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    FC binding protein and method for manufacturing same
    1.
    发明授权
    FC binding protein and method for manufacturing same 有权
    FC结合蛋白及其制造方法

    公开(公告)号：US09453066B2

    公开(公告)日：2016-09-27

    申请号：US13583550

    申请日：2011-03-10

    申请人： Kouta Hatayama ,  Yoshiharu Asaoka ,  Toru Tanaka ,  Teruhiko Ide

    发明人： Kouta Hatayama ,  Yoshiharu Asaoka ,  Toru Tanaka ,  Teruhiko Ide

    IPC分类号： C07K1/00 ,  A23J1/00 ,  C07K14/735 ,  C07K1/22 ,  C07K17/08 ,  C07K16/00

    CPC分类号： C07K14/70535 ,  C07K1/22 ,  C07K17/08 ,  C07K2319/21

    摘要： Disclosed are: an Fc binding protein having increased stability with respect to heat, acid, and/or alkalinity compared with the wild type; a method for producing same; and a method for specifically isolating protein containing an Fc binding protein binding site using said Fc binding protein as a ligand for affinity chromatography.An Fc binding protein was obtained having increased stability with respect to heat, acid, and/or alkalinity compared with the wild-type human Fc receptor by means of substituting at least one specific amino acid residue in the extracellular domain of the wild-type human Fc receptor with another amino acid residue. The Fc binding protein is useful as a ligand for affinity chromatography for example by immobilizing in a solid phase. Also, when the Fc binding protein is expressed using a host that has been transformed with an expression vector containing a polynucleotide coding for said protein, the amount of produced protein is increased compared with using a wild-type human Fc receptor.

    摘要翻译： 获得了与野生型人Fc受体相比，通过用野生型人细胞外结构域中的至少一个特定氨基酸残基取代的具有相对于热，酸和/或碱度的稳定性增加的Fc结合蛋白质 Fc受体与另一个氨基酸残基。 Fc结合蛋白可用作亲和层析的配体，例如通过固定在固相中。 此外，当使用已经用含有编码所述蛋白质的多核苷酸的表达载体转化的宿主来表达Fc结合蛋白时，与使用野生型人Fc受体相比，产生的蛋白质的量增加。

    FC BINDING PROTEIN AND METHOD FOR MANUFACTURING SAME
    3.
    发明申请
    FC BINDING PROTEIN AND METHOD FOR MANUFACTURING SAME 有权
    FC结合蛋白及其制造方法

    公开(公告)号：US20130079499A1

    公开(公告)日：2013-03-28

    申请号：US13583550

    申请日：2011-03-10

    申请人： Kouta Hatayama ,  Yoshiharu Asaoka ,  Toru Tanaka ,  Teruhiko Ide

    发明人： Kouta Hatayama ,  Yoshiharu Asaoka ,  Toru Tanaka ,  Teruhiko Ide

    IPC分类号： C07K14/735 ,  C07K17/08 ,  C07K1/22

    CPC分类号： C07K14/70535 ,  C07K1/22 ,  C07K17/08 ,  C07K2319/21

    摘要： Disclosed are: an Fc binding protein having increased stability with respect to heat, acid, and/or alkalinity compared with the wild type; a method for producing same; and a method for specifically isolating protein containing an Fc binding protein binding site using said Fc binding protein as a ligand for affinity chromatography.An Fc binding protein was obtained having increased stability with respect to heat, acid, and/or alkalinity compared with the wild-type human Fc receptor by means of substituting at least one specific amino acid residue in the extracellular domain of the wild-type human Fc receptor with another amino acid residue. The Fc binding protein is useful as a ligand for affinity chromatography for example by immobilizing in a solid phase. Also, when the Fc binding protein is expressed using a host that has been transformed with an expression vector containing a polynucleotide coding for said protein, the amount of produced protein is increased compared with using a wild-type human Fc receptor.

