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公开(公告)号：US20240269148A1
公开(公告)日：2024-08-15
申请号：US18443160
申请日：2024-02-15
IPC分类号： A61K31/567 , A61K35/44 , A61K45/06 , A61P35/00
CPC分类号： A61K31/567 , A61K35/44 , A61K45/06 , A61P35/00
摘要： Parallels between pregnancy and cancer have been historically made, however, the ability to leverage abortogenic immunity against neoplasia has not been widely examined. The current invention provides means of suppressing tumor associated immune inhibition through administration of progesterone and/or glucocorticoid receptor antagonists such as RU-486. In one embodiment the invention provides the concurrent utilization RI-486 and anti-angiogenic immunotherapy. In another embodiment, abortogenic inhibitors of immunity such as indolamine 2,3 dioxygenase are administered together with RU-486 and/or anti-angiogenic immunotherapy. Various antiangiogenic agents can be utilized in the practice of the invention including the ValloVax immunotherapy and/or the StemVacs-V therapy.
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公开(公告)号：US11957727B2
公开(公告)日：2024-04-16
申请号：US17395249
申请日：2021-08-05
IPC分类号： A61K36/82 , A61K31/09 , A61K31/122 , A61K31/26 , A61K31/353 , A61K36/31 , A61K36/45 , A61K36/71 , A61P25/28
CPC分类号： A61K36/82 , A61K31/09 , A61K31/122 , A61K31/26 , A61K31/353 , A61K36/31 , A61K36/45 , A61K36/71 , A61P25/28
摘要： Disclosed are means, methods, and therapeutic compositions for prevention of memory loss during situations of neuroinflammation. In one embodiment the invention teaches administration of the therapeutic combination of ingredients comprising of pterostilbene, Nigella sativa, sulforaphane, and epigallocatechin-3-gallate (EGCG) to a mammal suffering from inflammation in order to preserver memory function.
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公开(公告)号：US20220403330A1
公开(公告)日：2022-12-22
申请号：US17748189
申请日：2022-05-19
发明人： Thomas E. Ichim , Famela Ramos , James Veltmeyer , Timothy G. Dixon , Feng Lin
摘要： Disclosed are novel means, protocols, and compositions of matter for eliciting an immune response against blood vessels supplying neoplastic tissue. In one embodiment pluripotent stem cells are transfected with one or more genes capable of eliciting immunity. In some embodiments such genes are engineered under control of specific promoters to allow for various specificities of activity. In one specific embodiment pluripotent stem cells engineered to endow properties capable of inducing expression of the α-Gal epitope (Galα1,3Galα1,4G1cNAc-R).
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公开(公告)号：US20220023237A1
公开(公告)日：2022-01-27
申请号：US17383269
申请日：2021-07-22
IPC分类号： A61K31/155 , A61K36/82 , A61K36/45 , A61K36/31 , A23L33/105
摘要： Disclosed are compositions of matter, treatments and protocols useful for prevention of SARS-CoV-2 infection, as well as inhibition of viral propagation and acceleration of viral cure. In some embodiments the invention teaches the administration of a therapeutic combination of ingredients comprising of metformin, pterostilbene, nigella sativa, sulforaphane, and epigallocatechin-3-gallate (EGCG) to a mammal at risk of infection with SARS-CoV-2. In another embodiment, the invention teaches administration of said therapeutic combination to a mammal infected with said SARS-CoV-2. In some embodiments dosage of said therapeutic combination is based on inflammatory and/or immunological parameters observed in patients with COVID-19.
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公开(公告)号：US20220235325A1
公开(公告)日：2022-07-28
申请号：US17585377
申请日：2022-01-26
发明人： Thomas Ichim , Timothy G. Dixon , James Veltmeyer , Famela Ramos
IPC分类号： C12N5/0784
摘要： Disclosed are means, methods, and compositions of matter useful for enhancement of dendritic cell activity. In one embodiment the invention provides the use of GABA agonists such as homotaurine for stimulation of dendritic cell activity. In one embodiment said dendritic cell activity is enhancement of natural killer cell activity and/or of T cell activity. In one embodiment NK cell activity is ability to induce cytotoxicity in neoplastically transformed cells, whereas T cell activity is either cytokine production for CD4 cells or cytotoxicity for CD8 cells.
