公开(公告)号：US07215996B2

公开(公告)日：2007-05-08

申请号：US10499253

申请日：2002-10-04

申请人： Kjell Norén ,  Karin Ljungström ,  Sven Kalling ,  Lars Mandal ,  Anders Björling

发明人： Kjell Norén ,  Karin Ljungström ,  Sven Kalling ,  Lars Mandal ,  Anders Björling

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： In an implantable heart stimulating device, system and method, electrical stimulation pulses are delivered to first and second ventricles of a heart with a variable time interval therebetween, and signals are sensed at two different positions in the heart, from which an impedance value is derived. A minimum value and a maximum value of the impedance value are determined during a heart cycle, and a relationship between the minimum and maximum values also is determined. The time interval is varied and the relationship is monitored over a number of heart cycles. The time interval is set so that the relationship satisfies a predetermined requirement.

摘要翻译： 在可植入心脏刺激装置，系统和方法中，将电刺激脉冲以其间具有可变时间间隔输送到心脏的第一和第二心室，并且在心脏中的两个不同位置处感测信号，从其中导出阻抗值 。 在心脏周期期间确定阻抗值的最小值和最大值，并且还确定最小值与最大值之间的关系。 时间间隔变化，并且在许多心脏周期上监测关系。 设定时间间隔使得该关系满足预定的要求。

公开(公告)号：US07164947B2

公开(公告)日：2007-01-16

申请号：US10619354

申请日：2003-07-14

申请人： Nils Holmström ,  Anders Björling ,  Kjell Norén ,  Karin Ljungström ,  Sven Kalling

发明人： Nils Holmström ,  Anders Björling ,  Kjell Norén ,  Karin Ljungström ,  Sven Kalling

IPC分类号： A61N1/365

CPC分类号： A61N1/36521 ,  A61N1/3627

摘要： A heart stimulator for electric stimulation of a patient's heart has an impedance measuring unit that measures the impedance between at least two measurement electrodes implanted in a patient such that volume changes of at least one of the chambers of the left heart result in changes in the measured impedance. An analyzer analyzes the measured impedance for the control of the stimulation of the heart. A calculation unit calculates an average impedance morphology curve during a time interval of several cardiac cycles. The analyzer analyzes the average impedance morphology curve for use for the control of the stimulation to optimize the patient hemodynamics.

摘要翻译： 用于对患者心脏进行电刺激的心脏刺激器具有阻抗测量单元，其测量植入患者体内的至少两个测量电极之间的阻抗，使得左心脏的至少一个腔室的体积变化导致测量的变化 阻抗。 分析仪分析测量的阻抗以控制心脏的刺激。 计算单元在几个心动周期的时间间隔内计算平均阻抗形态曲线。 分析仪分析用于控制刺激的平均阻抗形态曲线，以优化患者的血液动力学。

公开(公告)号：US20050125042A1

公开(公告)日：2005-06-09

申请号：US10499253

申请日：2002-10-04

申请人： Kjell Noren ,  Karin Ljungstrom ,  Sven Kalling ,  Lars Mandal ,  Anders Bjorling

发明人： Kjell Noren ,  Karin Ljungstrom ,  Sven Kalling ,  Lars Mandal ,  Anders Bjorling

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： In an implantable heart stimulating device, system and method, electrical stimulation pulses are delivered to first and second ventricles of a heart with a variable time interval therebetween, and signals are sensed at two different positions in the heart, from which an impedance value is derived. A minimum value and a maximum value of the impedance value are determined during a heart cycle, and a relationship between the minimum and maximum values also is determined. The time interval is varied and the relationship is monitored over a number of heart cycles. The time interval is set so that the relationship satisfies a predetermined requirement.

