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21 条记录 (耗时 0.028 秒)

    Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity
    1.
    发明授权
    Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity 失效
    具有抗肿瘤活性的羟基和氨基取代的四氢呋喃衍生物

    公开(公告)号：US06864283B2

    公开(公告)日：2005-03-08

    申请号：US10203918

    申请日：2001-02-16

    申请人： Tatsuo Higa ,  Junichi Tanaka ,  Dolores Garcia Gravalos

    发明人： Tatsuo Higa ,  Junichi Tanaka ,  Dolores Garcia Gravalos

    IPC分类号： A61K31/341 ,  A61K35/56 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07D307/22 ,  A61K31/34 ,  C07D307/02 ,  C07F4/28

    CPC分类号： C07D307/22

    摘要： Compounds of formula (I) wherein R1is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, or substituted or unsubstituted aryl; or R1 together with R2 forms a saturated or unsaturated heterocyclic ring; R2 and R3 are each, independently, selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, or substituted or unsubstituted aryl; or one of R2 or R3 together with R1 forms a saturated or unsaturated heterocyclic ring; or R2 and R3 together form a saturated or unsaturated heterocyclic ring; R4 is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18, alkynyl, or substituted or unsubstituted aryl, wherein R′ is selected from the group consisting of H, OH, NO2, NH2, SH, CN, halogen, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted and unsubstituted aryl; R″ is selected from the group consisting of H, OH, NO2, NH2, SH, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted and unsubstituted aryl; wherein X1, X2 X3 on formula I are independently placed in any particular position of the chain and independently selected from H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHC(O)R′, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic, wherein substituent groups defined by R′ are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHC(O)R′, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaromatic; wherein x is 6 to 20; and wherein the dotted lined is one or several optional double bonds placed in any particular position of the side chain; or pharmaceutically acceptable salts thereof are useful as antitumor compounds and include compound IK-8-73-4 of structure (a) which was isolated from a sponge Pachastrissa sp.

    摘要翻译： 其中R 1选自H，C（= O）R'，P（= O）R'R“，S（= O）R'R”，取代或未取代的C 1 -C 18烷基， 取代或未取代的C 2 -C 18烯基，取代或未取代的C 2 -C 18炔基或取代或未取代的芳基; 或R 1与R 2一起形成饱和或不饱和杂环; R 2和R 3各自独立地选自H，C（= O）R'，P（= O）R'R“，S（= O）R'R”，取代或未取代的C 1 -C 18烷基， 取代或未取代的C 2 -C 18烯基，取代或未取代的C 2 -C 18炔基或取代或未取代的芳基; 或R 2或R 3中的一个与R 1一起形成饱和或不饱和杂环; 或R 2和R 3一起形成饱和或不饱和杂环; R 4选自H，C（= O）R'，P（= O）R'R“，S（= O）R'R”，取代或未取代的C 1 -C 18烷基，取代或未取代的C 2 -C 18 烯基，取代或未取代的C 2 -C 18炔基或取代或未取代的芳基，其中R'选自H，OH，NO 2，NH 2，SH，CN，卤素，C（= O）H，C（ C = O）CH 3，CO 2 H，CO 2 CH 3，取代或未取代的C 1 -C 18烷基，取代或未取代的C 2 -C 18烯基，取代或未取代的C 2 -C 18炔基，取代和未取代的芳基; R“选自H，OH，NO 2，NH 2，SH，CN，卤素，= O，C（= O）H，C（= O）CH 3，CO 2 H，CO 2 CH 3，取代或未取代的C1- C18烷基，取代或未取代的C2-C18烯基，取代或未取代的C2-C18

    Antitumor alkaloids
    4.
    发明授权
    Antitumor alkaloids 失效
    抗肿瘤生物碱

    公开(公告)号：US4895854A

    公开(公告)日：1990-01-23

    申请号：US228868

    申请日：1988-08-05

    申请人： Tatsuo Higa ,  Ryuichi Sakai

    发明人： Tatsuo Higa ,  Ryuichi Sakai

    IPC分类号： C07D519/00

    CPC分类号： C07D519/00

    摘要： This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge genus Haliclona.

    摘要翻译： 本发明涉及抗肿瘤生物碱组合物，制备组合物的方法和利用该组合物抑制肿瘤的方法。 更具体地，组合物是衍生自海洋生物体的海洋海绵属Haliclona的抗肿瘤生物碱。

    Antitumor alkaloids
    5.
    发明授权
    Antitumor alkaloids 失效
    抗肿瘤生物碱

    公开(公告)号：US4895852A

    公开(公告)日：1990-01-23

    申请号：US124672

    申请日：1987-11-24

    申请人： Tatsuo Higa ,  Ryuichi Sakai ,  Toshio Ichiba

    发明人： Tatsuo Higa ,  Ryuichi Sakai ,  Toshio Ichiba

    IPC分类号： C07D519/00

    CPC分类号： C07D519/00

    摘要： This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge Xestospongia, sp.

    摘要翻译： 本发明涉及抗肿瘤生物碱组合物，制备组合物的方法和利用该组合物抑制肿瘤的方法。 更具体地，组合物是衍生自海洋生物的抗肿瘤生物碱，即海洋海绵Xestospongia，sp。

    Antiviral guanidine derivatives compositions and their methods of use
    8.
    发明授权
    Antiviral guanidine derivatives compositions and their methods of use 失效
    抗病毒胍衍生物组合物及其使用方法

    公开(公告)号：US4851441A

    公开(公告)日：1989-07-25

    申请号：US153469

    申请日：1988-01-28

    申请人： Tatsuo Higa ,  Ryuichi Sakai

    发明人： Tatsuo Higa ,  Ryuichi Sakai

    IPC分类号： C07C279/08 ,  C07D239/42

    CPC分类号： C07D239/42 ,  C07C279/08

    摘要： This invention relates to antiviral organic guanidine derivatives compositions; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are tubastrines derived from marine coral Tubastrea aurea.

    摘要翻译： 本发明涉及抗病毒有机胍衍生物组合物; 制备抗病毒组合物的方法; 以及利用该组合物抑制病毒的方法。 更具体地，组合物是衍生自海洋珊瑚Tubastrea aurea的大豆。