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    Substituted benzene derivatives or salts thereof
    4.
    发明授权
    Substituted benzene derivatives or salts thereof 失效
    取代的苯衍生物或其盐

    公开(公告)号：US07786106B2

    公开(公告)日：2010-08-31

    申请号：US12356376

    申请日：2009-01-20

    申请人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    发明人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    IPC分类号： A61K31/551 ,  C07D243/08

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/14 ,  C07H15/203 ,  C07H15/26

    摘要： There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl) carbamoyl]-6′-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.

    摘要翻译： 提供了基于活化凝血因子X的抑制具有抗凝血作用的化合物，并且可用作血栓形成或栓塞引起的疾病的抗凝剂或预防/治疗剂。 有效成分是诸如4'-溴-2' - [（5-氯-2-吡啶基）氨基甲酰基] -6' - （b-）-D-吡喃半乳糖氧基-1-异丙基哌啶-4-甲酰苯胺，2' - （ -2'-乙酰氨基-2-脱氧-α-D-吡喃葡萄糖基氧基）-4'-溴-6' - [（5-氯-2-吡啶基）氨基甲酰基] -1-异丙基哌啶-4-甲酰苯胺等或其盐 。

    SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF
    5.
    发明申请
    SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF 失效
    取代的苯甲酸衍生物或其盐

    公开(公告)号：US20090137498A1

    公开(公告)日：2009-05-28

    申请号：US12356376

    申请日：2009-01-20

    申请人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    发明人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    IPC分类号： A61K31/704 ,  C07D211/26

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/14 ,  C07H15/203 ,  C07H15/26

    摘要： There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl)carbamoyl]-6′-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.

    摘要翻译： 提供了基于活化凝血因子X的抑制具有抗凝血作用的化合物，并且可用作血栓形成或栓塞引起的疾病的抗凝剂或预防/治疗剂。 有效成分是诸如4'-溴-2' - [（5-氯-2-吡啶基）氨基甲酰基] -6'-β-D-吡喃半乳糖氧基-1-异丙基哌啶-4-甲酰苯胺，2' - （2 - 乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基氧基）-4'-溴-6' - [（5-氯-2-吡啶基）氨基甲酰基] -1-异丙基哌啶-4-甲酰苯胺等或其盐。