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公开(公告)号：US10857277B2
公开(公告)日：2020-12-08
申请号：US13586824
申请日：2012-08-15
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
摘要： Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.
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公开(公告)号：US20140190876A1
公开(公告)日：2014-07-10
申请号：US13791755
申请日：2013-03-08
CPC分类号： A61M1/1696 , A61M1/284 , A61M1/287 , A61M1/288 , A61M1/3413 , A61M1/3472 , A61M1/3679 , A61M2205/3303 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , B01D15/08 , B01D15/361 , B01J20/0292 , B01J20/048 , B01J20/06 , B01J20/08 , B01J20/20 , B01J20/28052 , B01J39/10 , B01J39/12 , B01J39/18 , B01J41/10 , B01J41/12 , B01J47/012 , B01J47/026 , B01J47/14 , B01J2220/49
摘要： A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid. The system has a sorbent regeneration system for regeneration of the fluid and has a sorbent cartridge that has at least one material layer. The fluid is conveyed through the sorbent cartridge and contacts at least one sensor after having contacted at least one material layer.
摘要翻译： 一种用于测量流体至少一种组分的溶质浓度的基于吸附剂的监测系统。 该系统具有用于再生流体的吸附剂再生系统，并具有至少一个材料层的吸附剂盒。 流体通过吸附剂药筒输送，并且在接触至少一个材料层之后接触至少一个传感器。
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公开(公告)号：US08593816B2
公开(公告)日：2013-11-26
申请号：US13239037
申请日：2011-09-21
申请人： Rajesh V. Iyer , Michael G. Marinkov , Lea A. Nygren , Jeffrey J. Clayton , James Strom , Thomas E. Meyer , Steven T. Deininger , Wayne R. Kuechenmeister
发明人： Rajesh V. Iyer , Michael G. Marinkov , Lea A. Nygren , Jeffrey J. Clayton , James Strom , Thomas E. Meyer , Steven T. Deininger , Wayne R. Kuechenmeister
CPC分类号： A61N1/3754 , H01R24/68 , H01R43/20 , H01R2107/00
摘要： A connector assembly for an implantable medical device includes a plurality of feedthroughs mounted in a conductive array plate, each feedthrough in the plurality of feedthroughs including a feedthrough pin electrically isolated from the conductive array plate by an insulator and an electronic module assembly including a plurality of conductive strips set in a non-conductive block. The plurality of conductive strips is in physical and electrical contact with the feedthrough pins at an angle of less than 135 degrees. The connector assembly further includes at least one circuit, the circuit including a plurality of conductors corresponding to the plurality of feedthroughs. The plurality of conductors of the circuit is in physical and electrical contact with a corresponding one of the conductive strips of the plurality of conductive strips of the electronic module assembly at an angle of less than 135 degrees.
摘要翻译： 用于可植入医疗装置的连接器组件包括安装在导电阵列板中的多个馈通，多个馈通中的每个馈通包括通过绝缘体与导电阵列板电绝缘的馈通引脚，以及包括多个 导电条设置在非导电块中。 多个导电条以小于135度的角度与馈通销物理和电接触。 连接器组件还包括至少一个电路，该电路包括对应于多个馈通的多个导体。 电路的多个导体以小于135度的角度物理和电接触电子模块组件的多个导电条中的相应导电条之一。
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4.发明授权Potassium loaded ion-exchange material for use in a dialysate regeneration system 有权用于透析液再生系统的负载钾的离子交换材料公开(公告)号：US09399090B2
公开(公告)日：2016-07-26
申请号：US13757796
申请日：2013-02-02
CPC分类号： A61M1/1656 , A61M1/1654 , A61M1/1666 , A61M1/1668 , A61M1/1672 , A61M1/1696 , A61M1/287 , A61M2205/3317
摘要： Systems and methods for managing the potassium concentration of a dialysate fluid during hemodialysis therapy using cation exchange materials that do not release sodium ions.
