公开(公告)号：US07398126B2

公开(公告)日：2008-07-08

申请号：US10473552

申请日：2002-03-25

申请人： Rolf Hill ,  Sven Kalling ,  Martin Obel ,  Maria Wargelius

发明人： Rolf Hill ,  Sven Kalling ,  Martin Obel ,  Maria Wargelius

IPC分类号： A61N1/05 ,  A61K9/22

CPC分类号： A61N1/0568

摘要： In an electrically conductive lead adapted for implantation in a human or animal body, and a method for making such a lead, a drug-dispensing member is disposed at a distal end portion of the lead, at which an electrode member is disposed that is adapted to emit and/or sense electrical signals associated with medical therapy. The drug-dispensing member has a configuration so that, after implantation, the amount of drug released into the body per time unit is automatically controlled to smoothly vary with time from al larger amount to a smaller amount in accordance with a predetermined relationship of the amount of drug released as a function of time.

摘要翻译： 在适于植入人体或动物体内的导电引线以及制造这种引线的方法中，药物分配部件设置在引线的远端部分处，电极部件设置在该远端部分 以发射和/或感测与医学治疗相关的电信号。 药物分配构件具有这样的结构，使得在植入后，自动控制每时间单位释放到体内的药物的量，以随着时间的推移而随着时间的推移而随着时间的推移而随着时间的推移而变化， 的药物释放作为时间的函数。

公开(公告)号：US20060235325A1

公开(公告)日：2006-10-19

申请号：US10524196

申请日：2003-06-23

申请人： Nils Holmstrom ,  Martin Obel ,  Anna Norlin ,  Kenneth Dahlberg ,  Anders Bjorling ,  Sven Kalling ,  Karin Ljungstrom ,  Kjell Noren

发明人： Nils Holmstrom ,  Martin Obel ,  Anna Norlin ,  Kenneth Dahlberg ,  Anders Bjorling ,  Sven Kalling ,  Karin Ljungstrom ,  Kjell Noren

IPC分类号： A61B5/05 ,  A61B5/02

CPC分类号： A61B5/0538 ,  A61B5/053 ,  A61N1/3627

摘要： A congestive heart failure monitor has an impedance measuring unit that measures the impedance between at least two electrodes implanted in a patient, to use a detected change of the measured impedance as an indication of a change in the left atrium volume. Any analyzing unit analyzes the measured impedance and detects insipient congestive heart failure dependent on a quotient of a maximum value of the measured impedance and a minimum value of the measured impedance during a cardiac cycle.

摘要翻译： 充血性心力衰竭监测器具有阻抗测量单元，其测量植入患者中的至少两个电极之间的阻抗，以使用检测到的测量阻抗的变化作为左心房体积变化的指示。 任何分析单元分析所测量的阻抗，并根据所测量的阻抗的最大值和心动周期内所测量的阻抗的最小值来检测不利的充血性心力衰竭。

公开(公告)号：US06748273B1

公开(公告)日：2004-06-08

申请号：US10031548

申请日：2002-06-03

申请人： Martin Obel ,  Niklas Sköldengen ,  Jan Lindberg

发明人： Martin Obel ,  Niklas Sköldengen ,  Jan Lindberg

IPC分类号： A61N137

CPC分类号： G01R31/3662 ,  A61N1/3708

摘要： In a method and an apparatus for detecting the status of a battery in an implantable heart stimulator, the battery impedances measured and an increased value of the measured impedance is detected, from which an impedance based value of the remaining battery capacity is determined. The increase in impedance is analyzed to determine whether the impedance increase is a reliable indicator of the remaining battery capacity. If it is determined that the impedance increase is not reliable for determining the battery capacity, the total charge depletion of the battery is measured and a charge depletion-based value of the remaining battery capacity is determined.

