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公开(公告)号：US20240216472A1
公开(公告)日：2024-07-04
申请号：US18404724
申请日：2024-01-04
CPC分类号： A61K38/2066 , A61K9/0019 , A61K38/1709 , A61K45/06 , A61P37/06
摘要： Disclosed are means, methods, and compositions of matter useful for induction of antigen specific suppression of immunity and/or tolerogenesis through administration of tolerogenic agents together with antigens and/or modified antigens delivered via multiple intradermal injections. In one embodiment the invention teaches the use of a tattoo gun or a similar device to administer over an extended area of skin a compound which induces a tolerogenic microenvironment and subsequently administration of said antigen in the artificially created microenvironment. The essence of the disclosed invention is the superior tolerogenic effects observed when tolerogenic stimuli and antigen are administered over an extended area of skin through the use of a tattoo gun or similar device
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公开(公告)号：US20240082356A1
公开(公告)日：2024-03-14
申请号：US18465972
申请日：2023-09-12
CPC分类号： A61K38/193 , A61K31/09 , A61K35/28 , A61P11/00
摘要： Disclosed are means of inducing pulmonary regeneration and/or protection from oxidative stress by stimulation of endogenous stem cell mobilization together with one or more inhibitors of NF-kappa B and/or one or more inhibitors of oxidative stress. The invention discloses the unexpected finding that G-CSF administration enhances oxidative stress and pulmonary damage, however, coadministration with pterostilbene, results in synergistic suppression of COPD pathology.
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公开(公告)号：US20230301938A1
公开(公告)日：2023-09-28
申请号：US18106925
申请日：2023-02-07
发明人： Thomas ICHIM , Timothy G. DIXON
IPC分类号： A61K31/09 , A61K31/122 , A61K31/26 , A61K36/71 , A61K36/82
CPC分类号： A61K31/09 , A61K31/122 , A61K31/26 , A61K36/71 , A61K36/82
摘要： Disclosed are means and methods of treating cognitive dysfunction associated with COVID-19 and/or other associated with inflammatory conditions. In one embodiment treatment of COVID-19 cognitive dysfunction performed by administration of nutraceutical means, wherein said nutraceuticals are administered at a frequency and/or concentration sufficient to induce proliferation of endogenous neural progenitor cells and/or protect cells from inflammatory damage. In one embodiment said nutraceuticals are comprised of green tea extract, and/or nigella sativa, and/or pterostilbene, and/or sulforaphane. In some embodiments nutraceutical compositions are utilized to overcome treatment resistant of currently used antidepressants.
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公开(公告)号：US20230085607A1
公开(公告)日：2023-03-16
申请号：US17931872
申请日：2022-09-13
发明人： Thomas E. Ichim , Famela Ramos , James Veltmeyer , Timothy G. Dixon , Feng Lin , Wais Kaihani
IPC分类号： A61K31/7048 , A61K31/353 , A61K31/09 , A61K31/122 , A61K31/26 , A61K36/82 , A61K36/45 , A61K36/71 , A61K36/31
摘要： Disclosed are novel mechanisms of action of ivermectin therapy as related to treatment of COVID-19 and means of augmenting therapeutic activities by co-administration with one or more of the following: pterostilbene, thymoquinone, epigallocatechin-3-gallate, and sulforaphane. In one embodiment the invention provides enhanced reduction of inflammation induced pulmonary leakage without augmenting immune suppressive mechanisms.
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公开(公告)号：US20230057957A1
公开(公告)日：2023-02-23
申请号：US17821754
申请日：2022-08-23
IPC分类号： A61K35/51 , A61K38/20 , C12N5/0775
摘要： The invention discloses means of treating lung degenerative diseases including chronic obstructive pulmonary disease (CODP) using umbilical cord mesenchymal stem cells such as JadiCells alone, and/or using said cells under conditions that are activated in order to endow enhanced regenerative activity. In one embodiment said activation of said mesenchymal stem cells is performed through stimulation with a toll like receptor agonist at a concentration and duration sufficient to induce a >50% increase in keratinocyte growth factor expression from said stem cells. In another embodiment the invention provides the use of JadiCells as a means of producing exosomes, wherein said exosomes possess therapeutic properties capable of reducing inflammation, fibrosis and degeneration associated with COPD, as well as stimulation of regenerative activity. In some JadiCells are activated by a treatment with Activated Protein C.