    摘要翻译： 公开了：与野生型相比，相对于热，酸和/或碱度具有增加的稳定性的Fc结合蛋白; 其制造方法; 以及使用所述Fc结合蛋白作为亲和层析的配体来特异性分离含有Fc结合蛋白结合位点的蛋白质的方法。 获得了与野生型人Fc受体相比，通过用野生型人细胞外结构域中的至少一个特定氨基酸残基取代的具有相对于热，酸和/或碱度的稳定性增加的Fc结合蛋白 Fc受体与另一个氨基酸残基。 Fc结合蛋白可用作亲和层析的配体，例如通过固定在固相中。 此外，当使用已经用含有编码所述蛋白质的多核苷酸的表达载体转化的宿主来表达Fc结合蛋白时，与使用野生型人Fc受体相比，产生的蛋白质的量增加。

    Microorganism and method for producing carotenoid using it
    4.
    发明授权
    Microorganism and method for producing carotenoid using it 有权
    微生物和使用它生产类胡萝卜素的方法

    公开(公告)号：US08030022B2

    公开(公告)日：2011-10-04

    申请号：US12095511

    申请日：2006-10-19

    申请人： Toru Tanaka ,  Teruhiko Ide

    发明人： Toru Tanaka ,  Teruhiko Ide

    IPC分类号： C12P23/00

    CPC分类号： C12R1/01 ,  C12P23/00

    摘要： A carotenoid producing bacterium belonging to the genus Paracoccus that selectively produces canthaxanthin so that the amount thereof is not less than 90 percent by weight of the total amount of produced carotenoids including β-carotene, β-cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3′-hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin, and astaxanthin. A method for producing canthaxanthin by culturing the above bacterium, and then collecting carotenoids from bacterial cells or a culture solution after the culturing.

    摘要翻译： 属于副球菌属的类胡萝卜素生产菌选择性地生产角黄素，使其量不少于生产的类胡萝卜素总量的90％（重量），包括胡萝卜素，苦参碱，氢化chin酮，角黄素，3- 羟基ech en酮，3'-羟基ech in酮，玉米黄质，磷酸黄嘌呤，洋ix素和虾青素。 通过培养上述细菌生产角黄素的方法，然后在培养后从细菌细胞或培养液中收集类胡萝卜素。

    NOVEL MICROORGANISM AND METHOD FOR PRODUCING CAROTENOID USING THE SAME
    5.
    发明申请
    NOVEL MICROORGANISM AND METHOD FOR PRODUCING CAROTENOID USING THE SAME 有权
    新型微生物及其制造方法

    公开(公告)号：US20100285524A1

    公开(公告)日：2010-11-11

    申请号：US12095511

    申请日：2006-10-19

    申请人： Toru Tanaka ,  Teruhiko Ide

    发明人： Toru Tanaka ,  Teruhiko Ide

    IPC分类号： C12P23/00 ,  C12N1/20 ,  C12N1/21

    CPC分类号： C12R1/01 ,  C12P23/00

    摘要： [Object] To provide a canthaxanthin selective producing bacterium being able to easily extract and purify canthaxanthin, which is one of carotenoids, and a method for producing canthaxanthin by a culture method.[Solving Means] A carotenoid producing bacterium belonging to the genus Paracoccus is provided which selectively produces canthaxanthin so that the amount thereof is not less than 90 percent by weight of the total amount of produced carotenoids including β-carotene, β-cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3′-hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin, and astaxanthin. In addition, a method for producing canthaxanthin is provided which has the steps of culturing the above bacterium, and then collecting carotenoids from bacterial cells or a culture solution after the culturing.

    摘要翻译： 本发明提供能够容易地提取和纯化作为类胡萝卜素的角黄素的角黄素选择性生产菌，以及通过培养方法制备角黄素的方法。 [解决方案]提供属于副球菌属的类胡萝卜素生产细菌，其选择性地产生角黄素，其量不小于包含“胡萝卜素”，“副霉黄素”的生产的类胡萝卜素总量的90重量％ 海参酮，角黄素，3-羟基喹喔啉酮，3'-羟基喹喔啉酮，玉米黄质，磷酸黄嘌呤，亚二黄素和虾青素。 此外，提供了一种生产角黄素的方法，其具有培养上述细菌的步骤，然后在培养后从细菌细胞或培养液中收集类胡萝卜素。

    Tetrahydroisoquinoline derivatives, processes for producing the same and fungicides containing the same
    6.
    发明授权
    Tetrahydroisoquinoline derivatives, processes for producing the same and fungicides containing the same 失效
    四氢异喹啉衍生物，其制备方法和含有它们的杀真菌剂

