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公开(公告)号：US08410193B2
公开(公告)日：2013-04-02
申请号：US12367521
申请日：2009-02-07
申请人： Thomas E. Day
发明人： Thomas E. Day
CPC分类号： A61L27/306 , A61L2430/02
摘要： A method of preparing a ceramic-resin composite material for bone repair, including preparing a predetermined amount of pH controlled substantially anhydrous coupling agent by mixing a liquid silane material, alcohol and organic acid, producing particulate bioactive glass having a desired particle size of less than about 53 mesh, measuring a desired quantity of the particulate bioactive glass into a mixing vessel, heating the mixing vessel and particulate bioactive glass to about 100 degrees Celsius, mixing the heated quantity of particulate bioactive glass and spraying a predetermined amount of substantially anhydrous coupling agent into the heated quantity of particulate bioactive glass to define an admixture, mixing the admixture for sufficient time to define a quantity of substantially evenly coated particles, heating the quantity of substantially evenly coated particles for sufficient time to evolve excess solvent therefrom, and incorporating the quantity of substantially evenly coated particles into a resinous matrix to define a bone replacement medium.
摘要翻译： 一种制备用于骨修复的陶瓷 - 树脂复合材料的方法，包括通过混合液体硅烷材料，醇和有机酸来制备预定量的pH控制的基本上无水的偶联剂，制备具有小于等于 约53目，将所需量的颗粒生物活性玻璃测量到混合容器中，将混合容器和颗粒生物活性玻璃加热至约100摄氏度，将加热量的颗粒生物活性玻璃混合并喷洒预定量的基本上无水的偶联剂 进入加热量的颗粒状生物活性玻璃以限定混合物，将混合物混合足够的时间以限定一定量的基本上均匀包覆的颗粒，加热基本上均匀包覆的颗粒的量足够的时间以从其中释放过量的溶剂，并且将数量 大致均匀c 将卵石颗粒转化成树脂基质以限定骨置换介质。
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公开(公告)号：US20140180434A1
公开(公告)日：2014-06-26
申请号：US13721724
申请日：2012-12-20
申请人： Thomas E. Day , Erik M. Erbe , Steven B. Jung
发明人： Thomas E. Day , Erik M. Erbe , Steven B. Jung
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2210/0004 , A61F2210/0076 , A61L27/10 , A61L27/12 , A61L27/427 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.
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公开(公告)号：US08567162B2
公开(公告)日：2013-10-29
申请号：US12914376
申请日：2010-10-28
申请人： Charanpreet S. Bagga , Hyun W. Bae , Thomas E. Day
发明人： Charanpreet S. Bagga , Hyun W. Bae , Thomas E. Day
CPC分类号： A61F2/28 , A61F2/0095 , A61F2002/30957 , A61F2002/4495 , A61F2310/00329
摘要： The present disclosure relates to a dynamic bioactive bone graft material and a method of handling the material to prepare an implant. In one embodiment, a method of preparing a dynamic bioactive bone graft implant is provided. The method includes the step of providing a porous, fibrous composition of bioactive glass fibers, wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and wherein the porosity of the matrix ranges from about 100 nanometers to about 1 millimeter. The porous, fibrous composition is introduced into a mold tray, and a shaped implant is created using the mold tray. The composition may be wetted with a fluid such as saline or a naturally occurring body fluid like blood prior to creating the shaped implant. In another embodiment, the porous, fibrous composition is provided with the mold tray as a kit.
摘要翻译： 本公开涉及动态生物活性骨移植材料和处理材料以制备植入物的方法。 在一个实施方案中，提供了制备动态生物活性骨移植物植入物的方法。 该方法包括提供生物活性玻璃纤维的多孔纤维组合物的步骤，其中纤维的特征在于纤维直径范围为约5纳米至约100微米，并且其中基质的孔隙率为约100纳米至约1 毫米。 将多孔的纤维组合物引入模具托盘中，并使用模具托盘产生成形植入物。 在产生成形植入物之前，组合物可以用流体如盐水或天然存在的体液如血液润湿。 在另一个实施方案中，多孔纤维组合物作为试剂盒设置有模托盘。
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公开(公告)号：US20110213468A1
公开(公告)日：2011-09-01
申请号：US12367521
申请日：2009-02-07
申请人： Thomas E. Day
发明人： Thomas E. Day
CPC分类号： A61L27/306 , A61L2430/02
摘要： A method of preparing a ceramic-resin composite material for bone repair, including preparing a predetermined amount of pH controlled substantially anhydrous coupling agent by mixing a liquid silane material, alcohol and organic acid, producing particulate bioactive glass having a desired particle size of less than about 53 mesh, measuring a desired quantity of the particulate bioactive glass into a mixing vessel, heating the mixing vessel and particulate bioactive glass to about 100 degrees Celsius, mixing the heated quantity of particulate bioactive glass and spraying a predetermined amount of substantially anhydrous coupling agent into the heated quantity of particulate bioactive glass to define an admixture, mixing the admixture for sufficient time to define a quantity of substantially evenly coated particles, heating the quantity of substantially evenly coated particles for sufficient time to evolve excess solvent therefrom, and incorporating the quantity of substantially evenly coated particles into a resinous matrix to define a bone replacement medium.
