公开(公告)号：US20080243025A1

公开(公告)日：2008-10-02

申请号：US11793849

申请日：2004-12-23

申请人： Nils Holmstrom ,  Malin Ohlander ,  Sven Kalling

发明人： Nils Holmstrom ,  Malin Ohlander ,  Sven Kalling

IPC分类号： A61B5/053

CPC分类号： A61B5/0535 ,  A61B5/0809 ,  A61N1/3627 ,  A61N1/3702

摘要： In a medical device and a method for operating the medical device, it is first determined whether a patient, at whom a medical measurement is to be made, satisfied specified criteria that will ensure comparability of the measurement results obtained from the patient. Only when the specified criteria had been satisfied is an electrical bio-impedance signal obtained from the patient. The cardiac component of the electrical bio-impedance signal is extracted, and is analyzed to identify a change in a medical condition of the patient.

摘要翻译： 在用于医疗装置的医疗装置和方法中，首先确定是否要进行医疗测量的患者满足将确保从患者获得的测量结果的可比性的指定标准。 只有当满足指定的标准是从患者获得的电生物阻抗信号。 提取电生物阻抗信号的心脏分量，并进行分析以识别患者的医疗状态的变化。

公开(公告)号：US08600497B1

公开(公告)日：2013-12-03

申请号：US11558088

申请日：2006-11-09

申请人： Weiqun Yang ,  Malin Ohlander ,  Louis Wong ,  Nils Holmstrom ,  Cem Shaquer ,  Euljoon Park ,  Dorin Panescu ,  Shahrooz Shahparnia ,  Andre Walker ,  Ajit Pillai ,  Mihir Naware

发明人： Weiqun Yang ,  Malin Ohlander ,  Louis Wong ,  Nils Holmstrom ,  Cem Shaquer ,  Euljoon Park ,  Dorin Panescu ,  Shahrooz Shahparnia ,  Andre Walker ,  Ajit Pillai ,  Mihir Naware

IPC分类号： A61B5/05 ,  A61N1/00

CPC分类号： A61B5/02028 ,  A61B5/0031 ,  A61B5/029 ,  A61B5/0538 ,  A61B5/08 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3702

摘要： An implantable device monitors and treats heart failure, pulmonary edema, and hemodynamic conditions and in some cases applies therapy. In one implementation, the implantable device applies a high-frequency multi-phasic pulse waveform over multiple-vectors through tissue. The waveform has a duration less than the charging time constant of electrode-electrolyte interfaces in vivo to reduce intrusiveness while increasing sensitivity and specificity for trending parameters. The waveform can be multiplexed over multiple vectors and the results cross-correlated or subjected to probabilistic analysis or thresholding schemata to stage heart failure or pulmonary edema. In one implementation, a fractionation morphology of a sensed impedance waveform is used to trend intracardiac pressure to stage heart failure and to regulate cardiac resynchronization therapy. The waveform also provides unintrusive electrode integrity checks and 3-D impedancegrams.

摘要翻译： 植入式装置监测和治疗心力衰竭，肺水肿和血液动力学状况，并且在某些情况下应用治疗。 在一个实施方案中，可植入装置通过组织在多个向量上施加高频多相脉冲波形。 该波形的持续时间小于体内电极 - 电解质界面的充电时间常数，以降低侵入性，同时增加趋势参数的灵敏度和特异性。 波形可以在多个载体上进行复用，并且结果相互关联或进行概率分析或阈值模式以分步心脏衰竭或肺水肿。 在一个实施方案中，使用感测阻抗波形的分级形态来趋向心脏内压力来分级心力衰竭并调节心脏再同步治疗。 该波形还提供非侵入式电极完整性检查和3-D阻抗图。

公开(公告)号：US20090118666A1

公开(公告)日：2009-05-07

申请号：US11363922

申请日：2006-02-28

申请人： Andreas Blomqvist ,  Malin Ohlander ,  Nils Holmstrom

发明人： Andreas Blomqvist ,  Malin Ohlander ,  Nils Holmstrom

IPC分类号： A61B5/145 ,  A61B5/02 ,  A61M37/00

CPC分类号： A61B5/053 ,  A61B5/14535 ,  A61N1/36521

摘要： In a method for detecting a change of a condition of a patient using an implantable medical device being connectable to the patient in at least one electrode configuration, at least one impedance measurement session is initiated to obtain at least one impedance value corresponding to an impedance of whole blood of the patient. At least one relative or absolute value of an amount of hematocrit in the blood of the patient is calculated using the at least one impedance value. A present hematocrit level is determined dependent on the at least one hematocrit value, with a change of the condition being derived from the present hematocrit level of the patient.