    公开(公告)号：US5401752A

    公开(公告)日：1995-03-28

    申请号：US820732

    申请日：1992-01-15

    申请人： Takumi Tokunaga ,  Teruhiko Ide ,  Hiroyuki Watanabe ,  Kenji Tsuzuki ,  Yasuhito Takasu

    发明人： Takumi Tokunaga ,  Teruhiko Ide ,  Hiroyuki Watanabe ,  Kenji Tsuzuki ,  Yasuhito Takasu

    IPC分类号： A01N43/42 ,  A01N47/06 ,  A01N47/22 ,  C07D217/04 ,  C07D217/12 ,  C07D217/16 ,  C07D217/24 ,  C07D217/26 ,  C07D405/04 ,  A01N43/40

    CPC分类号： C07D405/04 ,  A01N43/42 ,  A01N47/06 ,  A01N47/22 ,  C07D217/04 ,  C07D217/12 ,  C07D217/16 ,  C07D217/24 ,  C07D217/26

    摘要： Tetrahydroisoquinoline derivatives useful as fungicides are disclosed of formula [I]: ##STR1## wherein R.sup.1 represents C.sub.1 -C.sub.5 linear or branched alkyl, C.sub.2 -C.sub.5 linear or branched alkenyl, C.sub.2 -C.sub.5 linear or branched alkynyl; R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6, the same or different, represent hydrogen, C.sub.1 -C.sub.10 linear or branched alkyl, C.sub.3 -C.sub.10 linear or branched alkenyl, C.sub.2 -C.sub.10 linear or branched alkynyl, C.sub.1 -C.sub.10 linear or branched alkoxy, C.sub.2 -C.sub.10 linear or branched alkenyloxy, C.sub.2 -C.sub.10 linear or branched alkynyloxy, benzyloxy, hydroxy, haloalkyl, amino, mono- or di-substituted amino substituted with C.sub.1 -C.sub.4 linear or branched alkyl, phenyl or halogen; R.sup.2 and R.sup.3 may be bonded through a group of the formula --O--CH.sub.2).sub.m O-- wherein m represents integer of 1 or 2 or --CH.dbd.CH).sub.2 to form a ring; and R.sup.4 and R.sup.5 may be bonded through a group of the formula --O--CH.sub.2).sub.m O-- wherein m represents an integer of 1 or 2 or --CH.dbd.CH).sub.2 -- to form a ring.

    摘要翻译： 公开了用作杀真菌剂的四氢异喹啉衍生物：其中R 1表示C 1 -C 5直链或支链烷基，C 2 -C 5直链或支链烯基，C 2 -C 5直链或支链炔基的式[I] R2，R3，R4，R5和R6相同或不同，表示氢，C1-C10直链或支链烷基，C3-C10直链或支链烯基，C2-C10直链或支链炔基，C1-C10直链或支链烷氧基， C 2 -C 10直链或支链烯氧基，C 2 -C 10直链或支链炔氧基，苄氧基，羟基，卤代烷基，氨基，被C 1 -C 4直链或支链烷基，苯基或卤素取代的一取代或二取代的氨基; R2和R3可以通过式-O-CH2）mO-基团键合，其中m表示1或2的整数或-CH = CH）2以形成环; 并且R 4和R 5可以通过式-O-CH 2）m O - 的基团键合，其中m表示1或2的整数或-CH = CH）2 - 以形成环。

    Microorganism and method for producing canthaxanthin
    7.
    发明授权
    Microorganism and method for producing canthaxanthin 失效
    微生物和生产角黄素的方法

    公开(公告)号：US08569014B2

    公开(公告)日：2013-10-29

    申请号：US13206999

    申请日：2011-08-10

    申请人： Toru Tanaka ,  Teruhiko Ide

    发明人： Toru Tanaka ,  Teruhiko Ide

    IPC分类号： C12P23/00

    CPC分类号： C12R1/01 ,  C12P23/00

    摘要： A carotenoid producing bacterium belonging to the genus Paracoccus that selectively produces canthaxanthin so that the amount thereof is not less than 90 percent by weight of the total amount of produced carotenoids including β-carotene, β-cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3′-hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin, and astaxanthin. A method for producing canthaxanthin by culturing the above bacterium, and then collecting carotenoids from bacterial cells or a culture solution after the culturing.

