公开(公告)号：US07764039B2

公开(公告)日：2010-07-27

申请号：US11826972

申请日：2007-07-19

申请人： Takehiro Yamaguchi ,  Tetsuo Hishikawa ,  Yasushi Onishi ,  Kentaro Fujibayashi

发明人： Takehiro Yamaguchi ,  Tetsuo Hishikawa ,  Yasushi Onishi ,  Kentaro Fujibayashi

IPC分类号： G05B19/18

CPC分类号： G05B19/4061 ,  G05B2219/32342 ,  G05B2219/33301 ,  G05B2219/49141 ,  Y02P90/26

摘要： A numerical controller is capable of foreseeing the occurrence of interference during operation of a machine and securely preventing the interference. An advanced position calculating section determines advanced time for the next interference check, based on an end time point of an interference check by an interference checking device and the sum of a time required for the interference check, a time required for communication, a time required for decelerating and stopping a movable part, and a predetermined float. If an interference checking device detects interference, the interference checking device delivers an axis stop signal the movable part.

摘要翻译： 数字控制器能够预见机器运行过程中的干扰发生，并可靠地防止干扰。 高级位置计算部分基于干扰检查装置的干扰检查的结束时间点和干扰检查所需的时间之和，通信所需的时间，所需的时间，确定下次干扰检查的高级时间 用于减速和停止可移动部件和预定浮子。 如果干扰检查装置检测到干扰，则干扰检查装置向可移动部件传送轴停止信号。

公开(公告)号：USD541426S1

公开(公告)日：2007-04-24

申请号：US29221095

申请日：2005-01-10

申请人： Yoshiharu Sato ,  Takehiro Yamaguchi

设计人： Yoshiharu Sato ,  Takehiro Yamaguchi

公开(公告)号：US07969111B2

公开(公告)日：2011-06-28

申请号：US12258733

申请日：2008-10-27

申请人： Toshiaki Otsuki ,  Takehiro Yamaguchi

发明人： Toshiaki Otsuki ,  Takehiro Yamaguchi

IPC分类号： G05B19/404

CPC分类号： G05B19/404 ,  G05B2219/49344 ,  G05B2219/50297

摘要： A numerical controller capable of moving a tool end point position to an accurate position in a five-axis machining apparatus. Compensation amounts are set, which correspond to respective ones of a linear axis-dependent translational error, a rotary axis-dependent translational error, a linear axis-dependent rotational error, and a rotary axis-dependent rotational error, which are produced in the five-axis machining apparatus. A translational/rotational compensation amount Δ3D is determined from these compensation amounts and added to a command linear axis position Pm. As the compensation amounts, there is used a corresponding one of six-dimensional lattice point compensation vectors, which are determined in advance as errors due to the use of a mechanical system and measured at lattice points of lattices into which the entire machine movable region is divided.

摘要翻译： 一种能够将工具端点位置移动到五轴加工装置中的精确位置的数值控制器。 补偿量被设置为对应于线性轴相关平移误差，旋转轴相关平移误差，线性轴相关旋转误差和旋转轴相关旋转误差中的相应的，其在五 轴加工装置。 根据这些补偿量确定平移/旋转补偿量＆Dgr; 3D，并将其加到指令线性轴位置Pm。 作为补偿量，使用由于使用机械系统而预先确定为误差的六维网格点补偿向量中的相应的一个，并且在整个机器可移动区域为 分为。

公开(公告)号：US20090140684A1

公开(公告)日：2009-06-04

申请号：US12258733

申请日：2008-10-27

申请人： Toshiaki Otsuki ,  Takehiro Yamaguchi

发明人： Toshiaki Otsuki ,  Takehiro Yamaguchi

IPC分类号： G05B19/404

CPC分类号： G05B19/404 ,  G05B2219/49344 ,  G05B2219/50297

摘要： A numerical controller capable of moving a tool end point position to an accurate position in a five-axis machining apparatus. Compensation amounts are set, which correspond to respective ones of a linear axis-dependent translational error, a rotary axis-dependent translational error, a linear axis-dependent rotational error, and a rotary axis-dependent rotational error, which are produced in the five-axis machining apparatus. A translational/rotational compensation amount Δ3D is determined from these compensation amounts and added to a command linear axis position Pm. As the compensation amounts, there is used a corresponding one of six-dimensional lattice point compensation vectors, which are determined in advance as errors due to the use of a mechanical system and measured at lattice points of lattices into which the entire machine movable region is divided.