摘要翻译： 在用至少一个电极配置中使用可连接到患者的可植入医疗装置来检测患者病情变化的方法中，开始至少一个阻抗测量会话以获得至少一个阻抗值对应于 患者的全血。 使用至少一个阻抗值来计算患者血液中血细胞比容量的至少一个相对值或绝对值。 取决于至少一个血细胞比容值确定目前的血细胞比容水平，条件的变化来自患者的当前血细胞比容水平。

公开(公告)号：US20090099614A1

公开(公告)日：2009-04-16

申请号：US12280505

申请日：2006-02-28

申请人： Nils Holmstrom ,  Malin Ohlander

发明人： Nils Holmstrom ,  Malin Ohlander

IPC分类号： A61N1/00 ,  A61B19/00

CPC分类号： A61N1/3627 ,  A61B5/0402 ,  A61B5/7264 ,  A61N1/36514 ,  A61N1/3702

摘要： In a method and an apparatus for creating hemodynamic sensor signal templates using an implantable medical device connectable to a patient heart activity of the patient is sensed in order to identify a paste or sensed sequence of events of a heart cycle. Hemodynamic sensor signals for consecutive heart cycles are sensed and the sensed hemodynamic sensor signals for consecutive heart cycles are stored. The sensed sensor signals are classified dependent on at least one predetermined heart event sequence condition. A template may be created using the classified sensor signals.

摘要翻译： 在用于创建血液动力学传感器信号模板的方法和装置中，使用可植入的医疗装置来感测患者的心脏活动，以识别患者心脏周期的糊状物或感测的事件序列。 感测连续心脏循环的血液动力学传感器信号，并存储感测到的连续心脏循环的血液动力学传感器信号。 感测的传感器信号根据至少一个预定的心脏事件序列条件进行分类。 可以使用分类的传感器信号来创建模板。

公开(公告)号：US20080194998A1

公开(公告)日：2008-08-14

申请号：US11913785

申请日：2005-05-24

申请人： Nils Holmstrom ,  Malin Ohlander

发明人： Nils Holmstrom ,  Malin Ohlander

IPC分类号： A61B5/00

CPC分类号： A61B5/103 ,  A61B5/0205 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7264 ,  A61N1/3702

摘要： In a method, device and compute-readable medium for evaluating the prevalence of different postures of a patient, signals are sensed that indicate the posture of the patient during a monitoring period having a predetermined length, specific body postures of the patient are determined during this monitoring period from the sensed signals, the amount of time the patient spends in each of the specific postures is measured, information regarding each specific posture, and the associated amount of time spent in that posture, are stored, and the prevalence of the different postures of the patient is evaluated by classifying the stored information with respect to specific postures and the amount of time in each posture position.

摘要翻译： 在用于评估患者的不同姿势的患病率的装置和计算机可读介质中，感测到在具有预定长度的监测期间指示患者的姿势的信号，在该期间确定患者的特定身体姿势 测量从感测到的信号的监视期间，测量患者在每个特定姿势中花费的时间量，存储关于每个特定姿势的信息以及在该姿势中花费的相关时间量，以及不同姿势的流行 通过对存储的关于特定姿势的信息和每个姿势位置中的时间量进行分类来评估患者。

公开(公告)号：US20060235325A1

公开(公告)日：2006-10-19

申请号：US10524196

申请日：2003-06-23

申请人： Nils Holmstrom ,  Martin Obel ,  Anna Norlin ,  Kenneth Dahlberg ,  Anders Bjorling ,  Sven Kalling ,  Karin Ljungstrom ,  Kjell Noren

发明人： Nils Holmstrom ,  Martin Obel ,  Anna Norlin ,  Kenneth Dahlberg ,  Anders Bjorling ,  Sven Kalling ,  Karin Ljungstrom ,  Kjell Noren

IPC分类号： A61B5/05 ,  A61B5/02

CPC分类号： A61B5/0538 ,  A61B5/053 ,  A61N1/3627

摘要： A congestive heart failure monitor has an impedance measuring unit that measures the impedance between at least two electrodes implanted in a patient, to use a detected change of the measured impedance as an indication of a change in the left atrium volume. Any analyzing unit analyzes the measured impedance and detects insipient congestive heart failure dependent on a quotient of a maximum value of the measured impedance and a minimum value of the measured impedance during a cardiac cycle.

摘要翻译： 充血性心力衰竭监测器具有阻抗测量单元，其测量植入患者中的至少两个电极之间的阻抗，以使用检测到的测量阻抗的变化作为左心房体积变化的指示。 任何分析单元分析所测量的阻抗，并根据所测量的阻抗的最大值和心动周期内所测量的阻抗的最小值来检测不利的充血性心力衰竭。

公开(公告)号：US20130190582A1

公开(公告)日：2013-07-25

申请号：US13358063

申请日：2012-01-25

申请人： Nils Holmstrom ,  Michael Broome

发明人： Nils Holmstrom ,  Michael Broome

IPC分类号： A61B5/145 ,  A61B5/02

CPC分类号： A61B5/14503 ,  A61B5/1118 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/686

摘要： An ischemia detecting system has an implantable medical device connectable to an LV cardiac catheter with sensors for generating sensor signals representative of the concentration of a constituent in coronary venous blood at different sites in the coronary venous system. The sensor signals are co-processed by the system to detect an ischemic region of the subject's heart based on a relation between the sensor signals. The detection of the particular ischemic cardiac region is possible by conducting the concentration monitoring on either sides of a branching vein in the coronary venous system and co-processing the sensor signals.

