公开(公告)号：US5002661A

公开(公告)日：1991-03-26

申请号：US398739

申请日：1989-08-25

申请人： William L. Chick ,  Susan J. Sullivan ,  Kermit M. Borland ,  John M. Harvey ,  Thomas E. Muller ,  Karen E. Dunleavy ,  Donald P. King, Jr. ,  Edward J. Doherty ,  Barry A. Solomon ,  Amy L. Foley

发明人： William L. Chick ,  Susan J. Sullivan ,  Kermit M. Borland ,  John M. Harvey ,  Thomas E. Muller ,  Karen E. Dunleavy ,  Donald P. King, Jr. ,  Edward J. Doherty ,  Barry A. Solomon ,  Amy L. Foley

IPC分类号： A61M1/36 ,  A61F2/02 ,  A61L27/04 ,  A61L27/14 ,  A61M1/16 ,  A61M1/34

CPC分类号： A61M1/3472 ,  A61F2/022 ,  A61L27/04 ,  A61L27/14 ,  A61M1/3475 ,  A61M1/1678

摘要： A device which serves as an artificial pancreas comprises a hollow fiber having an inner diameter of about 5 mm which is surrounded by islets of Langerhans enclosed in a housing. The islets are suspended in a semi-solid matrix which ensures desired distribution of the cells about the hollow fiber. The hollow fiber and suspended islets are enclosed in a housing which further aids the desired distribution of islets about the hollow fiber. The hollow fiber has a porosity which selectively allows passage of substances having a molecular weight of less than about 100,000 Daltons. The semi-solid matrix in which the islets are embedded and suspended is formed of an appropriate supporting material such as alginate or agar.

摘要翻译： 用作人造胰腺的装置包括内径约5mm的中空纤维，其被包围在壳体中的朗格汉斯岛包围。 将胰岛悬浮在半固体基质中，确保细胞围绕中空纤维的期望分布。 中空纤维和悬挂的胰岛被封闭在壳体中，这进一步有助于围绕中空纤维的胰岛的期望分布。 中空纤维具有选择性地允许具有小于约100,000道尔顿的分子量的物质通过的孔隙率。 其中胰岛被嵌入和悬浮的半固体基质由合适的支撑材料如藻酸盐或琼脂形成。