摘要翻译： 使用不释放钠离子的阳离子交换材料，在血液透析治疗期间管理透析液的钾浓度的系统和方法。
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公开(公告)号：US09173987B2
公开(公告)日：2015-11-03
申请号：US13757717
申请日：2013-02-01
CPC分类号： A61M1/3627 , A61M1/16 , A61M1/1605 , A61M1/165 , A61M1/1658 , A61M1/1666 , A61M1/3609 , A61M1/3626 , A61M5/36 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/502 , A61M2205/505 , A61M2205/7536 , A61M2209/00 , B01D19/0031
摘要： A degassing module for removal of air and other gases during operation of a medical therapy device that delivers any one of hemodialysis, hemodiafiltration and hemofiltration. The degassing module has a flow-through first chamber that has a hydrophobic vent membrane that has an exterior and interior side forming a portion of the flow-through chamber. The hydrophobic vent membrane is positioned at a higher elevation on the flow-through chamber than a fluid outlet. Fluid flows through the flow-through chamber in a downward direction relative to the hydrophobic vent membrane. A flow-through chamber has a cross sectional area configured to provide for a downward flow velocity of the fluid to be less than the upward rise velocity of a smallest bubble to be removed from the fluid.
摘要翻译： 用于在输送任何一种血液透析，血液透析滤过和血液滤过的医疗治疗装置的操作期间去除空气和其它气体的脱气模块。 脱气模块具有流通的第一室，其具有疏水排气膜，其具有形成流通室的一部分的外部和内侧。 疏水通气膜在流通室上的位置处于比流体出口更高的高度。 流体相对于疏水通气膜沿向下的方向流过流通室。 流通室具有被配置为提供流体的向下流动速度的横截面积小于要从流体移除的最小气泡的向上升速。
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公开(公告)号：US20140220699A1
公开(公告)日：2014-08-07
申请号：US13837287
申请日：2013-03-15
CPC分类号： A61M1/1656 , A61M1/1605 , A61M1/1658 , A61M1/1668 , A61M1/1696 , A61M1/287 , A61M2205/3317 , A61M2205/7518 , G01N33/84
摘要： A pH-buffer measurement system that has at least one source for modifying the pH of a fluid entering the system, the source selected from an acid source and a base source. The acid source adds an acid equivalent to provide an acid reacted fluid and the base source adds a base equivalent to provide a base reacted fluid. The source is in fluid communication with a flow path and a component for determining a fluid characteristic of the acid reacted fluid or the base reacted fluid. The fluid characteristic that is measured is any one of a gas phase pressure, an electrical conductivity, or thermal conductivity.
摘要翻译： pH缓冲测量系统，其具有至少一个来源，用于改变进入系统的流体的pH，源自酸源和碱源。 酸源添加酸当量以提供酸反应的流体，并且碱源添加碱当量以提供碱反应的流体。 源与流路和用于确定酸反应流体或基底反应流体的流体特性的部件流体连通。 测量的流体特性是气相压力，导电性或热导率中的任一种。
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7.发明申请SODIUM AND BUFFER SOURCE CARTRIDGES FOR USE IN A MODULAR CONTROLLED COMPLIANT FLOW PATH 有权用于模块化控制的合规流程中的钠和缓冲源源公开(公告)号：US20140217030A1
公开(公告)日：2014-08-07
申请号：US13757722
申请日：2013-02-01
CPC分类号： A61M1/3621 , A61M1/16 , A61M1/1605 , A61M1/165 , A61M1/1658 , A61M1/1666 , A61M1/3609 , A61M1/3627 , A61M2205/3317 , A61M2205/3324 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , A61M2205/502 , A61M2205/505 , A61M2230/65
摘要： Systems and methods for using a sodium chloride source and a buffer source such as sodium bicarbonate in a controlled compliant flow path to generate from water a physiologically compatible fluid having a suitable level of a sodium ion and/or a buffer for use in hemodialysis, hemodiafiltration and hemofiltration. The system has a conditioning flow path that has at least a salination valve or salination pump, and at least one container has at least one solute in excess of the solubility of that solute. At least one of the solutes is a buffer source or sodium chloride. The conditioning flow path is in fluid communication with a controlled compliant flow path. The conditioning flow path can selectively meter fluid into and out of the controlled compliant flow path.