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公开(公告)号：US20220370561A1
公开(公告)日：2022-11-24
申请号：US17748943
申请日：2022-05-19
IPC分类号： A61K38/19 , A61K33/24 , A61K35/28 , A61K31/395
摘要： Disclosed are compositions of matter, therapeutics, and protocols useful for reduction and/or reversion of pulmonary fibrosis. In one specific embodiment lithium chloride is administered together with a regenerative cell in a patient suffering from, or at risk of pulmonary fibrosis. In one embodiment said lithium chloride is administered as an adjuvant to a regenerative therapy, wherein said regenerative therapy is a gene therapy, a protein therapy, a cell therapy, or a tissue transplant. In one embodiment lithium chloride, or a salt thereof is utilized alone, or with a regenerative means, to evoke preservation and/or elongation of telomere length in pulmonary tissue.
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公开(公告)号：US20220370499A1
公开(公告)日：2022-11-24
申请号：US17748997
申请日：2022-05-19
发明人： Thomas E. Ichim , Famela Ramos , James Veltmeyer , Timothy G. Dixon , Feng Lin , Wais Kaihani
IPC分类号： A61K35/17 , C12N5/0784 , C12N5/0789 , A61K39/00 , A61P37/06
摘要： Disclosed are novel means, protocols, and compositions of matter for creating targeted immune responses and/or induction of immunological memory towards the tumor vasculature. In one embodiment pluripotent stem cells are transfected with one or more genes capable of eliciting immunity, induced to differentiate into endothelial-like cells which resemble the tumor endothelial cells, and utilized as a vaccine. In some embodiment's genes are engineered under control of specific promoters to allow for various specificities of activity. In one specific embodiment pluripotent stem cells engineered to endow properties capable of inducing expression of the α-Gal epitope (Galα1,3Galα1,4GlcNAc-R). Addition of adjuvants to enhance antigen presentation of the vaccine composition, as well as means of stimulating systemic enhancement of circulating endothelial specific T cells are also disclosed.
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公开(公告)号：US20220280574A1
公开(公告)日：2022-09-08
申请号：US17687478
申请日：2022-03-04
摘要： The invention discloses compositions of matter, protocols, and therapeutic means for treatment of suicidal ideations and/or suppression of suicidal attempts. In one embodiment the invention provides the use of umbilical cord derived monocytes as a means of treatment. In another embodiment, monocytes are de-differentiated from adult monocytes using reprogramming means to create monocyte capable of producing anti-inflammatory as well as regenerative properties useful in reducing suicidal ideations and/or attempts.
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公开(公告)号：US20220267730A1
公开(公告)日：2022-08-25
申请号：US17677816
申请日：2022-02-22
发明人： Thomas E. Ichim , Timothy G. Dixon , Feng LIN , Famela Ramos , James Veltmeyer
IPC分类号： C12N5/0784 , C12N5/078
摘要： Disclosed are means, methods and compositions of matter useful for induction of immunity towards cancer stem cells by providing a dendritic cell, wherein said dendritic cells express BORIS and/or peptides derived from BORIS, wherein said dendritic cell is cultured in the presence of one or more immunocytes. In one embodiment said dendritic cells are derived from umbilical cord blood sources and allogeneic to T cells, which are expanded ex vivo and used for the purposes of immunotherapy.
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公开(公告)号：US20220249551A1
公开(公告)日：2022-08-11
申请号：US17667349
申请日：2022-02-08
摘要： Disclosed are means, methods and compositions of matter useful for induction of natural killer cell memory by administration of dendritic cells and/or exosomes thereof. In one embodiment a mammal suffering from cancer is administered allogeneic cord blood derived dendritic cells that are not pulsed exogenously. In one embodiment the dendritic cells are stimulated to possess chemotactic activity towards the tumor by culture of dendritic cell progenitors in hypoxia. Natural killer cell memory is induced, in part, by triggering of upregulation of cytokines associated with homeostatic expansion such as interleukin 7 and interleukin 15.
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