摘要翻译： 一种制备用于骨修复的陶瓷 - 树脂复合材料的方法，包括通过混合液体硅烷材料，醇和有机酸来制备预定量的pH控制的基本上无水的偶联剂，制备具有小于等于 约53目，将所需量的颗粒生物活性玻璃测量到混合容器中，将混合容器和颗粒生物活性玻璃加热至约100摄氏度，将加热量的颗粒生物活性玻璃混合并喷洒预定量的基本上无水的偶联剂 进入加热量的颗粒状生物活性玻璃以限定混合物，将混合物混合足够的时间以限定一定量的基本上均匀包覆的颗粒，加热基本上均匀包覆的颗粒的量足够的时间以从其中释放过量的溶剂，并且将数量 大致均匀c 将卵石颗粒转化成树脂基质以限定骨置换介质。
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公开(公告)号：US20110140316A1
公开(公告)日：2011-06-16
申请号：US12914376
申请日：2010-10-28
申请人： CHARANPREET S. BAGGA , Hyun W. Bae , Thomas E. Day
发明人： CHARANPREET S. BAGGA , Hyun W. Bae , Thomas E. Day
CPC分类号： A61F2/28 , A61F2/0095 , A61F2002/30957 , A61F2002/4495 , A61F2310/00329
摘要： The present disclosure relates to a dynamic bioactive bone graft material and a method of handling the material to prepare an implant. In one embodiment, a method of preparing a dynamic bioactive bone graft implant is provided. The method includes the step of providing a porous, fibrous composition of bioactive glass fibers, wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and wherein the porosity of the matrix ranges from about 100 nanometers to about 1 millimeter. The porous, fibrous composition is introduced into a mold tray, and a shaped implant is created using the mold tray. The composition may be wetted with a fluid such as saline or a naturally occurring body fluid like blood prior to creating the shaped implant. In another embodiment, the porous, fibrous composition is provided with the mold tray as a kit.
摘要翻译： 本公开涉及动态生物活性骨移植材料和处理材料以制备植入物的方法。 在一个实施方案中，提供了制备动态生物活性骨移植物植入物的方法。 该方法包括提供生物活性玻璃纤维的多孔纤维组合物的步骤，其中纤维的特征在于纤维直径范围为约5纳米至约100微米，并且其中基质的孔隙率为约100纳米至约1 毫米。 将多孔的纤维组合物引入模具托盘中，并使用模具托盘产生成形植入物。 在产生成形植入物之前，组合物可以用流体如盐水或天然存在的体液如血液润湿。 在另一个实施方案中，多孔纤维组合物作为试剂盒设置有模托盘。
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公开(公告)号：US20110144764A1
公开(公告)日：2011-06-16
申请号：US12914772
申请日：2010-10-28
申请人： CHARANPREET S. BAGGA , Hyun W. Bae , Thomas E. Day
发明人： CHARANPREET S. BAGGA , Hyun W. Bae , Thomas E. Day
CPC分类号： A61F2/28 , A61F2/30965 , A61F2002/30011 , A61F2002/30032 , A61F2002/3092 , A61F2250/0023 , A61F2250/003 , A61F2310/00329 , A61L27/10 , A61L27/56 , A61L2430/02
摘要： The present disclosure relates to a bone graft material and a bone graft implant formed from the material. In some embodiments, the bone graft implant comprises a porous matrix having a plurality of overlapping and interlocking bioactive glass fibers and a plurality of pores dispersed throughout the matrix, whereby the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the pores are characterized by pore diameters ranging from about 100 nanometers to about 1 millimeter. The implant may be formed into a desired shape for a clinical application. The embodiments may be employed to treat a bone defect. For example, the bone graft material may be wetted and molded into a suitable form for implantation. The implant may then be introduced into a prepared anatomical site.
摘要翻译： 本公开涉及由该材料形成的骨移植材料和骨移植物植入体。 在一些实施方案中，骨移植物植入物包括具有多个重叠和互锁的生物活性玻璃纤维的多孔基质和分散在整个基质中的多个孔，其中纤维的特征在于纤维直径范围为约5纳米至约100微米， 并且孔的特征在于孔直径范围为约100纳米至约1毫米。 植入物可以形成为期望的形状用于临床应用。 可以采用这些实施例来治疗骨缺损。 例如，骨移植材料可以被润湿并模制成适合的植入形式。 然后将植入物引入制备的解剖部位。
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公开(公告)号：US20100136086A1
公开(公告)日：2010-06-03
申请号：US12437531
申请日：2009-05-07
申请人： Thomas E. Day , Erik M. Erbe
发明人： Thomas E. Day , Erik M. Erbe
CPC分类号： A61L27/56 , A61F2/28 , A61F2002/3084 , A61L27/58 , A61L2400/12 , A61L2430/02
摘要： A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure and plurality of pores distributed throughout the scaffold. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material.