摘要翻译： 缺血检测系统具有可连接到具有传感器的LV心导管的可植入医疗装置，所述传感器用于产生代表冠状静脉系统不同部位冠状静脉血中成分浓度的传感器信号。 传感器信号由系统共同处理，以基于传感器信号之间的关系检测受试者心脏的缺血区域。 通过在冠状静脉系统中的分支静脉的两侧进行浓度监测并共同处理传感器信号，可以检测特定的缺血性心脏区域。

公开(公告)号：US20110257696A1

公开(公告)日：2011-10-20

申请号：US13140119

申请日：2008-12-17

申请人： Nils Holmstrom ,  Karin Ljungstrom ,  Michael Broome ,  Cecilia Emanuelsson

发明人： Nils Holmstrom ,  Karin Ljungstrom ,  Michael Broome ,  Cecilia Emanuelsson

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/7239 ,  A61B5/7289 ,  A61N1/36521 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/3686

摘要： In an implantable medical device and a method for monitoring ventricular synchronicity of a heart, impedance signals are measured that reflect septal wall movements and impedance amplitude peaks in the impedance signal are detected. A synchronicity index indicating a degree of synchronicity is determined based on detected impedance peaks, with at least two impedance peaks detected within a predetermined time window including a cardiac cycle or a part of a cardiac cycle indicating an increased dyssynchronicity in the ventricular contractions.

摘要翻译： 在可植入医疗装置和用于监测心脏心室同步性的方法中，测量阻抗信号，其反映了隔膜壁运动，并且检测阻抗信号中的阻抗幅度峰值。 基于检测到的阻抗峰值确定表示同步度的同步性指标，其中在包括心动周期的预定时间窗口或心跳周期的一部分中检测到至少两个阻抗峰值，指示心室收缩中的不同步性增加。

公开(公告)号：US20090076560A1

公开(公告)日：2009-03-19

申请号：US11885326

申请日：2005-03-02

申请人： Anders Bjorling ,  Nils Holmstrom

发明人： Anders Bjorling ,  Nils Holmstrom

IPC分类号： A61N1/37

CPC分类号： A61N1/3712 ,  A61N1/368 ,  A61N1/3684

摘要： In a biventricular heart stimulator and a method for controlling such a biventricular heart stimulator, successive stimulation pulses are delivered to the ventricles of a heart such that stimulation pulses in a single heartbeat cycle are respectively first delivered to the first ventricle and then to the second ventricle. Capture or loss of capture in response to stimulation pulses delivered to one ventricle is detected. As a result of a detected loss of capture, preventative measures are taken for preventing loss of capture in the other ventricle.

摘要翻译： 在双心室心脏刺激器和用于控制这种双心室心脏刺激器的方法中，连续的刺激脉冲被递送到心脏的心室，使得单个心跳周期中的刺激脉冲分别首先被传送到第一脑室，然后被传送到第二脑室 。 检测到响应于输送到一个脑室的刺激脉冲的捕获或丢失。 由于检测到的捕获损失，采取预防措施来防止在另一脑室中的捕获损失。

公开(公告)号：US20080306566A1

公开(公告)日：2008-12-11

申请号：US12095216

申请日：2005-12-16

申请人： Nils Holmstrom ,  Kjell Noren

发明人： Nils Holmstrom ,  Kjell Noren

IPC分类号： A61N1/365

CPC分类号： A61B7/00 ,  A61B7/04 ,  A61N1/36514 ,  A61N1/36578

摘要： A method for detecting a condition of a heart of a patient using an implantable medical device including the steps of sensing acoustic signals indicative of heart sounds of the heart of the patient; extracting signals corresponding to a first heart sound (S1) and a second heart sound (S2) from sensed signals; calculating an energy value corresponding to a signal corresponding to the first heart sound (S1) and an energy value corresponding to the second heart sound (S2); calculating a relation between the energy value corresponding to the first heart sound and the energy value corresponding to the second heart sound for successive cardiac cycles; and using at least one relation to detect the condition or a change of the condition. A medical device for determining the posture of a patient and a computer readable medium encoded with instructions are used to perform the inventive method.

摘要翻译： 一种使用可植入医疗装置检测患者心脏状况的方法，包括以下步骤：感测指示患者心脏心脏的声音的声信号; 从感测信号中提取对应于第一心音（S1）和第二心音（S2）的信号; 计算对应于对应于第一心音（S1）的信号的能量值和对应于第二心音（S2）的能量值; 计算对应于第一心音的能量值与对应于第二心音的能量值之间的关系，用于连续的心动周期; 并使用至少一个关系来检测条件或条件的变化。 用于确定患者姿势的医疗装置和用指令编码的计算机可读介质用于执行本发明的方法。