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公开(公告)号：US11077266B2
公开(公告)日：2021-08-03
申请号：US15904235
申请日：2018-02-23
发明人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito , Olivia Sobczyk , Anne Battisti-Charbonney , Daniel Michael Mandell
摘要： An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: —obtaining input of a series of logistically attainable PetX values for a series of respective breaths: —determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and—controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.
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2.发明申请公开(公告)号：US20160166154A1
公开(公告)日：2016-06-16
申请号：US14925725
申请日：2015-10-28
发明人： Joseph Fisher , David Preiss , Takafumi Azami , Alex Vesely , Eitan Prisman , Ron Somogyi , Steve Iscoe
IPC分类号： A61B5/0205 , A61B5/00
CPC分类号： A61B5/0205 , A61B5/083 , A61B5/14551 , A61B5/7225 , A61B5/7278 , A61M16/08 , A61M16/0833 , A61M16/085 , A61M16/0858 , A61M16/202 , A61M16/205 , A61M16/206 , A61M16/208 , A61M16/22
摘要： An apparatus to measure pulmonary blood flow and cardiac output (Q) comprising: a) a breathing circuit which, at exhalation, keeps exhaled gas separate from inhaled gas and at inhalation, when VE is greater than first gas set (FGS) flow, results in a subject inhaling FGS first and then a second gas set (SGS), for the balance of inhalation; b) a gas sensor for monitoring gas concentrations at the patient-circuit interface; c) a gas flow control means for controlling the rate of FGS flow into the breathing circuit; d) machine intelligence consisting of a computer or logic circuit capable of controlling the gas flow control means which receives the output of the gas sensor means and outputs pulmonary blood flow.
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公开(公告)号：US20230000389A1
公开(公告)日：2023-01-05
申请号：US17780816
申请日：2020-11-30
摘要： Alveolar dead space of a subject is determined by measuring an end tidal partial pressure of carbon dioxide during a sequence of normal breaths of the subject and, during a sequence of deep breaths by the subject, delivering a first volume of a first gas to the subject over a first portion of each inspiration by the subject. The first volume is less than or equal to an expected alveolar volume of the subject when the subject is breathing normally. A second volume of a second gas is delivered to the subject over a second portion of each inspiration. The second gas includes a neutral gas. An end tidal partial pressure of carbon dioxide is measured during the sequence of deep breaths. The alveolar dead space is computed using the end tidal partial pressures of carbon dioxide measured during the sequence of normal breaths and the sequence of deep breaths.
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公开(公告)号：US11464414B2
公开(公告)日：2022-10-11
申请号：US16503866
申请日：2019-07-05
发明人： Joseph Fisher , Michael Klein , James Duffin
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/029 , A61B5/083 , A61B5/08 , A61B5/026 , A61M16/00 , A61M16/12
摘要： A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non-invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a test criterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.
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公开(公告)号：US20210052220A1
公开(公告)日：2021-02-25
申请号：US17000229
申请日：2020-08-21
摘要： An apparatus and method for assessing vascular compliance in subjects with multiple sclerosis using sequential gas delivery is provided. The apparatus includes a gas delivery device and a processor. The processor controls the gas delivery device to deliver a first and second gas during a single inspiration. The first gas contains a mixture of oxygen and carbon dioxide necessary to target an end-tidal concentration of the two gases. The second gas includes a concentration of carbon dioxide equal to the target end-tidal concentration of carbon dioxide.
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公开(公告)号：US20200276406A1
公开(公告)日：2020-09-03
申请号：US16781665
申请日：2020-02-04
发明人： Michael KLEIN
摘要： An apparatus, method and system for delivering CO2 into an inspiratory gas stream to formulate a blended respiratory gas in a manner that continuously maintains a target CO2 concentration in a volume of the inspired respiratory gas, for example, over the course of a breath or a volumetrically definable part thereof or a series of partial or full breaths.
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公开(公告)号：US20200069194A1
公开(公告)日：2020-03-05
申请号：US16503866
申请日：2019-07-05
发明人： Joseph FISHER , Michael KLEIN , James DUFFIN
IPC分类号： A61B5/0205 , A61M16/12 , A61M16/00 , A61B5/00 , A61B5/026 , A61B5/08 , A61B5/083 , A61B5/029
摘要： A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non-invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a test criterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.
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公开(公告)号：US20170232223A1
公开(公告)日：2017-08-17
申请号：US15354884
申请日：2016-11-17
发明人： Joseph Fisher , James Duffin , Jorn Fierstra
CPC分类号： A61M16/12 , A61M16/0045 , A61M16/0078 , A61M16/0081 , A61M16/024 , A61M16/0833 , A61M16/0891 , A61M16/20 , A61M16/201 , A61M16/206 , A61M16/207 , A61M16/208 , A61M2202/0225 , A61M2230/202 , A61M2230/432
摘要： A breathing circuit for use in conjunction with a ventilator serving a mechanically-ventilated patient includes an expiratory gas airflow pathway; an inspiratory gas airflow pathway; and a gas mixing mechanism operable to mix inspiratory gas and expiratory gas in an amount sufficient to equilibrate the patient's PETCO2 and arterial PCO2 such that the patient's PETCO2 is a clinically reliable approximation of the patient's PaCO2.
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公开(公告)号：US20240358946A1
公开(公告)日：2024-10-31
申请号：US18579302
申请日：2022-07-18
发明人： Joseph Arnold FISHER , James DUFFIN , Olivia SOBCZYK , Ece Su SAYIN , David J. MIKULIS , Julien POUBLANC , Jacob B. SCHULMAN
CPC分类号： A61M16/024 , A61M16/12 , A61M2202/0208 , A61M2202/0225 , A61M2202/0266 , A61M2205/3303 , A61M2205/3334 , A61M2205/3368 , A61M2205/505 , A61M2210/1039 , A61M2230/205
摘要： The speed and range of the transition to low lung PO2 can be optimized such that it approaches the PO2 and timing profile of reoxygenation from a hypoxic profile. However, such hypoxic “spikes” are much more difficult to implement than re-oxygenation. A solution is to control the independent variables which contribute to hypoxia in the lung. These variables may be controlled in alone or in aggregate to minimize the time required to generate a target profile of transient lung hypoxia. In particular, a rapid decrease in [dOHb] can be implemented by breathing deeply, exhaling at least a portion of the functional residual capacity, lowering the PO2 at baseline, increasing the breathing rate, and increasing the PCO2 to shift the oxygen-hemoglobin dissociation curve to the right.
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公开(公告)号：US20240335128A1
公开(公告)日：2024-10-10
申请号：US18579311
申请日：2022-07-18
发明人： Joseph Arnold FISHER , James DUFFIN , Julien POUBLANC , Olivia SOBCZYK , David J. MIKULIS , Ece Su SAYIN
CPC分类号： A61B5/0263 , A61B5/0042 , A61B5/055 , A61B5/7257 , G01R33/5601 , A61B2576/026
摘要： A method of implementing changes in deoxyhemoglobin concentration, the method comprising: targeting a sequence of partial pressures of oxygen in arterial blood (PaCh) values in a subject using a sequential gas delivery device in a periodic input pattern; measuring a blood-oxygen level dependent (BOLD) signal in a voxel of the subject's brain using a magnetic resonance imaging device while targeting the sequence of values; comparing the pattern to the signal; and determining a vascular tissue characteristic (vessel type, vessel orientation, or pathological condition) for the voxel based on the comparison.
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