    摘要翻译： 属于副球菌属的产生类胡萝卜素的细菌选择性地生产角黄素，其量不小于包含β-胡萝卜素，β-隐黄质，海参酮，角黄素，3-羟基喹喔啉酮的生产类胡萝卜素总量的90重量％ 3'-羟基喹喔啉酮，玉米黄质，磷酸黄嘌呤，亚二黄素和虾青素。 通过培养上述细菌生产角黄素的方法，然后在培养后从细菌细胞或培养液中收集类胡萝卜素。

    Thiadiazole derivative, process for producing it and agricultural and horticultural fungicide using it as an active ingredient
    10.
    发明授权
    Thiadiazole derivative, process for producing it and agricultural and horticultural fungicide using it as an active ingredient 失效
    噻二唑衍生物，其生产方法和农业和园艺用杀真菌剂作为活性成分

    公开(公告)号：US5478849A

    公开(公告)日：1995-12-26

    申请号：US230789

    申请日：1994-04-21

    申请人： Yasuaki Hanasaki ,  Hiroyuki Watanabe ,  Kimio Katsuura ,  Masatoshi Fujiwara ,  Teruhiko Ide

    发明人： Yasuaki Hanasaki ,  Hiroyuki Watanabe ,  Kimio Katsuura ,  Masatoshi Fujiwara ,  Teruhiko Ide

    IPC分类号： A01N43/82 ,  A01N43/832 ,  A01N47/06 ,  A01N47/18 ,  C07D285/10

    CPC分类号： C07D285/10 ,  A01N43/82 ,  A01N47/06 ,  A01N47/18

    摘要： Disclosed is (a) 1,2,5-thiadiazole derivatives represented by the following formulae [I] or [III]: ##STR1## wherein X and Y are the same or different and each represents a hydrogen atom, a halogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, a nitro group, a trifluoromethyl group, a carboxyl group, an alkoxycarbonyl group having from 2 to 5 carbon atoms, a naphthyl group or a tetrahydronaphthyl group; and A represents an alkyl group having from 1 to 6 carbon atoms, --C(.dbd.O)OR.sup.1, --C(.dbd.O)NR.sup.2 R.sup.3, a phenyl group which may be substituted by at least one of an alkyl group having from 1 to 6 carbon atoms and an alkoxy group having from 1 to 4 carbon atoms, --CHR.sup.4 C(.dbd.O)R.sup.5 or --C(.dbd.O)R.sup.6, in which R.sup.1 represents an alkyl group having from 1 to 6 carbon atoms, R.sup.2 and R.sup.3 are the same or different and each represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms, R.sup.4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, R.sup.5 represents an alkoxy group having from 1 to 4 carbon atoms or an amino group which may be substituted by at least one of an alkyl group having from 1 to 4 carbon atoms and a phenyl group which may be substituted by at least one halogen atom, and R.sup.6 represents an alkyl group having from 1 to 6 carbon atoms, (b) a process for producing the compound represented by formula [I] and (c) an agricultural and horticultural fungicide comprising the compound represented by formula [III].

    摘要翻译： 公开了（a）由下式[I]或[III]表示的1,2,5-噻二唑衍生物：相同或不同，表示氢原子，卤素原子，1〜6的烷基 碳原子，具有1至4个碳原子的烷氧基，硝基，三氟甲基，羧基，具有2至5个碳原子的烷氧基羰基，萘基或四氢萘基; 并且A表示具有1至6个碳原子的烷基，-C（= O）OR 1，-C（= O）NR 2 R 3，可被至少一个具有1-6个碳原子的烷基取代的苯基 碳原子和具有1至4个碳原子的烷氧基，-CHR 4 C（= O）R 5或-C（= O）R 6，其中R 1表示具有1至6个碳原子的烷基，R 2和R 3为 相同或不同，各自表示氢原子或具有1至6个碳原子的烷基，R 4表示氢原子或具有1至4个碳原子的烷基，R 5表示具有1至4个碳原子的烷氧基 或可被至少一个具有1至4个碳原子的烷基和可被至少一个卤素原子取代的苯基取代的氨基，R 6表示具有1至6个碳原子的烷基 原子，（b）由式[I]和（c）代表的化合物的制备方法，包括该组合物的农业和园艺杀真菌剂 并由式[III]表示。