摘要翻译： 在可植入心脏刺激装置，系统和方法中，将电刺激脉冲以其间具有可变时间间隔输送到心脏的第一和第二心室，并且在心脏中的两个不同位置处感测信号，从其中导出阻抗值 。 在心脏周期期间确定阻抗值的最小值和最大值，并且还确定最小值与最大值之间的关系。 时间间隔变化，并且在许多心脏周期上监测关系。 设定时间间隔使得该关系满足预定的要求。

公开(公告)号：US20080243025A1

公开(公告)日：2008-10-02

申请号：US11793849

申请日：2004-12-23

申请人： Nils Holmstrom ,  Malin Ohlander ,  Sven Kalling

发明人： Nils Holmstrom ,  Malin Ohlander ,  Sven Kalling

IPC分类号： A61B5/053

CPC分类号： A61B5/0535 ,  A61B5/0809 ,  A61N1/3627 ,  A61N1/3702

摘要： In a medical device and a method for operating the medical device, it is first determined whether a patient, at whom a medical measurement is to be made, satisfied specified criteria that will ensure comparability of the measurement results obtained from the patient. Only when the specified criteria had been satisfied is an electrical bio-impedance signal obtained from the patient. The cardiac component of the electrical bio-impedance signal is extracted, and is analyzed to identify a change in a medical condition of the patient.

摘要翻译： 在用于医疗装置的医疗装置和方法中，首先确定是否要进行医疗测量的患者满足将确保从患者获得的测量结果的可比性的指定标准。 只有当满足指定的标准是从患者获得的电生物阻抗信号。 提取电生物阻抗信号的心脏分量，并进行分析以识别患者的医疗状态的变化。

公开(公告)号：US07398126B2

公开(公告)日：2008-07-08

申请号：US10473552

申请日：2002-03-25

申请人： Rolf Hill ,  Sven Kalling ,  Martin Obel ,  Maria Wargelius

发明人： Rolf Hill ,  Sven Kalling ,  Martin Obel ,  Maria Wargelius

IPC分类号： A61N1/05 ,  A61K9/22

CPC分类号： A61N1/0568

摘要： In an electrically conductive lead adapted for implantation in a human or animal body, and a method for making such a lead, a drug-dispensing member is disposed at a distal end portion of the lead, at which an electrode member is disposed that is adapted to emit and/or sense electrical signals associated with medical therapy. The drug-dispensing member has a configuration so that, after implantation, the amount of drug released into the body per time unit is automatically controlled to smoothly vary with time from al larger amount to a smaller amount in accordance with a predetermined relationship of the amount of drug released as a function of time.

摘要翻译： 在适于植入人体或动物体内的导电引线以及制造这种引线的方法中，药物分配部件设置在引线的远端部分处，电极部件设置在该远端部分 以发射和/或感测与医学治疗相关的电信号。 药物分配构件具有这样的结构，使得在植入后，自动控制每时间单位释放到体内的药物的量，以随着时间的推移而随着时间的推移而随着时间的推移而随着时间的推移而变化， 的药物释放作为时间的函数。

公开(公告)号：US20060235325A1

公开(公告)日：2006-10-19

申请号：US10524196

申请日：2003-06-23

申请人： Nils Holmstrom ,  Martin Obel ,  Anna Norlin ,  Kenneth Dahlberg ,  Anders Bjorling ,  Sven Kalling ,  Karin Ljungstrom ,  Kjell Noren

发明人： Nils Holmstrom ,  Martin Obel ,  Anna Norlin ,  Kenneth Dahlberg ,  Anders Bjorling ,  Sven Kalling ,  Karin Ljungstrom ,  Kjell Noren

IPC分类号： A61B5/05 ,  A61B5/02

CPC分类号： A61B5/0538 ,  A61B5/053 ,  A61N1/3627

摘要： A congestive heart failure monitor has an impedance measuring unit that measures the impedance between at least two electrodes implanted in a patient, to use a detected change of the measured impedance as an indication of a change in the left atrium volume. Any analyzing unit analyzes the measured impedance and detects insipient congestive heart failure dependent on a quotient of a maximum value of the measured impedance and a minimum value of the measured impedance during a cardiac cycle.

摘要翻译： 充血性心力衰竭监测器具有阻抗测量单元，其测量植入患者中的至少两个电极之间的阻抗，以使用检测到的测量阻抗的变化作为左心房体积变化的指示。 任何分析单元分析所测量的阻抗，并根据所测量的阻抗的最大值和心动周期内所测量的阻抗的最小值来检测不利的充血性心力衰竭。