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公开(公告)号：US20200179565A1
公开(公告)日：2020-06-11
申请号：US16313254
申请日：2017-06-08
发明人： Takashi YOKOO , Shuichiro YAMANAKA
摘要： The present invention provides a kidney production method including a step of tissue-specifically removing a metanephric mesenchyme of a metanephros of a non-human animal; a step of transplanting, into the metanephros, a kidney precursor cell derived from a non-human animal which is allogeneic or xenogeneic to the non-human animal; and a step of advancing development of the metanephros, which is a step in which the transplanted kidney precursor cell is differentiated and matured to form a part of the kidney.
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公开(公告)号：US11607425B2
公开(公告)日：2023-03-21
申请号：US16313253
申请日：2017-06-08
申请人： Takashi Yokoo , BIOS Co., Ltd
发明人： Takashi Yokoo , Shuichiro Yamanaka
摘要： The present invention provides a kidney production method including a step of tissue-specifically removing a metanephric mesenchyme of a metanephros of a non-human animal; a step of transplanting a human kidney precursor cell into the metanephros; and a step of advancing development of the metanephros, which is a step in which the transplanted human kidney precursor cell is differentiated and matured to form a part of the kidney.
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公开(公告)号：US20190269825A1
公开(公告)日：2019-09-05
申请号：US16313251
申请日：2017-06-08
发明人： Takashi YOKOO , Shuichiro YAMANAKA
摘要： The present invention provides an organ production method including a step of tissue-specifically removing a first portion of an organ of a non-human animal partway through development thereof; a step of transplanting, into a region from which the first portion has been removed, an organ precursor cell which is allogeneic or xenogeneic to the non-human animal; and a step of advancing development of the organ, which is a step in which the transplanted organ precursor cell is differentiated and matured to form a part of the organ.
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公开(公告)号：US08820816B2
公开(公告)日：2014-09-02
申请号：US13468023
申请日：2012-05-09
申请人： Masayoshi Iwabuchi , Shigeo Suzuki , Takashi Yokoo
发明人： Masayoshi Iwabuchi , Shigeo Suzuki , Takashi Yokoo
IPC分类号： B60J1/00
摘要： The present invention provides an outer panel for a back door that includes a glass-fitted opening and a plurality of guide grooves provided on an outer peripheral edge of the glass-fitted opening. Each of the guide grooves is arranged on opposing left and right sides on the outer peripheral edge and has a shallow groove and either a deep groove or a through hole.
摘要翻译： 本发明提供了一种用于后门的外板，其包括装有玻璃的开口和设置在玻璃装配开口的外周边缘上的多个引导槽。 每个引导槽布置在外周边缘的相对的左右两侧，并且具有浅槽和深槽或通孔。
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公开(公告)号：US20090304639A1
公开(公告)日：2009-12-10
申请号：US11919317
申请日：2005-10-25
申请人： Takashi Yokoo , Masataka Okabe , Tatsuo Hosoya
发明人： Takashi Yokoo , Masataka Okabe , Tatsuo Hosoya
CPC分类号： A61K35/28 , A61K35/12 , A61L27/3604 , A61L27/3641 , A61L27/3834 , C12N5/0686 , C12N2502/025 , C12N2506/1353
摘要： The present invention provides a means for achieving generation of a complex organ such as kidney and the like through the use of hMSCs to generate the human organ. The method for preparing a desired organ for transplantation to human by transplanting an isolated human mesenchymal stem cell to the embryo of a pregnant mammal host to induce differentiation of the mesenchymal stem cell is a method wherein the mesenchymal stem cell is transplanted into the embryo at a corresponding site for differentiation into the desired organ in the host at a transplantation time when the host is still at an immunologically tolerant stage.
摘要翻译： 本发明提供了通过使用hMSC来产生人体器官来实现肾脏等复合器官的产生的手段。 通过将分离的人间充质干细胞移植到怀孕哺乳动物宿主的胚胎以诱导间充质干细胞分化来制备移植给人的所需器官的方法是将间充质干细胞移植到胚胎中的方法 当宿主仍处于免疫耐受阶段时，在移植时将宿主分化为宿主所需器官的相应位点。
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公开(公告)号：US20090186004A1
公开(公告)日：2009-07-23
申请号：US12298099
申请日：2007-04-24
申请人： Akira Fukui , Takashi Yokoo , Masataka Okabe , Tatsuo Hosoya
发明人： Akira Fukui , Takashi Yokoo , Masataka Okabe , Tatsuo Hosoya
IPC分类号： A61K35/12
CPC分类号： A61L27/38 , A01K67/0271 , A01K2227/108 , A61K35/12 , A61L27/3604 , A61L27/3641 , C12N5/0686 , C12N2502/025 , C12N2506/1353
摘要： The present invention provides a method for preparing an organ, particularly a kidney, for transplantation into mammals. In detail, the present invention provides a method for preparing autotransplantation of autologous organs, particularly a kidney, wherein the isolated autologous mesenchymal stem cells are transplanted into an embryo inside a pregnant mammalian host or into an embryo dissected from a pregnant mammalian host at a desired site to induce differentiation, which is then transplanted into the individual.