摘要翻译： 在用于检测可植入心脏刺激器中的电池的状态的方法和装置中，检测电池阻抗并检测测量阻抗的增加的值，从而确定剩余电池容量的基于阻抗的值。 分析阻抗的增加以确定阻抗增加是否是剩余电池容量的可靠指标。 如果确定阻抗增加对于确定电池容量是不可靠的，则测量电池的总电荷消耗，并且确定剩余电池容量的基于电荷消耗的值。

公开(公告)号：US5464429A

公开(公告)日：1995-11-07

申请号：US114357

申请日：1993-09-01

申请人： Sven-Erik Hedberg ,  Martin Obel ,  Kurt Hoegnelid

发明人： Sven-Erik Hedberg ,  Martin Obel ,  Kurt Hoegnelid

IPC分类号： A61N1/39 ,  A61N1/362

CPC分类号： A61N1/3962

摘要： An apparatus for producing heart defibrillation sequences formed of stimulation pulses and defibrillation shocks contains a unit for delivering pulses through an intracardiac or epicardiac electrode, normally for cardiac pacing, and defibrillator circuitry for delivering defibrillation shocks through defibrillation electrodes. The unit for delivering pacing pulses has an output stage which is capable of generating a stimulation pulse, delivered to the heart via the pacing electrode, having a higher energy content than a pacing pulse, but considerably less energy than a conventional defibrillation shock. A control unit is connected to the unit for delivering stimulation pulses and to the defibrillator circuitry for forming a defibrillation sequence consisting of stimulation pulses and defibrillation shocks. The control unit determines the timing for delivering the stimulation pulses and the defibrillation shocks.

摘要翻译： 用于产生由刺激脉冲和除颤电击形成的心脏除颤序列的装置包含用于通过心脏或心外膜电极（通常用于心脏起搏）输送脉冲的单元，以及用于通过除颤电极输送除颤电击的除颤器电路。 用于输送起搏脉冲的单元具有输出级，其能够产生刺激脉冲，经由起搏电极传递到心脏，具有比起搏脉冲更高的能量含量，但是比传统除颤电击显着更少的能量。 控制单元连接到用于递送刺激脉冲的单元和去纤颤器电路，用于形成由刺激脉冲和除颤电击组成的除颤序列。 控制单元确定输送刺激脉冲和除颤电击的时间。

公开(公告)号：US5871507A

公开(公告)日：1999-02-16

申请号：US870935

申请日：1997-06-06

申请人： Martin Obel ,  Hans Stranberg ,  Wyn Davies

发明人： Martin Obel ,  Hans Stranberg ,  Wyn Davies

IPC分类号： A61N1/05 ,  A61N1/362 ,  A61N1/365 ,  A61N1/37

CPC分类号： A61N1/3704 ,  A61N1/3622

摘要： A heart stimulator, operable for single-chamber and/or dual-chamber pacing, includes a first unipolar electrical lead placeable in the atrium of a heart, and a second unipolar electrical lead placeable in the ventricle of the heart. In the heart stimulator, a differential detector is connected to each of these unipolar leads and detects a differential signal representative of cardiac activity between the atrial electrode and the ventricular electrode. The differential signal is supplied to decision logic which evaluates each of those outputs including using a morphology analysis, if necessary. Depending on the type of cardiac activity identified as a result of the evaluation, the decision logic supplies a signal to a control unit in the heart stimulator to cause the therapy administered by the heart stimulator to be altered as warranted. The decision logic may also derive a respiration signal from the differential signal, which can also be used to modify the administered therapy.

