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    MULTI-STAGED FILTRATION SYSTEM FOR BLOOD FLUID REMOVAL
    2.
    发明申请
    MULTI-STAGED FILTRATION SYSTEM FOR BLOOD FLUID REMOVAL 有权
    用于血液清除的多级过滤系统

    公开(公告)号：US20150258268A1

    公开(公告)日：2015-09-17

    申请号：US14369602

    申请日：2013-01-04

    申请人： Kenneth J. Collier ,  Bryant J. Pudil ,  Martin T. Gerber

    发明人： Kenneth J. Collier ,  Bryant J. Pudil ,  Martin T. Gerber

    IPC分类号： A61M1/34 ,  B01D63/00 ,  B01D61/14 ,  A61M1/16 ,  B01D15/08

    CPC分类号： A61M1/3472 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1633 ,  A61M1/34 ,  A61M1/3475 ,  A61M1/3479 ,  A61M1/3482 ,  A61M1/3486 ,  A61M2205/75 ,  B01D15/08 ,  B01D61/145 ,  B01D61/243 ,  B01D61/28 ,  B01D63/00 ,  B01D63/043 ,  B01D63/08 ,  B01D2313/40 ,  B01D2317/02 ,  B01D2319/06

    摘要： A device includes (i) a housing defining an interior, wherein the interior has a blood compartment, a plasma compartment, and a fluid compartment; (ii) a first filter disposed in the interior of the housing, and (iii) a second filter disposed in the interior of the housing. The first filter separates at least a portion of the blood compartment from at least a portion of the plasma compartment. The first filter is configured to allow plasma components, but not cell components, of blood to pass through the first filter from the blood compartment to the plasma compartment. The second filter separates at least a portion of the plasma compartment from at least a portion of the fluid compartment. The second filter is configured to allow fluid and small molecules, but not larger components, to pass through the second filter from the plasma compartment to the fluid compartment. The device may include a sorbent in the plasma compartment to remove or reduce the concentration of selected components of the plasma. In embodiments, a system including the device includes a sorbent with which the plasma may be contacted.

    摘要翻译： 一种装置包括（i）限定内部的壳体，其中内部具有血液隔室，等离子体隔室和流体隔室; （ii）设置在壳体内部的第一过滤器，和（iii）设置在壳体内部的第二过滤器。 第一过滤器将血液隔室的至少一部分与等离子体室的至少一部分分离。 第一过滤器被配置为允许血液的血浆成分但不是细胞成分从血液隔室通过第一过滤器到等离子体室。 第二过滤器将至少一部分等离子体隔室与流体室的至少一部分分开。 第二过滤器被配置为允许流体和小分子但不是较大的组分通过第二过滤器从等离子体室传递到流体室。 该装置可以包括在等离子体室中的吸附剂以去除或降低等离子体的选定组分的浓度。 在实施方案中，包括该装置的系统包括可与等离子体接触的吸附剂。

    Recombinant growth hormone releasing factor
    3.
    发明授权
    Recombinant growth hormone releasing factor 失效
    重组生长激素释放因子

    公开(公告)号：US4728609A

    公开(公告)日：1988-03-01

    申请号：US778779

    申请日：1985-09-24

    申请人： Ram S. Bhatt ,  Kenneth J. Collier ,  Robert M. Crowl ,  Mohindar S. Poonian

    发明人： Ram S. Bhatt ,  Kenneth J. Collier ,  Robert M. Crowl ,  Mohindar S. Poonian

    IPC分类号： C07H21/00 ,  C12P21/00 ,  C07H15/12 ,  C12N1/00 ,  C12N1/20 ,  C12N15/00 ,  C12P21/02

    CPC分类号： C07H21/00 ,  Y10S930/12

    摘要： Th preparation of a double-stranded polydeoxy ribonucleotide having cohesive termini each comprising one strand of a double-strand restriction endonuclease recognition site and, between the termini, a structural gene coating for the expression of recombinant growth hormone releasing factor, at least a majority of the codons and the coding strand of said gene being codons preferred for the expression of microbial genomes; a method of producing such DNA a recombinant microbial cloning vehicle comprising such DNA and the novel methods of producing said peptide are described.

    摘要翻译： 制备具有粘连末端的双链多脱氧核糖核苷酸，每个包含双链限制性内切核酸酶识别位点的一条链，并且在该末端之间，用于表达重组生长激素释放因子的结构基因包膜，至少大部分 所述基因的密码子和编码链是用于表达微生物基因组的密码子; 描述了生产这种DNA的方法，包含这种DNA的重组微生物克隆载体和产生所述肽的新方法。