：US11127582
申请日：2005-05-12
IPC分类号： A61K31/381 , A61K31/501 , C07D401/12 , C07D333/76
CPC分类号： C07D409/12 , C07D333/76 , C07D409/14 , C07D413/12 , C07D495/04
摘要： Compounds of formula (I): wherein: X is a group of formula (B): and R1, R2, R4, n, x, y and z are as defined within are described. Processes for their preparation and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor in a warm-blooded animal, such as a human being, are also described.
摘要翻译： 式（I）的化合物：其中：X是式（B）的基团：和R 1，R 2，R 4， n，x，y和z如上所述。 还描述了其制备方法及其在治疗由温血动物（例如人）中神经肽Y5受体介导的病症的用途。
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