摘要翻译： 在受控的顺应性流动路径中使用氯化钠源和缓冲源如碳酸氢钠的系统和方法，以从水中产生具有适合水平的钠离子和/或缓冲液的生理学相容的液体，用于血液透析，血液透析 和血液滤过。 该系统具有至少具有盐化阀或盐化泵的调节流动路径，并且至少一个容器具有超过该溶质的溶解度的至少一个溶质。 至少一种溶质是缓冲源或氯化钠。 调节流动路径与受控制的顺应流动路径流体连通。 调节流动路径可以选择性地将流体进入和流出被控制的顺应流动路径。
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8.发明申请POTASSIUM LOADED ION-EXCHANGE MATERIAL FOR USE IN A DIALYSATE REGENERATION SYSTEM 有权用于DIALYSATE再生系统的钾负载离子交换材料公开(公告)号：US20140158538A1
公开(公告)日：2014-06-12
申请号：US13757796
申请日：2013-02-02
IPC分类号： A61M1/16
CPC分类号： A61M1/1656 , A61M1/1654 , A61M1/1666 , A61M1/1668 , A61M1/1672 , A61M1/1696 , A61M1/287 , A61M2205/3317
摘要： Systems and methods for managing the potassium concentration of a dialysate fluid during hemodialysis therapy using cation exchange materials that do not release sodium ions.
摘要翻译： 使用不释放钠离子的阳离子交换材料，在血液透析治疗期间管理透析液的钾浓度的系统和方法。
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公开(公告)号：US20130070423A1
公开(公告)日：2013-03-21
申请号：US13239037
申请日：2011-09-21
申请人： Rajesh V. Iyer , Michael G. Marinkov , Lea A. Nygren , Jeffrey J. Clayton , James Strom , Thomas E. Meyer , Steven T. Deininger , Wayne R. Kuechenmeister
发明人： Rajesh V. Iyer , Michael G. Marinkov , Lea A. Nygren , Jeffrey J. Clayton , James Strom , Thomas E. Meyer , Steven T. Deininger , Wayne R. Kuechenmeister
CPC分类号： A61N1/3754 , H01R24/68 , H01R43/20 , H01R2107/00
摘要： A connector assembly for an implantable medical device includes a plurality of feedthroughs mounted in a conductive array plate, each feedthrough in the plurality of feedthroughs including a feedthrough pin electrically isolated from the conductive array plate by an insulator and an electronic module assembly including a plurality of conductive strips set in a non-conductive block. The plurality of conductive strips is in physical and electrical contact with the feedthrough pins at an angle of less than 135 degrees. The connector assembly further includes at least one circuit, the circuit including a plurality of conductors corresponding to the plurality of feedthroughs. The plurality of conductors of the circuit is in physical and electrical contact with a corresponding one of the conductive strips of the plurality of conductive strips of the electronic module assembly at an angle of less than 135 degrees.
摘要翻译： 用于可植入医疗装置的连接器组件包括安装在导电阵列板中的多个馈通，多个馈通中的每个馈通包括通过绝缘体与导电阵列板电绝缘的馈通引脚，以及包括多个 导电条设置在非导电块中。 多个导电条以小于135度的角度与馈通销物理和电接触。 连接器组件还包括至少一个电路，该电路包括对应于多个馈通的多个导体。 电路的多个导体以小于135度的角度物理和电接触电子模块组件的多个导电条中的相应导电条之一。
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公开(公告)号：US09144640B2
公开(公告)日：2015-09-29
申请号：US13836973
申请日：2013-03-15
IPC分类号： A61M1/16
CPC分类号： A61M1/1656 , A61M1/1654 , A61M1/1668 , A61M1/167 , A61M1/1696 , A61M1/287 , A61M1/3486 , A61M2205/02 , B01D15/08
摘要： A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.
摘要翻译： 一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。 流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合 并且与第一选择的再生物质流体连通地流过第二再生模块。
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