摘要翻译： 一种能够将工具端点位置移动到五轴加工装置中的精确位置的数值控制器。 补偿量被设置为对应于线性轴相关平移误差，旋转轴相关平移误差，线性轴相关旋转误差和旋转轴相关旋转误差中的相应的，其在五 轴加工装置。 根据这些补偿量确定平移/旋转补偿量Delta3D，并将其加到指令线性轴位置Pm。 作为补偿量，使用由于使用机械系统而预先确定为误差的六维网格点补偿向量中的相应的一个，并且在整个机器可移动区域为 分为。

公开(公告)号：US20060151899A1

公开(公告)日：2006-07-13

申请号：US10563101

申请日：2004-08-04

申请人： Akira Kato ,  Takehiro Yamaguchi ,  Teruko Nomura ,  Katsumi Onai

发明人： Akira Kato ,  Takehiro Yamaguchi ,  Teruko Nomura ,  Katsumi Onai

IPC分类号： B01J13/04

CPC分类号： A61K9/146 ,  A61K9/5146 ,  A61K9/5192

摘要： The present invention provides fine drug particles with submicron sizes excellent in long-term dispersibility. Specifically, it provides a method for producing ultrafine drug particles having an average particle size of 10 nm to 1000 nm, by 1) dissolving a drug in a good solvent or a mixture of good solvents to prepare a drug-containing solution; 2) mixing the drug-containing solution with a solvent being a poor solvent or a mixture of poor solvents for the drug and being miscible with the drug-containing solution in the good solvent or a mixture of good solvents; and 3) subjecting the prepared mixture directly to emulsification under a set processing pressure using a high-pressure homogenizer without carrying out a pretreatment step for adjusting the drug to have an average particle size of 100 μm or less, and an apparatus for producing the particles.

摘要翻译： 本发明提供具有优异的长期分散性的亚微米尺寸的精细药物颗粒。 具体地说，提供平均粒径为10nm〜1000nm的超细药物粒子的制造方法，1）将药物溶解在良溶剂或者良溶剂的混合物中，制备含药溶液; 2）将药物溶液与不良溶剂或溶剂不良溶剂的混合溶剂混合，并在良溶剂或良溶剂混合物中与药物溶液混溶; 和3）使用高压均化器在一定的处理压力下直接使制备的混合物进行乳化，而不进行用于调节药物以使平均粒径为100μm以下的预处理步骤，以及用于制备颗粒的装置 。

公开(公告)号：US08304204B2

公开(公告)日：2012-11-06

申请号：US12529487

申请日：2008-09-01

申请人： Takehiro Yamaguchi ,  Yuka Miyake

发明人： Takehiro Yamaguchi ,  Yuka Miyake

IPC分类号： C12Q1/60

CPC分类号： G01N33/92 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/44 ,  C12Q1/60 ,  G01N33/523 ,  G01N2333/904 ,  G01N2333/92

摘要： A method for measuring LDL cholesterol in a sample using a test piece is provided which involves a step of measuring the total cholesterol in the sample; a step of measuring the non-LDL cholesterol in the sample; and a step of subtracting the non-LDL cholesterol value from the total-cholesterol value to obtain the LDL cholesterol level.

摘要翻译： 提供了使用试验片测定样品中的LDL胆固醇的方法，其包括测量样品中总胆固醇的步骤; 测量样品中非低密度脂蛋白胆固醇的步骤; 以及从总胆固醇值中减去非LDL胆固醇值以获得LDL胆固醇水平的步骤。

公开(公告)号：US20100099125A1

公开(公告)日：2010-04-22

申请号：US12529487

申请日：2008-09-01

申请人： Takehiro Yamaguchi ,  Yuka Miyake

发明人： Takehiro Yamaguchi ,  Yuka Miyake

IPC分类号： C12Q1/60 ,  C12M1/34

CPC分类号： G01N33/92 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/44 ,  C12Q1/60 ,  G01N33/523 ,  G01N2333/904 ,  G01N2333/92

摘要： An LDL cholesterol measurement method that can be used with a test piece is provided. The LDL cholesterol measurement method for measuring LDL cholesterol in a sample has (A) a step of providing a total-cholesterol measurement portion and a non-LDL cholesterol measurement portion for measuring non-LDL cholesterol, which is cholesterol other than LDL cholesterol; (B) a step of measuring the total cholesterol in the sample in the total-cholesterol measurement portion; (C) a step of measuring the non-LDL cholesterol in the sample in the non-LDL cholesterol measurement portion; and (D) a step of obtaining the LDL cholesterol level in the sample by subtracting the non-LDL cholesterol value measured in the step (C) from the total-cholesterol value measured in the step (B).

摘要翻译： 提供了可与试验片一起使用的低密度脂蛋白胆固醇测定方法。 用于测定样品中的LDL胆固醇的低密度脂蛋白胆固醇测定方法具有（A）提供总胆固醇测定部位和非低密度脂蛋白胆固醇测定部，用于测定作为LDL胆固醇以外的胆固醇的非低密度脂蛋白胆固醇的步骤; （B）测定总胆固醇测定部中的样品中的总胆固醇的步骤; （C）测定非LDL胆固醇测定部中的样品中的非LDL胆固醇的步骤; 和（D）通过从步骤（B）中测量的总胆固醇值中减去步骤（C）中测量的非LDL胆固醇值，获得样品中的LDL胆固醇水平的步骤。