摘要翻译： 本发明提供了一种用于制备用于移植到哺乳动物中的器官，特别是肾的方法。 详细地，本发明提供了一种自体移植自体器官特别是肾的方法，其中将分离的自体间充质干细胞移植到怀孕的哺乳动物宿主内的胚胎中或以所需的方式从怀孕的哺乳动物宿主中解剖到胚胎中 诱导分化的位点，然后将其移植到个体中。
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公开(公告)号：US20190269733A1
公开(公告)日：2019-09-05
申请号：US16313253
申请日：2017-06-08
申请人： Takashi YOKOO , BIOS Co., Ltd
发明人： Takashi YOKOO , Shuichiro YAMANAKA
摘要： The present invention provides a kidney production method including a step of tissue-specifically removing a metanephric mesenchyme of a metanephros of a non-human animal; a step of transplanting a human kidney precursor cell into the metanephros; and a step of advancing development of the metanephros, which is a step in which the transplanted human kidney precursor cell is differentiated and matured to form a part of the kidney.
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公开(公告)号：US20110262959A1
公开(公告)日：2011-10-27
申请号：US13142222
申请日：2009-06-30
IPC分类号： C12Q1/02
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2227/106 , A01K2227/108 , A01K2267/03 , C12N15/873 , G01N33/5005
摘要： The present invention provides a method of evaluating the possibility of a stem cell being able to differentiate into a cell that constitutes a desired tissue in a living organism, comprising the following steps of: (1) transplanting a stem cell to be evaluated into a primordium of a desired tissue of a non-human mammal, (2) culturing the tissue primordium in vitro, and (3) determining the possibility that the stem cell differentiates into a cell that constitutes the tissue in a living organism, with the degree of the dispersion of cells derived from the transplanted stem cell in the cultured tissue primordium as an index.
摘要翻译： 本发明提供一种评估干细胞能够分化为构成生物体中所需组织的细胞的可能性的方法，包括以下步骤：（1）将要评估的干细胞移植到原基中 的非人哺乳动物的期望组织，（2）在体外培养组织原基，和（3）确定干细胞分化为构成活生物体组织的细胞的可能性，其程度为 作为指标，将来自移植干细胞的细胞分散在培养的组织原基中。
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公开(公告)号：US20080295593A1
公开(公告)日：2008-12-04
申请号：US12127441
申请日：2008-05-27
申请人： Takashi Yokoo
发明人： Takashi Yokoo
IPC分类号： G01F23/30
CPC分类号： G01F23/363 , F02M37/0029 , F02M37/0052 , F02M37/0082 , F02M37/10
摘要： A fuel supply system for supplying fuel from a fuel tank to an engine includes a fuel pump, a pressure regulator and a level sensor. The fuel pump pumps the fuel stored within the fuel tank. The pressure regulator regulates the pressure of the fuel before being supplied from the fuel pump to the engine and serves to return a surplus fuel into the fuel tank. The sensor detects the level of the fuel within the fuel tank and a surplus fuel is capable of being discharged to the sensor.
摘要翻译： 用于从燃料箱向发动机供应燃料的燃料供给系统包括燃料泵，压力调节器和液位传感器。 燃油泵泵送存储在燃油箱内的燃料。 压力调节器在从燃料泵供给到发动机之前调节燃料的压力，并且将多余的燃料返回到燃料箱中。 传感器检测燃料箱内燃料的水平，剩余的燃料能够排放到传感器。
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公开(公告)号：US11559605B2
公开(公告)日：2023-01-24
申请号：US16313254
申请日：2017-06-08
申请人： Takashi YOKOO , BIOS Co.. Ltd
发明人： Takashi Yokoo , Shuichiro Yamanaka
摘要： The present invention provides a kidney production method including a step of tissue-specifically removing a metanephric mesenchyme of a metanephros of a non-human animal; a step of transplanting, into the metanephros, a kidney precursor cell derived from a non-human animal which is allogeneic or xenogeneic to the non-human animal; and a step of advancing development of the metanephros, which is a step in which the transplanted kidney precursor cell is differentiated and matured to form a part of the kidney.
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