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公开(公告)号：US20220193127A1
公开(公告)日：2022-06-23
申请号：US17556985
申请日：2021-12-20
发明人： Thomas Ichim , Timothy G. Dixon , Famela Ramos , Wais Kaihani , James Veltmeyer , Kalina O'Connor
摘要： Disclosed are means, methods and compositions of matter useful for reduction of brain inflammation and prevention of opioid addiction and/or tolerance. In one embodiment the invention provides utilization of platelet rich plasma (PRP), alone, or admixed with regenerative/anti-inflammatory adjuvants, for reduction of neural inflammation. In one embodiments PRP is admixed with oxytocin and administered intranasally in a patient at risk of opioid addiction. In another embodiment, PRP is admixed with fortified and non-fortified nigella sativa oil, and/or pterostilbene and administered intranasally. Other embodiments include utilization of autologous stromal vascular fraction cells alone and/or admixed with regenerative/anti-inflammatory adjuvants.
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公开(公告)号：US12011462B2
公开(公告)日：2024-06-18
申请号：US17934460
申请日：2022-09-22
发明人： Thomas E. Ichim , Famela Ramos , James Veltmeyer , Timothy G. Dixon , Feng Lin , Kalina O'Connor
摘要： Disclosed are novel means of enhancing mesenchymal stem cell regenerative activities including, intra alia, production from pulmonary leakage and suppression of scar tissue formation by co-administration with T regulatory cells. In some embodiments the invention provides an interaction between T regulatory cells and mesenchymal stem cells in which T regulatory cells stimulate upregulation of mesenchymal stem cell activity in a GITR dependent manner.
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公开(公告)号：US11504410B2
公开(公告)日：2022-11-22
申请号：US17387158
申请日：2021-07-28
IPC分类号： A61K36/82 , A61K31/09 , A61K36/45 , A61K31/26 , A61K36/31 , A61K31/353 , A61K31/122 , A61K36/71
摘要： Disclosed are means, compositions of matter, and protocols useful for neuroprotection and neuroregeneration. In one embodiment the invention provides administration of pterostilbene alone or in combination with other ingredients to induce neuroprotection and/or neuroregeneration. The invention teaches protection/regeneration in conditions associated with neurological inflammation and/or other congenital or acquired neurodegenerative diseases.
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公开(公告)号：US20220175701A1
公开(公告)日：2022-06-09
申请号：US17545301
申请日：2021-12-08
IPC分类号： A61K31/138 , A61K36/235 , A61K36/82 , A61K31/09 , A61K31/095 , A61K45/06
摘要： Disclosed are means and methods of treating major depressive disorder and/or other disorders that predispose to suicide by administration of nutraceutical means, wherein said nutraceuticals are administered at a frequency and/or concentration sufficient to induce proliferation of endogenous neural progenitor cells. In one embodiment said nutraceuticals are comprised of green tea extract, and/or Nigella sativa, and/or pterostilbene, and/or sulforaphane. In some embodiment's nutraceutical compositions are utilized to overcome treatment resistant of currently used antidepressants.
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公开(公告)号：US20230085607A1
公开(公告)日：2023-03-16
申请号：US17931872
申请日：2022-09-13
发明人： Thomas E. Ichim , Famela Ramos , James Veltmeyer , Timothy G. Dixon , Feng Lin , Wais Kaihani
IPC分类号： A61K31/7048 , A61K31/353 , A61K31/09 , A61K31/122 , A61K31/26 , A61K36/82 , A61K36/45 , A61K36/71 , A61K36/31
摘要： Disclosed are novel mechanisms of action of ivermectin therapy as related to treatment of COVID-19 and means of augmenting therapeutic activities by co-administration with one or more of the following: pterostilbene, thymoquinone, epigallocatechin-3-gallate, and sulforaphane. In one embodiment the invention provides enhanced reduction of inflammation induced pulmonary leakage without augmenting immune suppressive mechanisms.
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