摘要翻译： 可用于单室和/或双室起搏的心脏刺激器包括可置于心脏心房中的第一单极电引线和可置于心脏心室中的第二单极电引线。 在心脏刺激器中，将差分检测器连接到这些单极引线中的每一个，并检测代表心房电极和心室电极之间的心脏活动的差分信号。 差分信号被提供给决策逻辑，如果需要，评估每个输出，包括使用形态学分析。 根据作为评估结果识别的心脏活动的类型，判定逻辑将信号提供给心脏刺激器中的控制单元，以使心脏刺激器施用的治疗被改变为必要的。 决策逻辑还可以从差分信号导出呼吸信号，其也可以用于修改施用的治疗。

公开(公告)号：US5836984A

公开(公告)日：1998-11-17

申请号：US954688

申请日：1997-10-20

申请人： Martin Obel

发明人： Martin Obel

IPC分类号： A61N1/365 ,  A61N1/37 ,  A61N1/00

CPC分类号： A61N1/3712

摘要： A heart stimulating device for avoiding problems related to fusion beats contains a pulse generator for delivering stimulation pulses to a patient's heart and having a basic escape interval, a detector with a filter which senses QRS characteristics in IEGM signals, a logic stage which controls the pulse generator, and a detector without a filter which senses QRS characteristics in IEGM signals. The logic stage activates the detector without a filter preceding an end of the basic escape interval and prolongs the basic escape interval by a predetermined extension interval if the detector without a filter senses a QRS indication.

摘要翻译： 用于避免与融合搏动有关的问题的心脏刺激装置包含用于将刺激脉冲传送到患者心脏并具有基本逃逸间隔的脉冲发生器，具有感测IEGM信号中的QRS特性的滤波器的检测器，控制脉冲的逻辑级 发生器和不具有感测IEGM信号中QRS特性的滤波器的检测器。 如果没有滤波器的检测器感测到QRS指示，则逻辑级激活检测器，而不需要在基本逃逸间隔结束之前的过滤器，并将基本逃逸间隔延长预定的延伸间隔。

公开(公告)号：US5480420A

公开(公告)日：1996-01-02

申请号：US299345

申请日：1994-09-01

申请人： Kurt Hoegnelid ,  Hans Thornander ,  Martin Obel

发明人： Kurt Hoegnelid ,  Hans Thornander ,  Martin Obel

IPC分类号： A61N1/05 ,  A61N1/362 ,  A61N1/04

CPC分类号： A61N1/056

摘要： A temporarily implantable electrode device, intended for sensing electrical signals from living tissue, has an insulating sheath of resorbable material, and at least one non-toxic, liquid conductor contained inside the insulating sheath in order to form an electrical conductor which, via an electrode adapted for interaction with living tissue can sense and carry electrical signals from living tissue to a medical apparatus connected to the electrode device. The resorbable material ultimately dissolves completely into the body of the subject in whom the electrode device was temporarily implanted, and the non-toxic, liquid conductor simultaneously mixes with other fluids, making explantation of the electrode device unnecessary.

摘要翻译： 用于感测来自活体组织的电信号的临时可植入电极装置具有可再吸收材料的绝缘护套，以及包含在绝缘护套内部的至少一种无毒液体导体，以便形成电导体，其经由电极 适于与生物体组织的相互作用可以感测并携带从生物组织到连接到电极装置的医疗装置的电信号。 可再吸收材料最终完全溶解到临时注入电极装置的被检体的体内，并且无毒的液体导体与其它流体同时混合，不需要电极装置的外植。

公开(公告)号：US5279293A

公开(公告)日：1994-01-18

申请号：US861150

申请日：1992-03-31

申请人： Hans Andersen ,  Martin Obel ,  Lars Wallen

发明人： Hans Andersen ,  Martin Obel ,  Lars Wallen

IPC分类号： A61N1/39 ,  A61N1/00

CPC分类号： A61N1/3943

摘要： An implantable defibrillator has a capacitor which, through a controllable switch arrangement, can either be connected to a voltage source for charging the capacitor, or connected across electrodes placed at the heart for delivering a defibrillation pulse. To calculate the minimum pulse energy required for successful defibrillation, ventricular fibrillation is first induced, so that a plurality of defibrillation attempts, with energy increasing from attempt-to-attempt can be undertaken until successful defibrillation occurs. For inducing ventricular fibrillation, the capacitor of the implantable defibrillator is connected to the voltage source until a prescribed charging voltage, which is significantly below the voltage necessary for defibrillation, is reached, and subsequently, the capacitor is disconnected from the voltage source during brief time spans at intervals within the framework of a sequence and is connected during those time spans to the electrodes. Between the time spans, the capacitor is again charged.