摘要翻译： 一种可再吸收的骨移植物支架材料，其包括限定支架结构的多个重叠和互锁纤维以及分布在整个支架中的多个孔。 纤维的特征在于纤维直径范围为约5纳米至约100微米，纤维为生物活性的可再吸收材料。
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公开(公告)号：US4487371A
公开(公告)日：1984-12-11
申请号：US377653
申请日：1982-05-13
申请人： Thomas E. Day
发明人： Thomas E. Day
CPC分类号： B02C18/062 , B02C18/2216
摘要： A novel comminution apparatus and method for comminuting a granular feed into a product having a predetermined particle size. The comminution apparatus includes a high-speed cutter member operating inside a screen enclosure having adjustable openings in the screen enclosure. A lever arm is used to adjust the relative openings between an inner screen and an outer screen of the screen enclosure with the size of the openings in the screen enclosure predetermining the particle size range passing therethrough. Rotation of the cutter member creates an air flow outwardly through the screen enclosure while an air recycle system directs the airflow across the outlet to a feed hopper to carry the particulate feed into contact with the cutter assembly.
摘要翻译： 一种用于将颗粒饲料粉碎成具有预定粒度的产品的新型粉碎设备和方法。 粉碎设备包括在屏幕外壳内具有可调节的开口的屏幕外壳内操作的高速切割器部件。 杠杆臂用于调整屏幕外壳的内屏幕和外屏幕之间的相对开口，屏幕外壳中的开口尺寸预先确定通过其的粒度范围。 切割器构件的旋转通过筛网外壳向外产生空气流，而空气循环系统将气流通过出口引导到进料斗，以使颗粒进料与切割器组件接触。
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公开(公告)号：US20140214173A1
公开(公告)日：2014-07-31
申请号：US14227019
申请日：2014-03-27
申请人： Thomas E. Day , Erik M. Erbe , Steven B. Jung
发明人： Thomas E. Day , Erik M. Erbe , Steven B. Jung
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2210/0004 , A61F2210/0076 , A61L27/10 , A61L27/12 , A61L27/427 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.
摘要翻译： 可再吸收的骨移植支架材料，包括限定支架结构的多个重叠和互锁纤维，分布在整个支架中的多个孔以及分布在整个孔中的多个玻璃微球。 纤维的特征在于纤维直径范围为约5纳米至约100微米，纤维为生物活性的可再吸收材料。 纤维通常占支架材料的约20至约40重量％，其中微球有助于平衡。
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公开(公告)号：US20110144763A1
公开(公告)日：2011-06-16
申请号：US12914468
申请日：2010-10-28
申请人： CHARANPREET S. BAGGA , HYUN W. BAE , THOMAS E. DAY
发明人： CHARANPREET S. BAGGA , HYUN W. BAE , THOMAS E. DAY
CPC分类号： A61L27/427 , A61L2400/12 , A61L2430/02
摘要： The present disclosure relates to a dynamic bioactive bone graft material having an engineered porosity. In one embodiment, a bone graft material is provided having bioactive glass fibers arranged in a porous matrix that is moldable into a desired shape for implantation. The material can be substantially without additives and can include at least one nanofiber. The porous matrix may include a combination of one or more pore sizes including nanopores, macropores, mesopores, and micropores. In another embodiment, a bone graft implant is provided having a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and having a distributed porosity based on a range of pores provided in the bioactive glass fibers. The distributed porosity can comprise a combination of macropores, mesopores, and micropores, and the matrix can be formable into a desired shape for implantation into a patient.
摘要翻译： 本公开涉及具有工程孔隙度的动态生物活性骨移植材料。 在一个实施方案中，提供骨移植材料，其具有布置在多孔基质中的生物活性玻璃纤维，其可模塑成用于植入的所需形状。 该材料可以基本上不含添加剂，并且可以包括至少一种纳米纤维。 多孔基质可以包括一个或多个孔径的组合，包括纳米孔，大孔，介孔和微孔。 在另一个实施方案中，提供骨移植物植入物，其具有包含多个重叠和互锁生物活性玻璃纤维的基质，并且基于生物活性玻璃纤维中提供的一定范围的孔具有分布孔隙率。 分布的孔隙可以包括大孔，中孔和微孔的组合，并且基质可以形成用于植入患者体内的所需形状。
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