公开(公告)号：US20100009003A1

公开(公告)日：2010-01-14

申请号：US12561776

申请日：2009-09-17

申请人： Koji UKAI ,  Yasuyuki Asai ,  Yoshiteru Kato ,  Takayuki Ohwaki ,  Shigeru Aoki ,  Yasuhiro Zaima ,  Takehiro Yamaguchi

发明人： Koji UKAI ,  Yasuyuki Asai ,  Yoshiteru Kato ,  Takayuki Ohwaki ,  Shigeru Aoki ,  Yasuhiro Zaima ,  Takehiro Yamaguchi

IPC分类号： A61K31/4439 ,  A61K9/14

CPC分类号： A61K9/0095 ,  A61K9/5078 ,  A61K31/717 ,  A61K45/06

摘要： The present invention provides a pharmaceutical preparation to be dispersed before administration which has an adequate viscosity and a suitable flowability even when dispersed in a small amount of water and can be easily administered through an NG tube is provided. Specifically, the pharmaceutical preparation to be dispersed before administration contains active granules containing a pharmaceutically active substance having an average particle diameter of 5 mm or less and a thickening agent, and can be administered through an NG tube by dispersing in water before administration.

摘要翻译： 本发明提供了即使分散在少量的水中也可以容易地通过NG管施用的具有足够的粘度和合适的流动性的在给药前分散的药物制剂。 具体地说，给药前待分散的药物制剂含有含有平均粒径为5mm以下的药物活性物质和增稠剂的活性颗粒，并且可以通过NG管通过在给药前在水中分散来给药。

公开(公告)号：US06939682B2

公开(公告)日：2005-09-06

申请号：US10415726

申请日：2001-11-07

申请人： Hiroshi Tamura ,  Susumu Nishino ,  Takehiro Yamaguchi ,  Koichi Hino

发明人： Hiroshi Tamura ,  Susumu Nishino ,  Takehiro Yamaguchi ,  Koichi Hino

IPC分类号： C12Q1/26 ,  C12Q1/32 ,  C12Q1/44 ,  C12Q1/60 ,  G01N33/52 ,  G01N33/92 ,  C12Q1/28

CPC分类号： G01N33/92 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/44 ,  C12Q1/60 ,  G01N33/523

摘要： The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer (2) is formed on a support (1), and an enzyme reagent for measuring cholesterol, a first surfactant that makes a solubility of a high-density lipoprotein (HDL) higher than that of a lipoprotein other than the HDL, and a second surfactant that inhibits the lipoprotein other than the HDL from dissolving are contained in the reagent layer (2).

摘要翻译： 本发明涉及具有简单结构的测试片，通过该试片可以使用少量试样容易地测量HDL胆固醇。 在载体（1）上形成试剂层（2），测定胆固醇用的酶试剂，高密度脂蛋白（HDL）的溶解度比HDL以外的脂蛋白高的第一表面活性剂， 并且在试剂层（2）中含有抑制HDL以外的脂蛋白溶解的第二表面活性剂。

公开(公告)号：US20080024083A1

公开(公告)日：2008-01-31

申请号：US11826972

申请日：2007-07-19

申请人： Takehiro Yamaguchi ,  Tetsuo Hishikawa ,  Yasushi Onishi ,  Kentaro Fujibayashi

发明人： Takehiro Yamaguchi ,  Tetsuo Hishikawa ,  Yasushi Onishi ,  Kentaro Fujibayashi

IPC分类号： G05B19/4061

CPC分类号： G05B19/4061 ,  G05B2219/32342 ,  G05B2219/33301 ,  G05B2219/49141 ,  Y02P90/26

摘要： Disclosed is a numerical controller capable of foreseeing the occurrence of interference during operation of a machine and securely preventing the interference. An advanced position calculating section determines advanced time for the next interference check, based on an end time point of an interference check by an interference checking device and the sum of a time required for the interference check, a time required for communication, a time required for decelerating and stopping a movable part, and a predetermined float. Further, an advanced position of the movable part at the advanced time is calculated based on pre-read program data and is outputted to the interference checking device. The interference checking device performs the interference check at the advanced position. If it detects interference, the interference checking device delivers an axis stop signal to a motion command output section, thereby stopping a motion command and decelerating and stopping the movable part. Since interference check timing is settled in accordance with the time required for the interference check, the occurrence of interference can be securely prevented without delay or advance.

摘要翻译： 公开了一种数字控制器，其能够预见机器操作期间的干扰发生，并可靠地防止干扰。 高级位置计算部分基于干扰检查装置的干扰检查的结束时间点和干扰检查所需的时间之和，通信所需的时间，所需的时间，确定下次干扰检查的高级时间 用于减速和停止可移动部件和预定浮子。 此外，基于预先读取的程序数据计算可动部件在高级时间的高位置，并将其输出到干扰检查装置。 干扰检查装置在高级位置进行干扰检查。 如果检测到干扰，则干扰检查装置向运动指令输出部输出轴停止信号，从而停止运动指令，减速停止可动部。 由于根据干扰检查所需的时间来确定干扰检查定时，所以可以在不延迟或提前的情况下可靠地防止发生干扰。