摘要翻译： 2.1。 已知的可植入除颤器包含电容器，该电容器可以通过可控开关装置连接到电压源，以便再充电，或者连接到置于心脏上的电极，以便发出除颤脉冲。 为了确定除颤的最小所需脉冲能量，首先诱发心室颤动，由此进行多次除颤尝试，每次进行能量增加，直到发生成功的除颤。 2.2。 为了能够通过可植入除颤器以简单的方式诱发心室颤动，电容器（1）连接到电压源（4），直到达到规定的充电电压; 此后，电容器（1）在频率框架内以间隔彼此相对的短时间段内与电压源（4）断开，并连接到电极（10和11）。

公开(公告)号：US20080249375A1

公开(公告)日：2008-10-09

申请号：US11666964

申请日：2004-11-02

申请人： Martin Obel

发明人： Martin Obel

IPC分类号： A61B5/02

CPC分类号： A61N1/08 ,  A61B5/029 ,  A61B5/0452 ,  A61B7/00 ,  A61N1/372

摘要： In a method and an arrangement for evaluating operational effectiveness of an implantable medical device for different lead placements associated with the medical device, a measuring unit records signals that are characteristic of cardiac activity at respectively different lead positions, and these signals are stored. A processor accesses the stored signals and, from the stored signals, determines a measure of cardiac activity at each of the lead positions. The recorded signals may be intracardiac ECG signals, surface ECG signals, heart sound signals obtained from a microphone, or impedance signals. The lead position at which the best hemodynamic behavior of the heart is identified from the analysis of the stored signals, and is determined as being the optimum site for placement of the electrode leads.

摘要翻译： 在用于评估与医疗装置相关联的不同引线布置的可植入医疗装置的操作有效性的方法和装置中，测量单元记录分别在不同引导位置处具有心脏活动特征的信号，并且存储这些信号。 处理器访问所存储的信号，并且从所存储的信号中确定每个引导位置处的心脏活动度量。 记录的信号可以是心内ECG信号，表面ECG信号，从麦克风获得的心音信号或阻抗信号。 从存储的信号的分析中识别心脏的最佳血液动力学行为的引导位置，并且被确定为用于放置电极引线的最佳位置。

公开(公告)号：US07330758B2

公开(公告)日：2008-02-12

申请号：US10396843

申请日：2003-03-25

申请人： Nils Holmström ,  Anna Norlin ,  Kenneth Dahlberg ,  Martin Obel

发明人： Nils Holmström ,  Anna Norlin ,  Kenneth Dahlberg ,  Martin Obel

IPC分类号： A61N1/365

CPC分类号： A61N1/36521 ,  A61B5/0535 ,  A61B5/7239 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A heart monitoring device has a control circuit that derives an impedance value indicative of the impedance between different electrode surfaces. The control circuit determines and monitors a negative rate of change of the impedance value and determines whether the negative rate of change, or its absolute value, increases or decreases over a number of heart cycles. Alternatively or additionally, the control circuit may determine and monitor a relationship between a positive rate of change and a negative rate of change of the impedance value. The device can, in particular, be used to detect and treat a diastolic dysfunction of a heart.

摘要翻译： 心脏监测装置具有控制电路，其导出指示不同电极表面之间的阻抗的阻抗值。 控制电路确定并监测阻抗值的负变化率，并确定负数变化率或其绝对值是否在多个心脏周期内增加或减少。 或者或另外，控制电路可以确定和监测正的变化率与阻抗值的负的变化率之间的关系。 该装置特别可用于检测和治疗心脏的舒张功能障碍。