利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

25 条记录 (耗时 0.043 秒)

    Substituted benzene derivatives or salts thereof
    5.
    发明授权
    Substituted benzene derivatives or salts thereof 失效
    取代的苯衍生物或其盐

    公开(公告)号：US07786106B2

    公开(公告)日：2010-08-31

    申请号：US12356376

    申请日：2009-01-20

    申请人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    发明人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    IPC分类号： A61K31/551 ,  C07D243/08

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/14 ,  C07H15/203 ,  C07H15/26

    摘要： There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl) carbamoyl]-6′-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.

    摘要翻译： 提供了基于活化凝血因子X的抑制具有抗凝血作用的化合物，并且可用作血栓形成或栓塞引起的疾病的抗凝剂或预防/治疗剂。 有效成分是诸如4'-溴-2' - [（5-氯-2-吡啶基）氨基甲酰基] -6' - （b-）-D-吡喃半乳糖氧基-1-异丙基哌啶-4-甲酰苯胺，2' - （ -2'-乙酰氨基-2-脱氧-α-D-吡喃葡萄糖基氧基）-4'-溴-6' - [（5-氯-2-吡啶基）氨基甲酰基] -1-异丙基哌啶-4-甲酰苯胺等或其盐 。

    SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF
    6.
    发明申请
    SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF 失效
    取代的苯甲酸衍生物或其盐

    公开(公告)号：US20090137498A1

    公开(公告)日：2009-05-28

    申请号：US12356376

    申请日：2009-01-20

    申请人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    发明人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    IPC分类号： A61K31/704 ,  C07D211/26

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/14 ,  C07H15/203 ,  C07H15/26

    摘要： There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl)carbamoyl]-6′-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.

    摘要翻译： 提供了基于活化凝血因子X的抑制具有抗凝血作用的化合物，并且可用作血栓形成或栓塞引起的疾病的抗凝剂或预防/治疗剂。 有效成分是诸如4'-溴-2' - [（5-氯-2-吡啶基）氨基甲酰基] -6'-β-D-吡喃半乳糖氧基-1-异丙基哌啶-4-甲酰苯胺，2' - （2 - 乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基氧基）-4'-溴-6' - [（5-氯-2-吡啶基）氨基甲酰基] -1-异丙基哌啶-4-甲酰苯胺等或其盐。

    Hexahydro-1,4-diazepine derivatives or salts thereof
    7.
    发明授权
    Hexahydro-1,4-diazepine derivatives or salts thereof 失效
    六氢-1,4-二氮杂衍生物或其盐

    公开(公告)号：US06333320B1

    公开(公告)日：2001-12-25

    申请号：US09463017

    申请日：2000-01-19

    申请人： Hiroyuki Koshio ,  Fukushi Hirayama ,  Tsukasa Ishihara ,  Masashi Funatsu ,  Tomihisa Kawasaki ,  Yuzo Matsumoto

    发明人： Hiroyuki Koshio ,  Fukushi Hirayama ,  Tsukasa Ishihara ,  Masashi Funatsu ,  Tomihisa Kawasaki ,  Yuzo Matsumoto

    IPC分类号： A61K3155

    CPC分类号： C07D405/12 ,  C07D243/08

    摘要： Hexahydro-1,4-diazepine derivatives represented by general formula (I); pharmaceutically acceptable salts thereof; and drugs containing the same as the active ingredient, such as activated blood coagulation factor X inhibitor, wherein A: phenylene, pyridylene, or the like; B: a 5- or 6-membered aryl or heteroaryl ring; X: —CO—, —CONH—, —CSNH—, —SO2—, —SO2NH—, or the like; Y: a bond or alkylene; R1: hydrogen, alkyl, —Y—(hetero) aryl, or the like; R2: hydrogen, alkoxy, —COOH, or the like; R3: amidino or a group capable of being converted into amidino; and R4, R5: each independently hydrogen or lower alkyl.

    摘要翻译： 由通式（I）表示的六氢-1,4-二氮杂衍生物; 其药学上可接受的盐; 以及与活性成分相同的药物，例如活化凝血因子X抑制剂，其中A：亚苯基，亚吡啶基等; B：5-或6-元芳基或杂芳基环; X：-CO - ， - CONH - ， - CSH - ， - SO 2 - ， - SO 2 NH-等; Y：一个键或亚烷基; R1：氢，烷基，-Y-（杂）芳基等; R2：氢，烷氧基，-COOH等; R3：脒基或能够转化为脒基的基团; 和R 4，R 5：各自独立地为氢或低级烷基。